Hepcidin expression in the liver: Relatively low level in patients with chronic hepatitis C

Molecular Medicine

Volumn 13, Issue 1-2, 2007, Pages 97-104

  Fujita, Naoki ^a   Sugimoto, Ryosuke ^a   Takeo, Masaki ^a   Urawa, Naohito ^a   Mifuji, Rumi ^a   Tanaka, Hideaki ^a   Kobayashi, Yoshinao ^a   Iwasa, Motoh ^a   Watanabe, Shozo ^b   Adachi, Yukihiko ^a   Kaito, Masahiko ^a  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b MIE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN; MESSENGER RNA;

ADULT; ALCOHOL LIVER DISEASE; ARTICLE; AUTOIMMUNE HEPATITIS; CONTROLLED STUDY; FEMALE; HEMATOLOGICAL PARAMETERS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; INFECTION; INFLAMMATION; IRON OVERLOAD; LIVER DISEASE; MALE; NONALCOHOLIC FATTY LIVER; PATHOGENESIS; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS;

ADULT; AGED; ALANINE TRANSAMINASE; ANTIMICROBIAL CATIONIC PEPTIDES; ASPARTATE AMINOTRANSFERASES; FEMALE; FERRITINS; HEMOGLOBINS; HEPACIVIRUS; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C, CHRONIC; HUMANS; IRON; IRON OVERLOAD; LIVER; LIVER DISEASES; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, VIRAL; TRANSFERRIN;

EID: 33847609799     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/2006-00057.Fujita     Document Type: Article

References (44)

1. Hentze MW, Muckenthaler MU, Andrews NC. (2004) Balancing acts: molecular control of mammalian iron metabolism. Cell 117:285-97.
2. Nicoras G, Viatte L, Bennoun M, Beaumont C, Kahn A, Vaulont S. (2002) Hepcidin, a new iron regulatory peptide. Blood Cells Mol. Dis. 29:327-35.
3. Ganz T. (2003) Hepcidin: a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102:783-8.
4. Nemeth E et al. (2004) Hepcidin regulates iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090-3.
5. Nicolas G et al. (2002) The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 110:1037-44.
6. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. (2004) IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 113:1271-6.
7. Di Bisceglie AM, Axiotis CA, Hoofnagle JH, Bacon BR. (1992) Measurements of iron status in patients with chronic hepatitis. Gastroenterology 102:2108-13.
8. Boucher E, Bourienne A, Adams P, Turlin B, Brissot B, Deugnier Y. (1997) Liver iron concentration and distribution in chronic hepatitis C before and after interferon treatment. Gut 41:115-20.
9. Metwally MA, Zein CO, Zein NN. (2004) Clinical significance of hepatic iron deposition and serum iron values in patients with chronic hepatitis C infection. Am. J. Gastroenterol. 99:286-91.
10. Tharburn D et al. (2002) The role of iron and haemochromatosis gene mutations in the progression of liver disease in chronic hepatitis C. Gut 50:248-52.
11. Tung BY, Emond MJ, Bromer MP, Raaka SD, Cotler SJ, Kowdley KV. (2003) Hepatitis C, iron status, and disease severity: relationship with HFE mutations. Gastroenterology 124:318-26.
12. Bassett SE et al. (1999) Effects of iron loading on pathogenicity in hepatitis C virus-infected chimpanzees. Hepatology 29:1884-92.
13. Olynyk JK et al. (1995) Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C. Gastroenterology 108:1104-9.
14. Souza RM, Freitas LAR, Lyra AC, Moraes CF, Braga EL, Lyra LGC. (2006) Effect of iron overload on the severity of liver histologic alterations and on the response to interferon and ribavirin therapy of patients with hepatitis C infection. Braz. J. Med. Biol. Res. 39:79-83.
15. Kawabata H, Yang R, Hirama T, Vuong PT, Kawano S, Gombart AF, Koeffler HP. (1999) Molecular cloning of transferrin receptor 2: a new member of the transferrin receptor-like family. J. Biol. Chem. 274:20826-32.
16. Takeo M, Kobayashi Y, Fujita N, et al. (2005) Upregulation of transferrin receptor 2 and ferroportin 1 mRNA in the liver of patients with chronic hepatitis C. J. Gastroenterol. Hepatol. 20:562-9.
17. Kawabata H, Germain RS, Vuong PT, Nakamaki T, Said JW, Koeffler HP. (2000) Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo. J. Biol. Chem. 275:16618-25.
18. Fleming RE et al. (2000) Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proc. Natl. Acad. Sci. U. S. A. 97:2214-9.
19. Camaschella C et al. (2000) The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat. Genet. 25:14-5.
20. Roetto A et al. (2001) New mutations inactivating transferrin receptor 2 in hemochromatosis type 3. Blood 97:2555-60.
21. Kawabata H et al. (2005) Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood 105:376-81.
22. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. (1994) Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 19:1513-20.
23. Deugnier YM et al. (1992) Liver pathology in genetic hemochromatosis: a review of 135 homozygous cases and their bioclinical correlations. Gastroenterology 102:2050-9.
24. Deugnier YM et al. (1993) Differentiation between heterozygotes and homozygotes in genetic hemochromatosis by means of a histological hepatic iron index: a study of 192 cases. Hepatology 17:30-4.
25. Silvia TSS et al. (2005) Iron overload in patients with chronic hepatitis C virus infection: clinical and histological study. J. Gastroenterol. Hepatol. 20:243-8.
26. Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O. (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276:7811-9.
27. Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, Adermann K. (2000) LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 480:147-50.
28. Park CH, Valore EV, Waring AJ, Ganz T. (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem. 276:7806-10.
29. Nicolas G, Beennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S. (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc. Natl. Acad. Sci. U. S. A. 98:8780-5.
30. Nicolas G et al. (2002) Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc. Natl. Acad. Sci. U. S. A. 99:4596-601.
31. Roetto A et al. (2003) Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat. Genet. 33:21-2.
32. Frazer DM, Wilkins SJ, Becker EM, Vulpe CD, Mckie AT, Trinder D, Anderson GJ. (2002) Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 123:835-44.
33. Lee P, Peng H, Gelbart T, Beutler E. (2004) The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta2-microglobulin-deficient hepatocytes. Proc. Natl. Acad. Sci. U. S. A. 101:9263-5.
34. Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. (2005) Hepcidin is decreased in TfR2-hemochromatosis. Blood 105:1803-6.
35. Montosi G et al. (2005) Kuppfer cells and macrophages are not required for hepatic hepcidin activation during iron overload. Hepatology 41:545-52.
36. Kobune M, Kohgo Y, Kato J, Miyazaki E, Niitsu Y. (1994) Interleukin-6 enhances hepatic transferrin uptake, and ferritin expression in rats. Hepatology 19:1468-75.
37. Ahmad KA et al. (2002) Decreased liver hepcidin expression in the Hfe knockout mouse. Blood Cell Mol. Dis. 29:361-6.
38. Bridle KR et al. (2003) Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homeostasis. Lancet 361:669-73.
39. Pietrangelo A. (2005) Non-HFE hemochromatosis. Semin. Liver Dis. 25:450-60.
40. Sohda T, Okubo R, Kamimura S, Ohkawara T. (2001) Hemochromatosis with HFE gene mutation in a Japanese patient. Am. J. Gastroenterol. 96:2487-8.
41. Koyama C et al. (2005) Two novel mutations, L490R and V561X, of the transferrin receptor 2 gene in Japanese patients with hemochromatosis. Hematologica 90:302-7.
42. Koyama C et al. (2005) Three patients with middle-age-onset hemochromatosis caused by novel mutations in the hemojuvelin gene. J. Hepatol. 43:740-2.
43. Koyama C et al. (2005) A Japanese family with ferroportin disease caused by a novel mutation of SLC40A1 gene: hyperferritinemia associated with a relatively low transferrin saturation of iron. Intern. Med. 44:990-3.
44. Aoki CA, Rossaro L, Ramsamooj R, Brandhagen D, Burritt MF, Bowlus CL. (2005) Liver hepcidin mRNA correlates with iron stores, but not inflammation, in patients with chronic hepatitis C. J. Clin. Gastroenterol. 39:71-4.