The effect of cathepsin K deficiency on airway development and TGF-β1 degradation

Respiratory Research

Volumn 12, Issue , 2011, Pages

  Zhang, Dongwei ^a   Leung, Nelson ^a   Weber, Ekkehard ^b   Saftig, Paul ^c   Brömme, Dieter ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

Cathepsin K; Extracellular matrix; Lung airway; Protease inhibitors; TGF 1

Indexed keywords

ALPHA ACTIN; CATHEPSIN K; COLLAGEN; CYTOKERATIN; GLYCOSAMINOGLYCAN; HYDROXYPROLINE; TRANSFORMING GROWTH FACTOR BETA1; VIMENTIN; CTSK PROTEIN, MOUSE; TGFB1 PROTEIN, MOUSE;

AIRWAY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATHEPSIN K DEFICIENCY; CELL PROLIFERATION; DEGRADATION; ENZYME DEFICIENCY; EXTRACELLULAR MATRIX; FEMALE; LUNG FIBROBLAST; LUNG HOMOGENATE; MOUSE; NONHUMAN; RESPIRATORY EPITHELIUM; SMOOTH MUSCLE FIBER; TRANSFORMING GROWTH FACTOR BETA1 DEGRADATION; WILD TYPE; AGE; AGING; AIRWAY REMODELING; ANALYSIS OF VARIANCE; ANIMAL; C57BL MOUSE; CELL CULTURE; ENZYMOLOGY; FIBROBLAST; GENETICS; GROWTH, DEVELOPMENT AND AGING; LUNG; METABOLISM; MOUSE MUTANT; PATHOLOGY; RESPIRATORY TRACT MUCOSA; WOUND HEALING;

AGE FACTORS; AGING; AIRWAY REMODELING; ANALYSIS OF VARIANCE; ANIMALS; CATHEPSIN K; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN; EXTRACELLULAR MATRIX; FEMALE; FIBROBLASTS; GLYCOSAMINOGLYCANS; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RESPIRATORY MUCOSA; TRANSFORMING GROWTH FACTOR BETA1; WOUND HEALING;

EID: 79957650183     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-12-72     Document Type: Article

References (49)

1. Yasuda Y, Kaleta J, Bromme D. The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics. Adv Drug Deliv Rev 2005, 57(7):973-993. 10.1016/j.addr.2004.12.013, 15876399.
2. Drake FH, Dodds RA, James IE, Connor JR, Debouck C, Richardson S, Lee-Rykaczewski E, Coleman L, Rieman D, Barthlow R, et al. Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts. J Biol Chem 1996, 271:12511-12516. 10.1074/jbc.271.21.12511, 8647859.
3. Hou WS, Li Z, Gordon RE, Chan K, Klein MJ, Levy R, Keysser M, Keyszer G, Bromme D. Cathepsin K is a critical protease in synovial fibroblast-mediated collagen degradation. Am J Pathol 2001, 159(6):2167-2177. 10.1016/S0002-9440(10)63068-4, 1850593, 11733367.
4. Bone HG, McClung MR, Roux C, Recker RR, Eisman JA, Verbruggen N, Hustad CM, DaSilva C, Santora AC, Ince BA. Odanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone density. J Bone Miner Res 2010, 25(5):937-947.
5. Eastell R, Nagase S, Ohyama M, Small M, Sawyer J, Boonen S, Spector T, Kuwayama T, Deacon S. Safety and efficacy of the Cathepsin K inhibitor, ONO-5334, in postmenopausal osteoporosis - the OCEAN study. J Bone Miner Res 2011,
6. Peroni A, Zini A, Braga V, Colato C, Adami S, Girolomoni G. Drug-induced morphea: report of a case induced by balicatib and review of the literature. J Am Acad Dermatol 2008, 59(1):125-129. 10.1016/j.jaad.2008.03.009, 18410981.
7. Bromme D, Lecaille F. Cathepsin K inhibitors for osteoporosis and potential off-target effects. Expert Opin Investig Drugs 2009, 18(5):585-600. 10.1517/13543780902832661, 3110777, 19388876.
8. Buhling F, Waldburg N, Kruger S, Rocken C, Wiesner O, Weber E, Welte T. Expression of cathepsins B, H, K, L, and S during human fetal lung development. Dev Dyn 2002, 225(1):14-21. 10.1002/dvdy.10134, 12203716.
9. Knaapi J, Lukkarinen H, Kiviranta R, Steiner A, Lassus P, Andersson S, Kaapa P. Cathepsin K expression is diminished in infants with bronchopulmonary dysplasia. Acta Paediatr 2006, 95(10):1298-1300. 10.1080/08035250600586492, 16982505.
10. van den Brule S, Misson P, Buhling F, Lison D, Huaux F. Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-beta. Respir Res 2005, 6:84. 10.1186/1465-9921-6-84, 1188077, 16045809.
11. Pardo A, Selman M. Molecular mechanisms of pulmonary fibrosis. Front Biosci 2002, 7:d1743-1761. 10.2741/pardo, 12133818.
12. Vignola AM, Mirabella F, Costanzo G, Di Giorgi R, Gjomarkaj M, Bellia V, Bonsignore G. Airway remodeling in asthma. Chest 2003, 123(3 Suppl):417S-422S.
13. Hirakawa H, Pierce RA, Bingol-Karakoc G, Karaaslan C, Weng M, Shi GP, Saad A, Weber E, Mariani TJ, Starcher B, et al. Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury. Am J Respir Crit Care Med 2007, 176(8):778-785. 10.1164/rccm.200704-519OC, 2020827, 17673697.
14. Koslowski R, Knoch K, Kuhlisch E, Seidel D, Kasper M. Cathepsins in bleomycin-induced lung injury in rat. Eur Respir J 2003, 22(3):427-435. 10.1183/09031936.03.00112903, 14516131.
15. Hashimoto S, Gon Y, Takeshita I, Matsumoto K, Maruoka S, Horie T. Transforming growth Factor-beta1 induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathway. Am J Respir Crit Care Med 2001, 163(1):152-157.
16. Kenyon NJ, Ward RW, Last JA. Airway fibrosis in a mouse model of airway inflammation. Toxicol Appl Pharmacol 2003, 186(2):90-100. 10.1016/S0041-008X(02)00025-X, 12639500.
17. Sagara H, Okada T, Okumura K, Ogawa H, Ra C, Fukuda T, Nakao A. Activation of TGF-beta/Smad2 signaling is associated with airway remodeling in asthma. J Allergy Clin Immunol 2002, 110(2):249-254. 10.1067/mai.2002.126078, 12170265.
18. Buhling F, Waldburg N, Gerber A, Hackel C, Kruger S, Reinhold D, Bromme D, Weber E, Ansorge S, Welte T. Cathepsin K expression in human lung. Adv Exp Med Biol 2000, 477:281-286.
19. Bühling F, Gerber A, Häckel C, Krüger S, Köhnlein T, Brömme D, Reinhold D, Ansorge F, Welte T. Expression of cathepsin K in lung epithelial cells. Am J Respir Crit Care Med 1999, 20:612-619.
20. Srivastava M, Steinwede K, Kiviranta R, Morko J, Hoymann HG, Langer F, Buhling F, Welte T, Maus UA. Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis. Respir Res 2008, 9:54. 10.1186/1465-9921-9-54, 2490691, 18638383.
21. Saftig P, Wehmeyer O, Hunziker E, Jones S, Boyde A, Rommerskirch W, von Figura K. Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin K-deficient mice. Proc Natl Acad Sci USA 1998, 95:13453-13458. 10.1073/pnas.95.23.13453, 24840, 9811821.
22. Sullivan P, Stephens D, Ansari T, Costello J, Jeffery P. Variation in the measurements of basement membrane thickness and inflammatory cell number in bronchial biopsies. Eur Respir J 1998, 12(4):811-815. 10.1183/09031936.98.12040811, 9817150.
23. Reddy GK, Enwemeka CS. A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem 1996, 29(3):225-229. 10.1016/0009-9120(96)00003-6, 8740508.
24. Linnevers CJ, McGrath ME, Armstrong R, Mistry FR, Barnes M, Klaus JL, Palmer JT, Katz BA, Brömme D. Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex. Protein Science 1997, 6:919-921. 2144758, 9098904.
25. Halayko AJ, Salari H, Ma X, Stephens NL. Markers of airway smooth muscle cell phenotype. Am J Physiol 1996, 270(6 Pt 1):L1040-1051.
26. Peng Q, Lai D, Nguyen TT, Chan V, Matsuda T, Hirst SJ. Multiple beta 1 integrins mediate enhancement of human airway smooth muscle cytokine secretion by fibronectin and type I collagen. J Immunol 2005, 174(4):2258-2264.
27. Brömme D, Klaus JL, Okamoto K, Rasnick D, Palmer JT. Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L. Biochem J 1996, 315:85-89. 1217200, 8670136.
28. Kotaru C, Schoonover KJ, Trudeau JB, Huynh ML, Zhou X, Hu H, Wenzel SE. Regional fibroblast heterogeneity in the lung: implications for remodeling. Am J Respir Crit Care Med 2006, 173(11):1208-1215. 10.1164/rccm.200508-1218OC, 2662967, 16543551.
29. Burgess JK, Ge Q, Poniris MH, Boustany S, Twigg SM, Black JL, Johnson PR. Connective tissue growth factor and vascular endothelial growth factor from airway smooth muscle interact with the extracellular matrix. Am J Physiol Lung Cell Mol Physiol 2006, 290(1):L153-161.
30. Skold CM. Remodeling in asthma and COPD--differences and similarities. Clin Respir J 4(Suppl 1):20-27.
31. Lagente V, Boichot E. Role of matrix metalloproteinases in the inflammatory process of respiratory diseases. J Mol Cell Cardiol 2010, 48(3):440-444. 10.1016/j.yjmcc.2009.09.017, 19818795.
32. Veillard F, Lecaille F, Lalmanach G. Lung cysteine cathepsins: intruders or unorthodox contributors to the kallikrein-kinin system?. Int J Biochem Cell Biol 2008, 40(6-7):1079-1094. 10.1016/j.biocel.2007.10.030, 18093865.
33. Buhling F, Rocken C, Brasch F, Hartig R, Yasuda Y, Saftig P, Bromme D, Welte T. Pivotal role of cathepsin K in lung fibrosis. Am J Pathol 2004, 164(6):2203-2216. 10.1016/S0002-9440(10)63777-7, 1615770, 15161653.
34. Deal C. Potential new drug targets for osteoporosis. Nat Clin Pract Rheumatol 2009, 5(1):20-27. 10.1038/ncprheum0977, 19098925.
35. Cohen L, E X, Tarsi J, Ramkumar T, Horiuchi TK, Cochran R, DeMartino S, Schechtman KB, Hussain I, Holtzman MJ, et al. Epithelial cell proliferation contributes to airway remodeling in severe asthma. Am J Respir Crit Care Med 2007, 176(2):138-145. 10.1164/rccm.200607-1062OC, 1994213, 17463414.
36. Turk B, Stoka V. Protease signalling in cell death: caspases versus cysteine cathepsins. FEBS Lett 2007, 581(15):2761-2767. 10.1016/j.febslet.2007.05.038, 17544407.
37. Richter A, Puddicombe SM, Lordan JL, Bucchieri F, Wilson SJ, Djukanovic R, Dent G, Holgate ST, Davies DE. The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol 2001, 25(3):385-391.
38. Johnson PR, Black JL, Carlin S, Ge Q, Underwood PA. The production of extracellular matrix proteins by human passively sensitized airway smooth-muscle cells in culture: the effect of beclomethasone. Am J Respir Crit Care Med 2000, 162(6):2145-2151.
39. Ten Hacken NH, Postma DS, Timens W. Airway remodeling and long-term decline in lung function in asthma. Curr Opin Pulm Med 2003, 9(1):9-14. 10.1097/00063198-200301000-00002, 12476078.
40. Royce SG, Tan L, Koek AA, Tang ML. Effect of extracellular matrix composition on airway epithelial cell and fibroblast structure: implications for airway remodeling in asthma. Ann Allergy Asthma Immunol 2009, 102(3):238-246. 10.1016/S1081-1206(10)60087-7, 19354071.
41. Ebina M, Takahashi T, Chiba T, Motomiya M. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am Rev Respir Dis 1993, 148(3):720-726.
42. Carroll N, Elliot J, Morton A, James A. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 1993, 147(2):405-410.
43. Johnson PR, Burgess JK, Underwood PA, Au W, Poniris MH, Tamm M, Ge Q, Roth M, Black JL. Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism. J Allergy Clin Immunol 2004, 113(4):690-696. 10.1016/j.jaci.2003.12.312, 15100675.
44. Deng H, Hershenson MB, Lei J, Anyanwu AC, Pinsky DJ, Bentley JK. Pulmonary artery smooth muscle hypertrophy: roles of glycogen synthase kinase-3beta and p70 ribosomal S6 kinase. Am J Physiol Lung Cell Mol Physiol 2010, 298(6):L793-803. 10.1152/ajplung.00108.2009, 20190034.
45. Parameswaran K, Willems-Widyastuti A, Alagappan VK, Radford K, Kranenburg AR, Sharma HS. Role of extracellular matrix and its regulators in human airway smooth muscle biology. Cell Biochem Biophys 2006, 44(1):139-146. 10.1385/CBB:44:1:139, 16456242.
46. Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 2003, 200(4):500-503. 10.1002/path.1427, 12845617.
47. Zou Y, Zhang RZ, Sabatelli P, Chu ML, Bonnemann CG. Muscle interstitial fibroblasts are the main source of collagen VI synthesis in skeletal muscle: implications for congenital muscular dystrophy types Ullrich and Bethlem. J Neuropathol Exp Neurol 2008, 67(2):144-154. 10.1097/nen.0b013e3181634ef7, 18219255.
48. Faouzi S, Le Bail B, Neaud V, Boussarie L, Saric J, Bioulac-Sage P, Balabaud C, Rosenbaum J. Myofibroblasts are responsible for collagen synthesis in the stroma of human hepatocellular carcinoma: an in vivo and in vitro study. J Hepatol 1999, 30(2):275-284. 10.1016/S0168-8278(99)80074-9, 10068108.
49. Sullivan DE, Ferris M, Nguyen H, Abboud E, Brody AR. TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation. J Cell Mol Med 2009, 13(8B):1866-1876. 10.1111/j.1582-4934.2008.00647.x, 2855747, 20141610.