1,4-Diaryl-substituted triazoles as cyclooxygenase-2 inhibitors: Synthesis, biological evaluation and molecular modeling studies

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 14, 2013, Pages 4288-4295

  Kaur, Jatinder ^a   Bhardwaj, Atul ^a   Sharma, Sai Kiran ^a   Wuest, Frank ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

1,4 Diaryl substituted triazoles; Click chemistry; COX 2; Cyclooxygenase; Inhibition; Molecular modeling

Indexed keywords

4 (4 4 TOLYL[1,2,3]TRIAZOL 1 YL METHYL)BENZENESULFONAMIDE; 4 (4 4 TOLYL[1,2,3]TRIAZOL 1 YL)BENZENESULFONAMIDE; 4 (4 PHENYL[1,2,3]TRIAZOL 1 YL METHYL)BENZENESULFONAMIDE; 4 (4 PHENYL[1,2,3]TRIAZOL 1 YL)BENZENESULFONAMIDE; 4 [2 (4 4 TOLYL[1,2,3]TRIAZOL 1 YL)ETHYL]BENZENESULFONAMIDE; 4 [2 (4 PHENYL[1,2,3]TRIAZOL 1 YL)ETHYL]BENZENESULFONAMIDE; 4 [2 [4 (4 CHLOROPHENYL) [1,2,3]TRIAZOL 1 YL]ETHYL]BENZENESULFONAMIDE; 4 [2 [4 (4 FLUOROPHENYL) [1,2,3]TRIAZOL 1 YL]ETHYL]BENZENESULFONAMIDE; 4 [2 [4 (4 METHOXYPHENYL) [1,2,3]TRIAZOL 1 YL]ETHYL]BENZENESULFONAMIDE; 4 [4 (4 CHLOROPHENYL) [1,2,3]TRIAZOL 1 YL METHYL]BENZENESULFONAMIDE; 4 [4 (4 CHLOROPHENYL) [1,2,3]TRIAZOL 1 YL]BENZENESULFONAMIDE; 4 [4 (4 FLUOROPHENYL) [1,2,3]TRIAZOL 1 YL METHYL]BENZENESULFONAMIDE; 4 [4 (4 FLUOROPHENYL) [1,2,3]TRIAZOL 1 YL]BENZENESULFONAMIDE; 4 [4 (4 METHOXYPHENYL) [1,2,3]TRIAZOL 1 YL METHYL]BENZENESULFONAMIDE; 4 [4 (4 METHOXYPHENYL) [1,2,3]TRIAZOL 1 YL]BENZENESULFONAMIDE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; MOLECULAR SIZE; STRUCTURE ACTIVITY RELATION;

CATALYTIC DOMAIN; CLICK CHEMISTRY; CYCLOOXYGENASE 2 INHIBITORS; ENZYME ACTIVATION; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; TRIAZOLES;

EID: 84879011739     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.04.074     Document Type: Article

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