Deregulated G1-S control and energy stress contribute to the synthetic-lethal interactions between inactivation of RB and TSC1 or TSC2

Journal of Cell Science

Volumn 126, Issue 9, 2013, Pages 2004-2013

  Gordon, Gabriel M ^a   Zhang, Tianyi ^a   Zhao, Jiong ^a   Du, Wei ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Cell death; Energy stress; G1 S control; LKB1; RB; TSC1; TSC2; Tumor

Indexed keywords

JANUS KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PEPTIDES AND PROTEINS; PROTEIN KINASE LKB1; PROTEIN TSC1; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; TUBERIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DE2F1 GENE; DNA DAMAGE; DNA REPLICATION; DROSOPHILA MELANOGASTER; GENE; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RHEB GENE; SIGNAL TRANSDUCTION;

CELL DEATH; ENERGY STRESS; G1-S CONTROL; LKB1; RB; TSC1; TSC2; TUMOR;

ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENERGY METABOLISM; G1 PHASE; MAP KINASE KINASE 4; PROTEIN KINASES; RETINOBLASTOMA PROTEIN; S PHASE; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS;

DROSOPHILA MELANOGASTER;

EID: 84878624741     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.121301     Document Type: Article

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