A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation

Journal of Biological Chemistry

Volumn 278, Issue 20, 2003, Pages 18207-18213

  Sparrow, Janet R ^a   Vollmer Snarr, Heidi R ^a   Zhou, Jilin ^a   Jang, Young P ^a   Jockusch, Steffen ^a   Itagaki, Yasuhiro ^a   Nakanishi, Koji ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; CHEMICAL BONDS; DNA; MASS SPECTROMETRY; PIGMENTS; VITAMINS;

AUTOFLUORESCENT PIGMENTS;

CELLS;

A2E EPOXIDE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BILBERRY EXTRACT; BUTYLCRESOL; CARBON; EPOXIDE; GINKGOLIDE B; PHENAZOPYRIDINE; PLANT EXTRACT; PNU 83836 E; RESVERATROL; RETINOID DERIVATIVE; SINGLET OXYGEN; TROLOX C; UNCLASSIFIED DRUG; 2 [[4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]METHYL] 3,4 DIHYDRO 2,5,7,8 TETRAMETHYL 2H 1 BENZOPYRAN 6 OL; 8 OXO 7 HYDRODEOXYGUANOSINE; 8-OXO-7-HYDRODEOXYGUANOSINE; A2E COMPOUND; CHROMAN DERIVATIVE; DEOXYGUANOSINE; DRUG DERIVATIVE; OXYGEN; PIPERAZINE DERIVATIVE; PYRIDINIUM DERIVATIVE; RETINOID;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BILBERRY; CELL DEATH; CHEMICAL BINDING; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; EPOXIDATION; HUMAN; HUMAN CELL; IRRADIATION; MASS SPECTROMETRY; OXIDATIVE STRESS; PATHOGENESIS; PIGMENT EPITHELIUM; PLANT; PRIORITY JOURNAL; RETINA MACULA DEGENERATION; CELL CULTURE; CELL SURVIVAL; CHEMICAL MODEL; CHEMISTRY; COMET ASSAY; CYTOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT; METABOLISM;

VACCINIUM MYRTILLUS;

ANTIOXIDANTS; APOPTOSIS; ASCORBIC ACID; CARBON; CELL SURVIVAL; CELLS, CULTURED; CHROMANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMET ASSAY; DEOXYGUANOSINE; DNA DAMAGE; HUMANS; LIGHT; MASS SPECTROMETRY; MODELS, CHEMICAL; OXYGEN; PIGMENT EPITHELIUM OF EYE; PIPERAZINES; PYRIDINIUM COMPOUNDS; RETINOIDS; VITAMIN E;

EID: 0037705336     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300457200     Document Type: Article

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