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Volumn 36, Issue 5, 2008, Pages 861-872

Role of grape seed extract on methotrexate induced oxidative stress in rat liver

Author keywords

Catalase; Grape Seed Extract; Malondialdehyde; Methotrexate; Superoxide Dismutase

Indexed keywords

CATALASE; GRAPE SEED EXTRACT; MALONALDEHYDE; METHOTREXATE; PLACEBO; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE;

EID: 57349194210     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X08006302     Document Type: Article
Times cited : (83)

References (56)
  • 1
    • 0021318441 scopus 로고
    • in vitro
    • Aebi, H. Catalase in vitro. Methods Enzymol. 105: 121-126, 1984.
    • (1984) Methods Enzymol , vol.105 , pp. 121-126
    • Aebi, H.C.1
  • 2
    • 0037619106 scopus 로고    scopus 로고
    • Biochemical evidence for free radical-induced lipid peroxidation as a mechanism for subchronic toxicity of malathion in blood and liver of rats
    • Akhgari, M., M. Abdollahi, A. Kebryaeezadeh, R. Hosseini and O. Sabzevari. Biochemical evidence for free radical-induced lipid peroxidation as a mechanism for subchronic toxicity of malathion in blood and liver of rats. Hum. Exp. Toxicol. 22: 205-211, 2003.
    • (2003) Hum. Exp. Toxicol , vol.22 , pp. 205-211
    • Akhgari, M.1    Abdollahi, M.2    Kebryaeezadeh, A.3    Hosseini, R.4    Sabzevari, O.5
  • 3
    • 0029074260 scopus 로고
    • Acetaminophen-induced hepatic injury in mice: The role of lipid peroxidation and effects of pretreatment with coenzyme Q10 and alpha-tocopherol
    • Amimoto, T., T. Matsura, S.Y. Koyama, T. Nakanishi, K. Yamada and G. Kajiyama. Acetaminophen-induced hepatic injury in mice: The role of lipid peroxidation and effects of pretreatment with coenzyme Q10 and alpha-tocopherol. Free Radic. Biol. Med. 19: 169-176, 1995.
    • (1995) Free Radic. Biol. Med , vol.19 , pp. 169-176
    • Amimoto, T.1    Matsura, T.2    Koyama, S.Y.3    Nakanishi, T.4    Yamada, K.5    Kajiyama, G.6
  • 4
    • 0038639281 scopus 로고    scopus 로고
    • Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes
    • Anderson, T., Y. Qin, L. Dey and C.S. Yuan. Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes. Pharmacol. Res. 47: 463-469, 2003.
    • (2003) Pharmacol. Res , vol.47 , pp. 463-469
    • Anderson, T.1    Qin, Y.2    Dey, L.3    Yuan, C.S.4
  • 6
    • 0030956480 scopus 로고    scopus 로고
    • Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro
    • Bagchi, D., A. Garg, R.L. Krohn, M. Bagchi, M.X. Tran and S.J. Stohs. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res. Commun. Mol. Pathol. Pharmacol. 95: 179-189, 1997.
    • (1997) Res. Commun. Mol. Pathol. Pharmacol , vol.95 , pp. 179-189
    • Bagchi, D.1    Garg, A.2    Krohn, R.L.3    Bagchi, M.4    Tran, M.X.5    Stohs, S.J.6
  • 7
    • 0034617986 scopus 로고    scopus 로고
    • Free radicals and grape seed proanthocyanidin extract: Importance in human health and disease prevention
    • Bagchi, D., M. Bagchi, S.J. Stohs, D.K. Das, S.D. Ray, C.A. Kuszynski, S.S. Joshi and H.G. Pruess. Free radicals and grape seed proanthocyanidin extract: Importance in human health and disease prevention. Toxicology 148: 187-197, 2000.
    • (2000) Toxicology , vol.148 , pp. 187-197
    • Bagchi, D.1    Bagchi, M.2    Stohs, S.J.3    Das, D.K.4    Ray, S.D.5    Kuszynski, C.A.6    Joshi, S.S.7    Pruess, H.G.8
  • 8
    • 14644446143 scopus 로고    scopus 로고
    • Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract
    • Bagchi, D., C.K. Sen, S.D. Ray, D.K. Das, M. Bagchi, H.G. Preuss and J.A. Vinson. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutat. Res. 523-524: 87-97, 2003.
    • (2003) Mutat. Res , vol.523-524 , pp. 87-97
    • Bagchi, D.1    Sen, C.K.2    Ray, S.D.3    Das, D.K.4    Bagchi, M.5    Preuss, H.G.6    Vinson, J.A.7
  • 10
    • 0032789085 scopus 로고    scopus 로고
    • Glutamine protects against doxorubicin-induced cardiotoxicity
    • Cao, Y., R. Kennedy and V.S. Klimberg. Glutamine protects against doxorubicin-induced cardiotoxicity. J. Surg. Res. 85: 178-182, 1999.
    • (1999) J. Surg. Res , vol.85 , pp. 178-182
    • Cao, Y.1    Kennedy, R.2    Klimberg, V.S.3
  • 12
    • 33746876627 scopus 로고    scopus 로고
    • N-acetylcysteine ameliorates methotrexate induced oxidative liver damage in rats
    • Cetinkaya, A., E. Bulbuloglu, E. Belge Kurutas and B. Kantarceken. N-acetylcysteine ameliorates methotrexate induced oxidative liver damage in rats. Med. Sci. Monit. 12: 274-278, 2006.
    • (2006) Med. Sci. Monit , vol.12 , pp. 274-278
    • Cetinkaya, A.1    Bulbuloglu, E.2    Belge Kurutas, E.3    Kantarceken, B.4
  • 13
    • 0030817853 scopus 로고    scopus 로고
    • An in vitro study on methotraxate hydoxylation in rat and human liver
    • Chladek, J., J. Martinkova and L. Sispera. An in vitro study on methotraxate hydoxylation in rat and human liver. Physiol Res. 46: 371-379, 1997.
    • (1997) Physiol Res , vol.46 , pp. 371-379
    • Chladek, J.1    Martinkova, J.2    Sispera, L.3
  • 14
    • 0029867672 scopus 로고    scopus 로고
    • Flavonoids-chemistry, metabolism cardioprotective effects and dietary sources
    • Cook, N.C. and S. Sammam. Flavonoids-chemistry, metabolism cardioprotective effects and dietary sources. J. Nutr. Biochem. 7: 66-76, 1996.
    • (1996) J. Nutr. Biochem , vol.7 , pp. 66-76
    • Cook, N.C.1    Sammam, S.2
  • 15
    • 0023028913 scopus 로고
    • Redox cycling of anthracyclin by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide and hydroxyl radical
    • Doroshow, J.H. and K.J.A. Davies. Redox cycling of anthracyclin by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide and hydroxyl radical. J. Biol. Chem. 261: 3068-3074, 1986.
    • (1986) J. Biol. Chem , vol.261 , pp. 3068-3074
    • Doroshow, J.H.1    Davies, K.J.A.2
  • 16
    • 0021070083 scopus 로고
    • Regulation of methotrexate polyglutamate accumulation in vitro: Effects of cellular folat content
    • Galivan, J., Z. Nimec and M. Balinska. Regulation of methotrexate polyglutamate accumulation in vitro: Effects of cellular folat content. Biochem. Pharmacol. 32: 3344-3347, 1983.
    • (1983) Biochem. Pharmacol , vol.32 , pp. 3344-3347
    • Galivan, J.1    Nimec, Z.2    Balinska, M.3
  • 17
    • 1842453341 scopus 로고    scopus 로고
    • Total phenolic contents and antibacterial activities of grape (Vitis vinifera L.) extracts
    • Goktürk-Baydar, N., G. Ozkan and O. Sagdic. Total phenolic contents and antibacterial activities of grape (Vitis vinifera L.) extracts. Food Control 15: 335-359, 2004.
    • (2004) Food Control , vol.15 , pp. 335-359
    • Goktürk-Baydar, N.1    Ozkan, G.2    Sagdic, O.3
  • 18
    • 33746262973 scopus 로고    scopus 로고
    • Determination of antibacterial effects and total phenolic contents of grape (Vitis vinifera L.) seed extracts
    • Gokturk Baydar, N., O. Sagdic, G. Ozkan and S. Cetin. Determination of antibacterial effects and total phenolic contents of grape (Vitis vinifera L.) seed extracts. Int. J. Food Sci. Technol. 41: 799-804, 2006.
    • (2006) Int. J. Food Sci. Technol , vol.41 , pp. 799-804
    • Gokturk Baydar, N.1    Sagdic, O.2    Ozkan, G.3    Cetin, S.4
  • 20
    • 0035032106 scopus 로고    scopus 로고
    • Antioxidants as adjuvant therapy in rheumatoid disease. A preliminary study
    • Helmy, M., M. Shohayeb, M.H. Helmy and E.A. el-Bassiouni. Antioxidants as adjuvant therapy in rheumatoid disease. A preliminary study. Arzneimittelforschung 51: 293-298, 2001.
    • (2001) Arzneimittelforschung , vol.51 , pp. 293-298
    • Helmy, M.1    Shohayeb, M.2    Helmy, M.H.3    el-Bassiouni, E.A.4
  • 21
    • 0037404909 scopus 로고    scopus 로고
    • Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats
    • Jahovic, N.,H. Cevik, A.O. Sehirli, B.C. Yegen and G. Sener. Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats. J. Pineal Res. 34: 282-287, 2003.
    • (2003) J. Pineal Res , vol.34 , pp. 282-287
    • Jahovic, N.1    Cevik, H.2    Sehirli, A.O.3    Yegen, B.C.4    Sener, G.5
  • 23
    • 0242695046 scopus 로고    scopus 로고
    • Jayaprakasha, G.K., B.S. Jena and K.K. Sakariah. Improved liquid chromatographic method for determination of organic acids in leaves, pulp, fruits, and rinds of Garcinia. J. AOC Int. 86: 1063-1068, 2003.
    • Jayaprakasha, G.K., B.S. Jena and K.K. Sakariah. Improved liquid chromatographic method for determination of organic acids in leaves, pulp, fruits, and rinds of Garcinia. J. AOC Int. 86: 1063-1068, 2003.
  • 25
    • 0019486066 scopus 로고
    • Methotrexate accumulation and folate depletion in cell as a possible mechanism of chronic toxicity to the drug
    • Kamen, B.A., P.A. Nylen, B.M. Camitta and J.R. Bertno.Methotrexate accumulation and folate depletion in cell as a possible mechanism of chronic toxicity to the drug. Br. J. Hematol. 49: 355-360, 1981.
    • (1981) Br. J. Hematol , vol.49 , pp. 355-360
    • Kamen, B.A.1    Nylen, P.A.2    Camitta, B.M.3    Bertno, J.R.4
  • 26
    • 26844561979 scopus 로고    scopus 로고
    • Reduction of the efficacy of methotrexate by the use of folic acid: Post hoc analysis from two randomized controlled studies
    • Khanna, D., G.S. Park, H.E. Paulus, K.M. Simpson, D. Elashoff, S.B. Cohen, P. Emery, C. Dorrier and D.E. Furst. Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies. Arthritis Rheum. 52: 3030-3038, 2005.
    • (2005) Arthritis Rheum , vol.52 , pp. 3030-3038
    • Khanna, D.1    Park, G.S.2    Paulus, H.E.3    Simpson, K.M.4    Elashoff, D.5    Cohen, S.B.6    Emery, P.7    Dorrier, C.8    Furst, D.E.9
  • 27
    • 0030752750 scopus 로고    scopus 로고
    • Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats
    • Kourounakis, A.P., E.A. Rekka and P.N. Kourounakis. Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats. J. Pharm. Pharmacol. 49: 938-942, 1997.
    • (1997) J. Pharm. Pharmacol , vol.49 , pp. 938-942
    • Kourounakis, A.P.1    Rekka, E.A.2    Kourounakis, P.N.3
  • 28
    • 0022547880 scopus 로고
    • Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients
    • Kremer, J.M., J Galivan, A. Streckfuss and B. Kamen. Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Arthritis. Rheum. 29: 832-835, 1986.
    • (1986) Arthritis. Rheum , vol.29 , pp. 832-835
    • Kremer, J.M.1    Galivan, J.2    Streckfuss, A.3    Kamen, B.4
  • 29
    • 0037357016 scopus 로고    scopus 로고
    • Oxidative stress associated hepatic and renal toxicity induced by ricin in mice
    • Kumar, O.,K. Sugendran and R. Vijayaraghavan. Oxidative stress associated hepatic and renal toxicity induced by ricin in mice. Toxicon 1: 333-338, 2003.
    • (2003) Toxicon , vol.1 , pp. 333-338
    • Kumar, O.1    Sugendran, K.2    Vijayaraghavan, R.3
  • 30
    • 0035213180 scopus 로고    scopus 로고
    • Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds
    • Li, W.G., X.Y. Zhang, Y.J. Wu and X. Tian. Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds. Acta Pharmacol. Sin. 22: 117-120, 2001.
    • (2001) Acta Pharmacol. Sin , vol.22 , pp. 117-120
    • Li, W.G.1    Zhang, X.Y.2    Wu, Y.J.3    Tian, X.4
  • 32
    • 0033429675 scopus 로고    scopus 로고
    • Inducers of cytochrome P450 2E1 enhance methotrexate-induced hepatotoxicity
    • Neuman, M.G., R.G. Cameron and J.A. Haber. Inducers of cytochrome P450 2E1 enhance methotrexate-induced hepatotoxicity. Clin. Biochem. 32: 519-536, 1999.
    • (1999) Clin. Biochem , vol.32 , pp. 519-536
    • Neuman, M.G.1    Cameron, R.G.2    Haber, J.A.3
  • 33
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa, W., N. Ohishi and K. Yagi. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95: 351-358, 1979.
    • (1979) Anal. Biochem , vol.95 , pp. 351-358
    • Ohkawa, W.1    Ohishi, N.2    Yagi, K.3
  • 35
    • 0028036133 scopus 로고
    • Oligomeric and polymeric procyanidins from grape seeds
    • Prieur, C., J. Rigaud and V. Cheynier. Oligomeric and polymeric procyanidins from grape seeds. Phytochemistry 36: 781-784, 1994.
    • (1994) Phytochemistry , vol.36 , pp. 781-784
    • Prieur, C.1    Rigaud, J.2    Cheynier, V.3
  • 36
    • 0035962240 scopus 로고    scopus 로고
    • Proanthocyanidins and grape seed extract
    • Rapport, L. and B. Lockwood. Proanthocyanidins and grape seed extract. Pharm. J. 266: 581-584, 2001.
    • (2001) Pharm. J , vol.266 , pp. 581-584
    • Rapport, L.1    Lockwood, B.2
  • 37
    • 0033198675 scopus 로고    scopus 로고
    • A novel proanthocyanidin IH636 grape seed extract increases in vivo bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver
    • Ray, S.D., M.A. Kumar and D. Bagchi. A novel proanthocyanidin IH636 grape seed extract increases in vivo bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver. Arch. Biochem. Biophys. 369: 42-58, 1999.
    • (1999) Arch. Biochem. Biophys , vol.369 , pp. 42-58
    • Ray, S.D.1    Kumar, M.A.2    Bagchi, D.3
  • 38
    • 0029888128 scopus 로고    scopus 로고
    • Structure-antioxidant activity relationships of flavonoids and phenolic acids
    • Rice-Evans, C.A., N.J. Miller and G. Paganga. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med. 20: 933-956, 1996.
    • (1996) Free Radic. Biol. Med , vol.20 , pp. 933-956
    • Rice-Evans, C.A.1    Miller, N.J.2    Paganga, G.3
  • 39
    • 0028940320 scopus 로고
    • Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism
    • Rouse, K., E. Nwokedi, J.E. Woodliff, J. Epstein and V.S. Klimberg. Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism. Ann. Surg. 221: 420-426, 1995.
    • (1995) Ann. Surg , vol.221 , pp. 420-426
    • Rouse, K.1    Nwokedi, E.2    Woodliff, J.E.3    Epstein, J.4    Klimberg, V.S.5
  • 40
    • 0035884851 scopus 로고    scopus 로고
    • Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/ reperfusion-induced activation of JNK-1 and C-Jun
    • Sato, M., D. Bagchi, A. Tosaki and D.K. Das. Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/ reperfusion-induced activation of JNK-1 and C-Jun. Free Radic. Biol. Med. 31: 729-737, 2001.
    • (2001) Free Radic. Biol. Med , vol.31 , pp. 729-737
    • Sato, M.1    Bagchi, D.2    Tosaki, A.3    Das, D.K.4
  • 42
    • 0033198675 scopus 로고    scopus 로고
    • A novel proanthocyanidin IH636 grape seed extract increases in vivo bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver
    • Shao, Z.H., L.B. Becker, T.L. VandenHoek, P.T. Schumacker, C.O. Li, D. Zhao, K. Wojcik, S.D. Ray, M.A. Kumar and D. Bagchi. A novel proanthocyanidin IH636 grape seed extract increases in vivo bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver. Arch. Biochem. Biophys. 369: 42-58, 1999.
    • (1999) Arch. Biochem. Biophys , vol.369 , pp. 42-58
    • Shao, Z.H.1    Becker, L.B.2    VandenHoek, T.L.3    Schumacker, P.T.4    Li, C.O.5    Zhao, D.6    Wojcik, K.7    Ray, S.D.8    Kumar, M.A.9    Bagchi, D.10
  • 43
    • 1842554875 scopus 로고    scopus 로고
    • Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells
    • Sharma, G., A.K. Tyagi, R.P. Singh, D.D. Chan and R. Agarwal. Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Breast Cancer Res. Treat. 85: 1-12, 2004.
    • (2004) Breast Cancer Res. Treat , vol.85 , pp. 1-12
    • Sharma, G.1    Tyagi, A.K.2    Singh, R.P.3    Chan, D.D.4    Agarwal, R.5
  • 44
    • 1642559404 scopus 로고    scopus 로고
    • Polyphenolics in grape seeds. Biochemistry and functionality
    • Shi, J., J. Yu, J.E. Pohorly and Y. Kakuda. Polyphenolics in grape seeds. Biochemistry and functionality. J. Med. Food 6: 291-299, 2003.
    • (2003) J. Med. Food , vol.6 , pp. 291-299
    • Shi, J.1    Yu, J.2    Pohorly, J.E.3    Kakuda, Y.4
  • 46
    • 0000359845 scopus 로고
    • Colorimetry of total phenolics with phosphomolibdic-phosphothungstic acid
    • Singleton, V.L and J.R. Rossi. Colorimetry of total phenolics with phosphomolibdic-phosphothungstic acid. Am. J. Enol. Viticul. 16: 1441-1458, 1965.
    • (1965) Am. J. Enol. Viticul , vol.16 , pp. 1441-1458
    • Singleton, V.L.1    Rossi, J.R.2
  • 48
    • 0029089043 scopus 로고    scopus 로고
    • Subramaniam, S., S. Subramaniam and C.S. Shyamala Devi. Vitamin E protects intestinal basolateral membrane from CMF-induced damages in rat. Indian J. Physiol. Pharmacol. 39: 263-266, 1995.
    • Subramaniam, S., S. Subramaniam and C.S. Shyamala Devi. Vitamin E protects intestinal basolateral membrane from CMF-induced damages in rat. Indian J. Physiol. Pharmacol. 39: 263-266, 1995.
  • 49
    • 3242888593 scopus 로고    scopus 로고
    • Theanine, a specific glutamate derivative in green tea, reduces the adverse reactions of doxorubicin by changing the glutathione level
    • Sugiyama, T. and Y. Sadzuka. Theanine, a specific glutamate derivative in green tea, reduces the adverse reactions of doxorubicin by changing the glutathione level. Cancer Lett. 30: 177-184, 2004.
    • (2004) Cancer Lett , vol.30 , pp. 177-184
    • Sugiyama, T.1    Sadzuka, Y.2
  • 50
    • 0023952554 scopus 로고
    • A simple method for clinical assay of superoxide dismutase
    • Sun, Y., L. W. Oberley and Y. Li. A simple method for clinical assay of superoxide dismutase. Clin. Chem. 34: 497-500, 1988.
    • (1988) Clin. Chem , vol.34 , pp. 497-500
    • Sun, Y.1    Oberley, L.W.2    Li, Y.3
  • 51
    • 18744364709 scopus 로고    scopus 로고
    • Oxidative stress mediated idiosyncratic drug toxicity
    • Tafazoli, S., D.D. Spehar and P.J. O'Brien. Oxidative stress mediated idiosyncratic drug toxicity. Drug Metab. Rev. 37: 311-325, 2005.
    • (2005) Drug Metab. Rev , vol.37 , pp. 311-325
    • Tafazoli, S.1    Spehar, D.D.2    O'Brien, P.J.3
  • 52
    • 0015664571 scopus 로고
    • Hepatotoxicity of long term methotrexate therapy for psoriasis
    • Tobias, H. and R. Auerbach. Hepatotoxicity of long term methotrexate therapy for psoriasis. Arch. Intern. Med. 132: 391-396, 1973.
    • (1973) Arch. Intern. Med , vol.132 , pp. 391-396
    • Tobias, H.1    Auerbach, R.2
  • 54
    • 0013102540 scopus 로고
    • The inhibition of dehydrogenases by folic acid and several of its analogs
    • Vogel, W.H., R. Snyder and M.P. Schulman. The inhibition of dehydrogenases by folic acid and several of its analogs. Biochim. Biophys. Res. Comm. 10: 97-101, 1963.
    • (1963) Biochim. Biophys. Res. Comm , vol.10 , pp. 97-101
    • Vogel, W.H.1    Snyder, R.2    Schulman, M.P.3
  • 56
    • 0034928799 scopus 로고    scopus 로고
    • Inhibition of carcinogenesis by dietary polyphenolic compounds
    • Yang, C.S., J.M. Landau, M.T. Huang and H.L. Newmark. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr. 21: 381-406, 2001.
    • (2001) Annu. Rev. Nutr , vol.21 , pp. 381-406
    • Yang, C.S.1    Landau, J.M.2    Huang, M.T.3    Newmark, H.L.4


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