DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival

Journal of Biological Chemistry

Volumn 286, Issue 35, 2011, Pages 30706-30713

  Luk, John M ^a,b   Burchard, Julja ^c,d   Zhang, Chunsheng ^c,e   Liu, Angela M ^b,f   Wong, Kwong F ^a   Shek, Felix H ^f   Lee, Nikki P ^f   Fan, Sheung Tat ^f   Poon, Ronnie T ^f   Ivanovska, Irena ^c,e   Philippar, Ulrike ^e   Cleary, Michele A ^d,e   Buser, Carolyn A ^e   Shaw, Peter M ^e   Lee, Chuen Neng ^b   Tenen, Daniel G ^a,g   Dai, Hongyue ^c,e   Mao, Mao ^c,h  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c ROSETTA INPHARMATICS   (United States)

^d Sirna Therapeutics Inc   (United States)

^e MERCK RESEARCH LABORATORIES   (United States)

^f UNIVERSITY OF HONG KONG   (Hong Kong)

^g HARVARD STEM CELL INSTITUTE   (United States)

^h PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER DETECTION; CELL MARKERS; EXPRESSION LEVELS; FETOPROTEIN; GENE TRANSCRIPTS; HEPATITIS B; HEPATOCELLULAR CARCINOMA; LIVER CANCERS; LIVER TUMORS; MAMMALIAN SPECIES; MICRORNAS; MOUSE MODELS; OVER-EXPRESSION; SURVIVAL RATE; TRANSGENICS; UP-REGULATION; WNT PATHWAY;

CHROMOSOMES; DISEASES; GENE EXPRESSION; MAMMALS; STEM CELLS; VIRUSES;

PATIENT TREATMENT;

ALPHA FETOPROTEIN; CD133 ANTIGEN; EPITHELIAL CELL ADHESION MOLECULE; MICRORNA; MICRORNA DLK1 DIO3; NESTIN; SCATTER FACTOR RECEPTOR; THY 1 ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SURVIVAL; CHROMOSOME 12Q; CHROMOSOME 14Q; CONTROLLED STUDY; GENE CLUSTER; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC CONSERVATION; GENOME IMPRINTING; HEPATITIS B; HUMAN; HUMAN TISSUE; ISOLATED LIVER; LIVER CELL CARCINOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TRANSGENIC MOUSE; UPREGULATION;

CARCINOMA, HEPATOCELLULAR; CHROMOSOMES, HUMAN, PAIR 14; COHORT STUDIES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; IODIDE PEROXIDASE; LIVER; LIVER NEOPLASMS; MEMBRANE PROTEINS; MICRORNAS; MULTIGENE FAMILY; PROGNOSIS; TISSUE DISTRIBUTION; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

HEPATITIS B VIRUS; MAMMALIA;

EID: 80052245751     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.229831     Document Type: Article

References (39)

1. Parkin, D. M., Bray, F., Ferlay, J., and Pisani, P. (2005) CA Cancer J. Clin. 55, 74-108
2. Lee, T. K., Castilho, A., Ma, S., and Ng, I. O. (2009) Liver Int. 29, 955-965
3. Sell, S., and Leffert, H. L. (2008) J. Clin. Oncol. 26, 2800-2805
4. Yang, Z. F., Ho, D. W., Ng, M. N., Lau, C. K., Yu, W. C., Ngai, P., Chu, P. W., Lam, C. T., Poon, R. T., and Fan, S. T. (2008) Cancer Cell 13, 153-166
5. Ma, S., Lee, T. K., Zheng, B. J., Chan, K. W., and Guan, X. Y. (2008) Oncogene 27, 1749-1758
6. Yamashita, T., Ji, J., Budhu, A., Forgues, M., Yang, W., Wang, H. Y., Jia, H., Ye, Q., Qin, L. X., Wauthier, E., Reid, L. M., Minato, H., Honda, M., Kaneko, S., Tang, Z. Y., and Wang, X. W. (2009) Gastroenterology 136, 1012-1024
7. Slack, F. J., and Weidhaas, J. B. (2008) N. Engl. J. Med. 359, 2720-2722
8. Calin, G. A., and Croce, C. M. (2006) Nat. Rev. Cancer 6, 857-866
9. He, L., and Hannon, G. J. (2004) Nat. Rev. Genet. 5, 522-531
10. Burchard, J., Zhang, C., Liu, A. M., Poon, R. T., Lee, N. P., Wong, K. F., Sham, P. C., Lam, B. Y., Ferguson, M. D., Tokiwa, G., Smith, R., Leeson, B., Beard, R., Lamb, J. R., Lim, L., Mao, M., Dai, H., and Luk, J. M. (2010) Mol. Syst. Biol. 6, 402
11. Esquela-Kerscher, A., and Slack, F. J. (2006) Nat. Rev. Cancer 6, 259-269
12. Tward, A. D., Jones, K. D., Yant, S., Cheung, S. T., Fan, S. T., Chen, X., Kay, M. A., Wang, R., and Bishop, J. M. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 14771-14776
13. Hao, K., Luk, J. M., Lee, N. P., Mao, M., Zhang, C., Ferguson, M. D., Lamb, J., Dai, H., Ng, I. O., Sham, P. C., and Poon, R. T. (2009) BMC Cancer 9, 389
14. Wang, R., Ferrell, L. D., Faouzi, S., Maher, J. J., and Bishop, J. M. (2001) J. Cell Biol. 153, 1023-1034
15. Raymond, C. K., Roberts, B. S., Garrett-Engele, P., Lim, L. P., and Johnson, J. M. (2005) RNA 11, 1737-1744
16. Liu, A. M., Zhang, C., Burchard, J., Fan, S. T., Wong, K. F., Dai, H., Poon, R. T., and Luk, J. M. (2011) Omics 15, 187-191
17. Eklund, A. C., Turner, L. R., Chen, P., Jensen, R. V., deFeo, G., Kopf-Sill, A. R., and Szallasi, Z. (2006) Nat. Biotechnol. 24, 1071-1073
18. Irizarry, R. A., Bolstad, B. M., Collin, F., Cope, L. M., Hobbs, B., and Speed, T. P. (2003) Nucleic Acids Res. 31, e15
19. Jackson, A. L., Bartz, S. R., Schelter, J., Kobayashi, S. V., Burchard, J., Mao, M., Li, B., Cavet, G., and Linsley, P. S. (2003) Nat. Biotechnol. 21, 635-637
20. Liu, A. M., Poon, R. T., and Luk, J. M. (2010) Biochem. Biophys. Res. Commun. 394, 623-627
21. Lee, N. P., Chen, L., Lin, M. C., Tsang, F. H., Yeung, C., Poon, R. T., Peng, J., Leng, X., Beretta, L., Sun, S., Day, P. J., and Luk, J. M. (2009) J. Proteome Res. 8, 1293-1303
22. Mok, B. W., Yeung, W. S., and Luk, J. M. (1999) FEBS Lett. 453, 243-248
23. Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., Harris, M. A., Hill, D. P., Issel-Tarver, L., Kasarskis, A., Lewis, S., Matese, J. C., Richardson, J. E., Ringwald, M., Rubin, G. M., and Sherlock, G. (2000) Nat. Genet. 25, 25-29
24. Lin, S. P., Youngson, N., Takada, S., Seitz, H., Reik, W., Paulsen, M., Cavaille, J., and Ferguson-Smith, A. C. (2003) Nat. Genet. 35, 97-102
25. Seitz, H., Royo, H., Bortolin, M. L., Lin, S. P., Ferguson-Smith, A. C., and Cavaillé, J. (2004) Genome Res. 14, 1741-1748
26. Liu, L., Luo, G. Z., Yang, W., Zhao, X., Zheng, Q., Lv, Z., Li, W., Wu, H. J., Wang, L., Wang, X. J., and Zhou, Q. (2010) J. Biol. Chem. 285, 19483-19490
27. Stadtfeld, M., Apostolou, E., Akutsu, H., Fukuda, A., Follett, P., Natesan, S., Kono, T., Shioda, T., and Hochedlinger, K. (2010) Nature 465, 175-181
28. Tierling, S., Dalbert, S., Schoppenhorst, S., Tsai, C. E., Oliger, S., Ferguson- Smith, A. C., Paulsen, M., and Walter, J. (2006) Genomics 87, 225-235
29. Jelinic, P., and Shaw, P. (2007) J. Pathol. 211, 261-268
30. Thorvaldsen, J. L., and Bartolomei, M. S. (2007) Cell 130, 958
31. Yao, X., Hu, J. F., Daniels, M., Shiran, H., Zhou, X., Yan, H., Lu, H., Zeng, Z., Wang, Q., Li, T., and Hoffman, A. R. (2003) J. Clin. Invest. 111, 265-273
32. Ip, W. K., Lai, P. B., Wong, N. L., Sy, S. M., Beheshti, B., Squire, J. A., and Wong, N. (2007) Cancer Lett. 250, 284-291
33. Jia, H. L., Ye, Q. H., Qin, L. X., Budhu, A., Forgues, M., Chen, Y., Liu, Y. K., Sun, H. C., Wang, L., Lu, H. Z., Shen, F., Tang, Z. Y., and Wang, X. W. (2007) Clin. Cancer Res. 13, 1133-1139
34. Wu, J., Qin, Y., Li, B., He, W. Z., and Sun, Z. L. (2008) Genomics 91, 443-450
35. Huang, J., Zhang, X., Zhang, M., Zhu, J. D., Zhang, Y. L., Lin, Y., Wang, K. S., Qi, X. F., Zhang, Q., Liu, G. Z., Yu, J., Cui, Y., Yang, P. Y., Wang, Z. Q., and Han, Z. G. (2007) Carcinogenesis 28, 1094-1103
36. Yamashita, T., Forgues, M., Wang, W., Kim, J. W., Ye, Q., Jia, H., Budhu, A., Zanetti, K. A., Chen, Y., Qin, L. X., Tang, Z. Y., and Wang, X. W. (2008) Cancer Res. 68, 1451-1461
37. Ma, S., Chan, K. W., Hu, L., Lee, T. K., Wo, J. Y., Ng, I. O., Zheng, B. J., and Guan, X. Y. (2007) Gastroenterology 132, 2542-2556
38. Yang, X. R., Xu, Y., Yu, B., Zhou, J., Qiu, S. J., Shi, G. M., Zhang, B. H., Wu, W. Z., Shi, Y. H., Wu, B., Yang, G. H., Ji, Y., and Fan, J. (2010) Gut 59, 953-962
39. Dixon-McIver, A., East, P., Mein, C. A., Cazier, J. B., Molloy, G., Chaplin, T., Andrew Lister, T., Young, B. D., and Debernardi, S. (2008) PLoSONE3, e2141