Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood-retinal barrier dysfunction

Biochemical Journal

Volumn 446, Issue 3, 2012, Pages 455-467

  Titchenell, Paul M ^a   Lin, Cheng Mao ^b   Keil, Jason M ^b   Sundstrom, Jeffrey M ^a   Smith, Charles D ^c   Antonetti, David A ^b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Atypical protein kinase C (aPKC); Blood brain barrier (BBB); Blood retinal barrier (BRB); Vascular endothelial growth factor (VEGF)

Indexed keywords

2 (2 CHLORO 5 NITRO BENZOYLAMINO) 4 (4 CHLORO PHENYL) THIOPHENE 3 CARBOXYLIC ACID ETHYL ESTER; 2 (2 CHLORO 5 NITRO BENZOYLAMINO) 5 METHYL 4 PHENYL THIOPHENE 3 CARBOXYLIC ACID ETHYL ESTER; 2 ACETYLAMINO 4 (4 CHLORO PHENYL) THIOPHENE 3 CARBOXYLIC ACID ETHYL ESTER; 2 ACETYLAMINO 5 METHYL 4 PHENYL THIOPHENE 3 CARBOXYLIC ACID ETHYL ESTER; 2 AMINO 4 (CHLOROPHENYL) THIOPHENE 3 3 CARBOXYLATATE; 2 AMINO 4 PHENYL THIOPHENE; PROTEIN KINASE INHIBITOR; THIOPHENE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD RETINA BARRIER; BRAIN TUMOR; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CELL PERMEABILIZATION; CONTROLLED STUDY; DIABETIC RETINOPATHY; IC 50; IN VIVO STUDY; MALE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TIGHT JUNCTION; UVEITIS;

ANIMALS; BLOOD-RETINAL BARRIER; CATTLE; DIABETIC RETINOPATHY; HUMANS; MALE; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; RECOMBINANT PROTEINS; RETINA; RETINAL VESSELS; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

RODENTIA;

EID: 84865584015     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20111961     Document Type: Article

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