Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation

Toxicology in Vitro

Volumn 24, Issue 1, 2010, Pages 61-70

  Lin, Kuei Li ^a   Su, Jung Chen ^a   Chien, Ching Ming ^a   Tseng, Chih Hua ^a   Chen, Yeh Long ^a   Chang, Long Sen ^b   Lin, Shinne Ren ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

ERK; JNK; MDA MB 231cells; NFD; p38 MAPK

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE; CASPASE 3; CASPASE 9; CHLOROACETALDEHYDE; CYCLIN A; CYCLIN B; CYCLIN DEPENDENT KINASE 2; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NAPHTHO[1,2 B]FURAN 4,5 DIONE; PHOSPHATIDYLSERINE; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL XL; STRESS ACTIVATED PROTEIN KINASE; SURVIVIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL COUNT; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; INHIBITION KINETICS; MITOCHONDRIAL MEMBRANE POTENTIAL; ONE POT SYNTHESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ANHYDRIDES; ANNEXIN A5; APOPTOSIS; BREAST NEOPLASMS; CASPASES; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOCHROMES C; CYTOSOL; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FLOW CYTOMETRY; HUMANS; MAP KINASE KINASE 4; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; NAPHTHALENES; S PHASE; SIGNAL TRANSDUCTION;

EID: 72049088250     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.09.002     Document Type: Article

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