Design and synthesis of new 1,3-benzdiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors

Archiv der Pharmazie

Volumn 345, Issue 4, 2012, Pages 257-264

  Zarghi, Afshin ^a   Zebardast, Tannaz ^a   Hajighasemali, Fatemeh ^b   Alipoor, Eskandar ^b   Daraie, Bahram ^c   Hedayati, Mehdi ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

^c TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

1,3 Benzdiazinan 4 ones; COX 2 inhibition; Docking studies; SAR

Indexed keywords

1,3 BENZDIAZINAN 4 ONE DERIVATIVE; 2 (4 CHLOROPHENYL) 3 (4 METHYLSULFONYLPHENYL) 1,3 BENZDIAZINAN 4 ONE; 2 (4 CHLOROPHENYL) 3 (4 METHYLTHIOPHENYL) 1,3 BENZDIAZINAN 4 ONE; 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL) 1,3 BENZDIAZINAN 4 ONE; 2 (4 FLUOROPHENYL) 3 (4 METHYLTHIOPHENYL) 1,3 BENZDIAZINAN 4 ONE; 2 (4 METHOXYPHENYL) 3 (4 METHYLSULFONYLPHENYL) 1,3 BENZDIAZINAN 4 ONE; 2 (4 METHYLPHENYL) 3 (4 METHYLSULFONYLPHENYL) 1,3 BENZDIAZINAN 4 ONE; 2 (4 METHYLPHENYL) 3 (4 METHYLTHIOPHENYL) 1,3 BENZDIAZINAN 4 ONE; 2 (4 METHYLSULFONYLPHENYL) 3 PHENYL 1,3 BENZDIAZINAN 4 ONE; 2 (4 METHYLTHIOPHENYL) 3 PHENYL 1,3 BENZDIAZINAN 4ONE; 3 (4 CHLOROPHENYL) 2 (4 METHYLSULFONYLPHENYL) 1,3 BENZDIAZINAN 4 ONE; 3 (4 CHLOROPHENYL) 2 (4 METHYLTHIOPHENYL) 1,3 BENZDIAZINAN 4 ONE; 3 (4 FLUOROPHENYL) 2 (4 METHYLSULFONYLPHENYL) 1,3 BENZDIAZINAN 4 ONE; 3 (4 FLUOROPHENYL) 2 (4 METHYLSULFONYLPHENYL) 1,3 BENZDIAZINANE 4 ONE; 3 (4 FLUOROPHENYL) 2 (4 METHYLTHIOPHENYL) 1,3 BENZDIAZINAN 4 ONE; 3 (4 METHOXYPHENYL) 2 (4 METHYLSULFONYLPHENYL) 1,3 BENZDIAZINAN 4 ONE; 3 (4 METHYLPHENYL) 2 (4 METHYLSULFONYLPHENYL) 1,3 BENZDIAZINAN 4 ONE; 3 (4 METHYLPHENYL) 2 (4 METHYLTHIOPHENYL) 1,3 BENZDIAZINAN 4 ONE; 3 (4 METHYLSULFONYLPHENYL) 2 PHENYL 1,3 BENZDIAZINAN 4 ONE; 3 (4 METHYLTHIOPHENYL) 2 PHENYL 1,3 BENZDIAZINAN 4 ONE; BENZYLSULFONYL FLUORIDE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ROFECOXIB; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; PRIORITY JOURNAL;

ANIMALS; BENZENE DERIVATIVES; CHEMISTRY, PHARMACEUTICAL; CYCLOOXYGENASE 2 INHIBITORS; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZINES;

EID: 84859700137     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201100138     Document Type: Article

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