The role of iron dysregulation in the pathogenesis of multiple sclerosis: An Egyptian study

Multiple Sclerosis

Volumn 14, Issue 5, 2008, Pages 602-608

  Abo Krysha, Noha ^a   Rashed, L ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

Iron; Multiple sclerosis; Transferrin receptor

Indexed keywords

CYTOKINE; IRON; MITOXANTRONE; STEROID; TRANSFERRIN RECEPTOR;

ADULT; AGE; ANAMNESIS; ANEMIA; ARTICLE; BLOOD ANALYSIS; BRAIN CAPILLARY; BRAIN FUNCTION; CAPILLARY ENDOTHELIUM; CELL TYPE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; DISEASE ACTIVITY; DISEASE COURSE; DISEASE DURATION; DRUG TARGETING; EGYPT; ENDOTHELIUM CELL; EVOKED RESPONSE; EXPANDED DISABILITY STATUS SCALE; FEMALE; HOSPITAL DEPARTMENT; HUMAN; IRON METABOLISM; IRON OVERLOAD; IRON TRANSPORT; LABORATORY TEST; MEDICAL EXAMINATION; MULTIPLE SCLEROSIS; NEUROIMAGING; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RATING SCALE; RELAPSE; SEX DIFFERENCE; UPREGULATION;

ACUTE DISEASE; ADOLESCENT; ADULT; EGYPT; EVOKED POTENTIALS, VISUAL; FEMALE; HUMANS; IRON; MAGNETIC RESONANCE IMAGING; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; OXIDATIVE STRESS; RECEPTORS, TRANSFERRIN; SOLUBILITY; UP-REGULATION;

EID: 46849118241     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458507085550     Document Type: Article

References (26)

1. Piñero, DJ, Connor, JR. Iron in the brain: an important contributor in normal and diseased states. Neuroscientist 2000; 6: 435-453.
2. Larkin, EC, Rao, A. Importance of fetal and neonatal iron: adequacy for normal development of the central nervous system. In: Brain, behaviour and iron in the infant diet. New York: Springer, 1990: 43-62.
3. Oka, A, Belliveau, MJ, Rosenberg, PA, Volpe, JJ. Vulnerability ofoligodendroglia to glutamate: pharmacology, mechanisms, and prevention. J Neurosci 1993; 13: 1441-1453.
4. Brock, JH, Stevenson, J. Replacement of transferrin in serum-free cultures of mitogen-stimulated mouse lymphocytes by a lipophilic iron chelator. Immunol Lett 1987; 15: 23-25.
5. Weinberg, ED. Cellular regulation of iron assimilation. Q Rev Biol 1989; 64: 261-290.
6. Testa, U, Petrini, M, Quafanta, MT, Pelosi-Testa, E, Mastroberardino, G, Camagna, A, et al. Iron up-modulates the expression of transferrin receptors during monocyte-macrophage maturation. J Biol Chem 1989; 264: 13181-13187.
7. Jefferies, WA, Brandon, MR, Hunt, SV, Williams, AF, Gatter, KC, Mason, DY. Transferrin receptor on endothelium of brain capillaries. Nature 1984; 312: 162-163.
8. Connor, JR, Menzies, SL. Cellular management of iron in the brain. J Neurol Sci Suppl 1995; 134: 33-44.
9. Poser, CM, Paty, DW, Scheinber, L, et al. New diagnostic criteria for multiple sclerosis; guidelines for research protocols. Ann Neurol 1983; 13; 227-231.
10. Noseworthy, JH, Vandervoot, MK, Wong, CJ, et al. Interrater variability with Expanded Disability Status Scales (EDSS) and functional system (FS) in a multiple sclerosis clinical trial. Neurology 1990; 40: 971-975.
11. Persijn, J, Silk, WVD, Riethorst, R. Determination of serum iron and latent binding capacity. Clin Chim Acta 1971; 35: 91-98.
12. Flower, CH, Skikne, BS, Covell, AM. Clinical measurement of STfR. J Lab Clin Med 1989; 114: 368-377.
13. Scarano, V, de Cristofaro, T, De Michele, G, Salvatore, E, De Biase, I, Monticelli, A, et al. Serum transferrin receptor levels in Friedreich's and other degenerative ataxias. Neurology 2001; 57: 159-160.
14. Moos, T, Morgan, EH. The metabolism of neuronal iron and its pathogenic role in neurological disease: review. Ann N Y Acad Sci 2004; 1012: 14-26.
15. LeVine, SM. Iron deposits in multiple sclerosis and Alzheimer's disease brains. Brain Res 1997; 760: 298-303.
16. Sfagos, C, Makis, AC, Chaidos, A, Hatzimichael, EC, Dalamaga, A, Kosma, K, et al. Serum ferritin, transferrin and soluble transferrin receptor levels in multiple sclerosis patients. Mult Scler 2005; 11: 272-275.
17. Piñero, DJ, Connor, JR. Iron in the brain: an important contributor in normal and diseased states. Mol Neurobiol 2000; 20: 77-95.
18. Roskams, Connor. Transferrin receptor expression in myelin deficient (MD) rats. J Neurosci Res 1992; 31: 421-442.
19. Moos, T, Morgan, EH. Transferrin and transferrin receptor function in brain barrier systems. Cell Mol Neurobiol 2000; 20: 77-95.
20. Mehindate, K, Sahlas, DJ, Frankel, D, Mawal, Y, Liberman, A, Corcos, J, et al. Proinflammatory cytokines promote glial heme oxygenase-1 expression and mitochondrial iron deposition: implications for multiple sclerosis. J Neurochem 2001; 77: 1386-1395.
21. Calabrese, V, Lodi, R, Tonon, C, D'Agata, V, Sapienza, M, Scapagnini, G, et al. Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia. J Neurol Sci 2005; 233: 145-162.
22. Exley, C, Mamutse, G, Korchazhkina, O, Pye, E, Strekopytov, S, Polwart, A, et al. Elevated urinary excretion of aluminium and iron in multiple sclerosis. Mult Scler 2006; 12: 533-540.
23. Syburra, C, Passi, S. Oxidative stress in patients with multiple sclerosis. Ukr Biokhim Zh 1999; 71: 112-115.
24. Zhang, X, Haaf, M, Todorich, B, Grosstephan, E, Schieremberg, H, Surguladze, N, et al. Cytokine toxicity to oligodendrocyte precursors is mediated by iron. Glia 2005; 52: 199-208.
25. Lynch, SG, Fonseca, T, Levine, SM. A multiple course trial of desferrioxamine in chronic progressive multiple sclerosis. Cell Mol Biol (Noisy-le-grand) 2000; 46: 865-869.
26. Brass, SD, Benedict, RH, Weinstock-Guttman, B, Munschauer, F, Bakshi, R. Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis. Mult Scler 2006; 12: 437-444.