Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanism

Journal of Cellular Physiology

Volumn 192, Issue 2, 2002, Pages 160-170

  Monea, Sara ^a   Lehti, Kaisa ^b   Keski Oja, Jorma ^b   Mignatti, Paolo ^a,c  

^a SA Localio Laboratory for General Surgery Research ^*  (United States)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 4; COMPLEMENTARY DNA; GELATINASE A; MATRIX METALLOPROTEINASE 14; METALLOPROTEINASE INHIBITOR; PLASMIN; PLASMIN INHIBITOR; PLASMINOGEN; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ARTICLE; CATALYSIS; COLLAGEN DEGRADATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

DNA, COMPLEMENTARY; ENZYME ACTIVATION; GELATINASES; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; PLASMIN; RECEPTORS, VITRONECTIN; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0036301176     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10126     Document Type: Article

References (60)

1. Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments
2. Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes
3. 3
4. Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
5. Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines
6. H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen
7. Human progelatinase A can be activated by matrilysin
8. Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase
9. 3 promotes maturation of MMP-2 in breast carcinoma cells
10. v subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase
11. Thrombin promotes activation of matrix metalloproteinase-2 produced by cultured vascular smooth muscle cells
12. Urokinase plasminogen activator and gelatinases are associated with membrane vesicles shed by human HT-1080 fibrosarcoma cells
13. Tissue cooperation in a proteolytic cascade activating human interstitial collagenase
14. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates
15. Structural biochemistry and activation of matrix metalloproteinases
16. A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases
17. Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63-kDa active species
18. Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface
19. Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain
20. Calcium ionophores decrease pericellular gelatinolytic activity via inhibition of 92-kDa gelatinase expression and decrease of 72-kDa, gelatinase activation
21. Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate
22. Membrane type 1 matrix metalloproteinase-associated degradation of tissue inhibitor of metalloproteinase 2 in human tumor cell lines
23. Metalloproteinases and their inhibitors in matrix remodeling
24. Control of type IV collagenase activity by components of the urokinase-plasmin system: A regulatory mechanism with cell-bound reactants
25. Biology and biochemistry of proteinases in tumor invasion
26. Nonenzymatic interactions between proteinases and the cell surface: Novel roles in normal and malignant cell physiology
27. Activation of TIMP-2/progelatinase A complex by stromelysin
28. Physiological mechanisms for metalloproteinase activation
29. Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties
30. Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties
31. Proteolytic activation of the precursor of membrane type 1 matrix metalloproteinase by human plasmin. A possible cell surface activator
32. 2(IV) chain of collagen IV
33. An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. II. Mammalian fibroblast cultures transformed by DNA and RNA tumor viruses
34. Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases
35. Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP
36. LeukolysinfMMP25/MT6-MMP: A novel matrix metalloproteinase specifically expressed in the leukocyte lineage
37. Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity
38. Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma
39. An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase
40. Plasminogen and plasmin
41. A matrix metalloproteinase expressed on the surface of invasive tumour cells
42. Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2
43. Cell surface binding and activation of gelatinase A induced by expression of membrane-type-1-matrix metalloproteinase (MT1-MMP)
44. Human 92- and 72-kDa type IV collagenases are elastases
45. Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: A role for inflammatory cells in tumor invasion and angiogenesis
46. The activation of ProMMP-2 (gelatinase A) by HT-1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP-14) to a 45-kDa form
47. Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2
48. Mechanism of cell activation of 72-kDA type IV collagenase. Isolation of the activated form of the membrane metalloproteinase
49. Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells
50. Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes
51. Activation of the precursor of gelatinase A/72-kDa type IV collagenase/MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasis
52. Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (membrane type 1)-MMP-dependent activation of pro-MMP-2
53. An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses
54. Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator
55. The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3
56. Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumors in vivo and in vitro
57. Complex regulation of membrane-type matrix metalloproteinase expression and matrix metalloproteinase-2 activation by concanavalin A in MDA-MB-231 human breast cancer cells
58. Thrombin induces the activation of progelatinase A in vascular endothelial cells. Physiologic regulation of angiogenesis
59. Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP)