The Elongation Complex Components BRD4 and MLLT3/AF9 Are Transcriptional Coactivators of Nuclear Retinoid Receptors

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Flajollet, Sébastien ^a,b,c,d   Rachez, Christophe ^e   Ploton, Maheul ^a,b,c,d   Schulz, Céline ^c   Gallais, Rozenn ^f   Métivier, Raphaël ^f   Pawlak, Michal ^a,b,c,d   Leray, Aymeric ^c   Issulahi, Al Amine ^c   Héliot, Laurent ^c   Staels, Bart ^a,b,c,d   Salbert, Gilles ^f   Lefebvre, Philippe ^a,b,c,d  

^a France   (France)

^b INSERM UMR1011 ^*  (France)

^c UNIV LILLE   (France)

^d INSTITUT PASTEUR DE LILLE   (France)

^e INSTITUT PASTEUR   (France)

^f UNIVERSITÉ DE RENNES 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALL1 FUSED GENE FROM CHROMOSOME 9 PROTEIN; BROMODOMAIN CONTAINING PROTEIN 4; COMPLEMENTARY DNA; MESSENGER RNA; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RNA POLYMERASE II; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AF9 GENE; ANIMAL CELL; ARTICLE; BRD4 GENE; CONTROLLED STUDY; DNA FINGERPRINTING; ENZYME ACTIVITY; GENE; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE SILENCING; MASS SPECTROMETRY; MOUSE; NONHUMAN; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RXRALPHA GENE; TRANSCRIPTION REGULATION;

ANTINEOPLASTIC AGENTS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLURIPOTENT STEM CELLS; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, RETINOIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRETINOIN;

EID: 84878847270     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064880     Document Type: Article

References (53)

1. Samarut E, Rochette-Egly C, (2012) Nuclear retinoic acid receptors: conductors of the retinoic acid symphony during development. Mol Cell Endocrinol 348: 348-360.
2. Ju BG, Lunyak VV, Perissi V, Garcia-Bassets I, Rose DW, et al. (2006) A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science 312: 1798-1802.
3. Pavri R, Lewis B, Kim TK, Dilworth FJ, Erdjument-Bromage H, et al. (2005) PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell 18: 83-96.
4. Martin PJ, Lardeux V, Lefebvre P, (2005) The proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein-protein interaction. Nucl Acids Res 33: 4311-4321.
5. Lefebvre B, Brand C, Flajollet S, Lefebvre P, (2006) Down-Regulation of the Tumor Suppressor Gene Retinoic Acid Receptor {beta}2 through the Phosphoinositide 3-Kinase/Akt Signaling Pathway. Mol Endocrinol 20: 2109-2121.
6. Lefebvre B, Ozato K, Lefebvre P, (2002) Phosphorylation of histone H3 is functionally linked to retinoic acid receptor β promoter activation. EMBO Rep 3: 340.
7. Dey A, Chitsaz F, Abbasi A, Misteli T, Ozato K, (2003) The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. PNAS 100: 8758.
8. Yang Z, Yik JH, Chen R, He N, Jang MK, et al. (2005) Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell 19: 535-545.
9. Zippo A, Serafini R, Rocchigiani M, Pennacchini S, Krepelova A, et al. (2009) Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation. Cell 138: 1122-1136.
10. Lefebvre P, Mouchon A, Lefebvre B, Formstecher P, (1998) Binding of retinoic acid receptor heterodimers to DNA- A role for histones NH2 termini. J Biol Chem 273: 12288-12295.
11. Flajollet S, Lefebvre B, Rachez C, Lefebvre P, (2006) Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation. J Biol Chem 281: 20338-20348.
12. Amann PM, Eichmüller SB, Schmidt J, Bazhin AV, (2011) Regulation of gene expression by retinoids. Curr Med Chem 18: 1405-1412.
13. Smith E, Lin C, Shilatifard A, (2011) The super elongation complex (SEC) and MLL in development and disease. Genes Dev 25: 661-672.
14. Luo Z, Lin C, Guest E, Garrett AS, Mohaghegh N, et al. (2012) The super elongation complex family of RNA polymerase II elongation factors: gene target specificity and transcriptional output. Mol Cell Biol 32: 2608-2617.
15. Depoix C, Delmotte MH, Formstecher P, Lefebvre P, (2001) Control of retinoic acid receptor heterodimerization by ligand-induced structural transitions. a novel mechanism of action for retinoid antagonists. J Biol Chem 276: 9452-9459.
16. De Falco, G, Bagella L, Claudio PP, De LA, Fu Y, et al. (2000) Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation. Oncogene 19: 373-379.
17. Rachez C, Suldan Z, Ward J, Chang CPB, Burakov D, et al. (1998) A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev 12: 1787-1800.
18. Sacchetti P, Carpentier R, Segard P, Olive-Cren C, Lefebvre P, (2006) Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor Nurr1. Nucl Acids Res 34: 5515-5527.
19. Brand C, Segard P, Plouvier P, Formstecher P, Danze PM, et al. (2002) Selective alteration of gene expression in response to natural and synthetic retinoids. BMC Pharmacol 2: 13.
20. Lefebvre B, Benomar Y, Guedin A, Langlois A, Hennuyer N, et al. (2010) Proteasomal degradation of retinoid X receptor α reprograms transcriptional activity of PPARγ in obese mice and humans. J Clin Invest 120: 1454-1468.
21. Briand O, Helleboid-Chapman A, Ploton M, Hennuyer N, Carpentier R, et al. (2012) The nuclear orphan receptor Nur77 Is a lipotoxicity sensor regulating glucose-induced insulin secretion in pancreatic β-cells. Mol Endocrinol 26: 399-413.
22. Metivier R, Penot G, Hubner MR, Reid G, Brand H, et al. (2003) Estrogen receptor-α directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115: 751-763.
23. Leray A, Riquet FB, Richard E, Spriet C, Trinel D, et al. (2009) Optimized protocol of a frequency domain fluorescence lifetime imaging microscope for FRET measurements. Microsc Res Technique 72: 371-379.
24. Nagpal S, Friant S, Nakshatri H, Chambon P, (1993) RARs and RXRs- evidence for 2 autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo. EMBO J 12: 2349-2360.
25. Rochette-Egly C, Adam S, Rossignol M, Egly JM, Chambon P, (1997) Stimulation of RAR α activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7. Cell 90: 97-107.
26. Keriel A, Stary A, Sarasin A, RochetteEgly C, Egly JM, (2002) XPD mutations prevent TFIIH-dependent transactivation by nuclear receptors and phosphorylation of RAR α. Cell 109: 125-135.
27. Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, et al. (2005) The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol Cell 19: 523-534.
28. Ottinger M, Christalla T, Nathan K, Brinkmann MM, Viejo-Borbolla A, et al. (2006) Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a. J Virol 80: 10772-10786.
29. Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, et al. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A 101: 12130-12135.
30. Yang F, Lio XY, Sharma MJ, Zarnegar M, Lim B, et al. (2001) Androgen receptor specifically interacts with a novel p21- activated kinase, PAK6. J Biol Chem 276: 15345-15353.
31. Lee SR, Ramos SM, Ko A, Masiello D, Swanson KD, et al. (2002) AR and ER interaction with a p21-activated kinase (PAK6). Mol Endocrinol 16: 85-99.
32. Soprano DR, Teets BW, Soprano KJ, (2007) Role of retinoic acid in the differentiation of embryonal carcinoma and embryonic stem cells. Vitam Horm 75: 69-95.
33. Schoorlemmer J, Vanpuijenbroek A, Vandeneijnden M, Jonk L, Pals C, et al. (1994) Characterization of a negative retinoic acid response element in the murine Oct4 promoter. Mol Cell Biol 14: 1122-1136.
34. Ross-Innes CS, Stark R, Holmes KA, Schmidt D, Spyrou C, et al. (2010) Cooperative interaction between retinoic acid receptor-α and estrogen receptor in breast cancer. Genes Dev 24: 171-182.
35. Lin C, Garrett AS, De KB, Smith ER, Gogol M, et al. (2011) Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC). Genes Dev 25: 1486-1498.
36. Bres V, Yoh SM, Jones KA, (2008) The multi-tasking P-TEFb complex. Curr Opin Cell Biol 20: 334-340.
37. Le May, N, Mota-Fernandes D, Velez-Cruz R, Iltis I, Biard D, et al. (2010) NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack. Mol Cell 38: 54-66.
38. Zhou Q, Li T, Price DH, (2012) RNA Polymerase II Elongation Control. Annu Rev Biochem 81: 119-143.
39. Mendoza-Parra MA, Walia M, Sankar M, Gronemeyer H, (2011) Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics. Mol Syst Biol 7: 538.
40. Slany RK, (2009) The molecular biology of mixed lineage leukemia. Haematologica 94: 984-993.
41. Glover-Cutter K, Larochelle S, Erickson B, Zhang C, Shokat K, et al. (2009) TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. Mol Cell Biol 29: 5455-5464.
42. Mahony S, Mazzoni EO, McCuine S, Young RA, Wichterle H, et al. (2011) Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis. Genome Biol 12: R2.
43. Sobhian B, Laguette N, Yatim A, Nakamura M, Levy Y, et al. (2010) HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. Mol Cell 38: 439-451.
44. Chen R, Liu M, Li H, Xue Y, Ramey WN, et al. (2008) PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. Genes Dev 22: 1356-1368.
45. Zhou M, Huang K, Jung KJ, Cho WK, Klase Z, et al. (2009) Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29. J Virol 83: 1036-1044.
46. He N, Liu M, Hsu J, Xue Y, Chou S, et al. (2010) HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. Mol Cell 38: 428-438.
47. Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM, (2012) BET bromodomain inhibition activates transcription via a transient release of P-TEFb from 7SK snRNP. J Biol Chem 287(43): 36609-16.
48. Hargreaves DC, Horng T, Medzhitov R, (2009) Control of inducible gene expression by signal-dependent transcriptional elongation. Cell 138: 129-145.
49. Wu SY, Chiang CM, (2007) The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation. J Biol Chem 282: 13141-13145.
50. Lee DK, Duan HO, Chang C, (2001) Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation. J Biol Chem 276: 9978-9984.
51. Iankova I, Petersen RK, Annicotte JS, Chavey C, Hansen JB, et al. (2006) Peroxisome proliferator-activated receptor γ recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis. Mol Endocrinol 20: 1494-1505.
52. Wittmann BM, Fujinaga K, Deng H, Ogba N, Montano MM, (2005) The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1. Oncogene 24: 5576-5588.
53. Rahl PB, Lin CY, Seila AC, Flynn RA, McCuine S, et al. (2010) c-Myc regulates transcriptional pause release. Cell 141: 432-445.