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Volumn 62, Issue 6, 2013, Pages 1808-1815

Using the past to inform the future: Anti-VEGF therapy as a road map to develop novel therapies for diabetic retinopathy

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOPOIETIN; ANGIOPOIETIN 1; ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; BEVACIZUMAB; BLOOD CLOTTING FACTOR 10; CXCL2 CHEMOKINE; E 10030; ELYEA; ETANERCEPT; FENOFIBRATE; GROWTH HORMONE; MELOXICAM; MONOCLONAL ANTIBODY; OCTREOTIDE; PEGAPTANIB; PENICILLIN DERIVATIVE; PIGMENT EPITHELIUM DERIVED FACTOR; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE C; PROTEIN KINASE C BETA; RANIBIZUMAB; RECOMBINANT ERYTHROPOIETIN; RUBOXISTAURIN; SMALL INTERFERING RNA; THROMBIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN INHIBITOR; WNT PROTEIN;

EID: 84878239450     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1744     Document Type: Review
Times cited : (55)

References (79)
  • 1
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977-986
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 2
    • 77955383844 scopus 로고    scopus 로고
    • Are individuals with diabetes seeing better? A long-term epidemiological perspective
    • Klein R, Klein BE. Are individuals with diabetes seeing better? A long-term epidemiological perspective. Diabetes 2010;59:1853-1860
    • (2010) Diabetes , vol.59 , pp. 1853-1860
    • Klein, R.1    Klein, B.E.2
  • 3
    • 0025892104 scopus 로고
    • Early photocoagulation for diabetic retinopathy. ETDRS report number 9
    • Early Treatment Diabetic Retinopathy Study Research Group
    • Early Treatment Diabetic Retinopathy Study Research Group. Early photocoagulation for diabetic retinopathy. ETDRS report number 9. Ophthalmology 1991;98(Suppl.):766-785
    • (1991) Ophthalmology , vol.98 , Issue.SUPPL. , pp. 766-785
  • 4
    • 33947508712 scopus 로고    scopus 로고
    • Laser treatment in diabetic retinopathy
    • DOI 10.1159/000098254
    • Neubauer AS, Ulbig MW. Laser treatment in diabetic retinopathy. Ophthalmologica 2007;221:95-102 (Pubitemid 46465434)
    • (2007) Ophthalmologica , vol.221 , Issue.2 , pp. 95-102
    • Neubauer, A.S.1    Ulbig, M.W.2
  • 6
    • 67749084303 scopus 로고    scopus 로고
    • Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: The diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005)
    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group
    • Nathan DM, Zinman B, Cleary PA, et al.; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group. Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005). Arch Intern Med 2009;169:1307-1316
    • (2009) Arch Intern Med , vol.169 , pp. 1307-1316
    • Nathan, D.M.1    Zinman, B.2    Cleary, P.A.3
  • 7
    • 84863401792 scopus 로고    scopus 로고
    • Ranibizumab for diabetic macular edema: Results from 2 phase III randomized trials: RISE and RIDE
    • RISE and RIDE Research Group
    • Nguyen QD, Brown DM, Marcus DM, et al.; RISE and RIDE Research Group. Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. Ophthalmology 2012;119:789-801
    • (2012) Ophthalmology , vol.119 , pp. 789-801
    • Nguyen, Q.D.1    Brown, D.M.2    Marcus, D.M.3
  • 8
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 9
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246:1306-1309 (Pubitemid 20066716)
    • (1989) Science , vol.246 , Issue.4935 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.-J.3    Goeddel, D.V.4    Ferrara, N.5
  • 11
    • 80054012347 scopus 로고    scopus 로고
    • Developmental and pathological angiogenesis
    • Chung AS, Ferrara N. Developmental and pathological angiogenesis. Annu Rev Cell Dev Biol 2011;27:563-584
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 563-584
    • Chung, A.S.1    Ferrara, N.2
  • 15
    • 0036517850 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression
    • Joussen AM, Poulaki V, Mitsiades N, et al. Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J 2002;16:438-440
    • (2002) FASEB J , vol.16 , pp. 438-440
    • Joussen, A.M.1    Poulaki, V.2    Mitsiades, N.3
  • 16
    • 0036491615 scopus 로고    scopus 로고
    • VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis
    • DOI 10.1016/S1535-6108(02)00031-4
    • Inoue M, Hager JH, Ferrara N, Gerber HP, Hanahan D. VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis. Cancer Cell 2002;1:193-202 (Pubitemid 41039165)
    • (2002) Cancer Cell , vol.1 , Issue.2 , pp. 193-202
    • Inoue, M.1    Hager, J.H.2    Ferrara, N.3    Gerber, H.-P.4    Hanahan, D.5
  • 18
    • 0000230096 scopus 로고
    • The mode of development of the vascular system of the retina with some observations on its significance for certain retinal disorders
    • Michelson IC. The mode of development of the vascular system of the retina with some observations on its significance for certain retinal disorders. Trans Ophthalmol Soc U K 1948;68:137-180
    • (1948) Trans Ophthalmol Soc U K , vol.68 , pp. 137-180
    • Michelson, I.C.1
  • 22
    • 0028786651 scopus 로고
    • Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
    • Aiello LP, Pierce EA, Foley ED, et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci USA 1995;92:10457-10461
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10457-10461
    • Aiello, L.P.1    Pierce, E.A.2    Foley, E.D.3
  • 26
    • 34748844162 scopus 로고    scopus 로고
    • Angiographic and optical coherence tomographic results of the MARINA study of ranibizumab in neovascular age-related macular degeneration
    • MARINA Study Group
    • Kaiser PK, Blodi BA, Shapiro H, Acharya NR; MARINA Study Group. Angiographic and optical coherence tomographic results of the MARINA study of ranibizumab in neovascular age-related macular degeneration. Ophthalmology 2007;114:1868-1875
    • (2007) Ophthalmology , vol.114 , pp. 1868-1875
    • Kaiser, P.K.1    Blodi, B.A.2    Shapiro, H.3    Acharya, N.R.4
  • 28
    • 0342632445 scopus 로고    scopus 로고
    • Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: One-year results of 2 randomized clinical trials - TAP report. Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group
    • Group ToA-RMDWPTS
    • Group ToA-RMDWPTS. Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials - TAP report. Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group. Arch Ophthalmol 1999;117:1329-1345
    • (1999) Arch Ophthalmol , vol.117 , pp. 1329-1345
  • 29
    • 65349108729 scopus 로고    scopus 로고
    • Bevacizumab (Avastin) for the treatment of ocular disease
    • Gunther JB, Altaweel MM. Bevacizumab (Avastin) for the treatment of ocular disease. Surv Ophthalmol 2009;54:372-400
    • (2009) Surv Ophthalmol , vol.54 , pp. 372-400
    • Gunther, J.B.1    Altaweel, M.M.2
  • 30
    • 77952891051 scopus 로고    scopus 로고
    • Ranibizumab for macular edema following branch retinal vein occlusion: Six-month primary end point results of a phase III study
    • Campochiaro PA, Heier JS, Feiner L, et al. Ranibizumab for macular edema following branch retinal vein occlusion: six-month primary end point results of a phase III study. Ophthalmology 2010;117:1102.e1-1112.e1
    • (2010) Ophthalmology , vol.117
    • Campochiaro, P.A.1    Heier, J.S.2    Feiner, L.3
  • 31
    • 77952889477 scopus 로고    scopus 로고
    • Ranibizumab for macular edema following central retinal vein occlusion: Six-month primary end point results of a phase III study
    • Brown DM, Campochiaro PA, Singh RP, et al. Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study. Ophthalmology 2010;117:1124.e1-1133.e1
    • (2010) Ophthalmology , vol.117
    • Brown, D.M.1    Campochiaro, P.A.2    Singh, R.P.3
  • 32
    • 25844513658 scopus 로고    scopus 로고
    • A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema
    • Macugen Diabetic Retinopathy Study Group
    • Cunningham ET Jr, Adamis AP, Altaweel M, et al.; Macugen Diabetic Retinopathy Study Group. A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmology 2005;112:1747-1757
    • (2005) Ophthalmology , vol.112 , pp. 1747-1757
    • Cunningham Jr., E.T.1    Adamis, A.P.2    Altaweel, M.3
  • 33
    • 77955657984 scopus 로고    scopus 로고
    • A review of clinical trials of anti-VEGF agents for diabetic retinopathy
    • Nicholson BP, Schachat AP. A review of clinical trials of anti-VEGF agents for diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 2010;248:915-930
    • (2010) Graefes Arch Clin Exp Ophthalmol , vol.248 , pp. 915-930
    • Nicholson, B.P.1    Schachat, A.P.2
  • 34
    • 72349083592 scopus 로고    scopus 로고
    • Diabetic macular oedema and visual loss: Relationship to location, severity and duration
    • Protein Kinase C Diabetic Retinopathy Study (PKC-DRS2) Study Group Copenh
    • Gardner TW, Larsen M, Girach A, Zhi X; Protein Kinase C Diabetic Retinopathy Study (PKC-DRS2) Study Group. Diabetic macular oedema and visual loss: relationship to location, severity and duration. Acta Ophthalmol (Copenh) 2009;87:709-713
    • (2009) Acta Ophthalmol , vol.87 , pp. 709-713
    • Gardner, T.W.1    Larsen, M.2    Girach, A.3    Zhi, X.4
  • 38
    • 84861918691 scopus 로고    scopus 로고
    • Protein kinase cβ phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo
    • Murakami T, Frey T, Lin C, Antonetti DA. Protein kinase cβ phosphorylates occludin regulating tight junction trafficking in vascular endothelial growth factor-induced permeability in vivo. Diabetes 2012;61:1573-1583
    • (2012) Diabetes , vol.61 , pp. 1573-1583
    • Murakami, T.1    Frey, T.2    Lin, C.3    Antonetti, D.A.4
  • 39
    • 33751520614 scopus 로고    scopus 로고
    • Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy
    • PKC-DRS2 Group
    • Aiello LP, Davis MD, Girach A, et al.; PKC-DRS2 Group. Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy. Ophthalmology 2006;113:2221-2230
    • (2006) Ophthalmology , vol.113 , pp. 2221-2230
    • Aiello, L.P.1    Davis, M.D.2    Girach, A.3
  • 40
    • 33645746316 scopus 로고    scopus 로고
    • The PAR-aPKC system: Lessons in polarity
    • Suzuki A, Ohno S. The PAR-aPKC system: lessons in polarity. J Cell Sci 2006;119:979-987
    • (2006) J Cell Sci , vol.119 , pp. 979-987
    • Suzuki, A.1    Ohno, S.2
  • 41
    • 84865584015 scopus 로고    scopus 로고
    • Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood-retinal barrier dysfunction
    • Titchenell PM, Lin CM, Keil JM, Sundstrom JM, Smith CD, Antonetti DA. Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood-retinal barrier dysfunction. Biochem J 2012;446:455-467
    • (2012) Biochem J , vol.446 , pp. 455-467
    • Titchenell, P.M.1    Lin, C.M.2    Keil, J.M.3    Sundstrom, J.M.4    Smith, C.D.5    Antonetti, D.A.6
  • 42
    • 78049280268 scopus 로고    scopus 로고
    • TNF-α signals through PKCζ/NF-κB to alter the tight junction complex and increase retinal endothelial cell permeability
    • Aveleira CA, Lin CM, Abcouwer SF, Ambrósio AF, Antonetti DA. TNF-α signals through PKCζ/NF-κB to alter the tight junction complex and increase retinal endothelial cell permeability. Diabetes 2010;59:2872-2882
    • (2010) Diabetes , vol.59 , pp. 2872-2882
    • Aveleira, C.A.1    Lin, C.M.2    Abcouwer, S.F.3    Ambrósio, A.F.4    Antonetti, D.A.5
  • 43
    • 33745712943 scopus 로고    scopus 로고
    • Effects of the chemokine CCL2 on blood-brain barrier permeability during ischemia-reperfusion injury
    • Dimitrijevic OB, Stamatovic SM, Keep RF, Andjelkovic AV. Effects of the chemokine CCL2 on blood-brain barrier permeability during ischemia-reperfusion injury. J Cereb Blood Flow Metab 2006;26:797-810
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 797-810
    • Dimitrijevic, O.B.1    Stamatovic, S.M.2    Keep, R.F.3    Andjelkovic, A.V.4
  • 44
    • 77955415859 scopus 로고    scopus 로고
    • Role of protein kinase Czeta in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers
    • Minshall RD, Vandenbroucke EE, Holinstat M, et al. Role of protein kinase Czeta in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers. Microvasc Res 2010;80:240-249
    • (2010) Microvasc Res , vol.80 , pp. 240-249
    • Minshall, R.D.1    Vandenbroucke, E.E.2    Holinstat, M.3
  • 45
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature 2011;473:298-307
    • (2011) Nature , vol.473 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 46
    • 79954600126 scopus 로고    scopus 로고
    • Double anti-angiogenic and anti-inflammatory protein Valpha targeting VEGF-A and TNF-alpha in retinopathy and psoriasis
    • Jung K, Lee D, Lim HS, et al. Double anti-angiogenic and anti-inflammatory protein Valpha targeting VEGF-A and TNF-alpha in retinopathy and psoriasis. J Biol Chem 2011;286:14410-14418
    • (2011) J Biol Chem , vol.286 , pp. 14410-14418
    • Jung, K.1    Lee, D.2    Lim, H.S.3
  • 51
    • 0142243109 scopus 로고    scopus 로고
    • Roles of PDGF in animal development
    • DOI 10.1242/dev.00721
    • Hoch RV, Soriano P. Roles of PDGF in animal development. Development 2003;130:4769-4784 (Pubitemid 37321862)
    • (2003) Development , vol.130 , Issue.20 , pp. 4769-4784
    • Hoch, R.V.1    Soriano, P.2
  • 52
    • 18544366585 scopus 로고    scopus 로고
    • Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
    • Enge M, Bjarnegård M, Gerhardt H, et al. Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J 2002;21:4307-4316
    • (2002) EMBO J , vol.21 , pp. 4307-4316
    • Enge, M.1    Bjarnegård, M.2    Gerhardt, H.3
  • 53
    • 70449108112 scopus 로고    scopus 로고
    • Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy
    • Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, et al. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med 2009;15:1298-1306
    • (2009) Nat Med , vol.15 , pp. 1298-1306
    • Geraldes, P.1    Hiraoka-Yamamoto, J.2    Matsumoto, M.3
  • 56
    • 33744728068 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization
    • DOI 10.2353/ajpath.2006.050588
    • Jo N, Mailhos C, Ju M, et al. Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. Am J Pathol 2006;168:2036-2053 (Pubitemid 43825322)
    • (2006) American Journal of Pathology , vol.168 , Issue.6 , pp. 2036-2053
    • Jo, N.1    Mailhos, C.2    Ju, M.3    Cheung, E.4    Bradley, J.5    Nishijima, K.6    Robinson, G.S.7    Adamis, A.P.8    Shima, D.T.9
  • 57
    • 77958450885 scopus 로고    scopus 로고
    • The role of wnt signaling in physiological and pathological angiogenesis
    • Dejana E. The role of wnt signaling in physiological and pathological angiogenesis. Circ Res 2010;107:943-952
    • (2010) Circ Res , vol.107 , pp. 943-952
    • Dejana, E.1
  • 58
    • 80054993016 scopus 로고    scopus 로고
    • Wnt signaling mediates pathological vascular growth in proliferative retinopathy
    • Chen J, Stahl A, Krah NM, et al. Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation 2011;124:1871-1881
    • (2011) Circulation , vol.124 , pp. 1871-1881
    • Chen, J.1    Stahl, A.2    Krah, N.M.3
  • 59
    • 77951050199 scopus 로고    scopus 로고
    • Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family
    • Zhang B, Abreu JG, Zhou K, et al. Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. Proc Natl Acad Sci USA 2010;107:6900-6905
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 6900-6905
    • Zhang, B.1    Abreu, J.G.2    Zhou, K.3
  • 60
    • 84868035449 scopus 로고    scopus 로고
    • Therapeutic potential of a monoclonal antibody blocking the Wnt pathway in diabetic retinopathy
    • Lee K, Hu Y, Ding L, et al. Therapeutic potential of a monoclonal antibody blocking the Wnt pathway in diabetic retinopathy. Diabetes 2012;61:2948-2957
    • (2012) Diabetes , vol.61 , pp. 2948-2957
    • Lee, K.1    Hu, Y.2    Ding, L.3
  • 61
    • 33644893607 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor
    • DOI 10.1096/fj.05-4313fje
    • Zhang SX, Wang JJ, Gao G, Shao C, Mott R, Ma JX. Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor. FASEB J 2006;20:323-325 (Pubitemid 46671158)
    • (2006) FASEB Journal , vol.20 , Issue.2 , pp. 323-325
    • Zhang, S.X.1    Wang, J.J.2    Gao, G.3    Shao, C.4    Mott, R.5    Ma, J.-X.6
  • 62
    • 79960341497 scopus 로고    scopus 로고
    • Identification of a novel inhibitor of the canonical Wnt pathway
    • Park K, Lee K, Zhang B, et al. Identification of a novel inhibitor of the canonical Wnt pathway. Mol Cell Biol 2011;31:3038-3051
    • (2011) Mol Cell Biol , vol.31 , pp. 3038-3051
    • Park, K.1    Lee, K.2    Zhang, B.3
  • 63
    • 23744444437 scopus 로고    scopus 로고
    • The potential role of octreotide in the treatment of diabetic retinopathy
    • DOI 10.2165/00024677-200504040-00001
    • Grant MB, Caballero S Jr. The potential role of octreotide in the treatment of diabetic retinopathy. Treat Endocrinol 2005;4:199-203 (Pubitemid 41126811)
    • (2005) Treatments in Endocrinology , vol.4 , Issue.4 , pp. 199-203
    • Grant, M.B.1    Caballero Jr., S.2
  • 66
    • 62649142360 scopus 로고    scopus 로고
    • Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy
    • Chen J, Connor KM, Aderman CM, Willett KL, Aspegren OP, Smith LE. Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci 2009;50:1329-1335
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1329-1335
    • Chen, J.1    Connor, K.M.2    Aderman, C.M.3    Willett, K.L.4    Aspegren, O.P.5    Smith, L.E.6
  • 67
    • 40649087674 scopus 로고    scopus 로고
    • Intravitreal injection of erythropoietin protects both retinal vascular and neuronal cells in early diabetes
    • Zhang J, Wu Y, Jin Y, et al. Intravitreal injection of erythropoietin protects both retinal vascular and neuronal cells in early diabetes. Invest Ophthalmol Vis Sci 2008;49:732-742
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 732-742
    • Zhang, J.1    Wu, Y.2    Jin, Y.3
  • 69
    • 0036517850 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression
    • Joussen AM, Poulaki V, Mitsiades N, et al. Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J 2002;16:438-440
    • (2002) FASEB J , vol.16 , pp. 438-440
    • Joussen, A.M.1    Poulaki, V.2    Mitsiades, N.3
  • 70
    • 79955943133 scopus 로고    scopus 로고
    • TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis
    • Huang H, Gandhi JK, Zhong X, et al. TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. Invest Ophthalmol Vis Sci 2011;52:1336-1344
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 1336-1344
    • Huang, H.1    Gandhi, J.K.2    Zhong, X.3
  • 71
    • 33845546564 scopus 로고    scopus 로고
    • Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy
    • DOI 10.1038/sj.eye.6702138, PII 6702138
    • Demircan N, Safran BG, Soylu M, Ozcan AA, Sizmaz S. Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy. Eye (Lond) 2006;20:1366-1369 (Pubitemid 44921137)
    • (2006) Eye , vol.20 , Issue.12 , pp. 1366-1369
    • Demircan, N.1    Safran, B.G.2    Soylu, M.3    Ozcan, A.A.4    Sizmaz, S.5
  • 72
    • 84873037534 scopus 로고    scopus 로고
    • Increased prostaglandin E2 (PGE2) levels in proliferative diabetic retinopathy, and correlation with VEGF and inflammatory cytokines
    • Schoenberger SD, Kim SJ, Sheng J, Rezaei KA, Lalezary M, Cherney E. Increased prostaglandin E2 (PGE2) levels in proliferative diabetic retinopathy, and correlation with VEGF and inflammatory cytokines. Invest Ophthalmol Vis Sci 2012;53:5906-5911
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 5906-5911
    • Schoenberger, S.D.1    Kim, S.J.2    Sheng, J.3    Rezaei, K.A.4    Lalezary, M.5    Cherney, E.6
  • 73
    • 17444405235 scopus 로고    scopus 로고
    • Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes - The EURODIAB Prospective Complications Study
    • DOI 10.1007/s00125-004-1628-8
    • Schram MT, Chaturvedi N, Schalkwijk CG, Fuller JH, Stehouwer CD; EURODIAB Prospective Complications Study Group. Markers of inflammation are cross-sectionally associated with microvascular complications and cardiovascular disease in type 1 diabetes - the EURODIAB Prospective Complications Study. Diabetologia 2005;48:370-378 (Pubitemid 40543311)
    • (2005) Diabetologia , vol.48 , Issue.2 , pp. 370-378
    • Schram, M.T.1    Chaturvedi, N.2    Schalkwijk, C.G.3    Fuller, J.H.4    Stehouwer, C.D.A.5
  • 74
    • 77956980190 scopus 로고    scopus 로고
    • Infliximab for diabetic macular edema refractory to laser photocoagulation: A randomized, double-blind, placebo-controlled, crossover, 32-week study
    • Sfikakis PP, Grigoropoulos V, Emfietzoglou I, et al. Infliximab for diabetic macular edema refractory to laser photocoagulation: a randomized, double-blind, placebo-controlled, crossover, 32-week study. Diabetes Care 2010;33:1523-1528
    • (2010) Diabetes Care , vol.33 , pp. 1523-1528
    • Sfikakis, P.P.1    Grigoropoulos, V.2    Emfietzoglou, I.3
  • 75
    • 77949537099 scopus 로고    scopus 로고
    • Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseases
    • Yoshimura T, Sonoda KH, Sugahara M, et al. Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseases. PLoS ONE 2009;4:e8158
    • (2009) PLoS ONE , vol.4
    • Yoshimura, T.1    Sonoda, K.H.2    Sugahara, M.3
  • 77
    • 0036122075 scopus 로고    scopus 로고
    • Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor
    • DOI 10.1172/JCI200214211
    • Han ED, MacFarlane RC, Mulligan AN, Scafidi J, Davis AE 3rd. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J Clin Invest 2002;109:1057-1063 (Pubitemid 34408580)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.8 , pp. 1057-1063
    • Han, E.D.1    MacFarlane, R.C.2    Mulligan, A.N.3    Scafidi, J.4    Davis III, A.E.5
  • 78
    • 49849090387 scopus 로고    scopus 로고
    • Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy
    • Gao BB, Chen X, Timothy N, Aiello LP, Feener EP. Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy. J Proteome Res 2008;7:2516-2525
    • (2008) J Proteome Res , vol.7 , pp. 2516-2525
    • Gao, B.B.1    Chen, X.2    Timothy, N.3    Aiello, L.P.4    Feener, E.P.5
  • 79
    • 79959461744 scopus 로고    scopus 로고
    • Plasma kallikrein mediates retinal vascular dysfunction and induces retinal thickening in diabetic rats
    • Clermont A, Chilcote TJ, Kita T, et al. Plasma kallikrein mediates retinal vascular dysfunction and induces retinal thickening in diabetic rats. Diabetes 2011;60:1590-1598
    • (2011) Diabetes , vol.60 , pp. 1590-1598
    • Clermont, A.1    Chilcote, T.J.2    Kita, T.3


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