Ursolic acid causes DNA-damage, P53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo

Atherosclerosis

Volumn 219, Issue 2, 2011, Pages 402-408

  Messner, Barbara ^a   Zeller, Iris ^a   Ploner, Christian ^b   Frotschnig, Sandra ^b   Ringer, Thomas ^c   Steinacher Nigisch, Anneliese ^a   Ritsch, Andreas ^b   Laufer, Günther ^a   Huck, Christian ^c   Bernhard, David ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Atherosclerosis; BAK; BCLXL; Cell death; DNA damage; Endothelial; IL 5; P53; Therapy; Triterpene; Ursolic acid

Indexed keywords

CASPASE; CELL DNA; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; PROTEIN BAK; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA; URSOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CELL PROLIFERATION; CELL VIABILITY; DNA STRAND BREAKAGE; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG DETERMINATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE ACTIVATION; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; APOLIPOPROTEINS E; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-X PROTEIN; CASPASES; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPERLIPIDEMIAS; INTERLEUKIN-5; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; PLAQUE, ATHEROSCLEROTIC; RNA INTERFERENCE; TIME FACTORS; TRANSFECTION; TRITERPENES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 82955203365     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.05.025     Document Type: Article

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