메뉴 건너뛰기




Volumn 3, Issue 6, 2012, Pages 755-762

Homocysteine Imbalance: A pathological metabolic marker

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; HOMOCYSTEINE;

EID: 84878098649     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.3945/an.112.002758     Document Type: Review
Times cited : (140)

References (98)
  • 1
    • 0026633925 scopus 로고
    • Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease
    • Kang S-S, Wong PW, Malinow MR. Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu Rev Nutr. 1992;12:279-98.
    • (1992) Annu Rev Nutr , vol.12 , pp. 279-298
    • Kang, S.-S.1    Wong, P.W.2    Malinow, M.R.3
  • 2
    • 0037364417 scopus 로고    scopus 로고
    • Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders
    • Mattson MP, Shea TB. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 2003;26:137-46.
    • (2003) Trends Neurosci , vol.26 , pp. 137-146
    • Mattson, M.P.1    Shea, T.B.2
  • 3
    • 0022519625 scopus 로고
    • Labile methyl groups and the promotion of cancer
    • Newberne PM, Rogers AE. Labile methyl groups and the promotion of cancer. Annu Rev Nutr. 1986;6:407-32.
    • (1986) Annu Rev Nutr , vol.6 , pp. 407-432
    • Newberne, P.M.1    Rogers, A.E.2
  • 4
    • 0025292327 scopus 로고
    • The role of nutrition in neural tube defects
    • Scott JM, Kirke PN, Weir DG. The role of nutrition in neural tube defects. Annu Rev Nutr. 1990;10:277-95.
    • (1990) Annu Rev Nutr , vol.10 , pp. 277-295
    • Scott, J.M.1    Kirke, P.N.2    Weir, D.G.3
  • 5
    • 77951121781 scopus 로고    scopus 로고
    • Homocysteine metabolism and its relation to health and disease
    • Williams KT, Schalinske KL. Homocysteine metabolism and its relation to health and disease. Biofactors. 2010;36:19-24.
    • (2010) Biofactors , vol.36 , pp. 19-24
    • Williams, K.T.1    Schalinske, K.L.2
  • 6
    • 84856474843 scopus 로고    scopus 로고
    • Intragenic DNA methylation:implications of this epigenetic mechanism for cancer research
    • Shenker N, Flanagan JM. Intragenic DNA methylation:implications of this epigenetic mechanism for cancer research. Br J Cancer. 2012;106:248-53.
    • (2012) Br J Cancer , vol.106 , pp. 248-253
    • Shenker, N.1    Flanagan, J.M.2
  • 7
    • 0036403334 scopus 로고    scopus 로고
    • Genetic effects of methylation diets
    • Van den Veyver IB. Genetic effects of methylation diets. Annu Rev Nutr. 2002;22:255-82.
    • (2002) Annu Rev Nutr , vol.22 , pp. 255-282
    • Van Den Veyver, I.B.1
  • 8
    • 0015501428 scopus 로고
    • Competing methyltransferase systems
    • Kerr SJ. Competing methyltransferase systems. J Biol Chem. 1972;247:4248-52.
    • (1972) J Biol Chem , vol.247 , pp. 4248-4252
    • Kerr, S.J.1
  • 9
    • 0004200052 scopus 로고
    • S-adenosylamino acids thirty years later:1951-1981
    • In:Usdin E, Borchardt RT, Creveling CR, edtors. The biochemistry of S-adenosylmethionine and related compounds. New York:Macmillan Publishers
    • Cantoni GL. S-adenosylamino acids thirty years later:1951-1981. In:Usdin E, Borchardt RT, Creveling CR, edtors. The biochemistry of S-adenosylmethionine and related compounds. New York:Macmillan Publishers; 1982. p. 3-10.
    • (1982) , pp. 3-10
    • Cantoni, G.L.1
  • 10
    • 0002616156 scopus 로고
    • The role of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in the control of biological methylations
    • In:Cavallini D, Gaull GE, Zappia V, editors. Natural sulfur compounds, New York:Plenum Press
    • Cantoni GL, Chiang PK. The role of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in the control of biological methylations. In:Cavallini D, Gaull GE, Zappia V, editors. Natural sulfur compounds, New York:Plenum Press; 1980. p. 67-80.
    • (1980) , pp. 67-80
    • Cantoni, G.L.1    Chiang, P.K.2
  • 11
    • 0016722112 scopus 로고
    • Labile methyl balances for normal humans on various dietary regimens
    • Mudd SH, Poole JR. Labile methyl balances for normal humans on various dietary regimens. Metabolism. 1975;24:721-35.
    • (1975) Metabolism , vol.24 , pp. 721-735
    • Mudd, S.H.1    Poole, J.R.2
  • 12
    • 0018934312 scopus 로고
    • Labile methyl group balances in the human:the role of sarcosine
    • Mudd SH, Ebert MH, Scriver CR. Labile methyl group balances in the human:the role of sarcosine. Metabolism. 1980;29:707-20.
    • (1980) Metabolism , vol.29 , pp. 707-720
    • Mudd, S.H.1    Ebert, M.H.2    Scriver, C.R.3
  • 14
    • 0002942853 scopus 로고
    • Biochemical role of folate in cellular metabolism
    • In:Bailey LB, editors. Folate in health and disease. New York:Marcel Dekker
    • Wagner C. Biochemical role of folate in cellular metabolism. In:Bailey LB, editors. Folate in health and disease. New York:Marcel Dekker; 1995. p. 23-42.
    • (1995) , pp. 23-42
    • Wagner, C.1
  • 15
    • 0023664009 scopus 로고
    • Allosteric inhibition of methylenetetrahydrofolate reductase by adenosylmethionine
    • Jencks DA, Matthews RG. Allosteric inhibition of methylenetetrahydrofolate reductase by adenosylmethionine. J Biol Chem. 1987;262:2485-93.
    • (1987) J Biol Chem , vol.262 , pp. 2485-2493
    • Jencks, D.A.1    Matthews, R.G.2
  • 16
    • 0014208254 scopus 로고
    • Feedback inhibition of methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine
    • Kutzbach C, Stokstad ELR. Feedback inhibition of methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine. Biochim Biophys Acta. 1967;139:217-20.
    • (1967) Biochim Biophys Acta , vol.139 , pp. 217-220
    • Kutzbach, C.1    Stokstad, E.L.R.2
  • 17
    • 0021867328 scopus 로고
    • Inhibition of glycine N-methyltransferase activity by folate derivatives:implications for regulation of methyl group metabolism
    • Wagner C, Briggs WT, Cook RJ. Inhibition of glycine N-methyltransferase activity by folate derivatives:implications for regulation of methyl group metabolism. Biochem Biophys Res Commun. 1985; 127:746-52.
    • (1985) Biochem Biophys Res Commun , vol.127 , pp. 746-752
    • Wagner, C.1    Briggs, W.T.2    Cook, R.J.3
  • 18
    • 0035195248 scopus 로고    scopus 로고
    • Methylation demand and homocysteine metabolism:effects of dietary provision of creatine and guanidinoacetate
    • Stead LM, Au KP, Jacobs RL, Brosnan ME, Brosnan JT. Methylation demand and homocysteine metabolism:effects of dietary provision of creatine and guanidinoacetate. Am J Physiol Endocrinol Metab. 2001; 281:E1095-100.
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Stead, L.M.1    Au, K.P.2    Jacobs, R.L.3    Brosnan, M.E.4    Brosnan, J.T.5
  • 19
    • 0023833533 scopus 로고
    • The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes
    • Yao ZM, Vance DE. The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J Biol Chem. 1988;263:2998-3004.
    • (1988) J Biol Chem , vol.263 , pp. 2998-3004
    • Yao, Z.M.1    Vance, D.E.2
  • 21
    • 0036829872 scopus 로고    scopus 로고
    • An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins
    • Noga AA, Zhao Y, Vance DE. An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins. J Biol Chem. 2002;277:42358-65.
    • (2002) J Biol Chem , vol.277 , pp. 42358-42365
    • Noga, A.A.1    Zhao, Y.2    Vance, D.E.3
  • 22
    • 33745176624 scopus 로고    scopus 로고
    • Glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme
    • Luka Z, Capdevila A, Mato JM, Wagner CA. Glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme. Transgenic Res. 2006;15:393-7.
    • (2006) Transgenic Res , vol.15 , pp. 393-397
    • Luka, Z.1    Capdevila, A.2    Mato, J.M.3    Wagner, C.A.4
  • 23
    • 34547782307 scopus 로고    scopus 로고
    • Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes
    • Resseguie M, Song J, Nuculescu MD, da Costa KA, Randall TA, Zeisel SH. Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J. 2007;21:2622-32.
    • (2007) FASEB J , vol.21 , pp. 2622-2632
    • Resseguie, M.1    Song, J.2    Nuculescu, M.D.3    da Costa, K.A.4    Randall, T.A.5    Zeisel, S.H.6
  • 24
    • 51649112963 scopus 로고    scopus 로고
    • Murine models of hyperhomocysteinemia and their vascular phenotypes
    • Dayal S, Lentz SR. Murine models of hyperhomocysteinemia and their vascular phenotypes. Arterioscler Thromb Vasc Biol. 2008;28:1596-605.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1596-1605
    • Dayal, S.1    Lentz, S.R.2
  • 28
    • 0031828880 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages
    • Nelen WLDM, Blom HJ, Thomas CMG, Steegers EAP, Boers GHJ, Eskes TKAB. Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages. J Nutr. 1998;128:1336-41.
    • (1998) J Nutr , vol.128 , pp. 1336-1341
    • Nelen, W.L.D.M.1    Blom, H.J.2    Thomas, C.M.G.3    Steegers, E.A.P.4    Boers, G.H.J.5    Eskes, T.K.A.B.6
  • 29
    • 1642312607 scopus 로고    scopus 로고
    • Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice
    • Devlin AM, Arning E, Bottiglieri T, Faraci FM, Rozen R, Lentz SR. Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. Blood. 2004;103:2624-9.
    • (2004) Blood , vol.103 , pp. 2624-2629
    • Devlin, A.M.1    Arning, E.2    Bottiglieri, T.3    Faraci, F.M.4    Rozen, R.5    Lentz, S.R.6
  • 31
    • 80054691714 scopus 로고    scopus 로고
    • Deletion of betainehomocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas
    • Teng YW, Mehedint MG, Garrow TA, Zeisel SH. Deletion of betainehomocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem. 2011;286:36258-67.
    • (2011) J Biol Chem , vol.286 , pp. 36258-36267
    • Teng, Y.W.1    Mehedint, M.G.2    Garrow, T.A.3    Zeisel, S.H.4
  • 34
    • 11844286970 scopus 로고    scopus 로고
    • Nutrition and aberrant DNA methylation patterns in atherosclerosis:more than just hyperhomocysteinemia?
    • Zaina S, Lindholm MW, Lund G. Nutrition and aberrant DNA methylation patterns in atherosclerosis:more than just hyperhomocysteinemia? J Nutr. 2005;135:5-8.
    • (2005) J Nutr , vol.135 , pp. 5-8
    • Zaina, S.1    Lindholm, M.W.2    Lund, G.3
  • 37
    • 33749329880 scopus 로고    scopus 로고
    • Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia
    • Dayal S, Wilson KM, Leo L, Arning E, Bottiglieri T, Lentz SR. Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia. Blood. 2006;108:2237-43.
    • (2006) Blood , vol.108 , pp. 2237-2243
    • Dayal, S.1    Wilson, K.M.2    Leo, L.3    Arning, E.4    Bottiglieri, T.5    Lentz, S.R.6
  • 38
    • 1542649923 scopus 로고    scopus 로고
    • Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice
    • Wilson KM, Lynch CM, Faraci FM, Lentz SR. Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice. J Thromb Haemost. 2003;1:2669-74.
    • (2003) J Thromb Haemost , vol.1 , pp. 2669-2674
    • Wilson, K.M.1    Lynch, C.M.2    Faraci, F.M.3    Lentz, S.R.4
  • 39
    • 31644451877 scopus 로고    scopus 로고
    • The association between homocysteine and myocardial infarction is independent of age, sex, blood pressure, cholesterol, smoking and markers of inflammation:the Glasgow Myocardial Infarction Study
    • Woodward M, Rumley A, Rumley C, Lewington S, Morrison CE, Lowe GD. The association between homocysteine and myocardial infarction is independent of age, sex, blood pressure, cholesterol, smoking and markers of inflammation:the Glasgow Myocardial Infarction Study. Blood Coagul Fibrinolysis. 2006;17:1-5.
    • (2006) Blood Coagul Fibrinolysis , vol.17 , pp. 1-5
    • Woodward, M.1    Rumley, A.2    Rumley, C.3    Lewington, S.4    Morrison, C.E.5    Lowe, G.D.6
  • 42
    • 84887366631 scopus 로고    scopus 로고
    • Cardiovascular effects of B-vitamins and/or N-3 fatty acids:the Su. Fol. Om3 trial
    • Feb 22
    • Blacher J, Czernichow S, Paillard F. Cardiovascular effects of B-vitamins and/or N-3 fatty acids:the Su. Fol. Om3 trial. Int J Cardiol. 2012 Feb 22.
    • (2012) Int J Cardiol
    • Blacher, J.1    Czernichow, S.2    Paillard, F.3
  • 44
    • 77957949167 scopus 로고    scopus 로고
    • Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality:meta-analysis of 8 randomized trials involving 37 485 individuals
    • Clarke R, Halsey J, Lewington S, Manson JE, Bønaa KH, Spence JD, Nygård O, Jamison R, Gariano JM, Guarino P, et al. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality:meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med. 2010;170:1622-31.
    • (2010) Arch Intern Med , vol.170 , pp. 1622-1631
    • Clarke, R.1    Halsey, J.2    Lewington, S.3    Manson, J.E.4    Bønaa, K.H.5    Spence, J.D.6    Nygård, O.7    Jamison, R.8    Gariano, J.M.9    Guarino, P.10
  • 45
    • 33845964945 scopus 로고    scopus 로고
    • Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism:a randomized, placebo-controlled, double-blind trial
    • den Heijer M, Willems HP, Blom HJ, Gerrits WB, Cattaneo M, Eichinger S, Rosendaal FR, Bos GM. Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism:a randomized, placebo-controlled, double-blind trial. Blood. 2007;109:139-44.
    • (2007) Blood , vol.109 , pp. 139-144
    • Den Heijer, M.1    Willems, H.P.2    Blom, H.J.3    Gerrits, W.B.4    Cattaneo, M.5    Eichinger, S.6    Rosendaal, F.R.7    Bos, G.M.8
  • 46
    • 34548566329 scopus 로고    scopus 로고
    • Veterans Affairs Site Investigators. Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease:a randomized controlled trial
    • Jamison RL, Hartigan P, Kaufman JS, Goldfarb DS, Warren SR, Guarino PD, Gaziano JM; Veterans Affairs Site Investigators. Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease:a randomized controlled trial. JAMA. 2007;298:1163-70.
    • (2007) JAMA , vol.298 , pp. 1163-1170
    • Jamison, R.L.1    Hartigan, P.2    Kaufman, J.S.3    Goldfarb, D.S.4    Warren, S.R.5    Guarino, P.D.6    Gaziano, J.M.7
  • 47
    • 33645753544 scopus 로고    scopus 로고
    • Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. Homocysteine lowering with folic acid and B vitamins in vascular disease
    • Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, McQueen MJ, Probstfield J, Fodor G, Held C, et al. Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med. 2006;354:1567-77.
    • (2006) N Engl J Med , vol.354 , pp. 1567-1577
    • Lonn, E.1    Yusuf, S.2    Arnold, M.J.3    Sheridan, P.4    Pogue, J.5    Micks, M.6    McQueen, M.J.7    Probstfield, J.8    Fodor, G.9    Held, C.10
  • 48
    • 36248955119 scopus 로고    scopus 로고
    • Homocysteine, vitamins, and vascular disease prevention
    • McCully KS. Homocysteine, vitamins, and vascular disease prevention. Am J Clin Nutr. 2007;86:1563S-8S.
    • (2007) Am J Clin Nutr , vol.86
    • McCully, K.S.1
  • 50
    • 80053250105 scopus 로고    scopus 로고
    • Associations of plasma homocysteine levels with arterial stiffness in prehypertensive individuals
    • Kim BJ, Seo M, Huh J, Kwon C, Kim J, Sung K, Kim B, Kang J. Associations of plasma homocysteine levels with arterial stiffness in prehypertensive individuals. Clin Exp Hypertens. 2011;33:411-7.
    • (2011) Clin Exp Hypertens , vol.33 , pp. 411-417
    • Kim, B.J.1    Seo, M.2    Huh, J.3    Kwon, C.4    Kim, J.5    Sung, K.6    Kim, B.7    Kang, J.8
  • 51
    • 78649671320 scopus 로고    scopus 로고
    • Homocysteine impairs coronary artery endothelial function by inhibiting tetrabiopterin in patients with hyperhomocysteinemia
    • He L, Zeng H, Fuwang L, Feng J, Liu S, Liu J, Yu J, Mao J, Hong T, Chen A, et al. Homocysteine impairs coronary artery endothelial function by inhibiting tetrabiopterin in patients with hyperhomocysteinemia. Am J Physiol Endocrinol Metab. 2010;299:E1061-5.
    • (2010) Am J Physiol Endocrinol Metab , vol.299
    • He, L.1    Zeng, H.2    Fuwang, L.3    Feng, J.4    Liu, S.5    Liu, J.6    Yu, J.7    Mao, J.8    Hong, T.9    Chen, A.10
  • 52
    • 66549090409 scopus 로고    scopus 로고
    • MTHFR 677 C>T polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis
    • Antoniades C, Shirodaria C, Leeson P, Baarholm O, Van-Assche T, Cunnington C, Pillai R, Ratnatunga C, Tousoulis D, Stefanadis C, et al. MTHFR 677 C>T polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis. Circulation. 2009;119:2507-15.
    • (2009) Circulation , vol.119 , pp. 2507-2515
    • Antoniades, C.1    Shirodaria, C.2    Leeson, P.3    Baarholm, O.4    Van-Assche, T.5    Cunnington, C.6    Pillai, R.7    Ratnatunga, C.8    Tousoulis, D.9    Stefanadis, C.10
  • 53
    • 84887345301 scopus 로고    scopus 로고
    • Homocysteine-lowering treatment with folic acid, cobalamin, and pyroidoxine does not suppress blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with prior TIA or stroke
    • Hankey G, Eikelbloom P, Dusitanond P, Thom J, Loh K, van Bockxmeer F, Jamrozik K. Homocysteine-lowering treatment with folic acid, cobalamin, and pyroidoxine does not suppress blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with prior TIA or stroke. Stroke. 2005;36:474.
    • (2005) Stroke , vol.36 , pp. 474
    • Hankey, G.1    Eikelbloom, P.2    Dusitanond, P.3    Thom, J.4    Loh, K.5    van Bockxmeer, F.6    Jamrozik, K.7
  • 54
    • 80755142809 scopus 로고    scopus 로고
    • Correction of endothelial dysfunction after selective homocysteine lowering gene therapy reduces arterial thrombogenicity but has no effect on atherogenesis
    • Jacobs F, Van Craeyveld E, Muthuramu I, Gordts S, Emmerechts J, Hoylaerts M, Herljgers P, De Geest B. Correction of endothelial dysfunction after selective homocysteine lowering gene therapy reduces arterial thrombogenicity but has no effect on atherogenesis. J Mol Med. 2011;89:1051-8.
    • (2011) J Mol Med , vol.89 , pp. 1051-1058
    • Jacobs, F.1    Van Craeyveld, E.2    Muthuramu, I.3    Gordts, S.4    Emmerechts, J.5    Hoylaerts, M.6    Herljgers, P.7    De Geest, B.8
  • 56
    • 84867412559 scopus 로고    scopus 로고
    • Plasma total homocysteine is a determinant of carotid intima-media thickness and circulating endothelial progenitor cells in patients with newly diagnosed hypertension
    • Bogdanski P, Miller-Kasprzak E, Pupek-Musialik D, Jablecka A, Lacinski M, Jagodzinski P, Jakubowski H. Plasma total homocysteine is a determinant of carotid intima-media thickness and circulating endothelial progenitor cells in patients with newly diagnosed hypertension. Clin Chem Lab Med. 2012;50:1107-13.
    • (2012) Clin Chem Lab Med , vol.50 , pp. 1107-1113
    • Bogdanski, P.1    Miller-Kasprzak, E.2    Pupek-Musialik, D.3    Jablecka, A.4    Lacinski, M.5    Jagodzinski, P.6    Jakubowski, H.7
  • 58
    • 0034789257 scopus 로고    scopus 로고
    • Blood S-adenosylmethionine concentrations and lymphocyte methylenetetrahydrofolate reductase activity in diabetes mellitus and diabetic nephropathy
    • Poirier LA, Brown AT, Fink LM, Wise CK, Randolph CJ, Delongchamp RR, Fonseca VA. Blood S-adenosylmethionine concentrations and lymphocyte methylenetetrahydrofolate reductase activity in diabetes mellitus and diabetic nephropathy. Metabolism. 2001;50:1014-8.
    • (2001) Metabolism , vol.50 , pp. 1014-1018
    • Poirier, L.A.1    Brown, A.T.2    Fink, L.M.3    Wise, C.K.4    Randolph, C.J.5    Delongchamp, R.R.6    Fonseca, V.A.7
  • 60
    • 0031737909 scopus 로고    scopus 로고
    • Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat
    • Jacobs RL, House JD, Brosnan ME, Brosnan JT. Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat. Diabetes. 1998;47:1967-70.
    • (1998) Diabetes , vol.47 , pp. 1967-1970
    • Jacobs, R.L.1    House, J.D.2    Brosnan, M.E.3    Brosnan, J.T.4
  • 61
    • 0035941350 scopus 로고    scopus 로고
    • Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver
    • Jacobs RL, Steads LM, Brosnan ME, Brosnan JT. Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver. J Biol Chem. 2001;276:43740-7.
    • (2001) J Biol Chem , vol.276 , pp. 43740-43747
    • Jacobs, R.L.1    Steads, L.M.2    Brosnan, M.E.3    Brosnan, J.T.4
  • 63
    • 8544257376 scopus 로고    scopus 로고
    • Modulation of methyl group metabolism by streptozotocin-induced diabetes and alltrans-retinoic acid
    • Nieman KM, Rowling MJ, Garrow TA, Schalinske KL. Modulation of methyl group metabolism by streptozotocin-induced diabetes and alltrans-retinoic acid. J Biol Chem. 2004;279:45708-12.
    • (2004) J Biol Chem , vol.279 , pp. 45708-45712
    • Nieman, K.M.1    Rowling, M.J.2    Garrow, T.A.3    Schalinske, K.L.4
  • 66
    • 2642513835 scopus 로고    scopus 로고
    • Modulation of cystathionine b-synthase level regulates total serum homocysteine in mice
    • Wang L, Jhee K-H, Hua X, DiBello PM, Jacobsen DW, Kruger WD. Modulation of cystathionine b-synthase level regulates total serum homocysteine in mice. Circ Res. 2004;94:1318-24.
    • (2004) Circ Res , vol.94 , pp. 1318-1324
    • Wang, L.1    Jhee, K.-H.2    Hua, X.3    DiBello, P.M.4    Jacobsen, D.W.5    Kruger, W.D.6
  • 67
    • 33845335189 scopus 로고    scopus 로고
    • Hepatic phosphatidyl-ethanolamine N-methyltransferase expression is increased in diabetic rats
    • Hartz CS, Nieman KM, Jacobs RL, Vance DE, Schalinske KL. Hepatic phosphatidyl-ethanolamine N-methyltransferase expression is increased in diabetic rats. J Nutr. 2006;136:3005-9.
    • (2006) J Nutr , vol.136 , pp. 3005-3009
    • Hartz, C.S.1    Nieman, K.M.2    Jacobs, R.L.3    Vance, D.E.4    Schalinske, K.L.5
  • 68
    • 80052057983 scopus 로고    scopus 로고
    • Insulin abrogates perturbation of methyl group and homocysteine metabolism in diabetic rats
    • Nieman KM, Schalinske KL. Insulin abrogates perturbation of methyl group and homocysteine metabolism in diabetic rats. Am J Physiol Endocrinol Metab. 2011;301:E560-5.
    • (2011) Am J Physiol Endocrinol Metab , vol.301
    • Nieman, K.M.1    Schalinske, K.L.2
  • 70
    • 84856977834 scopus 로고    scopus 로고
    • Tissue-specific alterations of methyl group metabolism and DNA hypermethylation in the Zucker (type 2) diabetic fatty (ZDF) rat
    • Williams KT, Schalinske KL. Tissue-specific alterations of methyl group metabolism and DNA hypermethylation in the Zucker (type 2) diabetic fatty (ZDF) rat. Diabetes Metab Res Rev. 2012;28:123-31.
    • (2012) Diabetes Metab Res Rev , vol.28 , pp. 123-131
    • Williams, K.T.1    Schalinske, K.L.2
  • 74
    • 80052686745 scopus 로고    scopus 로고
    • MMP-9, homocysteine and CRP circulating levels are associated with intraluminal thrombus thickness of abdominal aortic aneurysms:new implication of the old biomarkers
    • Wiernicki I, Millo B, Safranow K, Gorecka-Szyld B, Gutowski P. MMP-9, homocysteine and CRP circulating levels are associated with intraluminal thrombus thickness of abdominal aortic aneurysms:new implication of the old biomarkers. Dis Markers. 2011;31:67-74.
    • (2011) Dis Markers , vol.31 , pp. 67-74
    • Wiernicki, I.1    Millo, B.2    Safranow, K.3    Gorecka-Szyld, B.4    Gutowski, P.5
  • 75
    • 0033636608 scopus 로고    scopus 로고
    • Increased levels of homocysteine in patients with Crohn's disease are related to folate levels
    • Chowers Y, Sela BA, Holland R, Fidder H, Simoni FB, Bar-Meir S. Increased levels of homocysteine in patients with Crohn's disease are related to folate levels. Am J Gastroenterol. 2000;95:3498-502.
    • (2000) Am J Gastroenterol , vol.95 , pp. 3498-3502
    • Chowers, Y.1    Sela, B.A.2    Holland, R.3    Fidder, H.4    Simoni, F.B.5    Bar-Meir, S.6
  • 76
  • 77
    • 0035090211 scopus 로고    scopus 로고
    • Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne
    • Schulpis KH, Karikas GA, Georgala S, Michas T, Tsakiris S. Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne. Int J Dermatol. 2001;40:33-6.
    • (2001) Int J Dermatol , vol.40 , pp. 33-36
    • Schulpis, K.H.1    Karikas, G.A.2    Georgala, S.3    Michas, T.4    Tsakiris, S.5
  • 78
    • 79955618320 scopus 로고    scopus 로고
    • Isotretinoin use and the risk of inflammatory bowel disease
    • author reply 1002-3
    • Thakrar BT, Robinson NJ. Isotretinoin use and the risk of inflammatory bowel disease. Am J Gastroenterol. 2011;106:1000-2, author reply 1002-3.
    • (2011) Am J Gastroenterol , vol.106 , pp. 1000-1002
    • Thakrar, B.T.1    Robinson, N.J.2
  • 82
    • 59749090027 scopus 로고    scopus 로고
    • Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone
    • Herrmann M, Tami A, Wildemann B, Wolny M, Wagner A, Schorr H, Taban-Shomal O, Umanskaya N, Ross S, Garcia P, et al. Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone. Bone. 2009;44:467-75.
    • (2009) Bone , vol.44 , pp. 467-475
    • Herrmann, M.1    Tami, A.2    Wildemann, B.3    Wolny, M.4    Wagner, A.5    Schorr, H.6    Taban-Shomal, O.7    Umanskaya, N.8    Ross, S.9    Garcia, P.10
  • 83
  • 85
    • 36849023126 scopus 로고    scopus 로고
    • The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients:a 1-year double blind placebo controlled trial
    • Herrmann M, Umanskaya N, Traber L, Schmidt-Gayk H, Menke W, Lanzer G, Lenhart M, Peter Schmidt J, Herrmann W. The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients:a 1-year double blind placebo controlled trial. Clin Chem Lab Med. 2007;45:1785-92.
    • (2007) Clin Chem Lab Med , vol.45 , pp. 1785-1792
    • Herrmann, M.1    Umanskaya, N.2    Traber, L.3    Schmidt-Gayk, H.4    Menke, W.5    Lanzer, G.6    Lenhart, M.7    Peter Schmidt, J.8    Herrmann, W.9
  • 86
    • 84861816548 scopus 로고    scopus 로고
    • Relationship between serum homocysteine levels and depressive symptoms:the Cooper Center Longitudinal Study
    • Gu P, Defina LF, Leonard D, John S, Weiner MF, Brown ES. Relationship between serum homocysteine levels and depressive symptoms:the Cooper Center Longitudinal Study. J Clin Psychiatry. 2012;73:691-5.
    • (2012) J Clin Psychiatry , vol.73 , pp. 691-695
    • Gu, P.1    Defina, L.F.2    Leonard, D.3    John, S.4    Weiner, M.F.5    Brown, E.S.6
  • 87
    • 80054886647 scopus 로고    scopus 로고
    • Testing homocysteine-induced neurotransmitter deficiency, and depression of mood hypothesis in clinical practice
    • Gariballa S. Testing homocysteine-induced neurotransmitter deficiency, and depression of mood hypothesis in clinical practice. Age Ageing. 2011;40:702-5.
    • (2011) Age Ageing , vol.40 , pp. 702-705
    • Gariballa, S.1
  • 88
    • 41149163183 scopus 로고    scopus 로고
    • Parkinson's disease:clinical features and diagnosis
    • Jankovic J. Parkinson's disease:clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008;79:368-76.
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , pp. 368-376
    • Jankovic, J.1
  • 89
    • 2942525889 scopus 로고    scopus 로고
    • Bottiglieri T, Diaz-Arrastia R. Elevated plasma homocysteine level in patients with Parkinson disease:motor, affective, and cognitive associations
    • O'Suilleabhain PE, Sung V, Hernandez C, Lacritz L, Dewey RB, Jr., Bottiglieri T, Diaz-Arrastia R. Elevated plasma homocysteine level in patients with Parkinson disease:motor, affective, and cognitive associations. Arch Neurol. 2004;61:865-8.
    • (2004) Arch Neurol , vol.61 , pp. 865-868
    • O'Suilleabhain, P.E.1    Sung, V.2    Hernandez, C.3    Lacritz, L.4    Dewey Jr., R.B.5
  • 92
    • 34248381286 scopus 로고    scopus 로고
    • Nutritional therapies in Parkinson's disease
    • Evatt ML. Nutritional therapies in Parkinson's disease. Curr Treat Options Neurol. 2007;9:198-204.
    • (2007) Curr Treat Options Neurol , vol.9 , pp. 198-204
    • Evatt, M.L.1
  • 97
    • 77957848546 scopus 로고    scopus 로고
    • Normalization of hyperhomocysteinemia improves cognitive deficits and ameliorates brain amyloidosis of a transgenic mouse model of Alzheimer's disease
    • Zhuo JM, Pratico D. Normalization of hyperhomocysteinemia improves cognitive deficits and ameliorates brain amyloidosis of a transgenic mouse model of Alzheimer's disease. FASEB J. 2010;24:3895-902.
    • (2010) FASEB J , vol.24 , pp. 3895-3902
    • Zhuo, J.M.1    Pratico, D.2
  • 98
    • 79957547981 scopus 로고    scopus 로고
    • A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people
    • Kwok T, Lee J, Law C, Pan P, Yung C, Choi K, Lam L. A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people. Clin Nutr. 2011;30:297-302.
    • (2011) Clin Nutr , vol.30 , pp. 297-302
    • Kwok, T.1    Lee, J.2    Law, C.3    Pan, P.4    Yung, C.5    Choi, K.6    Lam, L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.