Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 3, 2009, Pages 1146-1151

  Wuest, Frank ^a   Tang, Xinli ^a   Kniess, Torsten ^b   Pietzsch, Jens ^b   Suresh, Mavanur ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

Author keywords

Click chemistry; Cyclooxygenase 1 and 2 inhibitors; Triazoles

Indexed keywords

1 AZIDO 4 (METHYLSULFONYL)BENZENE; ACETYLENE DERIVATIVE; BENZENE DERIVATIVE; CELECOXIB; COPPER; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; METHANE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROSTAGLANDIN SYNTHASE; RUTHENIUM; SULFONE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CYCLOADDITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

CATALYSIS; COPPER; CYCLOOXYGENASE INHIBITORS; INHIBITORY CONCENTRATION 50; RUTHENIUM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 58949086472     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.032     Document Type: Article

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