Increased levels of platelet-derived growth factor in vitreous fluid of patients with proliferative diabetic retinopathy

Experimental and Clinical Endocrinology and Diabetes

Volumn 108, Issue 2, 2000, Pages 106-109

  Freyberger, H ^a   Brocker M ^a   Yakut, H ^a   Hammer, J ^a   Effert, R ^b   Schifferdecker, E ^a   Schatz, H ^a   Derwahl, M ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Growth factors; PDGF; Proliferative diabetic retinopathy

Indexed keywords

PLATELET DERIVED GROWTH FACTOR AB; THROMBOCYTE FACTOR 4;

ANGIOGENESIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC RETINOPATHY; HUMAN; IRIS RUBEOSIS; ISCHEMIA; PRIORITY JOURNAL; PROTEIN CONTENT; VITREOUS BODY;

BODY FLUIDS; DIABETIC RETINOPATHY; HUMANS; PLATELET FACTOR 4; PLATELET-DERIVED GROWTH FACTOR; REFERENCE VALUES; RETINAL DISEASES; VITREOUS BODY;

EID: 0034093621     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2000-5803     Document Type: Article

References (16)

1. Ferns GA, Raines EW, Sprügel KH, Motani AS, Reidy MA, Ross R: Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science 253: 1129-1132, 1991
2. Flyvbjerg A: Growth factors and diabetic complications. Diabet. Med. 7: 387-399, 1990
3. Hayek A, Culler FL, Beattie GM, Lopez AD, Cuevas P, Baird A: An in vivo model for study of the angiogenic effects of basic fibroblast growth factor. Biochem. Biophys. Res. Commun. 147: 876-880, 1987
4. Heldin C-H, Westermark B: Platelet-derived growth factor: mechanism of action and possible in vivo function. Cell Regulation 1: 555-566, 1990
5. Inaba T, Ishibashi S, Gotoda T, Kawamura M, Morino N, Nojima Y, Kawakami M, Yazaki Y, Yamada N: Enhanced expression of platelet-derived growth factor-β receptor by high glucose. Involvement of platelet-derived growth factor in diabetic angiopathy. Diabetes 45: 507-512, 1996
6. Koyama N, Watanabe S, Tezuka M, Morisaki N, Saito Y, Yoshida S: Migratory and proliferative effect of platelet-derived growth factor in rabbit retinal endothelial cells: evidence of an autocrine pathway of platelet-derived growth factor. J. Cell. Physiol. 158: 1-6, 1996
7. Merimee TJ: Diabetic retinopathy, a synthesis of perspectives. N. Engl. J. Med. 322: 978-983, 1990
8. Meyer-Schwickerath R, Pfeiffer A, Blum WF, Freyberger H, Klein M, Losche C, Rollmann R, Schatz H: Vitreous levels of the insulin-like growth factors I and II and the insulin-like growth factor binding protein 2 and 3, increase in neovascular eye diseases. Studies in nondiabetic and diabetic subjects. J. Clin. Invest. 92: 2620-2625, 1993
9. Nagaoka J, Trapnell BC, Cystal RG: Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis. J. Clin. Invest. 85: 2023-2027, 1990
10. Pe'er J, Shweiki D, Itin A, Hemo I, Gnessin H, Keshet E: Hypoxia-induced expression of vascular endothelial growth factor by retina cells is a common factor in neovasculariuing ocular diseases. Lab. Invest. 72: 638-645, 1995
11. Pfeiffer A, Middelberg-Bisping K, Drewes C, Schatz H: Elevated plasma levels of transforming growth factor-β in NIDDM. Diabetes Care 19: 1113-1117, 1996
12. Pfeiffer A, Schatz H: Diabetic microvascular complications and growth factors. Exp. Clin. Endocrinol. Diabetes 103: 7-14, 1995
13. Robbins SG, Mixon RN, Wilson DJ, Hart CE, Robertson JE, Westra I, Planck SR, Rosenbaum JT: Platelet-derived growth factor ligands and receptors immunolocalized in proliferative retinal diseases. Invest. Ophthalmol. Vis. Sci. 35: 3649-3663, 1994
14. Report of the National Commission on Diabetes to the Congress of the United States. DHEW publication No. (NIH) 76-1018.
15. Ross R: Mechanisms of atherosclerosis - a review. Adv. Nephrol. Necker Hosp. 19: 79-86, 1990
16. Ross R, Raines EW, Bowen-Pope DF: The biology of platelet-derived growth factor. Cell 46: 155-169, 1986