Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice

Epilepsia

Volumn 52, Issue 11, 2011, Pages 2065-2075

  Sunnen, C Nicole ^a,b   Brewster, Amy L ^a,c   Lugo, Joaquin N ^a,c   Vanegas, Fabiola ^a,c   Turcios, Eric ^a,c   Mukhi, Shivani ^a,c   Parghi, Deena ^d   D'Arcangelo, Gabriella ^e   Anderson, Anne E ^a,b,c,d  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b Departments of Neuroscience   (United States)

^c Departments of Pediatrics   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e State University of New Jersey   (United States)

Author keywords

Cortical dysplasia; Mammalian target of rapamycin complex 1; Mossy fiber sprouting; Pten; Tuberous sclerosis complex

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; NEURON SPECIFIC ENOLASE; NEURON SUBSET SPECIFIC PTEN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAPAMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CLINICAL PROTOCOL; CONTROLLED STUDY; CORTICAL DYSPLASIA; DISEASE COURSE; DISEASE DURATION; DRUG EFFICACY; ELECTROENCEPHALOGRAPHY; EPILEPSY; KNOCKOUT MOUSE; MALE; MOSSY FIBER; MOUSE; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STAINING; SURVIVAL RATE;

ANIMALS; DENTATE GYRUS; DISEASE PROGRESSION; ELECTROENCEPHALOGRAPHY; EPILEPSY; FEMALE; MALE; MICE; NERVE FIBERS; PTEN PHOSPHOHYDROLASE; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 80155189536     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2011.03280.x     Document Type: Article

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