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Volumn 8, Issue 5, 2013, Pages

Spatiotemporal Characterization of mTOR Kinase Activity Following Kainic Acid Induced Status Epilepticus and Analysis of Rat Brain Response to Chronic Rapamycin Treatment

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN;

EID: 84878396610     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064455     Document Type: Article
Times cited : (43)

References (73)
  • 1
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S, Peterson TR, Sabatini DM, (2010) Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Molecular Cell 40: 310-322.
    • (2010) Molecular Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 2
    • 33644683295 scopus 로고    scopus 로고
    • Glutamatergic regulation of the p70S6 kinase in primary mouse neurons
    • Lenz G, Avruch J, (2005) Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. The Journal of Biological Chemistry 280: 38121-38124.
    • (2005) The Journal of Biological Chemistry , vol.280 , pp. 38121-38124
    • Lenz, G.1    Avruch, J.2
  • 5
    • 75749114797 scopus 로고    scopus 로고
    • mTOR signaling: at the crossroads of plasticity, memory and disease
    • Hoeffer CA, Klann E, (2010) mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci 33: 67-75.
    • (2010) Trends Neurosci , vol.33 , pp. 67-75
    • Hoeffer, C.A.1    Klann, E.2
  • 6
    • 77952749932 scopus 로고    scopus 로고
    • PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis
    • Faghiri Z, Bazan NG, (2010) PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. Experimental Eye Research 90: 718-725.
    • (2010) Experimental Eye Research , vol.90 , pp. 718-725
    • Faghiri, Z.1    Bazan, N.G.2
  • 7
    • 28244475972 scopus 로고    scopus 로고
    • Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy, and survival in irradiated MCF-7 cells
    • Paglin S, Lee N-Y, Nakar C, Fitzgerald M, Plotkin J, et al. (2005) Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy, and survival in irradiated MCF-7 cells. Cancer Research 65: 11061-11070.
    • (2005) Cancer Research , vol.65 , pp. 11061-11070
    • Paglin, S.1    Lee, N.-Y.2    Nakar, C.3    Fitzgerald, M.4    Plotkin, J.5
  • 10
    • 70350455151 scopus 로고    scopus 로고
    • Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway
    • Morita T, Sobue K, (2009) Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway. The Journal of Biological Chemistry 284: 27734-27745.
    • (2009) The Journal of Biological Chemistry , vol.284 , pp. 27734-27745
    • Morita, T.1    Sobue, K.2
  • 11
    • 33646582664 scopus 로고    scopus 로고
    • Hypothalamic mTOR signaling regulates food intake
    • Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, et al. (2006) Hypothalamic mTOR signaling regulates food intake. Science 312: 927-930.
    • (2006) Science , vol.312 , pp. 927-930
    • Cota, D.1    Proulx, K.2    Smith, K.A.3    Kozma, S.C.4    Thomas, G.5
  • 12
    • 77951778497 scopus 로고    scopus 로고
    • Mammalian target of rapamycin signaling modulates photic entrainment of the suprachiasmatic circadian clock
    • Cao R, Li A, Cho HY, Lee B, Obrietan K, (2010) Mammalian target of rapamycin signaling modulates photic entrainment of the suprachiasmatic circadian clock. J Neurosci 30: 6302-6314.
    • (2010) J Neurosci , vol.30 , pp. 6302-6314
    • Cao, R.1    Li, A.2    Cho, H.Y.3    Lee, B.4    Obrietan, K.5
  • 13
    • 84878381792 scopus 로고    scopus 로고
    • The enzymes. New York: Academic Press
    • The enzymes. New York: Academic Press.
  • 14
    • 0041758428 scopus 로고    scopus 로고
    • Tuberous sclerosis: from tubers to mTOR
    • Kwiatkowski DJ, (2003) Tuberous sclerosis: from tubers to mTOR. Annals of Human Genetics 67: 87-96.
    • (2003) Annals of Human Genetics , vol.67 , pp. 87-96
    • Kwiatkowski, D.J.1
  • 15
    • 1542577673 scopus 로고    scopus 로고
    • Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis
    • Kwiatkowski DJ, (2003) Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis. Cancer Biology & Therapy 2: 471-476.
    • (2003) Cancer Biology & Therapy , vol.2 , pp. 471-476
    • Kwiatkowski, D.J.1
  • 16
    • 33846915925 scopus 로고    scopus 로고
    • Kainic acid induces early and transient autophagic stress in mouse hippocampus
    • Shacka JJ, Lu J, Xie Z-L, Uchiyama Y, Roth KA, et al. (2007) Kainic acid induces early and transient autophagic stress in mouse hippocampus. Neuroscience Letters 414: 57-60.
    • (2007) Neuroscience Letters , vol.414 , pp. 57-60
    • Shacka, J.J.1    Lu, J.2    Xie, Z.-L.3    Uchiyama, Y.4    Roth, K.A.5
  • 18
    • 67649382228 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
    • Buckmaster PS, Ingram EA, Wen X, (2009) Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. The Journal of Neuroscience: The Official AZSJournal of the Society for Neuroscience 29: 8259-8269.
    • (2009) The Journal of Neuroscience: The Official AZSJournal of the Society for Neuroscience , vol.29 , pp. 8259-8269
    • Buckmaster, P.S.1    Ingram, E.A.2    Wen, X.3
  • 19
    • 76249084241 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies
    • Wong M, (2010) Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies. Epilepsia 51: 27-36.
    • (2010) Epilepsia , vol.51 , pp. 27-36
    • Wong, M.1
  • 20
    • 79957864093 scopus 로고    scopus 로고
    • Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis
    • McDaniel SS, Wong M, (2011) Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis. Neuroscience Letters 497: 231-239.
    • (2011) Neuroscience Letters , vol.497 , pp. 231-239
    • McDaniel, S.S.1    Wong, M.2
  • 21
    • 45849110311 scopus 로고    scopus 로고
    • Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function
    • Meikle L, Pollizzi K, Egnor A, Kramvis I, Lane H, et al. (2008) Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 28: 5422-5432.
    • (2008) The Journal of Neuroscience: The Official Journal of the Society for Neuroscience , vol.28 , pp. 5422-5432
    • Meikle, L.1    Pollizzi, K.2    Egnor, A.3    Kramvis, I.4    Lane, H.5
  • 22
    • 42949140259 scopus 로고    scopus 로고
    • Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    • Zeng L-H, Xu L, Gutmann DH, Wong M, (2008) Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Annals of Neurology 63: 444-453.
    • (2008) Annals of Neurology , vol.63 , pp. 444-453
    • Zeng, L.-H.1    Xu, L.2    Gutmann, D.H.3    Wong, M.4
  • 23
    • 77955845741 scopus 로고    scopus 로고
    • Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
    • Huang X, Zhang H, Yang J, Wu J, McMahon J, et al. (2010) Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy. Neurobiology of Disease 40: 193-199.
    • (2010) Neurobiology of Disease , vol.40 , pp. 193-199
    • Huang, X.1    Zhang, H.2    Yang, J.3    Wu, J.4    McMahon, J.5
  • 25
    • 80255137186 scopus 로고    scopus 로고
    • Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy
    • Buckmaster PS, Wen X, (2011) Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy. Epilepsia 52: 2057-2064.
    • (2011) Epilepsia , vol.52 , pp. 2057-2064
    • Buckmaster, P.S.1    Wen, X.2
  • 26
    • 80155189536 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice
    • Sunnen CN, Brewster AL, Lugo JN, Vanegas F, Turcios E, et al. (2011) Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice. Epilepsia 52: 2065-2075.
    • (2011) Epilepsia , vol.52 , pp. 2065-2075
    • Sunnen, C.N.1    Brewster, A.L.2    Lugo, J.N.3    Vanegas, F.4    Turcios, E.5
  • 27
    • 6344245674 scopus 로고    scopus 로고
    • Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
    • Gangloff YG, Mueller M, Dann SG, Svoboda P, Sticker M, et al. (2004) Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol 24: 9508-9516.
    • (2004) Mol Cell Biol , vol.24 , pp. 9508-9516
    • Gangloff, Y.G.1    Mueller, M.2    Dann, S.G.3    Svoboda, P.4    Sticker, M.5
  • 28
    • 3242721268 scopus 로고    scopus 로고
    • mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
    • Murakami M, Ichisaka T, Maeda M, Oshiro N, Hara K, et al. (2004) mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol 24: 6710-6718.
    • (2004) Mol Cell Biol , vol.24 , pp. 6710-6718
    • Murakami, M.1    Ichisaka, T.2    Maeda, M.3    Oshiro, N.4    Hara, K.5
  • 29
    • 79952763934 scopus 로고    scopus 로고
    • Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
    • Stoica L, Zhu PJ, Huang W, Zhou H, Kozma SC, et al. (2011) Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage. Proc Natl Acad Sci U S A 108: 3791-3796.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3791-3796
    • Stoica, L.1    Zhu, P.J.2    Huang, W.3    Zhou, H.4    Kozma, S.C.5
  • 30
    • 77951227122 scopus 로고    scopus 로고
    • Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments
    • Caccamo A, Majumder S, Richardson A, Strong R, Oddo S, (2010) Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem 285: 13107-13120.
    • (2010) J Biol Chem , vol.285 , pp. 13107-13120
    • Caccamo, A.1    Majumder, S.2    Richardson, A.3    Strong, R.4    Oddo, S.5
  • 31
    • 84858342119 scopus 로고    scopus 로고
    • Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1beta and enhancing NMDA signaling
    • Majumder S, Caccamo A, Medina DX, Benavides AD, Javors MA, et al. (2012) Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1beta and enhancing NMDA signaling. Aging Cell 11: 326-335.
    • (2012) Aging Cell , vol.11 , pp. 326-335
    • Majumder, S.1    Caccamo, A.2    Medina, D.X.3    Benavides, A.D.4    Javors, M.A.5
  • 32
    • 0041817635 scopus 로고    scopus 로고
    • Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory
    • Tischmeyer W, Schicknick H, Kraus M, Seidenbecher CI, Staak S, et al. (2003) Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory. Eur J Neurosci 18: 942-950.
    • (2003) Eur J Neurosci , vol.18 , pp. 942-950
    • Tischmeyer, W.1    Schicknick, H.2    Kraus, M.3    Seidenbecher, C.I.4    Staak, S.5
  • 33
    • 33845606405 scopus 로고    scopus 로고
    • Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons
    • Parsons RG, Gafford GM, Helmstetter FJ, (2006) Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons. J Neurosci 26: 12977-12983.
    • (2006) J Neurosci , vol.26 , pp. 12977-12983
    • Parsons, R.G.1    Gafford, G.M.2    Helmstetter, F.J.3
  • 34
    • 84862794788 scopus 로고    scopus 로고
    • Blocking mTORC1 activity by rapamycin leads to impairment of spatial memory retrieval but not acquisition in C57BL/6J mice
    • Deli A, Schipany K, Rosner M, Hoger H, Pollak A, et al. (2012) Blocking mTORC1 activity by rapamycin leads to impairment of spatial memory retrieval but not acquisition in C57BL/6J mice. Behav Brain Res 229: 320-324.
    • (2012) Behav Brain Res , vol.229 , pp. 320-324
    • Deli, A.1    Schipany, K.2    Rosner, M.3    Hoger, H.4    Pollak, A.5
  • 35
    • 77954146395 scopus 로고    scopus 로고
    • Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): a double-edged sword?
    • Zeng LH, McDaniel S, Rensing NR, Wong M, (2010) Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): a double-edged sword? Cell Cycle 9: 2281-2285.
    • (2010) Cell Cycle , vol.9 , pp. 2281-2285
    • Zeng, L.H.1    McDaniel, S.2    Rensing, N.R.3    Wong, M.4
  • 36
    • 0031747177 scopus 로고    scopus 로고
    • Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy
    • Hellier JL, Patrylo PR, Buckmaster PS, Dudek FE, (1998) Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy. Epilepsy Res 31: 73-84.
    • (1998) Epilepsy Res , vol.31 , pp. 73-84
    • Hellier, J.L.1    Patrylo, P.R.2    Buckmaster, P.S.3    Dudek, F.E.4
  • 40
    • 33646341231 scopus 로고    scopus 로고
    • A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
    • Bachmann RA, Kim J-H, Wu A-L, Park I-H, Chen J, (2006) A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1. The Journal of Biological Chemistry 281: 7357-7363.
    • (2006) The Journal of Biological Chemistry , vol.281 , pp. 7357-7363
    • Bachmann, R.A.1    Kim, J.-H.2    Wu, A.-L.3    Park, I.-H.4    Chen, J.5
  • 42
    • 7744224557 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites
    • Takei N, Inamura N, Kawamura M, Namba H, Hara K, et al. (2004) Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 24: 9760-9769.
    • (2004) The Journal of Neuroscience: The Official Journal of the Society for Neuroscience , vol.24 , pp. 9760-9769
    • Takei, N.1    Inamura, N.2    Kawamura, M.3    Namba, H.4    Hara, K.5
  • 43
    • 33750587650 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia
    • Ljungberg MC, Bhattacharjee MB, Lu Y, Armstrong DL, Yoshor D, et al. (2006) Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia. Annals of Neurology 60: 420-429.
    • (2006) Annals of Neurology , vol.60 , pp. 420-429
    • Ljungberg, M.C.1    Bhattacharjee, M.B.2    Lu, Y.3    Armstrong, D.L.4    Yoshor, D.5
  • 44
    • 0031055117 scopus 로고    scopus 로고
    • Fos induction following systemic kainic acid: early expression in hippocampus and later widespread expression correlated with seizure
    • Willoughby JO, Mackenzie L, Medvedev A, Hiscock JJ, (1997) Fos induction following systemic kainic acid: early expression in hippocampus and later widespread expression correlated with seizure. Neuroscience 77: 379-392.
    • (1997) Neuroscience , vol.77 , pp. 379-392
    • Willoughby, J.O.1    Mackenzie, L.2    Medvedev, A.3    Hiscock, J.J.4
  • 45
    • 0032444348 scopus 로고    scopus 로고
    • Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins
    • Herdegen T, Leah JD, (1998) Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res Brain Res Rev 28: 370-490.
    • (1998) Brain Res Brain Res Rev , vol.28 , pp. 370-490
    • Herdegen, T.1    Leah, J.D.2
  • 46
    • 0025602493 scopus 로고
    • Effects of kainic acid-induced seizures and ischemia on c-fos-like proteins in rat brain
    • Popovici T, Represa A, Crepel V, Barbin G, Beaudoin M, et al. (1990) Effects of kainic acid-induced seizures and ischemia on c-fos-like proteins in rat brain. Brain Res 536: 183-194.
    • (1990) Brain Res , vol.536 , pp. 183-194
    • Popovici, T.1    Represa, A.2    Crepel, V.3    Barbin, G.4    Beaudoin, M.5
  • 47
    • 65649090185 scopus 로고    scopus 로고
    • Identification of cAMP-dependent kinase as a third in vivo ribosomal protein S6 kinase in pancreatic beta-cells
    • Moore CE, Xie J, Gomez E, Herbert TP, (2009) Identification of cAMP-dependent kinase as a third in vivo ribosomal protein S6 kinase in pancreatic beta-cells. J Mol Biol 389: 480-494.
    • (2009) J Mol Biol , vol.389 , pp. 480-494
    • Moore, C.E.1    Xie, J.2    Gomez, E.3    Herbert, T.P.4
  • 48
    • 34347242470 scopus 로고    scopus 로고
    • RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
    • Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, et al. (2007) RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem 282: 14056-14064.
    • (2007) J Biol Chem , vol.282 , pp. 14056-14064
    • Roux, P.P.1    Shahbazian, D.2    Vu, H.3    Holz, M.K.4    Cohen, M.S.5
  • 49
    • 33745150462 scopus 로고    scopus 로고
    • Ribosomal protein S6 phosphorylation: from protein synthesis to cell size
    • Ruvinsky I, Meyuhas O, (2006) Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci 31: 342-348.
    • (2006) Trends Biochem Sci , vol.31 , pp. 342-348
    • Ruvinsky, I.1    Meyuhas, O.2
  • 50
    • 38449112392 scopus 로고    scopus 로고
    • Astrocytic function and its alteration in the epileptic brain
    • Jabs R, Seifert G, Steinhäuser C, (2008) Astrocytic function and its alteration in the epileptic brain. Epilepsia 49Suppl 2: 3-12.
    • (2008) Epilepsia , vol.49 , pp. 3-12
    • Jabs, R.1    Seifert, G.2    Steinhäuser, C.3
  • 52
    • 67650465533 scopus 로고    scopus 로고
    • Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy
    • Friedman A, Kaufer D, Heinemann U, (2009) Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy. Epilepsy Research 85: 142-149.
    • (2009) Epilepsy Research , vol.85 , pp. 142-149
    • Friedman, A.1    Kaufer, D.2    Heinemann, U.3
  • 53
    • 27244443051 scopus 로고    scopus 로고
    • Quinine, a blocker of neuronal cx36 channels, suppresses seizure activity in rat neocortex in vivo
    • Gajda Z, Szupera Z, Blazso G, Szente M, (2005) Quinine, a blocker of neuronal cx36 channels, suppresses seizure activity in rat neocortex in vivo. Epilepsia 46: 1581-1591.
    • (2005) Epilepsia , vol.46 , pp. 1581-1591
    • Gajda, Z.1    Szupera, Z.2    Blazso, G.3    Szente, M.4
  • 54
    • 33846330866 scopus 로고    scopus 로고
    • Anticonvulsive effects of carbenoxolone on penicillin-induced epileptiform activity: an in vivo study
    • Bostanci MO, Bagirici F, (2007) Anticonvulsive effects of carbenoxolone on penicillin-induced epileptiform activity: an in vivo study. Neuropharmacology 52: 362-367.
    • (2007) Neuropharmacology , vol.52 , pp. 362-367
    • Bostanci, M.O.1    Bagirici, F.2
  • 55
    • 77953512889 scopus 로고    scopus 로고
    • mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes
    • Tsang CK, Liu H, Zheng XFS, (2010) mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes. Cell Cycle (Georgetown, Tex) 9: 953-957.
    • (2010) Cell Cycle (Georgetown, Tex) , vol.9 , pp. 953-957
    • Tsang, C.K.1    Liu, H.2    Zheng, X.F.S.3
  • 56
    • 77952036652 scopus 로고    scopus 로고
    • Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells
    • Shor B, Wu J, Shakey Q, Toral-Barza L, Shi C, et al. (2010) Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells. J Biol Chem 285: 15380-15392.
    • (2010) J Biol Chem , vol.285 , pp. 15380-15392
    • Shor, B.1    Wu, J.2    Shakey, Q.3    Toral-Barza, L.4    Shi, C.5
  • 57
    • 84891621769 scopus 로고    scopus 로고
    • Beyond control of protein translation: What we have learned about the non-canonical regulation and function of mammalian target of rapamycin (mTOR)
    • Malik AR, Urbanska M, Macias M, Skalecka A, Jaworski J (2012) Beyond control of protein translation: What we have learned about the non-canonical regulation and function of mammalian target of rapamycin (mTOR). Biochim Biophys Acta.
    • (2012) Biochim Biophys Acta
    • Malik, A.R.1    Urbanska, M.2    Macias, M.3    Skalecka, A.4    Jaworski, J.5
  • 58
    • 84862994959 scopus 로고    scopus 로고
    • Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy
    • Sha LZ, Xing XL, Zhang D, Yao Y, Dou WC, et al. (2012) Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy. PLoS One 7: e39152.
    • (2012) PLoS One , vol.7
    • Sha, L.Z.1    Xing, X.L.2    Zhang, D.3    Yao, Y.4    Dou, W.C.5
  • 59
    • 7744224557 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites
    • Takei N, Inamura N, Kawamura M, Namba H, Hara K, et al. (2004) Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. J Neurosci 24: 9760-9769.
    • (2004) J Neurosci , vol.24 , pp. 9760-9769
    • Takei, N.1    Inamura, N.2    Kawamura, M.3    Namba, H.4    Hara, K.5
  • 60
    • 0028346535 scopus 로고
    • Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors
    • Wetmore C, Olson L, Bean AJ, (1994) Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. J Neurosci 14: 1688-1700.
    • (1994) J Neurosci , vol.14 , pp. 1688-1700
    • Wetmore, C.1    Olson, L.2    Bean, A.J.3
  • 61
    • 0021045654 scopus 로고
    • Kainic acid induced seizures: neurochemical and histopathological changes
    • Sperk G, Lassmann H, Baran H, Kish SJ, Seitelberger F, et al. (1983) Kainic acid induced seizures: neurochemical and histopathological changes. Neuroscience 10: 1301-1315.
    • (1983) Neuroscience , vol.10 , pp. 1301-1315
    • Sperk, G.1    Lassmann, H.2    Baran, H.3    Kish, S.J.4    Seitelberger, F.5
  • 62
    • 33748857971 scopus 로고    scopus 로고
    • Functional changes in astroglial cells in epilepsy
    • Binder DK, Steinhäuser C, (2006) Functional changes in astroglial cells in epilepsy. Glia 54: 358-368.
    • (2006) Glia , vol.54 , pp. 358-368
    • Binder, D.K.1    Steinhäuser, C.2
  • 64
    • 78650777704 scopus 로고    scopus 로고
    • The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes
    • Lisi L, Navarra P, Feinstein DL, Dello Russo C, (2011) The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes. J Neuroinflammation 8: 1.
    • (2011) J Neuroinflammation , vol.8 , pp. 1
    • Lisi, L.1    Navarra, P.2    Feinstein, D.L.3    Dello Russo, C.4
  • 65
    • 33646000806 scopus 로고    scopus 로고
    • Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels
    • Binder DK, Yao X, Zador Z, Sick TJ, Verkman AS, et al. (2006) Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia 53: 631-636.
    • (2006) Glia , vol.53 , pp. 631-636
    • Binder, D.K.1    Yao, X.2    Zador, Z.3    Sick, T.J.4    Verkman, A.S.5
  • 67
    • 33846886486 scopus 로고    scopus 로고
    • The role of extracellular matrix in CNS regeneration
    • Busch SA, Silver J, (2007) The role of extracellular matrix in CNS regeneration. Current Opinion in Neurobiology 17: 120-127.
    • (2007) Current Opinion in Neurobiology , vol.17 , pp. 120-127
    • Busch, S.A.1    Silver, J.2
  • 69
    • 84891596694 scopus 로고    scopus 로고
    • Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy
    • Sliwa A, Plucinska G, Bednarczyk J, Lukasiuk K (2011) Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy. Neurosci Lett.
    • (2011) Neurosci Lett
    • Sliwa, A.1    Plucinska, G.2    Bednarczyk, J.3    Lukasiuk, K.4
  • 70
    • 33750924816 scopus 로고    scopus 로고
    • The blood-brain barrier and epilepsy
    • Oby E, Janigro D, (2006) The blood-brain barrier and epilepsy. Epilepsia 47: 1761-1774.
    • (2006) Epilepsia , vol.47 , pp. 1761-1774
    • Oby, E.1    Janigro, D.2
  • 71
    • 36249023723 scopus 로고    scopus 로고
    • Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons
    • Ruegg S, Baybis M, Juul H, Dichter M, Crino PB, (2007) Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons. Epilepsy Res 77: 85-92.
    • (2007) Epilepsy Res , vol.77 , pp. 85-92
    • Ruegg, S.1    Baybis, M.2    Juul, H.3    Dichter, M.4    Crino, P.B.5
  • 73
    • 84875331396 scopus 로고    scopus 로고
    • Duration of rapamycin treatment has differential effects on metabolism in mice
    • Fang Y, Westbrook R, Hill C, Boparai RK, Arum O, et al. (2013) Duration of rapamycin treatment has differential effects on metabolism in mice. Cell Metab 17: 456-462.
    • (2013) Cell Metab , vol.17 , pp. 456-462
    • Fang, Y.1    Westbrook, R.2    Hill, C.3    Boparai, R.K.4    Arum, O.5


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