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Volumn 20, Issue 3, 2008, Pages 334-340

The multi-tasking P-TEFb complex

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; MESSENGER RNA; METHYLTRANSFERASE; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; PROTEIN BRD4; PROTEIN H2BUB; PROTEIN H3S10; PROTEIN IWS1; PROTEIN SKIP; PROTEIN SPT6; TRANSACTIVATOR PROTEIN;

EID: 44649154972     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2008.04.008     Document Type: Review
Times cited : (186)

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    • Bres V., Gomes N., Pickle L., and Jones K.A. A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat. Genes Dev 19 (2005) 1211-1226. SKIP, a splicing and transcription factor, is shown to associate with P-TEFb, enhance HIV-1 Tat transactivation and stimulate transcription elongation in vitro. SKIP is recruited to the HIV-1 promoter independently of U5snRNPs, suggesting distinct roles in transcription and splicing.
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    • Konev A.Y., Tribus M., Park S.Y., Podhraski V., Lim C.Y., Emelyanov A.V., Vershilova E., Pirrotta V., Kadonaga J.T., Lusser A., et al. CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo. Science 317 (2007) 1087-1090. CHD1 is shown to be required for the genome-wide replication-independent incorporation of histone H3.3 in Drosophila chromatin. Elimination of CHD1 in zygotes blocked H3.3 incorporation and inhibited mitosis.
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    • Transcriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regions
    • Spt6, a histone H3-H4 chaperone and transcription elongation factor, is shown to be required for histone reassembly and displacement of TBP and RNAPII upon transcription repression. Failure to execute Spt6-mediated histone reassembly enables transcription to persist despite in the absence of DNA-binding activators.
    • Adkins M.W., and Tyler J.K. Transcriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regions. Mol Cell 21 (2006) 405-416. Spt6, a histone H3-H4 chaperone and transcription elongation factor, is shown to be required for histone reassembly and displacement of TBP and RNAPII upon transcription repression. Failure to execute Spt6-mediated histone reassembly enables transcription to persist despite in the absence of DNA-binding activators.
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    • The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export
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    • Nojima T., Hirose T., Kimura H., and Hagiwara M. The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export. J Biol Chem 282 (2007) 15645-15651. This paper reports an association between CBP20 and REF1/Aly that is splicing-independent and required for export of intronless mRNAs.
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    • Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin
    • This paper defines the structural domains of Rpd3 required for binding to H3K36me3 chromatin and recruiting HDACs to reset the chromatin to a hypoacetylated state that blocks cryptic transcription.
    • Li B., Gogol M., Carey M., Lee D., Seidel C., and Workman J.L. Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin. Science 316 (2007) 1050-1054. This paper defines the structural domains of Rpd3 required for binding to H3K36me3 chromatin and recruiting HDACs to reset the chromatin to a hypoacetylated state that blocks cryptic transcription.
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    • H3K36me3 chromatin, found in actively transcribed regions, is shown to direct the MSL complex to the male X chromosome to upregulate transcription. This targeting is mediated by MSL3, which binds H3K36me3 directly.
    • Larschan E., Alekseyenko A.A., Gortchakov A.A., Peng S., Li B., Yang P., Workman J.L., Park P.J., and Kuroda M.I. MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism. Mol Cell 28 (2007) 121-133. H3K36me3 chromatin, found in actively transcribed regions, is shown to direct the MSL complex to the male X chromosome to upregulate transcription. This targeting is mediated by MSL3, which binds H3K36me3 directly.
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    • The RNA polymerase II CTD kinase Ctk1 functions in translation elongation
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    • Rother S., and Strasser K. The RNA polymerase II CTD kinase Ctk1 functions in translation elongation. Genes Dev 21 (2007) 1409-1421. P-TEFb/Ctk1 is shown to associate with polysomes and stimulate mRNA translation in yeast, acting partly through phosphorylation of Rps2 small ribosome subunit.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.