Hepatic effects of long-term methotrexate use in the treatment of inflammatory bowel disease

American Journal of Gastroenterology

Volumn 95, Issue 11, 2000, Pages 3150-3156

  Te, Helen S ^a   Schiano, Thomas D ^b   Kuan, Shih Fan ^a   Hanauer, Stephen B ^a   Conjeevaram, Hari S ^a   Baker, Alfred L ^a  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHOTREXATE;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DRUG MONITORING; DRUG TISSUE LEVEL; ENTERITIS; FEMALE; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; LIVER TOXICITY; MALE; PRACTICE GUIDELINE; PRIORITY JOURNAL;

ADULT; BIOPSY; COLITIS, ULCERATIVE; CROHN DISEASE; FEMALE; FOLIC ACID ANTAGONISTS; HEPATITIS, TOXIC; HUMANS; LIVER; MALE; METHOTREXATE; TIME FACTORS;

EID: 0033755922     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9270(00)02080-3     Document Type: Article

References (38)

1. Methotrexate in psoriasis: Revised guidelines
2. Methotrexate
3. Methotrexate in rheumatoid arthritis
4. Methotrexate for rheumatoid arthritis. Suggested guidelines for monitoring liver toxicity. American College of Rheumatology
5. Methotrexate: The emerging drug of choice for serious rheumatoid arthritis
6. Efficacy of low-dose methotrexate in rheumatoid arthritis
7. Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease
8. Methotrexate for inflammatory bowel disease: Pharmacology and preliminary results
9. Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators
10. Methotrexate in Crohn's disease. How is it doing?
11. Methotrexate for the treatment of refractory Crohn's disease
12. A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease
13. Methotrexate update
14. Methotrexate in rheumatoid arthritis: Toxicity issues
15. One-second biopsy of the liver - Problems of its clinical application
16. Methotrexate revisited: Effects of long-term treatment in psoriasis
17. Hepatotoxicity of methotrexate in the treatment of psoriasis
18. Liver biopsies from psoriatics related to methotrexate therapy. 1. Findings in 123 consecutive nonmethotrexate treated patients
19. Psoriasis-liver-methotrexate interactions
20. Liver biopsies from psoriatics related to methotrexate therapy. 2. Findings before and after methotexate therapy in 88 patients. A blind study
21. Complications in methotrexate treatment of psoriasis with particular reference to liver fibrosis
22. Methotrexate induced liver cirrhosis. Studies including serial liver biopsies during continued treatment
23. Methotrexate hepatotoxicity in psoriasis. Consideration of liver biopsies at regular intervals
24. Liver biopsies from psoriatics related to methotrexate therapy. 3. Findings in post-methotrexate liver biopsies from 160 psoriatics
25. Structural and functional abnormalities of the liver in psoriasis before and during methotrexate therapy
26. Methotrexate and histologic hepatic abnormalities: A meta-analysis
27. Determinants of serious liver disease among patients receiving low-dose methotrexate for rheumatoid arthritis
28. Cirrhosis in patients with rheumatoid arthritis receiving low dose methotrexate
29. Does chronic methotrexate (MTX) cause liver toxicity when used for refractory inflammatory bowel disease (IBD)?
30. The incidence and significance of liver dysfunction in Crohn's disease
31. The liver in Crohn's disease
32. Cholestasis in Crohn's disease: A diagnostic challenge
33. Liver disease in Crohn's disease. A study of 100 consecutive patients
34. Liver damage in juvenile inflammatory bowel disease
35. The spectrum of hepatic dysfunction in inflammatory bowel disease
36. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis
37. The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A metaanalysis of randomized controlled trials
38. Methotrexate in rheumatoid arthritis: An update with focus on mechanisms involved in toxicity