Always cleave up your mess: Targeting collagen degradation to treat tissue fibrosis

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 304, Issue 11, 2013, Pages

  McKleroy, William ^a   Lee, Ting Hein ^a   Atabai, Kamran ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Collagen degradation; Extracellular matrix; Matrix metalloproteinases; Pulmonary fibrosis; UIP

Indexed keywords

CATHEPSIN K; COLLAGEN; COLLAGEN FIBER; COLLAGENASE 3; ELASTASE; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; LYSINE; MATRILYSIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 18; MONOMER; NEUTROPHIL COLLAGENASE; PROLINE; UNCLASSIFIED DRUG;

ADULT RESPIRATORY DISTRESS SYNDROME; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CHEMICAL COMPOSITION; COLLAGEN DEGRADATION; COLLAGEN SYNTHESIS; CROSS LINKING; CYSTIC FIBROSIS; DISEASE COURSE; EXTRACELLULAR SPACE; FIBROBLAST; HUMAN; HYDROXYLATION; INFLAMMATION; INTERSTITIAL PNEUMONIA; INTRACELLULAR SPACE; LUNG FIBROSIS; MACROPHAGE; MYOFIBROBLAST; PNEUMONIA; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW;

COLLAGEN DEGRADATION; EXTRACELLULAR MATRIX; MATRIX METALLOPROTEINASES; PULMONARY FIBROSIS; UIP;

ANIMALS; COLLAGEN; COLLAGENASES; EXTRACELLULAR MATRIX; FIBROBLASTS; HUMANS; LUNG; LYSOSOMES; MACROPHAGES; PULMONARY FIBROSIS;

EID: 84878661078     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00418.2012     Document Type: Review

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