Meta-analysis: Hyperhomocysteinaemia in inflammatory bowel diseases

Alimentary Pharmacology and Therapeutics

Volumn 34, Issue 10, 2011, Pages 1173-1184

  Oussalah, A ^a,b   Gueant J L ^a,b   Peyrin Biroulet, L ^b  

^a INSERM   (France)

^b UNIVERSITY HOSPITAL OF NANCY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

AMINO ACID BLOOD LEVEL; ARTICLE; CROHN DISEASE; DISEASE ASSOCIATION; DNA POLYMORPHISM; ENTERITIS; FOLIC ACID BLOOD LEVEL; GENE; GENOTYPE; HUMAN; HYPERHOMOCYSTEINEMIA; MTHFR GENE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SYSTEMATIC REVIEW; THROMBOSIS; ULCERATIVE COLITIS;

CASE-CONTROL STUDIES; FOLIC ACID; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; INFLAMMATORY BOWEL DISEASES; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); ODDS RATIO; POLYMORPHISM, GENETIC; RISK FACTORS; THROMBOEMBOLISM;

EID: 80055017405     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2011.04864.x     Document Type: Article

References (65)

1. Selhub J,. Homocysteine metabolism. Annu Rev Nutr 1999; 19: 217-46. (Pubitemid 29380603)
2. Refsum H, Ueland PM, Nygard O, Vollset SE,. Homocysteine and cardiovascular disease. Annu Rev Med 1998; 49: 31-62. (Pubitemid 28197439)
3. Van den Veyver IB,. Genetic effects of methylation diets. Annu Rev Nutr 2002; 22: 255-82.
4. Ray JG,. Meta-analysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease. Arch Intern Med 1998; 158: 2101-6. (Pubitemid 28482092)
5. Peyrin-Biroulet L, Rodriguez-Gueant RM, Chamaillard M, et al. Vascular and cellular stress in inflammatory bowel disease: revisiting the role of homocysteine. Am J Gastroenterol 2007; 102: 1108-15. (Pubitemid 46698241)
6. Lambert D, Benhayoun S, Adjalla C, et al. Crohn's disease and vitamin B12 metabolism. Dig Dis Sci 1996; 41: 1417-22. (Pubitemid 26245923)
7. Gueant JL, Gueant-Rodriguez RM, Anello G, et al. Genetic determinants of folate and vitamin B12 metabolism: a common pathway in neural tube defect and Down syndrome? Clin Chem Lab Med 2003; 41: 1473-7. (Pubitemid 37493563)
8. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-3.
9. Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996; 93: 7-9. (Pubitemid 26006560)
10. Zintzaras E,. Genetic variants of homocysteine/folate metabolism pathway and risk of inflammatory bowel disease: a synopsis and meta-analysis of genetic association studies. Biomarkers 2010; 15: 69-79.
11. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000; 283: 2008-12. (Pubitemid 30214957)
12. Mantel N, Haenszel W,. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22: 719-48.
13. DerSimonian R, Laird N,. Meta-analysis in clinical trials. Control Clin Trials 1986; 7: 177-88. (Pubitemid 17189972)
14. Higgins JP, Thompson SG, Deeks JJ, Altman DG,. Measuring inconsistency in meta-analyses. BMJ 2003; 327: 557-60. (Pubitemid 37088507)
15. Egger M, Davey Smith G, Schneider M, Minder C,. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629-34. (Pubitemid 27387172)
16. Rosenthal R,. Meta-Analytic Procedures for Social Research. Beverly Hills: Sage Publications, 1984.
17. Cattaneo M, Vecchi M, Zighetti ML, et al. High prevalence of hyperchomocysteinemia in patients with inflammatory bowel disease: a pathogenic link with thromboembolic complications? Thromb Haemost 1998; 80: 542-5. (Pubitemid 28479334)
18. Mahmud N, Molloy A, McPartlin J, et al. Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications. Gut 1999; 45: 389-94. (Pubitemid 29400715)
19. Chowers Y, Sela BA, Holland R, Fidder H, Simoni FB, Bar-Meir S,. Increased levels of homocysteine in patients with Crohn's disease are related to folate levels. Am J Gastroenterol 2000; 95: 3498-502.
20. Koutroubakis IE, Dilaveraki E, Vlachonikolis IG, et al. Hyperhomocysteinemia in Greek patients with inflammatory bowel disease. Dig Dis Sci 2000; 45: 2347-51. (Pubitemid 32198631)
21. Oldenburg B, Fijnheer R, van der Griend R, van Berge-Henegouwen GP, Koningsberger JC,. Homocysteine in inflammatory bowel disease: a risk factor for thromboembolic complications? Am J Gastroenterol 2000; 95: 2825-30.
22. Maire F, Beaugerie L, Cohen M, et al. Factors associated with hyperhomocysteinemia in Crohn's disease. Gastroenterol Clin Biol 2001; 25: 745-8. (Pubitemid 32995312)
23. Papa A, De Stefano V, Danese S, et al. Hyperhomocysteinemia and prevalence of polymorphisms of homocysteine metabolism-related enzymes in patients with inflammatory bowel disease. Am J Gastroenterol 2001; 96: 2677-82.
24. Romagnuolo J, Fedorak RN, Dias VC, Bamforth F, Teltscher M,. Hyperhomocysteinemia and inflammatory bowel disease: prevalence and predictors in a cross-sectional study. Am J Gastroenterol 2001; 96: 2143-9. (Pubitemid 32660911)
25. Vasilopoulos S, Saiean K, Emmons J, et al. Terminal ileum resection is associated with higher plasma homocysteine levels in Crohn's disease. J Clin Gastroenterol 2001; 33: 132-6. (Pubitemid 32685923)
26. Bjerregaard LT, Nederby NJ, Fredholm L, Brandslund I, Munkholm P, Hey H,. Hyperhomocysteinaemia, coagulation pathway activation and thrombophilia in patients with inflammatory bowel disease. Scand J Gastroenterol 2002; 37: 62-7. (Pubitemid 34074735)
27. Nakano E, Taylor CJ, Chada L, McGaw J, Powers HJ,. Hyperhomocystinemia in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2003; 37: 586-90. (Pubitemid 39280867)
28. Danese S, Sgambato A, Papa A, et al. Homocysteine triggers mucosal microvascular activation in inflammatory bowel disease. Am J Gastroenterol 2005; 100: 886-95. (Pubitemid 40592384)
29. Fernandez-Miranda C, Martinez Prieto M, Casis Herce B, et al. Hyperhomocysteinemia and methylenetetrahydrofolate reductase 677C - >T and 1298A - >C mutations in patients with inflammatory bowel disease. Rev Esp Enferm Dig 2005; 97: 497-504. (Pubitemid 41474589)
30. Mahmood A, Needham J, Prosser J, et al. Prevalence of hyperhomocysteinaemia, activated protein C resistance and prothrombin gene mutation in inflammatory bowel disease. Eur J Gastroenterol Hepatol 2005; 17: 739-44. (Pubitemid 40896420)
31. Zezos P, Papaioannou G, Nikolaidis N, Vasiliadis T, Giouleme O, Evgenidis N,. Hyperhomocysteinemia in ulcerative colitis is related to folate levels. World J Gastroenterol 2005; 11: 6038-42. (Pubitemid 41749223)
32. Drzewoski J, Gasiorowska A, Malecka-Panas E, Bald E, Czupryniak L,. Plasma total homocysteine in the active stage of ulcerative colitis. J Gastroenterol Hepatol 2006; 21: 739-43.
33. Roblin X, Germain E, Phelip JM, et al. Factors associated with hyperhomocysteinemia in inflammatory bowel disease: prospective study in 81 patients. Rev Med Interne 2006; 27: 106-10. (Pubitemid 43188740)
34. Yilmaz S, Bayan K, Tuzun Y, Batun S, Altintas A,. A comprehensive analysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease: data from Turkey. J Thromb Thrombolysis 2006; 22: 205-12. (Pubitemid 44857782)
35. Banait VS, Sandeep MS, Shetty S, et al. Hypercoagulable state in idiopathic ulcerative colitis: role of hyperhomocysteinemia and hyperfibrinogenemia. Indian J Gastroenterol 2008; 27: 94-8.
36. Erzin Y, Uzun H, Celik AF, Aydin S, Dirican A, Uzunismail H,. Hyperhomocysteinemia in inflammatory bowel disease patients without past intestinal resections: correlations with cobalamin, pyridoxine, folate concentrations, acute phase reactants, disease activity, and prior thromboembolic complications. J Clin Gastroenterol 2008; 42: 481-6. (Pubitemid 351572253)
37. Peyrin-Biroulet L, Gueant-Rodriguez RM, Chen M, Bronowicki JP, Bigard MA, Gueant JL,. Association of MTRR 66A>G polymorphism with superoxide dismutase and disease activity in patients with Crohn's disease. Am J Gastroenterol 2008; 103: 399-406. (Pubitemid 351248710)
38. Wiese D, Lashner B, Seidner D,. Measurement of nutrition status in Crohn's disease patients receiving infliximab therapy. Nutr Clin Pract 2008; 23: 551-6.
39. Zepeda-Gomez S, Montano-Loza A, Zapata-Colindres JC, Vargas-Vorackova F, Majluf-Cruz A, Uscanga L,. Oral challenge with a methionine load in patients with inflammatory bowel disease: a better test to identify hyperhomocysteinemia. Inflamm Bowel Dis 2008; 14: 383-8. (Pubitemid 351441328)
40. Akbulut S, Altiparmak E, Topal F, Ozaslan E, Kucukazman M, Yonem O,. Increased levels of homocysteine in patients with ulcerative colitis. World J Gastroenterol 2010; 16: 2411-6.
41. Dagli N, Poyrazoglu OK, Dagli AF, et al. Is inflammatory bowel disease a risk factor for early atherosclerosis? Angiology 2010; 61: 198-204.
42. Jiang Y, Zhao J, Jiang T, et al. Genetic polymorphism of methylenetetrahydrofolate reductase G1793A, hyperhomocysteinemia, and folate deficiency correlate with ulcerative colitis in central China. J Gastroenterol Hepatol 2010; 25: 1157-61.
43. Kallel L, Feki M, Sekri W, et al. Prevalence and risk factors of hyperhomocysteinemia in Tunisian patients with Crohn's disease. J Crohn's Colitis 2011; 5: 110-4.
44. Oldenburg B, Van Tuyl BA, van der Griend R, Fijnheer R, van Berge Henegouwen GP,. Risk factors for thromboembolic complications in inflammatory bowel disease: the role of hyperhomocysteinaemia. Dig Dis Sci 2005; 50: 235-40. (Pubitemid 40311526)
45. Mansoor MA, Bergmark C, Svardal AM, Lonning PE, Ueland PM,. Redox status and protein binding of plasma homocysteine and other aminothiols in patients with early-onset peripheral vascular disease. Homocysteine and peripheral vascular disease. Arterioscler Thromb Vasc Biol 1995; 15: 232-40.
46. Koutroubakis IE, Malliaraki N, Dimoulios PD, Karmiris K, Castanas E, Kouroumalis EA,. Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease. Dig Dis Sci 2004; 49: 1433-7. (Pubitemid 39273618)
47. Poddar R, Sivasubramanian N, DiBello PM, Robinson K, Jacobsen DW,. Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease. Circulation 2001; 103: 2717-23. (Pubitemid 32538788)
48. Schroder M, Kaufman RJ,. The mammalian unfolded protein response. Annu Rev Biochem 2005; 74: 739-89. (Pubitemid 40995523)
49. Kim YI,. Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility. J Nutr 2005; 135: 2703-9.
50. Saibeni S, Cattaneo M, Vecchi M, et al. Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants. Am J Gastroenterol 2003; 98: 112-7. (Pubitemid 36135178)
51. Fernandez-Banares F, Abad-Lacruz A, Xiol X, et al. Vitamin status in patients with inflammatory bowel disease. Am J Gastroenterol 1989; 84: 744-8. (Pubitemid 19184375)
52. Rocha R, Santana GO, Almeida N, Lyra AC,. Analysis of fat and muscle mass in patients with inflammatory bowel disease during remission and active phase. Br J Nutr 2009; 101: 676-9.
53. Hartman C, Eliakim R, Shamir R,. Nutritional status and nutritional therapy in inflammatory bowel diseases. World J Gastroenterol 2009; 15: 2570-8.
54. Vagianos K, Bector S, McConnell J, Bernstein CN,. Nutrition assessment of patients with inflammatory bowel disease. JPEN J Parenter Enteral Nutr 2007; 31: 311-9. (Pubitemid 47025695)
55. Chen M, Peyrin-Biroulet L, George A, et al. Methyl deficient diet aggravates experimental colitis in rats. J Cell Mol Med 2010 [Epub ahead of print].
56. Morgenstern I, Raijmakers MT, Peters WH, Hoensch H, Kirch W,. Homocysteine, cysteine, and glutathione in human colonic mucosa: elevated levels of homocysteine in patients with inflammatory bowel disease. Dig Dis Sci 2003; 48: 2083-90. (Pubitemid 37410102)
57. Chiarello PG, Penaforte FR, Japur CC, Souza CD, Vannucchi H, Troncon LE,. Increased folate intake with no changes in serum homocysteine and decreased levels of C-reactive protein in patients with inflammatory bowel diseases. Dig Dis Sci 2009; 54: 627-33.
58. Zeisel SH, da Costa KA,. Choline: an essential nutrient for public health. Nutr Rev 2009; 67: 615-23.
59. den Heijer M, Rosendaal FR, Blom HJ, Gerrits WB, Bos GM,. Hyperhomocysteinemia and venous thrombosis: a meta-analysis. Thromb Haemost 1998; 80: 874-7. (Pubitemid 28556684)
60. Eichinger S, Stumpflen A, Hirschl M, et al. Hyperhomocysteinemia is a risk factor of recurrent venous thromboembolism. Thromb Haemost 1998; 80: 566-9. (Pubitemid 28479339)
61. Grainge MJ, West J, Card TR,. Venous thromboembolism during active disease and remission in inflammatory bowel disease: a cohort study. Lancet 2010; 375: 657-63.
62. Kappelman MD, Horvath-Puho E, Sandler RS, et al. Thromboembolic risk among Danish children and adults with inflammatory bowel diseases: a population-based nationwide study. Gut 2011; 60: 937-43.
63. Twig G, Zandman-Goddard G, Szyper-Kravitz M, Shoenfeld Y,. Systemic thromboembolism in inflammatory bowel disease: mechanisms and clinical applications. Ann N Y Acad Sci 2005; 1051: 166-73. (Pubitemid 41362744)
64. Murthy SK, Nguyen GC,. Venous thromboembolism in inflammatory bowel disease: an epidemiological review. Am J Gastroenterol 2011; 106: 713-8.
65. Gueant-Rodriguez RM, Gueant JL, Debard R, et al. Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations. Am J Clin Nutr 2006; 83: 701-7. (Pubitemid 44699219)