Hepatic phosphatidylethanolamine N-methyltransferase expression is increased in diabetic rats

Journal of Nutrition

Volumn 136, Issue 12, 2006, Pages 3005-3009

  Hartz, Cara S ^a   Nieman, Kristin M ^a   Jacobs, René L ^b,c   Vance, Dennis E ^b,d   Schalinske, Kevin L ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c CANADIAN INSTITUTES OF HEALTH RESEARCH   (Canada)

^d Alberta Heritage Foundation of Medical Research   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; PIG INSULIN; RETINOIC ACID; S ADENOSYLMETHIONINE; STREPTOZOCIN;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; LIPOGENESIS; MALE; NONHUMAN; PHOSPHOLIPID METHYLATION; PROTEIN EXPRESSION; RAT;

EID: 33845335189     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.12.3005     Document Type: Article

References (52)

1. Zeisel SH. Choline. In: Shils ME, Olson JA, Shike M, Ross A, editors. Modern nutrition in health and disease. 9th ed. Philadelphia: Lippincott Williams & Wilkins; 1999. p. 513-23.
2. Kuksis A, Mookerjea S. Inositol. Nutr Rev. 1978;36:233-8.
3. Yao ZM, Vance DE. The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J Biol Chem. 1988;263:2998-3004.
4. DeLong CJ, Shen YJ, Thomas MJ, Cui Z. Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway. J Biol Chem. 1999;274:29683-8.
5. Vance DE, Walkey CJ. Roles for the methylation of phosphatidylethanolamine. Curr Opin Lipidol. 1998;9:125-30.
6. Sundler R, Akesson B. Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different substrates 10. J Biol Chem. 1975;250:3359-67.
7. Mudd SH, Poole JR. Labile methyl balances for normal humans on various dietary regimens. Metabolism. 1975;24:721-35.
8. Jacobs RL, Stead LM, Devlin C, Tabas I, Brosnan ME, Brosnan JT, Vance DE. Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. J Biol Chem. 2005;280:28299-305.
9. Refsum H, Ueland PM, Nygard O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med. 1998;49:31-62.
10. Robinson K. Homocysteine and coronary artery disease. In: Carmel R, Jacobsen DW, editors. Homocysteine in Health and Disease. Cambridge: Cambridge University Press; 2001. p. 371-83.
11. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA. 1995;274:1049-57.
12. McMullen MH, Rowling MJ, Ozias MK, Schalinske KL. Activation and induction of glycine N-methyltransferase by retinoids are tissue- and gender-specific. Arch Biochem Biophys. 2002;401:73-80.
13. Nieman KM, Rowling MJ, Garrow TA, Schalinske KL. Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. J Biol Chem. 2004;279:45708-12.
14. Ozias MK, Schalinske KL. All-trans-retinoic acid rapidly induces glycine N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats. J Nutr. 2003;133:4090-4.
15. Rowling MJ, Schalinske KL. Retinoic acid and glucocorticoid treatment induce hepatic glycine N-methyltransferase and lower plasma homocysteine concentrations in rats and rat hepatoma cells. J Nutr. 2003;133:3392-8.
16. Cabrero C, Merida I, Ortiz P, Varela I, Mato JM. Effects of alloxan on S-adenosylmethionine metabolism in the rat liver. Biochem Pharmacol. 1986;35:2261-4.
17. Hoffman DR, Haning JA, Cornatzer WE. Effect of alloxan diabetes on phosphatidylcholine biosynthetic enzymes. Proc Soc Exp Biol Med. 1981;167:143-6.
18. Tashiro S, Sudou K, Imoh A, Koide M, Akazawa Y. Phosphatidylethanolamine methyltransferase activity in developing, demyelinating, and diabetic mouse brain. Tohoku J Exp Med. 1983;141 Suppl:485-90.
19. Xue GP, Snoswell AM. Disturbance of methyl group metabolism in alloxan-diabetic sheep. Biochem Int. 1985;10:897-905.
20. Panagia V, Taira Y, Ganguly PK, Tuns S, Dhalla NS. Alterations in phospholipid N-methylation of cardiac subcellular membranes due to experimentally induced diabetes in rats. J Clin Invest. 1990;86:777-84.
21. Wijekoon EP, Hall B, Ratnam S, Brosnan ME, Zeisel SH, Brosnan JT. Homocysteine metabolism in ZDF (type 2) diabetic rats. Diabetes. 2005;54:3245-51.
22. Geelen MJH, Groener JEM, Dehaas CGM, Wisserhof TA, Vangolde LMG. Influence of insulin and glucagon on synthesis of glycerolipids in rat hepatocytes. FEBS Lett. 1978;90:57-60.
23. Geelen MJH, Groener JEM, Dehaas CGM, Vangolde LMG. Influence of glucagon on the synthesis of phosphatidylcholines and phosphatidylethanolamines in monolayer-cultures of rat hepatocytes. FEBS Lett. 1979;105:27-30.
24. Castano JG, Alemany S, Nieto A, Mato JM. Activation of phospholipid methyltransferase by glucagon in rat hepatocytes. J Biol Chem. 1980;255:9041-3.
25. Cui Z, Vance JE, Chen MH, Voelker DR, Vance DE. Cloning and expression of a novel phosphatidylethanolamine N-methyltransferase. A specific biochemical and cytological marker for a unique membrane fraction in rat liver. J Biol Chem. 1993;268:16655-63.
26. Schalinske KL, Steele RD. 13-cis-retinoic acid alters methionine metabolism in rats. J Nutr. 1991;121:1714-9.
27. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-54.
28. Duce AM, Ortiz P, Cabrero C, Mato JM. S-Adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis. Hepatology. 1988;8:65-8.
29. Bremer J. Phosphatidylethanolamine: adenosylmethionine methyltransferase(s) from animal liver. Methods Enzymol. 1969;14:125-8.
30. Hoffman DR, Cornatzer WE. Microsomal phosphatidylethanolamine methyltransferase: some physical and kinetic properties. Lipids. 1981;16:533-40.
31. Ubbink JB, Hayward Vermaak WJ, Bissbort S. Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum. J Chromatogr. 1991;565:441-6.
32. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957;226:497-509.
33. Palacios LE, Wang T. Egg-yolk lipid fractionation and lecithin characterization. JAOCS (J Am Oil Chem Soc). 2005;85:571-8.
34. Villanueva GR, Herreros M, Perez-Barriocanal F, Bolanos JP, Bravo P, Marin JJ. Enhancement of bile acid-induced biliary lipid secretion by streptozotocin in rats: role of insulin deficiency. J Lab Clin Med. 1990;115:441-8.
35. Igolnikov AC, Green RM. Mice heterozygous for the Mdr2 gene demonstrate decreased PEMTactivity and diminished steatohepatitis on the MCD diet. J Hepatol. 2006;44:586-92.
36. Noga AA, Zhao Y, Vance DE. An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins. J Biol Chem. 2002;277:42358-65.
37. Shields DJ, Lingrell S, Agellon LB, Brosnan JT, Vance DE. Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase. J Biol Chem. 2005;280:27339-44.
38. Li Z, Agellon LB, Vance DE. Phosphatidylcholine homeostasis and liver failure. J Biol Chem. 2005;280:37798-802.
39. Jacobs RL, House JD, Brosnan ME, Brosnan JT. Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat. Diabetes. 1998;47:1967-70.
40. Ratnam S, Maclean KN, Jacobs RL, Brosnan ME, Kraus JP, Brosnan JT. Hormonal regulation of cystathionine beta-synthase expression in liver. J Biol Chem. 2002;277:42912-8.
41. Loo G, Smith JT. Effect of pyridoxine deficiency on phospholipid methylation in rat liver microsomes. Lipids. 1986;21:409-12.
42. Vance DE, Ridgway ND. The methylation of phosphatidylethanolamine. Prog Lipid Res. 1988;27:61-79.
43. Ratnam S, Wijekoon EP, Hall B, Garrow TA, Brosnan ME, Brosnan JT. Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver. Am J Physiol Endocrinol Metab. 2006;290:E933-9.
44. Pan HJ, Reifsnyder P, Vance DE, Xiao Q, Leiter EH. Pharmacogenetic analysis of rosiglitazone-induced hepatosteatosis in new mouse models of type 2 diabetes. Diabetes. 2005;54:1854-62.
45. Alam BS, Alam SQ. Excessive intake of 13-cis retinoic acid and fatty acid composition of tissues. J Nutr. 1983;113:64-9.
46. Fell D, Steele RD. Effect of retinol toxicity on hepatic S-adenosylmethionine-dependent transmethylation in rats. Drug Nutr Interact. 1987;5:1-7.
47. Hofmann MA, Kohl B, Zumbach MS, Borcea V, Bierhaus A, Henkels M, Amiral J, Fiehn W, Ziegler R, et al. Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM. Diabetes Care. 1997;20:1880-6.
48. Hoogeveen EK, Kostense PJ, Jakobs C, Dekker JM, Nijpels G, Heine RJ, Bouter LM, Stehouwer CD. Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes: 5-year follow-up of the Hoorn Study. Circulation. 2000;101:1506-11.
49. Meigs JB, Jacques PF, Selhub J, Singer DE, Nathan DM, Rifai N, D'Agostino RB Sr, Wilson PW. Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. Diabetes Care. 2001;24:1403-10.
50. Poirier LA, Brown AT, Fink LM, Wise CK, Randolph CJ, Delongchamp RR, Fonseca VA. Blood S-adenosylmethionine concentrations and lymphocyte methylenetetrahydrofolate reductase activity in diabetes mellitus and diabetic nephropathy. Metabolism. 2001;50:1014-8.
51. Robillon JF, Canivet B, Candito M, Sadoul JL, Jullien D, Morand P, Chambon P, Freychet P. Type 1 diabetes mellitus and homocyst(e)ine. Diabete Metab. 1994;20:494-6.
52. Tessari P, Coracina A, Kiwanuka E, Vedovato M, Vettore M, Valerio A, Zaramella M, Garibotto G. Effects of insulin on methionine and homocysteine kinetics in type 2 diabetes with nephropathy. Diabetes. 2005;54:2968-76.