Friedreich's ataxia and iron metabolism

Brain and Development

Volumn 22, Issue 8, 2000, Pages 465-468

  Gordon, Neil ^a  

^a Huntlywood   (United Kingdom)

Author keywords

Cell damage; Friedreich's ataxia; Iron metabolism; Treatment

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; DEFEROXAMINE; FERRITIN; FRATAXIN; IDEBENONE; IRON CHELATING AGENT;

AUTOSOMAL RECESSIVE INHERITANCE; CELL DAMAGE; CHROMOSOME 9; FRIEDREICH ATAXIA; GENE MAPPING; HUMAN; IRON METABOLISM; IRON TRANSPORT; OXIDATIVE STRESS; POINT MUTATION; REVIEW;

CYTOSOL; FRIEDREICH ATAXIA; HUMANS; IRON METABOLISM DISORDERS; IRON-BINDING PROTEINS; MITOCHONDRIA; MITOCHONDRIAL MYOPATHIES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR);

EID: 0033709847     PISSN: 03877604     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0387-7604(00)00175-3     Document Type: Review

References (33)

1. A study of iron metabolism in neuropsychiatric patients: Hallervorden-Spatz disease
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3. Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue
4. Frataxin gene of Friedreich's ataxia is targeted to mitochondria
5. The yeast frataxin homologue mediates mitochondrial iron efflux: evidence for a mitochondrial iron cycle
6. Deletion of the yeast homologue of the human gene associated with Friedreich's ataxia elicits iron accumulation in mitochondria
7. Frataxin is reduced in Friedreich ataxia patients and is associated with mitochondrial membranes
8. Increased serum transferrin receptor concentrations in Friedreich's ataxia
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13. Unique origin and specific ethnic distribution of the Friedreich ataxia GAA expansion
14. Early onset of Friedreich's ataxia in a compound heterozygote
15. Genetic homogeneity at the Friedreich ataxia locus on chromosome 9
16. Atypical Friedreich ataxia phenotype associated with a novel missense mutation in the X25 gene
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30. Direct evidence that mitochondrial iron accumulation occurs in Friedreich ataxia
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32. The importance of selenium to human health
33. Friedreich ataxia: an overview