메뉴 건너뛰기




Volumn 61, Issue 11, 2012, Pages 2948-2957

Therapeutic potential of a monoclonal antibody blocking the Wnt pathway in diabetic retinopathy

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; BETA CATENIN; GLUCOSE; INTERCELLULAR ADHESION MOLECULE 1; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2F1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 84868035449     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0300     Document Type: Article
Times cited : (74)

References (39)
  • 1
    • 0348048874 scopus 로고    scopus 로고
    • Diabetic retinopathy
    • Frank RN. Diabetic retinopathy. N Engl J Med 2004;350:48-58
    • (2004) N Engl J Med , vol.350 , pp. 48-58
    • Frank, R.N.1
  • 3
    • 0031006861 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy
    • Miller JW, Adamis AP, Aiello LP. Vascular endothelial growth factor in ocular neovascularization and proliferative diabetic retinopathy. Diabetes Metab Rev 1997;13:37-50
    • (1997) Diabetes Metab Rev , vol.13 , pp. 37-50
    • Miller, J.W.1    Adamis, A.P.2    Aiello, L.P.3
  • 4
    • 0842313052 scopus 로고    scopus 로고
    • Connective tissue growth factor is up-regulated in the diabetic retina: Amelioration by angiotensin-converting enzyme inhibition
    • Tikellis C, Cooper ME, Twigg SM, Burns WC, Tolcos M. Connective tissue growth factor is up-regulated in the diabetic retina: amelioration by angiotensin-converting enzyme inhibition. Endocrinology 2004;145:860-866
    • (2004) Endocrinology , vol.145 , pp. 860-866
    • Tikellis, C.1    Cooper, M.E.2    Twigg, S.M.3    Burns, W.C.4    Tolcos, M.5
  • 5
    • 7044228789 scopus 로고    scopus 로고
    • A Central role for inflammation in the pathogenesis of diabetic retinopathy
    • Joussen AM, Poulaki V, Le ML, et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J 2004;18:1450-1452
    • (2004) FASEB J , vol.18 , pp. 1450-1452
    • Joussen, A.M.1    Poulaki, V.2    Le, M.L.3
  • 6
    • 0037600389 scopus 로고    scopus 로고
    • Diabetic retinopathy. Pathophysiology and therapy of hypoxia-induced inflammation
    • [in German]
    • Joussen AM, Fauser S, Krohne TU, Lemmen KD, Lang GE, Kirchhof B. [Diabetic retinopathy. Pathophysiology and therapy of hypoxia-induced inflammation] [in German]. Ophthalmologe 2003;100:363-370
    • (2003) Ophthalmologe , vol.100 , pp. 363-370
    • Joussen, A.M.1    Fauser, S.2    Krohne, T.U.3    Lemmen, K.D.4    Lang, G.E.5    Kirchhof, B.6
  • 7
    • 34247394257 scopus 로고    scopus 로고
    • Oxidative stress and diabetic retinopathy
    • Kowluru RA, Chan PS. Oxidative stress and diabetic retinopathy. Exp Diabetes Res 2007;2007:43603
    • (2007) Exp Diabetes Res , vol.2007 , pp. 43603
    • Kowluru, R.A.1    Chan, P.S.2
  • 8
    • 54949157448 scopus 로고    scopus 로고
    • Oxidative stress and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives
    • Madsen-Bouterse SA, Kowluru RA. Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Rev Endocr Metab Disord 2008;9:315-327
    • (2008) Rev Endocr Metab Disord , vol.9 , pp. 315-327
    • Madsen-Bouterse, S.A.1    Kowluru, R.A.2
  • 9
    • 73549107654 scopus 로고    scopus 로고
    • Activation of the wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models
    • Chen Y, Hu Y, Zhou T, et al. Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models. Am J Pathol 2009;175:2676-2685
    • (2009) Am J Pathol , vol.175 , pp. 2676-2685
    • Chen, Y.1    Hu, Y.2    Zhou, T.3
  • 10
    • 8444251784 scopus 로고    scopus 로고
    • The wnt signaling pathway in development and disease
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004;20:781-810
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 11
    • 2342430345 scopus 로고    scopus 로고
    • LDL receptor-related proteins 5 and 6 in wnt/beta-catenin signaling: Arrows point the way
    • He X, Semenov M, Tamai K, Zeng X. LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. Development 2004; 131:1663-1677
    • (2004) Development , vol.131 , pp. 1663-1677
    • He, X.1    Semenov, M.2    Tamai, K.3    Zeng, X.4
  • 12
    • 47049121052 scopus 로고    scopus 로고
    • Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the wnt co-receptor LRP6
    • MacDonald BT, Yokota C, Tamai K, Zeng X, He X. Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6. J Biol Chem 2008;283:16115-16123
    • (2008) J Biol Chem , vol.283 , pp. 16115-16123
    • MacDonald, B.T.1    Yokota, C.2    Tamai, K.3    Zeng, X.4    He, X.5
  • 13
    • 28644439005 scopus 로고    scopus 로고
    • A dual-kinase mechanism for wnt co-receptor phosphorylation and activation
    • Zeng X, Tamai K, Doble B, et al. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 2005;438:873-877
    • (2005) Nature , vol.438 , pp. 873-877
    • Zeng, X.1    Tamai, K.2    Doble, B.3
  • 14
    • 0038745735 scopus 로고    scopus 로고
    • Beta-catenin regulates vascular endothelial growth factor expression in colon cancer
    • Easwaran V, Lee SH, Inge L, et al. beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res 2003;63:3145-3153
    • (2003) Cancer Res , vol.63 , pp. 3145-3153
    • Easwaran, V.1    Lee, S.H.2    Inge, L.3
  • 15
    • 77954272869 scopus 로고    scopus 로고
    • Inhibition of connective tissue growth factor overexpression in diabetic retinopathy by SERPINA3K via blocking the WNT/beta-catenin pathway
    • Zhang B, Zhou KK, Ma JX. Inhibition of connective tissue growth factor overexpression in diabetic retinopathy by SERPINA3K via blocking the WNT/beta-catenin pathway. Diabetes 2010;59:1809-1816
    • (2010) Diabetes , vol.59 , pp. 1809-1816
    • Zhang, B.1    Zhou, K.K.2    Ma, J.X.3
  • 16
    • 38949194936 scopus 로고    scopus 로고
    • Initiation of wnt signaling: Control of wnt coreceptor lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions
    • Zeng X, Huang H, Tamai K, et al. Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development 2008;135:367-375
    • (2008) Development , vol.135 , pp. 367-375
    • Zeng, X.1    Huang, H.2    Tamai, K.3
  • 17
    • 77957348383 scopus 로고    scopus 로고
    • The pathogenic role of the canonical wnt pathway in age-related macular degeneration
    • Zhou T, Hu Y, Chen Y, et al. The pathogenic role of the canonical Wnt pathway in age-related macular degeneration. Invest Ophthalmol Vis Sci 2010;51:4371-4379
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 4371-4379
    • Zhou, T.1    Hu, Y.2    Chen, Y.3
  • 18
    • 77951050199 scopus 로고    scopus 로고
    • Blocking the wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family
    • Zhang B, Abreu JG, Zhou K, et al. Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. Proc Natl Acad Sci USA 2010;107:6900-6905
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 6900-6905
    • Zhang, B.1    Abreu, J.G.2    Zhou, K.3
  • 19
    • 79960341497 scopus 로고    scopus 로고
    • Identification of a novel inhibitor of the canonical wnt pathway
    • Park K, Lee K, Zhang B, et al. Identification of a novel inhibitor of the canonical Wnt pathway. Mol Cell Biol 2011;31:3038-3051
    • (2011) Mol Cell Biol , vol.31 , pp. 3038-3051
    • Park, K.1    Lee, K.2    Zhang, B.3
  • 20
    • 0036228537 scopus 로고    scopus 로고
    • Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium - Derived factor in brown norway and sprague dawley rats contributing to different susceptibilities to retinal neovascularization
    • Gao G, Li Y, Fant J, Crosson CE, Becerra SP, Ma JX. Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium - derived factor in brown norway and sprague dawley rats contributing to different susceptibilities to retinal neovascularization. Diabetes 2002;51: 1218-1225
    • (2002) Diabetes , vol.51 , pp. 1218-1225
    • Gao, G.1    Li, Y.2    Fant, J.3    Crosson, C.E.4    Becerra, S.P.5    Ma, J.X.6
  • 21
    • 0035096388 scopus 로고    scopus 로고
    • Sensitive blood-retinal barrier breakdown quantitation using evans blue
    • Xu Q, Qaum T, Adamis AP. Sensitive blood-retinal barrier breakdown quantitation using Evans blue. Invest Ophthalmol Vis Sci 2001;42:789-794
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 789-794
    • Xu, Q.1    Qaum, T.2    Adamis, A.P.3
  • 22
    • 0035882030 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor by the wnt and K-ras pathways in colonic neoplasia
    • Zhang X, Gaspard JP, Chung DC. Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res 2001;61:6050-6054
    • (2001) Cancer Res , vol.61 , pp. 6050-6054
    • Zhang, X.1    Gaspard, J.P.2    Chung, D.C.3
  • 23
    • 78951469821 scopus 로고    scopus 로고
    • The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy
    • Zhou T, Zhou KK, Lee K, et al. The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy. Diabetologia 2011;54:459-468
    • (2011) Diabetologia , vol.54 , pp. 459-468
    • Zhou, T.1    Zhou, K.K.2    Lee, K.3
  • 24
    • 80054027552 scopus 로고    scopus 로고
    • Frizzled 4 is required for retinal angiogenesis and maintenance of the blood-retina barrier
    • Paes KT, Wang E, Henze K, et al. Frizzled 4 is required for retinal angiogenesis and maintenance of the blood-retina barrier. Invest Ophthalmol Vis Sci 2011;52:6452-6461
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 6452-6461
    • Paes, K.T.1    Wang, E.2    Henze, K.3
  • 25
    • 12144289950 scopus 로고    scopus 로고
    • Vascular development in the retina and inner ear: Control by norrin and frizzled-4, a high-affinity ligand-receptor pair
    • Xu Q, Wang Y, Dabdoub A, et al. Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 2004;116:883-895
    • (2004) Cell , vol.116 , pp. 883-895
    • Xu, Q.1    Wang, Y.2    Dabdoub, A.3
  • 26
    • 34547797469 scopus 로고    scopus 로고
    • Vascular injury during elevated glucose can be mitigated by erythropoietin and wnt signaling
    • Chong ZZ, Shang YC, Maiese K. Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling. Curr Neurovasc Res 2007;4:194-204
    • (2007) Curr Neurovasc Res , vol.4 , pp. 194-204
    • Chong, Z.Z.1    Shang, Y.C.2    Maiese, K.3
  • 28
    • 47549113841 scopus 로고    scopus 로고
    • IGFBP-4 is an inhibitor of canonical wnt signalling required for cardiogenesis
    • Zhu W, Shiojima I, Ito Y, et al. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008;454:345-349
    • (2008) Nature , vol.454 , pp. 345-349
    • Zhu, W.1    Shiojima, I.2    Ito, Y.3
  • 29
    • 0033289483 scopus 로고    scopus 로고
    • Regulators of vascular permeability: Potential sites for intervention in the treatment of macular edema
    • Gillies MC. Regulators of vascular permeability: potential sites for intervention in the treatment of macular edema. Doc Ophthalmol 1999;97: 251-260
    • (1999) Doc Ophthalmol , vol.97 , pp. 251-260
    • Gillies, M.C.1
  • 30
    • 23144443684 scopus 로고    scopus 로고
    • Old and new drug targets in diabetic retinopathy: From biochemical changes to inflammation and neurodegeneration
    • Leal EC, Santiago AR, Ambrósio AF. Old and new drug targets in diabetic retinopathy: from biochemical changes to inflammation and neurodegeneration. Curr Drug Targets CNS Neurol Disord 2005;4:421-434
    • (2005) Curr Drug Targets CNS Neurol Disord , vol.4 , pp. 421-434
    • Leal, E.C.1    Santiago, A.R.2    Ambrósio, A.F.3
  • 31
    • 70349816653 scopus 로고    scopus 로고
    • Eyeing up new wnt pathway players
    • Clevers H. Eyeing up new Wnt pathway players. Cell 2009;139:227-229
    • (2009) Cell , vol.139 , pp. 227-229
    • Clevers, H.1
  • 32
    • 18244427021 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein-5 binds to axin and regulates the canonical wnt signaling pathway
    • Mao J, Wang J, Liu B, et al. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell 2001;7:801-809
    • (2001) Mol Cell , vol.7 , pp. 801-809
    • Mao, J.1    Wang, J.2    Liu, B.3
  • 33
    • 77958599987 scopus 로고    scopus 로고
    • Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies
    • Gong Y, Bourhis E, Chiu C, et al. Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies. PLoS ONE 2010;5:e12682
    • (2010) PLoS ONE , vol.5
    • Gong, Y.1    Bourhis, E.2    Chiu, C.3
  • 34
    • 79955663810 scopus 로고    scopus 로고
    • Anti-VEGF compounds in the treatment of neovascular age related macular degeneration
    • Campa C, Harding SP. Anti-VEGF compounds in the treatment of neovascular age related macular degeneration. Curr Drug Targets 2011;12:173-181
    • (2011) Curr Drug Targets , vol.12 , pp. 173-181
    • Campa, C.1    Harding, S.P.2
  • 35
    • 77949436790 scopus 로고    scopus 로고
    • Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for diabetic macular oedema
    • Parravano M, Menchini F, Virgili G. Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for diabetic macular oedema. Cochrane Database Syst Rev 2009 (4):CD007419
    • (2009) Cochrane Database Syst Rev , Issue.4
    • Parravano, M.1    Menchini, F.2    Virgili, G.3
  • 36
    • 33744728068 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization
    • Jo N, Mailhos C, Ju M, et al. Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. Am J Pathol 2006; 168:2036-2053
    • (2006) Am J Pathol , vol.168 , pp. 2036-2053
    • Jo, N.1    Mailhos, C.2    Ju, M.3
  • 38
    • 33744472747 scopus 로고    scopus 로고
    • Wnt/frizzled signaling in the vasculature: New angiogenic factors in sight
    • Masckauchán TN, Kitajewski J. Wnt/Frizzled signaling in the vasculature: new angiogenic factors in sight. Physiology (Bethesda) 2006;21: 181-188
    • (2006) Physiology (Bethesda) , vol.21 , pp. 181-188
    • Masckauchán, T.N.1    Kitajewski, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.