Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis

EMBO Journal

Volumn 23, Issue 15, 2004, Pages 3020-3030

  Chung, Linda ^a,b   Dinakarpandian, Deendayal ^b   Yoshida, Naoto ^b   Layer Fields, Janelle L ^a,c   Fields, Gregg B ^a,c   Visse, Robert ^a   Nagase, Hideaki ^a,b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

Collagenase; Enzyme mechanism; Matrix metalloproteinase; Protein unfolding; Triple helix

Indexed keywords

ALANINE; COLLAGEN; COLLAGEN TYPE 1; COLLAGENASE; GLUTAMIC ACID; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE;

ALPHA CHAIN; AMINO ACID SUBSTITUTION; ANEURYSM; ARTHRITIS; ARTICLE; ATHEROSCLEROSIS; CANCER; COLLAGEN DEGRADATION; EMBRYO DEVELOPMENT; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME STRUCTURE; FIBROSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN HYDROLYSIS; TISSUE REGENERATION; TISSUE REMODELING; TISSUE REPAIR; TRIPLE HELIX;

AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; COLLAGEN; GLUTAMIC ACID; HYDROLYSIS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 3; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE;

VERTEBRATA;

EID: 4143066015     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600318     Document Type: Article

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