The role of SIRT1/AKT/ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells

Toxicology in Vitro

Volumn 27, Issue 6, 2013, Pages 1728-1736

  Chou, Wen Wen ^a,b   Chen, Ku Chung ^a,b   Wang, Yung Song ^a,b   Wang, Jaw Yuan ^a,b   Liang, Chung Ling ^c   Juo, Suh Hang Hank ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c Bright Eyes Clinic   (Taiwan)

Author keywords

AKT; Resveratrol; RPE; SIRT1; Ultraviolet B

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RESVERATROL; SIRTUIN 1;

ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL DAMAGE; CELL DEATH; CONTROLLED STUDY; DNA METHYLATION; DOSE RESPONSE; DOWN REGULATION; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SPECIFICITY; EYE PROTECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PHOTOTOXICITY; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRESS; ULTRAVIOLET B RADIATION;

5-AZA-2′-DEOXYCYTIDINE; AKT; AZA; MAP KINASES; MITOGEN-ACTIVATED PROTEIN (MAP) KINASES; PHOSPHATIDYLINOSITOL-3-KINASE; PI3K; REACTIVE OXYGEN SPECIES; RESVERATROL; RETINAL PIGMENT EPITHELIAL; ROS; RPE; SIRT1; ULTRAVIOLET B;

CELL CYCLE; CELL LINE; CELL SURVIVAL; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; SIRTUIN 1; ULTRAVIOLET RAYS;

EID: 84878800344     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.05.002     Document Type: Article

References (57)

1. Afaq F., Adhami V.M., Ahmad N. Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice. Toxicol. Appl. Pharmacol. 2003, 186:28-37.
2. Aki T., Yamaguchi K., Fujimiya T., Mizukami Y. Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2. Oncogene 2003, 22:8529-8535.
3. Aziz M.H., Afaq F., Ahmad N. Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin. Photochem. Photobiol. 2005, 81:25-31.
4. Balaiya S., Murthy R.K., Brar V.S., Chalam K.V. Evaluation of ultraviolet light toxicity on cultured retinal pigment epithelial and retinal ganglion cells. Clin. Ophthalmol. 2010, 4:33-39.
5. Bitterman K.J., Anderson R.M., Cohen H.Y., Latorre-Esteves M., Sinclair D.A. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J. Biol. Chem. 2002, 277:45099-45107.
6. Blander G., Guarente L. The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 2004, 73:417-435.
7. Boettner E.A., Wolter J.R. Transmission of the ocular media. Invest. Ophthalmol. 1962, 1:776-783.
8. Borra M.T., Smith B.C., Denu J.M. Mechanism of human SIRT1 activation by resveratrol. J. Biol. Chem. 2005, 280:17187-17195.
9. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657.
10. 2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes. J. Cell. Mol. Med. 2009, 13:3632-3643.
11. Chan C.M., Huang J.H., Lin H.H., Chiang H.S., Chen B.H., Hong J.Y., Hung C.F. Protective effects of (-)-epigallocatechin gallate on UVA-induced damage in ARPE19 cells. Mol. Vis. 2008, 14:2528-2534.
12. Chen G., Shu J., Stacey D.W. Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide. Oncogene 1997, 15:1643-1651.
13. Chou W.W., Guh J.Y., Tsai J.F., Hwang C.C., Chiou S.J., Chuang L.Y. Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells. J. Cell. Biochem. 2009, 107:408-417.
14. Chou W.W., Wang Y.S., Chen K.C., Wu J.M., Liang C.L., Juo S.H. Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells. Cell. Immunol. 2012, 273:79-84.
15. Chuang L.Y., Guh J.Y., Wang K.A., Huang Y.J., Huang J.S. Role of nitric oxide in high glucose-induced mitogenic response in renal fibroblasts. Mol. Endocrinol. 2006, 20:2548-2558.
16. Di Girolamo N. Signalling pathways activated by ultraviolet radiation: role in ocular and cutaneous health. Curr. Pharm. Des. 2010, 16:1358-1375.
17. Dulic V., Lees E., Reed S.I. Association of human cyclin E with a periodic G1-S phase protein kinase. Science 1992, 257:1958-1961.
18. Ekholm S.V., Zickert P., Reed S.I., Zetterberg A. Accumulation of cyclin E is not a prerequisite for passage through the restriction point. Mol. Cell. Biol. 2001, 21:3256-3265.
19. Fan W., Luo J. SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Mol. Cell. 2010, 39:247-258.
20. Frojdo S., Cozzone D., Vidal H., Pirola L. Resveratrol is a class IA phosphoinositide 3-kinase inhibitor. Biochem. J. 2007, 406:511-518.
21. Gaillard E.R., Merriam J., Zheng L., Dillon J. Transmission of light to the young primate retina: possible implications for the formation of lipofuscin. Photochem. Photobiol. 2011, 87:18-21.
22. Glickman R.D. Phototoxicity to the retina: mechanisms of damage. Int. J. Toxicol. 2002, 21:473-490.
23. Hawes B.E., Luttrell L.M., van Biesen T., Lefkowitz R.J. Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway. J. Biol. Chem. 1996, 271:12133-12136.
24. Herzinger T., Funk J.O., Hillmer K., Eick D., Wolf D.A., Kind P. Ultraviolet B irradiation-induced G2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase. Oncogene 1995, 11:2151-2156.
25. Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.L., Scherer B., Sinclair D.A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003, 425:191-196.
26. Huang C., Li J., Ding M., Leonard S.S., Wang L., Castranova V., Vallyathan V., Shi X. UV Induces phosphorylation of protein kinase B (Akt) at Ser-473 and Thr-308 in mouse epidermal Cl 41 cells through hydrogen peroxide. J. Biol. Chem. 2001, 276:40234-40240.
27. Ibrahim O.M., Kojima T., Wakamatsu T.H., Dogru M., Matsumoto Y., Ogawa Y., Ogawa J., Negishi K., Shimazaki J., Sakamoto Y., Sasaki H., Tsubota K. Corneal and retinal effects of ultraviolet-B exposure in a soft contact lens mouse model. Invest. Ophthalmol. Vis. Sci. 2012, 8:9.
28. Ichihashi M., Ueda M., Budiyanto A., Bito T., Oka M., Fukunaga M., Tsuru K., Horikawa T. UV-induced skin damage. Toxicology 2003, 189:21-39.
29. Katiyar S.K., Afaq F., Azizuddin K., Mukhtar H. Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (-)-epigallocatechin-3-gallate. Toxicol. Appl. Pharmacol. 2001, 176:110-117.
30. Katiyar S.K., Afaq F., Perez A., Mukhtar H. Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress. Carcinogenesis 2001, 22:287-294.
31. Kerr J.B., McElroy C.T. Evidence for large upward trends of ultraviolet-B radiation linked to ozone depletion. Science 1993, 262:1032-1034.
32. King W.G., Mattaliano M.D., Chan T.O., Tsichlis P.N., Brugge J.S. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation. Mol. Cell. Biol. 1997, 17:4406-4418.
33. King R.E., Kent K.D., Bomser J.A. Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition. Chem. Biol. Interact. 2005, 151:143-149.
34. Kubota S., Kurihara T., Ebinuma M., Kubota M., Yuki K., Sasaki M., Noda K., Ozawa Y., Oike Y., Ishida S., Tsubota K. Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation. Am. J. Pathol. 2010, 177:1725-1731.
35. Lin K.L., Su J.C., Chien C.M., Tseng C.H., Chen Y.L., Chang L.S., Lin S.R. Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation. Toxicol. In Vitro 2010, 24:61-70.
36. Liu Z.M., Chen G.G., Vlantis A.C., Tse G.M., Shum C.K., van Hasselt C.A. Calcium-mediated activation of PI3K and p53 leads to apoptosis in thyroid carcinoma cells. Cell. Mol. Life Sci. 2007, 64:1428-1436.
37. Lodovici M., Caldini S., Morbidelli L., Akpan V., Ziche M., Dolara P. Protective effect of 4-coumaric acid from UVB ray damage in the rabbit eye. Toxicology 2009, 255:1-5.
38. Lu X., Liu J., Legerski R.J. Cyclin E is stabilized in response to replication fork barriers leading to prolonged S phase arrest. J. Biol. Chem. 2009, 284:35325-35337.
39. Mainster M.A., Turner P.L. Ultraviolet-B phototoxicity and hypothetical photomelanomagenesis: intraocular and crystalline lens photoprotection. Am. J. Ophthalmol. 2010, 149:543-549.
40. Matsui H., Lin L.R., Singh D.P., Shinohara T., Reddy V.N. Lens epithelium-derived growth factor: increased survival and decreased DNA breakage of human RPE cells induced by oxidative stress. Invest. Ophthalmol. Vis. Sci. 2001, 42:2935-2941.
41. McCarty C.A., Taylor H.R. A review of the epidemiologic evidence linking ultraviolet radiation and cataracts. Dev. Ophthalmol. 2002, 35:21-31.
42. Michan S., Sinclair D. Sirtuins in mammals: insights into their biological function. Biochem. J. 2007, 404:1-13.
43. Park K., Lee J.H. Protective effects of resveratrol on UVB-irradiated HaCaT cells through attenuation of the caspase pathway. Oncol. Rep. 2008, 19:413-417.
44. Patton W.P., Routledge M.N., Jones G.D., Lewis S.E., Archer D.B., Davies R.J., Chakravarthy U. Retinal pigment epithelial cell DNA is damaged by exposure to benzo[a]pyrene, a constituent of cigarette smoke. Exp. Eye Res. 2002, 74:513-522.
45. Peus D., Vasa R.A., Beyerle A., Meves A., Krautmacher C., Pittelkow M.R. UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes. J. Invest. Dermatol. 1999, 112:751-756.
46. Riau A.K., Wong T.T., Finger S.N., Chaurasia S.S., Hou A.H., Chen S., Yu S.J., Tong L. Aberrant DNA methylation of matrix remodeling and cell adhesion related genes in pterygium. PLoS One 2011, 6:e14687.
47. Sablina A.A., Chumakov P.M., Levine A.J., Kopnin B.P. P53 activation in response to microtubule disruption is mediated by integrin-Erk signaling. Oncogene 2001, 20:899-909.
48. Shimamura H., Terada Y., Okado T., Tanaka H., Inoshita S., Sasaki S. The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad. J. Am. Soc. Nephrol. 2003, 14:1427-1434.
49. Soleas G.J., Diamandis E.P., Goldberg D.M. Wine as a biological fluid: history, production, and role in disease prevention. J. Clin. Lab. Anal. 1997, 11:287-313.
50. Sparrow J.R., Vollmer-Snarr H.R., Zhou J., Jang Y.P., Jockusch S., Itagaki Y., Nakanishi K. A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation. J. Biol. Chem. 2003, 278:18207-18213.
51. Tang Q., Gonzales M., Inoue H., Bowden G.T. Roles of Akt and glycogen synthase kinase 3beta in the ultraviolet B induction of cyclooxygenase-2 transcription in human keratinocytes. Cancer Res. 2001, 61:4329-4332.
52. Tang D., Wu D., Hirao A., Lahti J.M., Liu L., Mazza B., Kidd V.J., Mak T.W., Ingram A.J. ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J. Biol. Chem. 2002, 277:12710-12717.
53. Tokuda K., Zorumski C.F., Izumi Y. Effects of ascorbic acid on UV light-mediated photoreceptor damage in isolated rat retina. Exp. Eye Res. 2007, 84:537-543.
54. Welsh G.I., Foulstone E.J., Young S.W., Tavare J.M., Proud C.G. Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. Biochem. J. 1994, 303(Pt 1):15-20.
55. Wu Z., Lauer T.W., Sick A., Hackett S.F., Campochiaro P.A. Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3. J. Biol. Chem. 2007, 282:22414-22425.
56. Xu J.Y., Wu L.Y., Zheng X.Q., Lu J.L., Wu M.Y., Liang Y.R. Green tea polyphenols attenuating ultraviolet B-induced damage to human retinal pigment epithelial cells in vitro. Invest. Ophthalmol. Vis. Sci. 2010, 51:6665-6670.
57. Youn H.Y., Bantseev V., Bols N.C., Cullen A.P., Sivak J.G. In vitro assays for evaluating the ultraviolet B-induced damage in cultured human retinal pigment epithelial cells. J. Photochem. Photobiol. B 2007, 88:21-28.