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Volumn 56, Issue 2, 2011, Pages 406-416

Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen i expression

Author keywords

Cirrhosis; Fibrogenesis; Hepatic stellate cell; Matrix metalloproteinase 2; Type I collagen

Indexed keywords

CARBON TETRACHLORIDE; COLLAGEN TYPE 1; GELATINASE A; MESSENGER RNA;

EID: 79952183801     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-010-1296-0     Document Type: Article
Times cited : (71)

References (39)
  • 1
    • 0028947020 scopus 로고
    • Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type i collagen generating the specific 3/4- and 1/4-length fragments
    • 1:CAS:528:DyaK2MXksVCntrk%3D 10.1074/jbc.270.11.5872 7890717
    • RT Aimes JP Quigley 1995 Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type i collagen generating the specific 3/4- and 1/4-length fragments J Biol Chem 270 5872 5876 1:CAS:528:DyaK2MXksVCntrk%3D 10.1074/jbc.270.11.5872 7890717
    • (1995) J Biol Chem , vol.270 , pp. 5872-5876
    • Aimes, R.T.1    Quigley, J.P.2
  • 2
    • 0024431505 scopus 로고
    • Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen
    • MJ Arthur SL Friedman FJ Roll DM Bissell 1989 Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type iv) collagen J Clin Invest 84 1076 1085 1:CAS:528:DyaL1MXlvFWqu7o%3D 10.1172/JCI114270 2551922 (Pubitemid 19247576)
    • (1989) Journal of Clinical Investigation , vol.84 , Issue.4 , pp. 1076-1085
    • Arthur, M.J.P.1    Friedman, S.L.2    Roll, F.J.3    Bissell, D.M.4
  • 3
    • 0027970351 scopus 로고
    • Expression of gelatinase A, a mediator of extracellular matrix remodeling, by tracheal gland serous cells in culture and in vivo
    • JM Tournier M Polette J Hinnrasky J Beck, et al. 1994 Expression of gelatinase a, a mediator of extracellular matrix remodeling, by tracheal gland serous cells in culture and in vivo J Biol Chem 269 25454 25464 1:CAS:528:DyaK2cXmtVWlu7Y%3D 7929245 (Pubitemid 24336233)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.41 , pp. 25454-25464
    • Tournier, J.-M.1    Polette, M.2    Hinnrasky, J.3    Beck, J.4    Werb, Z.5    Basbaum, C.6
  • 4
    • 0028906431 scopus 로고
    • Increased expression of matrix metalloproteinase-ii in experimental liver fibrosis in rats
    • 1:CAS:528:DyaK2MXltlentL8%3D 10.1002/hep.1840210328 7875677
    • T Takahara K Furui J Funaki Y Nakayama, et al. 1995 Increased expression of matrix metalloproteinase-ii in experimental liver fibrosis in rats Hepatology 21 787 795 1:CAS:528:DyaK2MXltlentL8%3D 10.1002/hep.1840210328 7875677
    • (1995) Hepatology , vol.21 , pp. 787-795
    • Takahara, T.1    Furui, K.2    Funaki, J.3    Nakayama, Y.4
  • 6
    • 0034814405 scopus 로고    scopus 로고
    • Extracellular matrix degradation and the role of hepatic stellate cells
    • DOI 10.1055/s-2001-17552
    • RC Benyon MJ Arthur 2001 Extracellular matrix degradation and the role of hepatic stellate cells Semin Liver Dis 21 373 384 1:CAS:528: DC%2BD3MXnvVant7o%3D 10.1055/s-2001-17552 11586466 (Pubitemid 32923766)
    • (2001) Seminars in Liver Disease , vol.21 , Issue.3 , pp. 373-384
    • Benyon, R.C.1    Arthur, M.J.P.2
  • 7
    • 20644465610 scopus 로고    scopus 로고
    • Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation
    • DOI 10.1002/hep.510300431
    • RC Benyon CJ Hovell M Da Gaca EH Jones, et al. 1999 Progelatinase a is produced and activated by rat hepatic stellate cells and promotes their proliferation Hepatology 30 977 986 1:CAS:528:DyaK1MXmslWgtLs%3D 10.1002/hep.510300431 10498650 (Pubitemid 29458287)
    • (1999) Hepatology , vol.30 , Issue.4 , pp. 977-986
    • Christopher Benyon, R.1    Hovell, C.J.2    Da Gaca, M.3    Jones, E.H.4    Iredale, J.P.5    Arthur, M.J.P.6
  • 9
    • 0032146551 scopus 로고    scopus 로고
    • Mechanisms of spontaneous resolution of rat liver fibrosis: Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
    • JP Iredale RC Benyon J Pickering M McCullen, et al. 1998 Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors J Clin Invest 102 538 549 1:CAS:528:DyaK1cXlt1egur8%3D 10.1172/JCI1018 9691091 (Pubitemid 28376157)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.3 , pp. 538-549
    • Iredale, J.P.1    Benyon, R.C.2    Pickering, J.3    McCullen, M.4    Northrop, M.5    Pawley, S.6    Hovell, C.7    Arthur, M.J.P.8
  • 10
    • 0036730388 scopus 로고    scopus 로고
    • Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2
    • DOI 10.1053/jhep.2002.35279
    • AM Preaux MP D'Ortho MP Bralet Y Laperche P Mavier 2002 Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2 Hepatology 36 615 622 1:CAS:528:DC%2BD38XnvVSkt7c%3D 10.1053/jhep.2002.35279 12198653 (Pubitemid 34977171)
    • (2002) Hepatology , vol.36 , Issue.3 , pp. 615-622
    • Preaux, A.-M.1    D'Ortho, M.-P.2    Bralet, M.-P.3    Laperche, Y.4    Mavier, P.5
  • 11
    • 0030884231 scopus 로고    scopus 로고
    • Unaltered secretion of β-amyloid precursor protein in gelatinase a (matrix metalloproteinase 2)-deficient mice
    • DOI 10.1074/jbc.272.36.22389
    • T Itoh T Ikeda H Gomi S Nakao, et al. 1997 Unaltered secretion of beta-amyloid precursor protein in gelatinase a (matrix metalloproteinase 2)-deficient mice J Biol Chem 272 22389 22392 1:CAS:528:DyaK2sXlvFGisb8%3D 10.1074/jbc.272.36.22389 9278386 (Pubitemid 27386043)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.36 , pp. 22389-22392
    • Itoh, T.1    Ikeda, T.2    Gomi, H.3    Nakao, S.4    Suzuki, T.5    Itohara, S.6
  • 13
    • 4444289142 scopus 로고    scopus 로고
    • Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes
    • DOI 10.1053/j.gastro.2004.04.062, PII S0016508504007723
    • R Safadi M Ohta CE Alvarez MI Fiel, et al. 2004 Immune stimulation of hepatic fibrogenesis by cd8 cells and attenuation by transgenic interleukin-10 from hepatocytes Gastroenterology 127 870 882 1:CAS:528:DC%2BD2cXovVSrs74%3D 10.1053/j.gastro.2004.04.062 15362042 (Pubitemid 39208419)
    • (2004) Gastroenterology , vol.127 , Issue.3 , pp. 870-882
    • Safadi, R.1    Ohta, M.2    Alvarez, C.E.3    Fiel, M.I.4    Bansal, M.5    Mehal, W.Z.6    Friedman, S.L.7
  • 14
    • 0033970969 scopus 로고    scopus 로고
    • Increased toxin-induced liver injury and fibrosis in interleukin-6- deficient mice
    • K Kovalovich RA DeAngelis W Li EE Furth, et al. 2000 Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice Hepatology 31 149 159 1:CAS:528:DC%2BD3cXks1Ohsg%3D%3D 10.1002/hep.510310123 10613740 (Pubitemid 30033701)
    • (2000) Hepatology , vol.31 , Issue.1 , pp. 149-159
    • Kovalovich, K.1    Deangelis, R.A.2    Li, W.3    Furth, E.E.4    Ciliberto, G.5    Taub, R.6
  • 15
    • 10844242987 scopus 로고    scopus 로고
    • Human hepatic stellate cell lines, LX-1 and LX-2: New tools for analysis of hepatic fibrosis
    • DOI 10.1136/gut.2004.042127
    • L Xu AY Hui E Albanis MJ Arthur, et al. 2005 Human hepatic stellate cell lines, LX-1 and LX-2: New tools for analysis of hepatic fibrosis Gut 54 142 151 1:CAS:528:DC%2BD2MXntFyjsg%3D%3D 10.1136/gut.2004.042127 15591520 (Pubitemid 40007234)
    • (2005) Gut , vol.54 , Issue.1 , pp. 142-151
    • Xu, L.1    Hui, A.Y.2    Albanis, E.3    Arthur, M.J.4    O'Byrne, S.M.5    Blaner, W.S.6    Mukherjee, P.7    Friedman, S.L.8    Eng, F.J.9
  • 16
    • 68949122522 scopus 로고    scopus 로고
    • Hepatic stellate cells express functional CXCR4: Role in stromal cell-derived factor -1α -mediated stellate cell activation
    • 1:CAS:528:DC%2BD1MXotVCmuro%3D 10.1002/hep.22890 19434726
    • F Hong A Tuyama T Lee J Loke, et al. 2009 Hepatic stellate cells express functional CXCR4: Role in stromal cell-derived factor -1α -mediated stellate cell activation Hepatology 49 2055 2067 1:CAS:528:DC%2BD1MXotVCmuro%3D 10.1002/hep.22890 19434726
    • (2009) Hepatology , vol.49 , pp. 2055-2067
    • Hong, F.1    Tuyama, A.2    Lee, T.3    Loke, J.4
  • 18
    • 0032744354 scopus 로고    scopus 로고
    • Quantitative zymography of matrix metalloproteinases by measuring hydroxyproline: Application to gelatinases A and B
    • DOI 10.1002/(SICI)1522-2683(19991001)20:14<2824::AID-ELPS2824>3.0. CO;2-H
    • J Le P Dauchot JL Perrot F Cambazard, et al. 1999 Quantitative zymography of matrix metalloproteinases by measuring hydroxyproline: Application to gelatinases a and b Electrophoresis 20 2824 2829 1:CAS:528:DyaK1MXmvFahsLg%3D 10.1002/(SICI)1522-2683(19991001)20:14<2824::AID-ELPS2824>3.0.CO;2-H 10546813 (Pubitemid 29517207)
    • (1999) Electrophoresis , vol.20 , Issue.14 , pp. 2824-2829
    • Le, J.1    Dauchot, P.2    Perrot, J.L.3    Cambazard, F.4    Frey, J.5    Chamson, A.6
  • 19
    • 0035170255 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy
    • DOI 10.1038/nm1101-1202
    • B Wielockx K Lannoy SD Shapiro T Itoh, et al. 2001 Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy Nat Med 7 1202 1208 1:CAS:528:DC%2BD3MXotlKlurY%3D 10.1038/nm1101-1202 11689884 (Pubitemid 33063775)
    • (2001) Nature Medicine , vol.7 , Issue.11 , pp. 1202-1208
    • Wielockx, B.1    Lannoy, K.2    Shapiro, S.D.3    Itoh, T.4    Itohara, S.5    Vandekerckhove, J.6    Libert, C.7
  • 20
    • 0032801286 scopus 로고    scopus 로고
    • Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy
    • DOI 10.1046/j.1440-1746.1999.01928.x
    • D Li SL Friedman 1999 Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy J Gastroenterol Hepatol 14 618 633 1:STN:280:DyaK1Mzms1yiug%3D%3D 10.1046/j.1440-1746.1999.01928.x 10440206 (Pubitemid 29350115)
    • (1999) Journal of Gastroenterology and Hepatology , vol.14 , Issue.7 , pp. 618-633
    • Li, D.1    Friedman, S.L.2
  • 21
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • DOI 10.1074/jbc.275.4.2247
    • SL Friedman 2000 Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury J Biol Chem 275 2247 2250 1:CAS:528:DC%2BD3cXpvFersQ%3D%3D 10.1074/jbc.275.4.2247 10644669 (Pubitemid 30081976)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.4 , pp. 2247-2250
    • Friedman, S.L.1
  • 22
    • 33746521801 scopus 로고
    • Seminars in medicine of the Beth Israel Hospital, Boston: The cellular basis of hepatic fibrosis - Mechanisms and treatment strategies
    • DOI 10.1056/NEJM199306243282508
    • SL Friedman 1993 Seminars in medicine of the beth Israel hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies N Engl J Med 328 1828 1835 1:STN:280:DyaK3s3nsFersg%3D%3D 10.1056/NEJM199304223281620 8502273 (Pubitemid 23174715)
    • (1993) New England Journal of Medicine , vol.328 , Issue.25 , pp. 1828-1835
    • Friedman, S.L.1
  • 23
    • 84955869519 scopus 로고
    • Liver fibrosis: Perspectives in pathobiochemical research and clinical outlook
    • 1:CAS:528:DyaK3MXltFWksLc%3D 1892952
    • AM Gressner 1991 Liver fibrosis: Perspectives in pathobiochemical research and clinical outlook Eur J Clin Chem Clin Biochem 29 293 311 1:CAS:528:DyaK3MXltFWksLc%3D 1892952
    • (1991) Eur J Clin Chem Clin Biochem , vol.29 , pp. 293-311
    • Gressner, A.M.1
  • 24
    • 0037221910 scopus 로고    scopus 로고
    • Liver fibrosis: Insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors
    • DOI 10.1053/gast.2003.50012
    • C Yang M Zeisberg B Mosterman A Sudhakar, et al. 2003 Liver fibrosis: Insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors Gastroenterology 124 147 159 1:CAS:528: DC%2BD3sXot1amsw%3D%3D 10.1053/gast.2003.50012 12512039 (Pubitemid 36055348)
    • (2003) Gastroenterology , vol.124 , Issue.1 , pp. 147-159
    • Yang, C.1    Zeisberg, M.2    Mosterman, B.3    Sudhakar, A.4    Yerramalla, U.5    Holthaus, K.6    Xu, L.7    Eng, F.8    Afdhal, N.9    Kalluri, R.10
  • 25
    • 0033921956 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat
    • T Knittel M Mehde A Grundmann B Saile, et al. 2000 Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat Histochem Cell Biol 113 443 453 1:CAS:528:DC%2BD3cXkvVOrtrc%3D 10933221 (Pubitemid 30436163)
    • (2000) Histochemistry and Cell Biology , vol.113 , Issue.6 , pp. 443-453
    • Knittel, T.1    Mehde, M.2    Grundmann, A.3    Saile, B.4    Scharf, J.-G.5    Ramadori, G.6
  • 26
    • 0035119323 scopus 로고    scopus 로고
    • Matrix metalloproteinase (MMP)-2, MMP-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C
    • DOI 10.1016/S0168-8278(00)00037-4, PII S0168827800000374
    • R Lichtinghagen D Michels CI Haberkorn B Arndt, et al. 2001 Matrix metalloproteinase (mmp)-2, mmp-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis c J Hepatol 34 239 247 1:CAS:528:DC%2BD3MXislCksLg%3D 10.1016/S0168-8278(00)00037-4 11281552 (Pubitemid 32176445)
    • (2001) Journal of Hepatology , vol.34 , Issue.2 , pp. 239-247
    • Lichtinghagen, R.1    Michels, D.2    Haberkorn, C.I.3    Arndt, B.4    Bahr, M.5    Flemming, P.6    Manns, M.P.7    Boeker, K.H.W.8
  • 27
    • 33750377555 scopus 로고    scopus 로고
    • Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats
    • Ebrahimkhani MR, Kiani S, Oakley F, Kendall T, et al. Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats. Gut. 2006.
    • (2006) Gut.
    • Ebrahimkhani, M.R.1    Kiani, S.2    Oakley, F.3    Kendall, T.4
  • 28
    • 4444269015 scopus 로고    scopus 로고
    • Treatment of thioacetamide-induced liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid
    • DOI 10.1016/j.jhep.2004.04.010, PII S0168827804001448
    • S Reif H Aeed Y Shilo R Reich, et al. 2004 Treatment of thioacetamide-induced liver cirrhosis by the ras antagonist, farnesylthiosalicylic acid J Hepatol 41 235 241 1:CAS:528:DC%2BD2cXmt1KjsL8%3D 10.1016/j.jhep.2004.04.010 15288472 (Pubitemid 39177627)
    • (2004) Journal of Hepatology , vol.41 , Issue.2 , pp. 235-241
    • Reif, S.1    Aeed, H.2    Shilo, Y.3    Reich, R.4    Kloog, Y.5    Kweon, Y.O.6    Bruck, R.7
  • 29
    • 0034891785 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases in spontaneous regression of liver fibrosis
    • 1:STN:280:DC%2BD3MvksFOhsg%3D%3D 11490813
    • HS Lee GT Huang LH Miau LL Chiou, et al. 2001 Expression of matrix metalloproteinases in spontaneous regression of liver fibrosis Hepato-Gastroenterology 48 1114 1117 1:STN:280:DC%2BD3MvksFOhsg%3D%3D 11490813
    • (2001) Hepato-Gastroenterology , vol.48 , pp. 1114-1117
    • Lee, H.S.1    Huang, G.T.2    Miau, L.H.3    Chiou, L.L.4
  • 32
    • 0034808233 scopus 로고    scopus 로고
    • Matrix as a modulator of hepatic fibrogenesis
    • DOI 10.1055/s-2001-17556
    • D Schuppan M Ruehl R Somasundaram EG Hahn 2001 Matrix as a modulator of hepatic fibrogenesis Semin Liver Dis 21 351 372 1:CAS:528:DC%2BD3MXnvVant70%3D 10.1055/s-2001-17556 11586465 (Pubitemid 32923765)
    • (2001) Seminars in Liver Disease , vol.21 , Issue.3 , pp. 351-372
    • Schuppan, D.1    Ruehl, M.2    Somasundaram, R.3    Hahn, E.G.4
  • 33
    • 0037077212 scopus 로고    scopus 로고
    • Proteolysis of latent transforming growth factor-β (TGF-β)-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-β from bone matrix
    • DOI 10.1074/jbc.M111663200
    • SL Dallas JL Rosser GR Mundy LF Bonewald 2002 Proteolysis of latent transforming growth factor-beta (tgf-beta)-binding protein-1 by osteoclasts. A cellular mechanism for release of tgf-beta from bone matrix J Biol Chem 277 21352 21360 1:CAS:528:DC%2BD38Xkslyqt7c%3D 10.1074/jbc.M111663200 11929865 (Pubitemid 34952275)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.24 , pp. 21352-21360
    • Dallas, S.L.1    Rosser, J.L.2    Mundy, G.R.3    Bonewald, L.F.4
  • 34
    • 46149083476 scopus 로고    scopus 로고
    • Reduced mmp-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy
    • 10.1007/s00395-008-0715-2 18347835
    • S Van Linthout U Seeland A Riad O Eckhardt, et al. 2008 Reduced mmp-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy Basic Res Cardiol 103 319 327 10.1007/s00395-008-0715-2 18347835
    • (2008) Basic Res Cardiol , vol.103 , pp. 319-327
    • Van Linthout, S.1    Seeland, U.2    Riad, A.3    Eckhardt, O.4
  • 35
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • M Egeblad Z Werb 2002 New functions for the matrix metalloproteinases in cancer progression Nat Rev Cancer 2 161 174 1:CAS:528:DC%2BD38Xis1KktL8%3D 10.1038/nrc745 11990853 (Pubitemid 37328786)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.3 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 36
    • 0037126045 scopus 로고    scopus 로고
    • Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury
    • 1:CAS:528:DC%2BD38XntVKktr8%3D 10.1161/01.CIR.0000028818.33488.7B 12234962
    • W Wang CJ Schulze WL Suarez-Pinzon JR Dyck, et al. 2002 Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury Circulation 106 1543 1549 1:CAS:528:DC%2BD38XntVKktr8%3D 10.1161/01.CIR.0000028818.33488.7B 12234962
    • (2002) Circulation , vol.106 , pp. 1543-1549
    • Wang, W.1    Schulze, C.J.2    Suarez-Pinzon, W.L.3    Dyck, J.R.4
  • 37
    • 3042745695 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 (mmp-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (adp-ribose) polymerase (parp) in vitro
    • 1:CAS:528:DC%2BD2cXjtVyrsro%3D 14766804
    • JA Kwan CJ Schulze W Wang H Leon, et al. 2004 Matrix metalloproteinase-2 (mmp-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (adp-ribose) polymerase (parp) in vitro FASEB J 18 690 692 1:CAS:528:DC%2BD2cXjtVyrsro%3D 14766804
    • (2004) FASEB J , vol.18 , pp. 690-692
    • Kwan, J.A.1    Schulze, C.J.2    Wang, W.3    Leon, H.4
  • 39
    • 0030768707 scopus 로고    scopus 로고
    • Evidence of a role for matrix metalloproteinases in cold preservation injury of the liver in humans and in the rat
    • AG Upadhya RP Harvey TK Howard JA Lowell, et al. 1997 Evidence of a role for matrix metalloproteinases in cold preservation injury of the liver in humans and in the rat Hepatology 26 922 928 1:CAS:528:DyaK2sXmslCit7s%3D 10.1002/hep.510260418 9328314 (Pubitemid 27413658)
    • (1997) Hepatology , vol.26 , Issue.4 , pp. 922-928
    • Upadhya, A.G.1    Harvey, R.P.C.2    Howard, T.K.3    Lowell, J.A.4    Shenoy, S.5    Strasberg, S.M.6


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