Calcium-mediated activation of PI3K and p53 leads to apoptosis in thyroid carcinoma cells

Cellular and Molecular Life Sciences

Volumn 64, Issue 11, 2007, Pages 1428-1436

  Liu, Z M ^a,b   Chen, G G ^a   Vlantis, A C ^a   Tse, G M ^a   Shum, C K Y ^a   Van Hasselt, C A ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Apoptosis; Cadmium; Calcium; p53; PI3K Akt; Thyroid cancer

Indexed keywords

CADMIUM; CALCIUM; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CARCINOMA CELL; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MITOCHONDRION; SIGNAL TRANSDUCTION; THYROID CARCINOMA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CADMIUM; CALCIUM; CARCINOMA; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; ENZYME ACTIVATION; HUMANS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; THYROID NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34250030044     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-007-7107-x     Document Type: Article

References (38)

1. McIver B., Haym I. D., Giuffrida D. F., Dvorak C. E., Grant C. S., Thompson G. B., van Heerden J. A. and Goellner J. R. (2001) Anaplastic thyroid carcinoma: A 50-year experience at a single institution. Surgery 130, 1028-1034.
2. Tennvall J., Lundell G., Hallquist A., Wahlberg P., Wallin G. and Tibblin S. (1994) Combined doxorubicin, hyperfractionated radiotherapy, and surgery in anaplastic thyroid carcinoma. Report on two protocols. The Swedish Anaplastic Thyroid Cancer Group. Cancer 74, 1348-1354.
3. Lee K. B., Parker R. J. and Reed E. (1995) Effect of cadmium on human ovarian cancer cells with acquired cisplatin resistance. Cancer Lett. 88, 57-66.
4. Waalkes M. P., Diwan B. A., Weghorst C. M., Ward J. M. and Rice J. M. (1991) Anti-carcinogenic effects of cadmium in B6C3F1 mouse liver and lung. Toxicol. Appl. Pharmacol. 110, 327-335.
5. Waalkes M. P., Diwan B. A., Weghorst C. M., Ward J. M., Rice J. M., Cherian M. G. and Goyer R. A. (1993) Further evidence of the tumor-suppression effects of cadmium in the B6C3F1 mouse liver and lung; late stage vulnerability of tumors of cadmium and the role of metallothionein. J. Pharmacol. Exp. Ther. 266, 1656-1663.
6. Soignet S. L., Maslak P., Wang Z. G., Jhanwar S., Calleja E., Dardashti L. J., Corso D., DeBlasio A., Gabrilove J., Scheinberg D. A., Pandolfi P. P. and Warrell R. P. Jr. (1998) Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. N. Engl. J. Med. 339, 1341-1348.
7. 3 exerts dose-dependent dual effects on APL cells. Blood 89, 3345-3353.
8. Berridge M. J., Lipp P. and Bootman M. D. (2000) The versatility and universality of calcium signalling. Nat. Rev. Mol. Cell. Biol. 1, 11-21.
9. Agell N., Bachs O., Rocamora N. and Villalonga P. (2002) Modulation of the Ras/Raf/MEK/ERK pathway by Ca(2+), and calmodulin. Cell. Signal. 14, 649-654.
10. Rizzuto R., Pinton P., Ferrari D., Chami M., Szabadkai G., Magalhaes P. J., Di Virgilio F. and Pozzan T. (2003) Calcium and apoptosis: facts and hypotheses. Oncogene 22, 8619-8627.
11. Scotto C., Delphin C., Deloulme J. C. and Baudier J. (1999) Concerted regulation of wild-type p53 nuclear accumulation and activation by S100B and calcium-dependent protein kinase C. Mol. Cell. Biol. 19, 7168-7180.
12. Crow T., Xue-Bian J. J., Siddiqi V. and Neary J. T. (2001) Serotonin activation of the ERK pathway in Hermissenda: Contribution of calcium-dependent protein kinase C. J Neurochem. 78, 358-364.
13. 2-terminal kinase (JNK/SAPK) in LLC-PK1 cells by cadmium. Biochem. Biophys. Res. Commun. 251, 527-532.
14. Stringaris A. K., Geisenhainer J., Bergmann F., Balshusemann C., Lee U., Zysk G., Mitchell T. J., Keller B. U., Kuhnt U., Gerber J., Spreer A., Bahr M., Michel U. and Nau R. (2002) Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase. Neurobiol. Dis. 11, 355-368.
15. Yano S., Tokumitsu H. and Soderling T. R. (1998) Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 396, 584-587.
16. Sionov R. V. and Haupt Y. (1999) The cellular response to p53: the decision between life and death. Oncogene 18, 6145.
17. Waga S., Hannon G., Beach D. and Stillman B. (1994) The p21 inhibitor of cyclin dependent kinases controls DNA replication by interaction with PCNA. Nature 369, 574-578.
18. Cantley L. C. (2002) The phosphoinositide 3-kinase pathway. Science 296, 1655-1657.
19. Shimamura H., Terada Y., Okado T., Tanaka H., Inoshita S. and Sasaki S. (2003) The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vivo via NF-kappaB and Bad. J. Am. Soc. Nephrol. 14, 1427-1434.
20. Shack S., Wang X. T., Kokkonen G. C., Gorospe M., Longo D. L. and Holbrook N. J. (2003) Caveolin-induced activation of the phosphatidylinositol 3- kinase/Akt pathway increases arsenite cytotoxicity. Mol. Cell. Biol. 23, 2407-2414.
21. Aki T., Mizukami Y., Oka Y., Yamaguchi K., Uemura K., Fujimiya T. and Yoshida K. (2001) Phosphoinositide 3-kinase accelerates necrotic cell death during hypoxia. Biochem. J. 358, 481-487.
22. Aki T., Yamaguchi K., Fujimiya T. and Mizukami Y. (2003) Phosphoinositide 3- kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2. Oncogene 22, 8529-8535.
23. Lee S. B., Cho E. S., Yang H. S., Kim H. and Um H. D. (2005) Serum withdrawal kills U937 cells by inducing a positive mutual interaction between reactive oxygen species and phosphoinositide 3-kinase. Cell. Signal. 17, 197-204.
24. Hart B. A., Lee C. H., Shukla G. S., Shukla A., Osier M., Eneman J. D. and Chiu J. F. (1999) Characterization of cadmium-induced apoptosis in rat lung epithelial cells: evidence for the participation of oxidant stress. Toxicology 133, 43-58.
25. Ishido M., Homma-Takeda S., Tohyama C. and Suzuki T. (1998) Apoptosis in rat renal proximal tubular cells induced by cadmium. J. Toxicol. Environ. Health A 55, 1-12.
26. Tzirogiannis K. N., Panoutsopoulos G. I., Demonakou M. D., Hereti R. I., Alexandropoulou K. N., Basayannis A. C. and Mykoniatis M. G. (2003) Time-course of cadmium-induced acute hepatotoxicity in the rat liver: the role of apoptosis. Arch. Toxicol. 77, 694-701.
27. McConkey D. J. and Orrennius S. (1997) The role of calcium in the regulation of apoptosis. Biochem. Biophys. Res. Commun. 239, 357-366.
28. El Azzouzi B., Tsangaris G. T., Pellegrini O., Manuel Y., Benveniste J. and Thomas Y. (1994) Cadmium induced apoptosis in a human T cell line. Toxicology 88, 127-139.
29. Beyersmann D. and Hechtenberg S. (1997) Cadmium, gene regulation, and cellular signalling in mammalian cells. Toxicol. Appl. Pharmacol. 144, 247-261.
30. Al Nasser I. A. (2000) Cadmium hepatotoxicity and alterations of the mitochondrial function. J. Toxicol. Clin. Toxicol. 38, 407-413.
31. Stridh H., Gigliotti D., Orrenius S. and Cotgreave I. (1999) The role of calcium in pre- and postmitochondrial events in tributyltin-induced T-cell apoptosis. Biochem. Biophys. Res. Commun. 266, 460-465.
32. Crompton M. (1999) The mitochondrial permeability transition pore and its role in cell death. Biochem. J. 341, 233-249.
33. Lewis T. S., Shapiro P. S. and Ahn N. G. (1998) Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74, 49-139.
34. Hendrickx N., Volanti C., Moens U., Seternes O. M., de Witte P., Vandenheede J. R., Piette J. and Agostinis P. (2003) Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. J. Biol. Chem. 278, 52231-52239.
35. Kuntzen C., Sonuc N., De Toni E. N., Opelz C., Mucha S. R., Gerbes A. L. and Eichhorst S. T. (2005) Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest. Cancer Res. 65, 6780-6788.
36. Potapova O., Gorospe M., Dougherty R. H., Dean N. M., Gaarde W. A. and Holbrook N. J. (2000) Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner. Mol. Cell. Biol. 20, 1713-1722.
37. Lane D. P. (1993) A death in the life of p53. Nature 362, 786-787.
38. Michael M. and Oren M. (2002) The p53 and Mdm2 families in cancer. Curr. Opin. Genet. Dev. 12, 53 -59.