메뉴 건너뛰기




Volumn 36, Issue 1, 2010, Pages 19-24

Homocysteine metabolism and its relation to health and disease

Author keywords

Folate; Homocysteine; Hyperhomocysteinemia; Methyl group metabolism

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PLACEBO; PYRIDOXINE; S ADENOSYLMETHIONINE; VITAMIN B GROUP;

EID: 77951121781     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.71     Document Type: Review
Times cited : (93)

References (75)
  • 1
    • 77951120061 scopus 로고    scopus 로고
    • Hepatic sulfur amino acid metabolism
    • Masella, R. and Mazza, G., eds. Wiley, Hoboken, New Jersey
    • Schalinske, K. L. (2009) Hepatic sulfur amino acid metabolism. In Glutathione and Sulfur Amino Acids in Human Health and Disease (Masella, R. and Mazza, G., eds.). pp. 73-90, Wiley, Hoboken, New Jersey.
    • (2009) Glutathione and Sulfur Amino Acids in Human Health and Disease , pp. 73-90
    • Schalinske, K.L.1
  • 2
    • 0015501428 scopus 로고
    • Competing methyltransferase systems
    • Kerr, S. J. (1972) Competing methyltransferase systems. J. Biol. Chem. 247, 4248-4252.
    • (1972) J. Biol. Chem. , vol.247 , pp. 4248-4252
    • Kerr, S.J.1
  • 3
    • 0004200052 scopus 로고
    • S-adenosylamino acids thirty years later: 1951-1981
    • Usdin, E., Borchardt, R. T., and Creveling, C. R., eds.. MacMillan Press, London
    • Cantoni, G. L. (1982) S-adenosylamino acids thirty years later: 1951-1981. In The Biochemistry of S-adenosylmethionine and Related Compounds (Usdin, E., Borchardt, R. T., and Creveling, C. R., eds.). pp. 3-10, MacMillan Press, London.
    • (1982) The Biochemistry of S-adenosylmethionine and Related Compounds , pp. 3-10
    • Cantoni, G.L.1
  • 4
    • 0002616156 scopus 로고
    • The role of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in the control of biological methylations
    • Cavallini, D., Gaull, G. E., and Zappia, V., eds.. Plenum Press, New York
    • Cantoni, G. L. and Chiang, P. K. (1980) The role of S- adenosylhomocysteine and S-adenosylhomocysteine hydrolase in the control of biological methylations. In Natural Sulfur Compounds (Cavallini, D., Gaull, G. E., and Zappia, V., eds.). pp. 67-80, Plenum Press, New York.
    • (1980) Natural Sulfur Compounds , pp. 67-80
    • Cantoni, G.L.1    Chiang, P.K.2
  • 5
    • 0026045338 scopus 로고
    • Betainehomocysteine methyltransferase: Organ distribution in man, pig and rat and subcellular distribution in the rat
    • McKeever, M. P., Weir, D. G., Molloy, A., and Scott, J. M. (1991) Betainehomocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat. Clin. Sci. 81, 551-556.
    • (1991) Clin. Sci. , vol.81 , pp. 551-556
    • McKeever, M.P.1    Weir, D.G.2    Molloy, A.3    Scott, J.M.4
  • 6
    • 0016722112 scopus 로고
    • Labile methyl balances for normal humans on various dietary regimens
    • Mudd, S. H. and Poole J. R. (1975) Labile methyl balances for normal humans on various dietary regimens. Metabolism 24, 721-735.
    • (1975) Metabolism , vol.24 , pp. 721-735
    • Mudd, S.H.1    Poole, J.R.2
  • 7
    • 0018934312 scopus 로고
    • Labile methyl group balances in the human: The role of sarcosine
    • Mudd, S. H., Ebert, M. H., and Scriver C. R. (1980) Labile methyl group balances in the human: the role of sarcosine. Metabolism 29, 707-720.
    • (1980) Metabolism , vol.29 , pp. 707-720
    • Mudd, S.H.1    Ebert, M.H.2    Scriver, C.R.3
  • 10
    • 0035195248 scopus 로고    scopus 로고
    • Methylation demand and homocysteine metabolism: Effects of dietary provision of creatine and guanidinoacetate
    • Stead, L. M., Au, K. P., Jacobs, R. L., Brosnan, M. E., and Brosnan, J. T. (2001) Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Am. J. Physiol. Endocrinol. Metab. 281, E1095-E1100.
    • (2001) Am. J. Physiol. Endocrinol. Metab. , vol.281
    • Stead, L.M.1    Au, K.P.2    Jacobs, R.L.3    Brosnan, M.E.4    Brosnan, J.T.5
  • 11
    • 0023833533 scopus 로고
    • The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes
    • Yao, Z. M. and Vance, D. E. (1988) The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J. Biol. Chem. 263, 2998-3004.
    • (1988) J. Biol. Chem. , vol.263 , pp. 2998-3004
    • Yao, Z.M.1    Vance, D.E.2
  • 12
    • 23344449775 scopus 로고    scopus 로고
    • Physiological regulation of phospholipid methylation alters plasma homocysteine in mice
    • Jacobs, R. L., Stead, L. M., Devlin, C., Tabas, I., Brosnan, M. E., Brosnan, J. T., and Vance, D. E. (2005) Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. J. Biol. Chem. 280, 28299-28305.
    • (2005) J. Biol. Chem. , vol.280 , pp. 28299-28305
    • Jacobs, R.L.1    Stead, L.M.2    Devlin, C.3    Tabas, I.4    Brosnan, M.E.5    Brosnan, J.T.6    Vance, D.E.7
  • 13
    • 0036829872 scopus 로고    scopus 로고
    • An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins
    • Noga, A. A., Zhao, Y., and Vance, D. E. (2002) An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins. J. Biol. Chem. 277, 42358-42365.
    • (2002) J. Biol. Chem. , vol.277 , pp. 42358-42365
    • Noga, A.A.1    Zhao, Y.2    Vance, D.E.3
  • 14
    • 0002942853 scopus 로고
    • Biochemical role of folate in cellular metabolism
    • Bailey, L. B., ed.. Marcel Dekker, Inc., New York
    • Wagner, C. (1995) Biochemical role of folate in cellular metabolism. In Folate in Health and Disease (Bailey, L. B., ed.). pp. 23-42, Marcel Dekker, Inc., New York.
    • (1995) Folate in Health and Disease , pp. 23-42
    • Wagner, C.1
  • 15
    • 33745176624 scopus 로고    scopus 로고
    • A Glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme
    • DOI 10.1007/s11248-006-0008-1
    • Luka, Z., Capdevila, A., Mato, J. M., and Wagner, C. A. (2006) Glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme. Transgenic Res. 15, 393-397. (Pubitemid 43901497)
    • (2006) Transgenic Research , vol.15 , Issue.3 , pp. 393-397
    • Luka, Z.1    Capdevila, A.2    Mato, J.M.3    Wagner, C.4
  • 17
    • 8544257376 scopus 로고    scopus 로고
    • Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid
    • Nieman, K. M., Rowling, M. J., Garrow, T. A., and Schalinske, K. L. (2004) Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. J. Biol. Chem. 279, 45708-45712.
    • (2004) J. Biol. Chem. , vol.279 , pp. 45708-45712
    • Nieman, K.M.1    Rowling, M.J.2    Garrow, T.A.3    Schalinske, K.L.4
  • 18
    • 0344738802 scopus 로고    scopus 로고
    • All-trans-retinoic acid rapidly induces glycine N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats
    • Ozias, M. K. and Schalinske, K. L. (2003) All-trans-retinoic acid rapidly induces glycine N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats. J. Nutr. 133, 4090-4094.
    • (2003) J. Nutr. , vol.133 , pp. 4090-4094
    • Ozias, M.K.1    Schalinske, K.L.2
  • 19
    • 0036194094 scopus 로고    scopus 로고
    • Vitamin A and its derivatives induce hepatic glycine N-methyltransferase and hypomethylation of DNA in rats
    • Rowling, M. J., McMullen, M. H., and Schalinske, K. L. (2002) Vitamin A and its derivatives induce hepatic glycine N-methyltransferase and hypomethylation of DNA in rats. J. Nutr. 132, 365-369.
    • (2002) J. Nutr. , vol.132 , pp. 365-369
    • Rowling, M.J.1    McMullen, M.H.2    Schalinske, K.L.3
  • 21
    • 0030027668 scopus 로고    scopus 로고
    • Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
    • Jacques, P. F., Bostom, A. G., Williams, R. R., Ellison, R. C., Eckfeldt, J. H., Rosenberg, I. H., Selhub, J., and Rozen, R. (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93, 7-9. (Pubitemid 26006560)
    • (1996) Circulation , vol.93 , Issue.1 , pp. 7-9
    • Jacques, P.F.1    Bostom, A.G.2    Williams, R.R.3    Ellison, R.C.4    Eckfeldt, J.H.5    Rosenberg, I.H.6    Selhub, J.7    Rozen, R.8
  • 22
    • 0031828880 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages
    • Nelen, W. L. D. M., Blom, H. J., Thomas, C. M. G., Steegers, E. A. P., Boers, G. H. J., and Eskes, T. K. A. B. (1998) Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages. J. Nutr. 128, 1336-1341.
    • (1998) J. Nutr. , vol.128 , pp. 1336-1341
    • Nelen, W.L.D.M.1    Blom, H.J.2    Thomas, C.M.G.3    Steegers, E.A.P.4    Boers, G.H.J.5    Eskes, T.K.A.B.6
  • 24
    • 31544434231 scopus 로고    scopus 로고
    • The glycine N-methyltransferase (GNMT) 1289 C>T variant influences plasma total homocysteine concentrations in young women after restricting folate intake
    • Beagle, B., Yang, T. L., Hung, J., Cogger, E. A., Moriarty, D. J., and Caudill, M. A. (2005) The glycine N-methyltransferase (GNMT) 1289 C->T variant influences plasma total homocysteine concentrations in young women after restricting folate intake. J. Nutr. 135, 2780-2785. (Pubitemid 43156541)
    • (2005) Journal of Nutrition , vol.135 , Issue.12 , pp. 2780-2785
    • Beagle, B.1    Yang, T.L.2    Hung, J.3    Cogger, E.A.4    Moriarty, D.J.5    Caudill, M.A.6
  • 25
    • 64049097931 scopus 로고    scopus 로고
    • Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methyltenetetrahydrofolate reductase 677TT genotype
    • Caudill, M. A., Dellschaft, N., Solis, C., Hinkis, S., Ivanov, A. A., Mash-Barboza, S., Randall, K. E., Jackson, B., Solomita, G. N., and Vermeylen, F. (2009) Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methyltenetetrahydrofolate reductase 677TT genotype. J. Nutr. 139, 727-733.
    • (2009) J. Nutr. , vol.139 , pp. 727-733
    • Caudill, M.A.1    Dellschaft, N.2    Solis, C.3    Hinkis, S.4    Ivanov, A.A.5    Mash-Barboza, S.6    Randall, K.E.7    Jackson, B.8    Solomita, G.N.9    Vermeylen, F.10
  • 26
    • 7944239638 scopus 로고    scopus 로고
    • Methionine synthase reductase 66A->G polymorphism is associated with increased plasma homocysteine concentration when combined with the homozygous methylenetetrahydrofoalte reducgtase 677C->T variant
    • Vaughn, J. D., Bailey, L. B., Shelnutt, K. P., Dunwoody, K. M., Maneval, D. R., Davis, S. R., Quinlivan, E. P., Gregory, J. F. III, Theriaque, D. W., and Kauwell, G. P. (2004) Methionine synthase reductase 66A->G polymorphism is associated with increased plasma homocysteine concentration when combined with the homozygous methylenetetrahydrofoalte reducgtase 677C->T variant. J. Nutr. 134, 2985-2990.
    • (2004) J. Nutr. , vol.134 , pp. 2985-2990
    • Vaughn, J.D.1    Bailey, L.B.2    Shelnutt, K.P.3    Dunwoody, K.M.4    Maneval, D.R.5    Davis, S.R.6    Quinlivan, E.P.7    Gregory III, J.F.8    Theriaque, D.W.9    Kauwell, G.P.10
  • 28
    • 66849118826 scopus 로고    scopus 로고
    • High casein diet decreases plasma homocysteine concentration in rats
    • Ohuchi, S., Matsumoto, Y., Morita, T., and Sugiyama, K. (2009) High casein diet decreases plasma homocysteine concentration in rats. J. Nutr. Sci. Vitaminol. 55, 22-30.
    • (2009) J. Nutr. Sci. Vitaminol. , vol.55 , pp. 22-30
    • Ohuchi, S.1    Matsumoto, Y.2    Morita, T.3    Sugiyama, K.4
  • 29
    • 67650727123 scopus 로고    scopus 로고
    • Hepatic cysthathionine b-synthase activity does not increase in response to methionine supplementation in rats fed a low casein diet: Association with plasma homocysteine concentrations
    • Ohuchi, S., Morita, T., Mori, M., and Sugiyama, K. (2009) Hepatic cysthathionine b-synthase activity does not increase in response to methionine supplementation in rats fed a low casein diet: association with plasma homocysteine concentrations. J. Nutr. Sci. Vitaminol. 55, 178-185.
    • (2009) J. Nutr. Sci. Vitaminol. , vol.55 , pp. 178-185
    • Ohuchi, S.1    Morita, T.2    Mori, M.3    Sugiyama, K.4
  • 30
    • 33646809032 scopus 로고    scopus 로고
    • Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice
    • Collinsova, M., Strakova, J., Jiracek, J., and Garrow, T. A. (2006) Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. J. Nutr. 136, 1493-1497. (Pubitemid 43765351)
    • (2006) Journal of Nutrition , vol.136 , Issue.6 , pp. 1493-1497
    • Collinsova, M.1    Strakova, J.2    Jiracek, J.3    Garrow, T.A.4
  • 31
    • 0000167774 scopus 로고
    • Disorders of transsulfuration
    • Scriver, C. R., Beaudt, W. S., Sly, D., and Valle, D., eds.. McGraw-Hill, New York
    • Mudd, S. H., Levy, H. L., and Skovby, F. (1995) Disorders of transsulfuration. In The Metabolic and Molecular Basis of Inherited Disease (Scriver, C. R., Beaudt, W. S., Sly, D., and Valle, D., eds.). pp. 1279- 1327. McGraw-Hill, New York.
    • (1995) The Metabolic and Molecular Basis of Inherited Disease , pp. 1279-1327
    • Mudd, S.H.1    Levy, H.L.2    Skovby, F.3
  • 32
    • 2642513835 scopus 로고    scopus 로고
    • Modulation of cystathionine β-synthase level regulates total serum homocysteine in mice
    • Wang, L., Jhee, K.-H., Hua, X., DiBello, P. M., Jacobsen, D. W., and Kruger, W. D. (2004) Modulation of cystathionine β-synthase level regulates total serum homocysteine in mice. Circ. Res. 94, 1318-1324.
    • (2004) Circ. Res. , vol.94 , pp. 1318-1324
    • Wang, L.1    Jhee, K.-H.2    Hua, X.3    DiBello, P.M.4    Jacobsen, D.W.5    Kruger, W.D.6
  • 33
    • 30744462183 scopus 로고    scopus 로고
    • Homocysteine metabolism in ZDF (Type 2) diabetic rats
    • DOI 10.2337/diabetes.54.11.3245
    • Wijekoon, E. P., Hall, B., Ratnam, S., Brosnan, M. E., Zeisel, S. H., and Brosnan, J. T. (2005) Homocysteine metabolism in ZDF (type 2) diabetic rats. Diabetes 54, 3245-3251. (Pubitemid 43334381)
    • (2005) Diabetes , vol.54 , Issue.11 , pp. 3245-3251
    • Wijekoon, E.P.1    Hall, B.2    Ratnam, S.3    Brosnan, M.E.4    Zeisel, S.H.5    Brosnan, J.T.6
  • 35
    • 0026633925 scopus 로고
    • Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease
    • Kang, S.-S., Wong, P. W., and Malinow, M. R. (1992) Hyperhomocyst(e) inemia as a risk factor for occlusive vascular disease. Annu. Rev. Nutr. 12, 279-298.
    • (1992) Annu. Rev. Nutr. , vol.12 , pp. 279-298
    • Kang, S.-S.1    Wong, P.W.2    Malinow, M.R.3
  • 37
    • 0032704132 scopus 로고    scopus 로고
    • Folate and cancer prevention: A new medical application of folate beyond hyperhomocysteinemia and neural tube defects
    • Kim, Y.-I. (1999) Folate and cancer prevention: a new medical application of folate beyond hyperhomocysteinemia and neural tube defects. Nutr. Rev. 57, 314-321.
    • (1999) Nutr. Rev. , vol.57 , pp. 314-321
    • Kim, Y.-I.1
  • 38
    • 0037364417 scopus 로고    scopus 로고
    • Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders
    • DOI 10.1016/S0166-2236(03)00032-8
    • Mattson, M. P. and Shea, T. B. (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci. 26, 137-146. (Pubitemid 36183675)
    • (2003) Trends in Neurosciences , vol.26 , Issue.3 , pp. 137-146
    • Mattson, M.P.1    Shea, T.B.2
  • 40
    • 25844468337 scopus 로고    scopus 로고
    • Effects of insulin on methionine and homocysteine kinetics in type 2 diabetes with nephropathy
    • DOI 10.2337/diabetes.54.10.2968
    • Tessari, P., Coracina, A., Kiwanuka, E., Vedovato, M., Vettore, M., Valerio, A., Zaramella, M., and Garibotto, G. (2005) Effects of insulin on methionine and homocysteine kinetics in type 2 diabetes with nephropathy. Diabetes 54, 2968-2976. (Pubitemid 41401094)
    • (2005) Diabetes , vol.54 , Issue.10 , pp. 2968-2976
    • Tessari, P.1    Coracina, A.2    Kiwanuka, E.3    Vedovato, M.4    Vettore, M.5    Valerio, A.6    Zaramella, M.7    Garibotto, G.8
  • 41
    • 36248955119 scopus 로고    scopus 로고
    • Homocysteine, vitamins, and vascular disease prevention
    • McCully, K. S. (2007) Homocysteine, vitamins, and vascular disease prevention. Am. J. Clin. Nutr. 86, 1563S-1568S.
    • (2007) Am. J. Clin. Nutr. , vol.86
    • McCully, K.S.1
  • 43
    • 0034649324 scopus 로고    scopus 로고
    • Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine
    • Chambers, J. C., Ueland, P. M., Obeid, O. A., Wrigley, J., Refsum, H., and Kooner, J. S. (2000) Improved vascular endothelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine. Circulation 102, 2479-4783.
    • (2000) Circulation , vol.102 , pp. 2479-4783
    • Chambers, J.C.1    Ueland, P.M.2    Obeid, O.A.3    Wrigley, J.4    Refsum, H.5    Kooner, J.S.6
  • 44
    • 0037190083 scopus 로고    scopus 로고
    • 6 on clinical outcome after percutaneous coronary intervention: The Swiss heart study: A randomized controlled trial
    • Schnyder, G., Roffi, M., Flammer, Y., Pin, R., and Hess, O. M. (2002) Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial. JAMA 288, 973-979. (Pubitemid 34920462)
    • (2002) Journal of the American Medical Association , vol.288 , Issue.8 , pp. 973-979
    • Schnyder, G.1    Roffi, M.2    Flammer, Y.3    Pin, R.4    Hess, O.M.5
  • 46
    • 0033852888 scopus 로고    scopus 로고
    • Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease
    • Title, L. M., Cummings, P. M., Giddens, K., Genest, J. J. Jr., and Nassar, B. A. (2000) Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease. J. Am. Coll. Cardiol. 26, 758-765.
    • (2000) J. Am. Coll. Cardiol. , vol.26 , pp. 758-765
    • Title, L.M.1    Cummings, P.M.2    Giddens, K.3    Genest Jr., J.J.4    Nassar, B.A.5
  • 50
    • 49949101867 scopus 로고    scopus 로고
    • Mortality and cardiovascular events in patients treated with homocysteinelowering B vitamins after coronary angiography: A randomized controlled trial
    • Ebbing, M., Bleie, Ø., Ueland, P. M., Nordrehaug, J. E., Nilsen, D. W., Vollset, S. E., Refsum, H., Pedersen, E. K., and Nygård, O. (2008) Mortality and cardiovascular events in patients treated with homocysteinelowering B vitamins after coronary angiography: a randomized controlled trial. JAMA 300, 795-804.
    • (2008) JAMA , vol.300 , pp. 795-804
    • Ebbing, M.1    Bleie, Ø.2    Ueland, P.M.3    Nordrehaug, J.E.4    Nilsen, D.W.5    Vollset, S.E.6    Refsum, H.7    Pedersen, E.K.8    Nygård, O.9
  • 52
    • 53549135776 scopus 로고    scopus 로고
    • The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: A randomized controlled trial and meta-analysis
    • Potter, K., Hankey, G. J., Green, D. J., Eikelboom, J., Jamrozik, K., and Arnolda, L. F. (2008) The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis. BMC Cardiovasc. Disord. 8, 24.
    • (2008) BMC Cardiovasc. Disord. , vol.8 , pp. 24
    • Potter, K.1    Hankey, G.J.2    Green, D.J.3    Eikelboom, J.4    Jamrozik, K.5    Arnolda, L.F.6
  • 53
    • 34250658841 scopus 로고    scopus 로고
    • Homocysteine-lowering therapy and risk for venous thromboembolism: A randomized trial
    • Heart Outcomes Prevention Evaluation 2 (HOPE-2) Investigators
    • Ray, J. G., Kearon, C., Yi, Q., Sheridan, P., and Lonn, E.; Heart Outcomes Prevention Evaluation 2 (HOPE-2) Investigators. (2007) Homocysteine-lowering therapy and risk for venous thromboembolism: a randomized trial. Ann. Intern. Med. 146, 761-767.
    • (2007) Ann. Intern. Med. , vol.146 , pp. 761-767
    • Ray, J.G.1    Kearon, C.2    Yi, Q.3    Sheridan, P.4    Lonn, E.5
  • 54
    • 43049176549 scopus 로고    scopus 로고
    • Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: A randomized trial
    • DOI 10.1001/jama.299.17.2027
    • Albert, C. M., Cook, N. R., Gaziano, J. M., Zaharris, E., MacFadyen, J., Danielson, E., Buring, J. E., and Manson, J. E. (2008) Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA 299, 2027-2036. (Pubitemid 351656584)
    • (2008) JAMA - Journal of the American Medical Association , vol.299 , Issue.17 , pp. 2027-2036
    • Albert, C.M.1    Cook, N.R.2    Gaziano, J.M.3    Zaharris, E.4    MacFadyen, J.5    Danielson, E.6    Buring, J.E.7    Manson, J.E.8
  • 55
    • 33845964945 scopus 로고    scopus 로고
    • Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial
    • DOI 10.1182/blood-2006-04-014654
    • den Heijer, M., Willems, H. P., Blom, H. J., Gerrits, W. B., Cattaneo, M., Eichinger, S., Rosendaal, F. R., and Bos, G. M. (2007) Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial. Blood 109, 139-144. (Pubitemid 46053054)
    • (2007) Blood , vol.109 , Issue.1 , pp. 139-144
    • Den Heijer, M.1    Willems, H.P.J.2    Blom, H.J.3    Gerrits, W.B.J.4    Cattaneo, M.5    Eichinger, S.6    Rosendaal, F.R.7    Bos, G.M.J.8
  • 56
    • 34548566329 scopus 로고    scopus 로고
    • Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: A randomized controlled trial
    • Veterans affairs site investigators
    • Jamison, R. L., Hartigan, P., Kaufman, J. S., Goldfarb, D. S., Warren, S. R., Guarino, P. D., and Gaziano, J. M. (2007) Veterans affairs site investigators. Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial. JAMA 298, 1163-1170.
    • (2007) JAMA , vol.298 , pp. 1163-1170
    • Jamison, R.L.1    Hartigan, P.2    Kaufman, J.S.3    Goldfarb, D.S.4    Warren, S.R.5    Guarino, P.D.6    Gaziano, J.M.7
  • 57
    • 1342309318 scopus 로고    scopus 로고
    • Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: The vitamin intervention for stroke prevention (VISP) randomized controlled trial
    • Toole, J. F., Malinow, M. R., Chambless, L. E., Spence, J. D., Pettigrew, L. C., Howard, V. J., Sides, E. G., Wang, C. H., and Stampfer, M. (2004) Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the vitamin intervention for stroke prevention (VISP) randomized controlled trial. JAMA 291, 565-575.
    • (2004) JAMA , vol.291 , pp. 565-575
    • Toole, J.F.1    Malinow, M.R.2    Chambless, L.E.3    Spence, J.D.4    Pettigrew, L.C.5    Howard, V.J.6    Sides, E.G.7    Wang, C.H.8    Stampfer, M.9
  • 58
    • 59449107315 scopus 로고    scopus 로고
    • Effect of long-term homocysteine reduction with B vitamins on arterial wall inflammation assessed by fluorodeoxyglucose positron emission tomography: A randomised double-blind, placebo-controlled trial
    • Potter, K., Lenzo, N., Eikelboom, J. W., Arnolda, L. F., Beer, C., and Hankey, G. J. (2009) Effect of long-term homocysteine reduction with B vitamins on arterial wall inflammation assessed by fluorodeoxyglucose positron emission tomography: a randomised double-blind, placebo-controlled trial. Cerebrovasc. Dis. 27, 259-265.
    • (2009) Cerebrovasc. Dis. , vol.27 , pp. 259-265
    • Potter, K.1    Lenzo, N.2    Eikelboom, J.W.3    Arnolda, L.F.4    Beer, C.5    Hankey, G.J.6
  • 59
    • 40849110313 scopus 로고    scopus 로고
    • Homocysteine lowering with folic acid and B vitamins in people with chronic kidney disease - Results of the renal Hope-2 study
    • HOPE-2 Investigators
    • Mann, J. F., Sheridan, P., McQueen, M. J., Held, C., Arnold, J. M. O., Fodor, G., Yusuf, S., and Lonn, E. M.; HOPE-2 Investigators. (2008) Homocysteine lowering with folic acid and B vitamins in people with chronic kidney disease - results of the renal Hope-2 study. Nephrol. Dial. Transplant. 23, 645-653.
    • (2008) Nephrol. Dial. Transplant. , vol.23 , pp. 645-653
    • Mann, J.F.1    Sheridan, P.2    McQueen, M.J.3    Held, C.4    Arnold, J.M.O.5    Fodor, G.6    Yusuf, S.7    Lonn, E.M.8
  • 60
    • 19944429119 scopus 로고    scopus 로고
    • Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: A randomized substudy of the VITATOPS trial
    • DOI 10.1161/01.STR.0000150494.91762.70
    • Dusitanond, P., Eikelboom, J. W., Hankey, G. J., Thom, J., Gilmore, G., Loh, K., Yi, Q., Klijn, C. J., Langton, P., van Bockxmeer, F. M., Baker, R., and Jamrozik, K. (2005) Homocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: a randomized substudy of the VITATOPS trial. Stroke 36, 144-146. (Pubitemid 40054191)
    • (2005) Stroke , vol.36 , Issue.1 , pp. 144-146
    • Dusitanond, P.1    Eikelboom, J.W.2    Hankey, G.J.3    Thom, J.4    Gilmore, G.5    Loh, K.6    Yi, Q.7    Klijn, C.J.M.8    Langton, P.9    Van Bockxmeer, F.M.10    Baker, R.11    Jamrozik, K.12
  • 63
    • 33746401500 scopus 로고    scopus 로고
    • Folic acid improves endothelial dysfunction in type 2 diabetes - An effect independent of homocysteine-lowering
    • Title, L. M., Ur, E., Giddens, K., McQueen, M. J., and Nassar, B. A. (2006) Folic acid improves endothelial dysfunction in type 2 diabetes - an effect independent of homocysteine-lowering. Vasc. Med. 11, 101-109.
    • (2006) Vasc. Med. , vol.11 , pp. 101-109
    • Title, L.M.1    Ur, E.2    Giddens, K.3    McQueen, M.J.4    Nassar, B.A.5
  • 64
    • 58249093736 scopus 로고    scopus 로고
    • Correlations between plasma homocysteine and folate concentrations and carotid atherosclerosis in high-risk individuals: Baseline data from the homocysteine and atherosclerosis reduction trial (HART)
    • Held, C., Sumner, G., Sheridan, P., McQueen, M., Smith, S., Dagenais, G., Yusuf, S., and Lonn, E. (2008) Correlations between plasma homocysteine and folate concentrations and carotid atherosclerosis in high-risk individuals: baseline data from the homocysteine and atherosclerosis reduction trial (HART). Vasc. Med. 13, 245-253.
    • (2008) Vasc. Med. , vol.13 , pp. 245-253
    • Held, C.1    Sumner, G.2    Sheridan, P.3    McQueen, M.4    Smith, S.5    Dagenais, G.6    Yusuf, S.7    Lonn, E.8
  • 66
    • 57449117345 scopus 로고    scopus 로고
    • A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease
    • Kang, J. H., Cook, N., Manson, J., Buring, J. E., Albert, C. M., and Grodstein, F. (2008) A trial of B vitamins and cognitive function among women at high risk of cardiovascular disease. Am. J. Clin. Nutr. 88, 1602-1610.
    • (2008) Am. J. Clin. Nutr. , vol.88 , pp. 1602-1610
    • Kang, J.H.1    Cook, N.2    Manson, J.3    Buring, J.E.4    Albert, C.M.5    Grodstein, F.6
  • 68
    • 36249003381 scopus 로고    scopus 로고
    • Efficacy of multivitamin supplementation containing vitamins B6 and B12 and folic acid as adjunctive treatment with a cholinesterase inhibitor in Alzheimer's disease: A 26-week, randomized, double-blind, placebo-controlled study in Taiwanese patients
    • Sun, Y., Lu, C. J., Chien, K. L., Chen, S. T., and Chen, R. C. (2007) Efficacy of multivitamin supplementation containing vitamins B6 and B12 and folic acid as adjunctive treatment with a cholinesterase inhibitor in Alzheimer's disease: a 26-week, randomized, double-blind, placebo-controlled study in Taiwanese patients. Clin. Ther. 29, 2204-2214.
    • (2007) Clin. Ther. , vol.29 , pp. 2204-2214
    • Sun, Y.1    Lu, C.J.2    Chien, K.L.3    Chen, S.T.4    Chen, R.C.5
  • 69
    • 68049137604 scopus 로고    scopus 로고
    • Effect of homocysteine-lowering treatment with folic acid and B vitamins on risk of type 2 diabetes mellitus in women: A randomized controlled trial
    • Song, Y., Cook, N. R., Albert, C. M., Van Denburgh, M., and Manson, J. E. (2009) Effect of homocysteine-lowering treatment with folic acid and B vitamins on risk of type 2 diabetes mellitus in women: a randomized controlled trial. Diabetes 58, 1921-1928.
    • (2009) Diabetes , vol.58 , pp. 1921-1928
    • Song, Y.1    Cook, N.R.2    Albert, C.M.3    Van Denburgh, M.4    Manson, J.E.5
  • 70
    • 36849023126 scopus 로고    scopus 로고
    • The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: A 1-year double blind placebo controlled trial
    • Herrmann, M., Umanskaya, N., Traber, L., Schmidt-Gayk, H., Menke, W., Lanzer, G., Lenhart, M., Peter Schmidt, J., and Herrmann, W. (2007) The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial. Clin. Chem. Lab. Med. 45, 1785-1792.
    • (2007) Clin. Chem. Lab. Med. , vol.45 , pp. 1785-1792
    • Herrmann, M.1    Umanskaya, N.2    Traber, L.3    Schmidt-Gayk, H.4    Menke, W.5    Lanzer, G.6    Lenhart, M.7    Peter Schmidt, J.8    Herrmann, W.9
  • 71
    • 33645555911 scopus 로고    scopus 로고
    • Folate supplementation does not affect biochemical markers of bone turnover
    • Herrmann, M., Stanger, O., Paulweber, B., Hufnagl, C., and Herrmann, W. (2006) Folate supplementation does not affect biochemical markers of bone turnover. Clin. Lab. 52, 131-136.
    • (2006) Clin. Lab. , vol.52 , pp. 131-136
    • Herrmann, M.1    Stanger, O.2    Paulweber, B.3    Hufnagl, C.4    Herrmann, W.5
  • 72
    • 14144253560 scopus 로고    scopus 로고
    • Effect of folate and mecobalamin on hip fractures in patients with stroke: A randomized controlled trial
    • DOI 10.1001/jama.293.9.1082
    • Sato, Y., Honda, Y., Iwamoto, J., Kanoko, T., and Satoh, K. (2005) Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial. JAMA 293, 1082-1088. (Pubitemid 40300282)
    • (2005) Journal of the American Medical Association , vol.293 , Issue.9 , pp. 1082-1088
    • Sato, Y.1    Honda, Y.2    Iwamoto, J.3    Kanoko, T.4    Satoh, K.5
  • 73
    • 61549126593 scopus 로고    scopus 로고
    • Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: The women's antioxidant and folic acid cardiovascular study
    • Christen, W. G., Glynn, R. J., Chew, E. Y., Albert, C. M., and Manson, J. E. (2009) Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the women's antioxidant and folic acid cardiovascular study. Arch. Intern. Med. 169, 335-341.
    • (2009) Arch. Intern. Med. , vol.169 , pp. 335-341
    • Christen, W.G.1    Glynn, R.J.2    Chew, E.Y.3    Albert, C.M.4    Manson, J.E.5
  • 74
    • 65249094749 scopus 로고    scopus 로고
    • Homocysteine-lowering therapy and stroke risk, severity, and disability: Additional findings from the HOPE 2 trial
    • Heart Outcomes Prevention Evaluation 2 Investigators
    • Saposnik, G., Ray, J. G., Sheridan, P., McQueen, M., and Lonn, E.; Heart Outcomes Prevention Evaluation 2 Investigators. (2009) Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial. Stroke 40, 1365-1372.
    • (2009) Stroke , vol.40 , pp. 1365-1372
    • Saposnik, G.1    Ray, J.G.2    Sheridan, P.3    McQueen, M.4    Lonn, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.