Control of retinoic acid receptor heterodimerization by ligand-induced structural transitions: A novel mechanism of action for retinoid antagonists

Journal of Biological Chemistry

Volumn 276, Issue 12, 2001, Pages 9452-9459

  Depoix, Christophe ^a   Delmotte, Marie Hélène ^a   Formstecher, Pierre ^a   Lefebvre, Philippe ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DIMERIZATION; DIMERS; DNA; GENES; MONOMERS;

BINDING AFFINITY; PHARMACOLOGICAL INHIBITIONS;

BIOCHEMISTRY;

ACTIVATION FUNCTION 2 PROTEIN; ALITRETINOIN; CELL PROTEIN; DIMER; DNA; GLUTATHIONE TRANSFERASE; LIGAND; MONOMER; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR AGONIST; RETINOIC ACID RECEPTOR ANTAGONIST; RETINOID; RETINOID ANTAGONIST; RETINOID DERIVATIVE; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIMERIZATION; DRUG MECHANISM; ENZYME ASSAY; GENE CONTROL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; MAMMAL CELL; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR STABILITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; TWO HYBRID SYSTEM; CHEMISTRY; DRUG ANTAGONISM; HELA CELL; METABOLISM; PROTEIN CONFORMATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

MAMMALIA;

DIMERIZATION; HELA CELLS; HUMANS; LIGANDS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, RETINOIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0035937734     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008004200     Document Type: Article

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