-
1
-
-
0033533527
-
Homocyst(e)ine and cardiovascular disease: A critical review of the epidemiologic evidence
-
Eikelboom JW, Lonn E, Genest JJ, Hankey G, Yusuf S. Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence. Ann Intern Med. 1999;131:363-375.
-
(1999)
Ann Intern Med
, vol.131
, pp. 363-375
-
-
Eikelboom, J.W.1
Lonn, E.2
Genest, J.J.3
Hankey, G.4
Yusuf, S.5
-
2
-
-
0034827690
-
Hyperhomocysteinemia as a risk factor for venous thrombosis
-
den Heijer M, Keijzer MB. Hyperhomocysteinemia as a risk factor for venous thrombosis. Clin Chem Lab Med. 2001;39:710-713.
-
(2001)
Clin Chem Lab Med
, vol.39
, pp. 710-713
-
-
Den Heijer, M.1
Keijzer, M.B.2
-
3
-
-
0037164104
-
Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
-
Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002;288:2015-2022.
-
(2002)
JAMA
, vol.288
, pp. 2015-2022
-
-
-
4
-
-
0030188563
-
The oxidant stress of hyperhomocyst(e)inemia
-
Loscalzo J. The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest. 1996;98:5-7.
-
(1996)
J Clin Invest
, vol.98
, pp. 5-7
-
-
Loscalzo, J.1
-
5
-
-
0002449167
-
Homocysteine and cardiovascular physiology
-
Carmel R, Jacobsen DW, eds. Cambridge, United Kingdom: Cambridge University Press
-
Lentz SR. Homocysteine and cardiovascular physiology. In: Carmel R, Jacobsen DW, eds. Homocysteine in Health and Disease. Cambridge, United Kingdom: Cambridge University Press; 2001:441-450.
-
(2001)
Homocysteine in Health and Disease
, pp. 441-450
-
-
Lentz, S.R.1
-
6
-
-
0037345584
-
Hyperhomocysteinemia: A million ways to lose control
-
Faraci FM. Hyperhomocysteinemia: a million ways to lose control. Arterioscler Thromb Vasc Biol. 2003;23:371-373.
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 371-373
-
-
Faraci, F.M.1
-
7
-
-
0032480790
-
Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults
-
Bellamy MF, Mcdowell IFW, Ramsey MW, et al. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation. 1998;98:1848-1852.
-
(1998)
Circulation
, vol.98
, pp. 1848-1852
-
-
Bellamy, M.F.1
Mcdowell, I.F.W.2
Ramsey, M.W.3
-
9
-
-
0033052019
-
Endothelial dysfunction by acute hyperhomocyst(e)inemia: Restoration by folic acid
-
Usui M, Matsuoka H, Miyazaki H, Ueda S, Okuda S, Imaizumi T. Endothelial dysfunction by acute hyperhomocyst(e)inemia: restoration by folic acid. Clin Sci. 1999;96:235-239.
-
(1999)
Clin Sci
, vol.96
, pp. 235-239
-
-
Usui, M.1
Matsuoka, H.2
Miyazaki, H.3
Ueda, S.4
Okuda, S.5
Imaizumi, T.6
-
10
-
-
0033554459
-
Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans
-
Kanani PM, Sinkey CA, Browning RL, Allaman M, Knapp HR, Haynes WG. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans. Circulation. 1999;100:1161-1168.
-
(1999)
Circulation
, vol.100
, pp. 1161-1168
-
-
Kanani, P.M.1
Sinkey, C.A.2
Browning, R.L.3
Allaman, M.4
Knapp, H.R.5
Haynes, W.G.6
-
11
-
-
0033537653
-
Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia. An effect reversible with vitamin C therapy
-
Chambers JC, McGregor A, Jean-Marie J, Obeid OA, Kooner JS. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia. An effect reversible with vitamin C therapy. Circulation. 1999;99:1156-1160.
-
(1999)
Circulation
, vol.99
, pp. 1156-1160
-
-
Chambers, J.C.1
McGregor, A.2
Jean-Marie, J.3
Obeid, O.A.4
Kooner, J.S.5
-
12
-
-
0030015522
-
Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia
-
Lentz SR, Sobey CG, Piegors DJ, et al. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J Clin Invest. 1996;98:24-29.
-
(1996)
J Clin Invest
, vol.98
, pp. 24-29
-
-
Lentz, S.R.1
Sobey, C.G.2
Piegors, D.J.3
-
13
-
-
0037339694
-
Increased superoxide production in coronary arteries in hyperhomocysteinemia: Role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase
-
Ungvari Z, Csiszar A, Edwards JG, et al. Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase. Arterioscler Thromb Vasc Biol. 2003;23:418-424.
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 418-424
-
-
Ungvari, Z.1
Csiszar, A.2
Edwards, J.G.3
-
14
-
-
0033849778
-
Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia
-
Eberhardt RT, Forgione MA, Cap A, et al. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest. 2000;106:483-491.
-
(2000)
J Clin Invest
, vol.106
, pp. 483-491
-
-
Eberhardt, R.T.1
Forgione, M.A.2
Cap, A.3
-
15
-
-
0033826673
-
Folate dependence of hyperhomocysteinemia and endothelial dysfunction in cystathionine beta-synthase-deficient mice
-
Lentz SR, Erger RA, Dayal S, et al. Folate dependence of hyperhomocysteinemia and endothelial dysfunction in cystathionine beta-synthase-deficient mice. Am J Physiol. 2000;278:H970-H975.
-
(2000)
Am J Physiol
, vol.278
-
-
Lentz, S.R.1
Erger, R.A.2
Dayal, S.3
-
16
-
-
0035827728
-
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice
-
Dayal S, Bottiglieri T, Arning E, et al. Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circ Res. 2001;88:1203-1209.
-
(2001)
Circ Res
, vol.88
, pp. 1203-1209
-
-
Dayal, S.1
Bottiglieri, T.2
Arning, E.3
-
17
-
-
0036144873
-
Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice
-
Weiss N, Heydrick S, Zhang YY, Bierl C, Cap A, Loscalzo J. Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice. Arterioscler Thromb Vasc Biol. 2002;22:34-41.
-
(2002)
Arterioscler Thromb Vasc Biol
, vol.22
, pp. 34-41
-
-
Weiss, N.1
Heydrick, S.2
Zhang, Y.Y.3
Bierl, C.4
Cap, A.5
Loscalzo, J.6
-
18
-
-
0025362827
-
Methionine metabolism in mammals
-
Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem. 1990;1:228-237.
-
(1990)
J Nutr Biochem
, vol.1
, pp. 228-237
-
-
Finkelstein, J.D.1
-
19
-
-
0034703084
-
Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation
-
Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem. 2000;275:29318-29323.
-
(2000)
J Biol Chem
, vol.275
, pp. 29318-29323
-
-
Yi, P.1
Melnyk, S.2
Pogribna, M.3
Pogribny, I.P.4
Hine, R.J.5
James, S.J.6
-
20
-
-
0038663165
-
Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia
-
Ingrosso D, Cimmino A, Perna AF, et al. Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia. Lancet. 2003;361:1693-1699.
-
(2003)
Lancet
, vol.361
, pp. 1693-1699
-
-
Ingrosso, D.1
Cimmino, A.2
Perna, A.F.3
-
21
-
-
0032831285
-
Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system
-
Post WS, Goldschmidt-Clermont PJ, Wilhide CC, et al. Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system. Cardiovasc Res. 1999;43:985-991.
-
(1999)
Cardiovasc Res
, vol.43
, pp. 985-991
-
-
Post, W.S.1
Goldschmidt-Clermont, P.J.2
Wilhide, C.C.3
-
23
-
-
0029049553
-
A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
-
Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111-113.
-
(1995)
Nat Genet
, vol.10
, pp. 111-113
-
-
Frosst, P.1
Blom, H.J.2
Milos, R.3
-
24
-
-
0030027668
-
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
-
Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 1996;93:7-9.
-
(1996)
Circulation
, vol.93
, pp. 7-9
-
-
Jacques, P.F.1
Bostom, A.G.2
Williams, R.R.3
-
25
-
-
0037163849
-
MTHFR 677C→T polymorphism and risk of coronary heart disease: A meta-analysis
-
Klerk M, Verhoef P, Clarke R, et al. MTHFR 677C→T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA. 2002;288:2023-2031.
-
(2002)
JAMA
, vol.288
, pp. 2023-2031
-
-
Klerk, M.1
Verhoef, P.2
Clarke, R.3
-
26
-
-
0035282903
-
Mice deficient in methylene tetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition
-
Chen Z, Karaplis AC, Ackerman SL, et al. Mice deficient in methylene tetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Hum Mol Genet. 2001;10:433-443.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 433-443
-
-
Chen, Z.1
Karaplis, A.C.2
Ackerman, S.L.3
-
27
-
-
0043235659
-
Effect of hyperhomocysteinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice
-
Virdis A, Iglarz M, Neves MF, et al. Effect of hyperhomocysteinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice. Arterioscler Thromb Vasc Biol. 2003;23:1352-1357.
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 1352-1357
-
-
Virdis, A.1
Iglarz, M.2
Neves, M.F.3
-
28
-
-
0003335339
-
Nutrient requirements of the mouse
-
Subcommittee on Laboratory Animal Nutrition, Committee on Animal Nutrition, Board on Agriculture, National Research Council. Washington, DC: National Academies Press
-
Nutrient requirements of the mouse. In: Subcommittee on Laboratory Animal Nutrition, Committee on Animal Nutrition, Board on Agriculture, National Research Council. Nutrient Requirements of Laboratory Animals. 4th rev ed. Washington, DC: National Academies Press; 1995:80-102.
-
(1995)
Nutrient Requirements of Laboratory Animals. 4th Rev Ed.
, pp. 80-102
-
-
-
29
-
-
0037112407
-
Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice
-
Didion SP, Ryan MJ, Didion LA, Fegan PE, Sigmund CD, Faraci FM. Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ Res. 2002;91:938-944.
-
(2002)
Circ Res
, vol.91
, pp. 938-944
-
-
Didion, S.P.1
Ryan, M.J.2
Didion, L.A.3
Fegan, P.E.4
Sigmund, C.D.5
Faraci, F.M.6
-
30
-
-
18544392716
-
Homocysteine and its disulfide derivatives: A suggested consensus terminology
-
Mudd SH, Finkelstein JD, Refsum H, et al. Homocysteine and its disulfide derivatives: a suggested consensus terminology. Arterioscler Thromb Vasc Biol. 2000;20:1704-1706.
-
(2000)
Arterioscler Thromb Vasc Biol
, vol.20
, pp. 1704-1706
-
-
Mudd, S.H.1
Finkelstein, J.D.2
Refsum, H.3
-
31
-
-
0033050869
-
Plasma total homocysteine measurement by ion-paired reversed-phase HPLC with electrochemical detection
-
Martin SC, Hilton AC, Bartlett WA, Jones AF. Plasma total homocysteine measurement by ion-paired reversed-phase HPLC with electrochemical detection. Biomed Chromatogr. 1999;13:81-82.
-
(1999)
Biomed Chromatogr
, vol.13
, pp. 81-82
-
-
Martin, S.C.1
Hilton, A.C.2
Bartlett, W.A.3
Jones, A.F.4
-
32
-
-
0025666354
-
Isocratic high performance liquid chromatography analysis of S-adenosylmethionine and S-adenosylhomocysteine in animal tissues: The effect of exposure to nitrous oxide
-
Bottiglieri T. Isocratic high performance liquid chromatography analysis of S-adenosylmethionine and S-adenosylhomocysteine in animal tissues: the effect of exposure to nitrous oxide. Biomed Chromatogr. 1990;4:239-241.
-
(1990)
Biomed Chromatogr
, vol.4
, pp. 239-241
-
-
Bottiglieri, T.1
-
33
-
-
0033533384
-
A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands
-
Pogribny I, Yi P, James SJ. A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands. Biochem Biophys Res Commun. 1999;262:624-628.
-
(1999)
Biochem Biophys Res Commun
, vol.262
, pp. 624-628
-
-
Pogribny, I.1
Yi, P.2
James, S.J.3
-
34
-
-
0035057410
-
C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: Incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular disease
-
Hanson NQ, Aras O, Yang F, Tsai MY. C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular disease. Clin Chem. 2001;47:661-666.
-
(2001)
Clin Chem
, vol.47
, pp. 661-666
-
-
Hanson, N.Q.1
Aras, O.2
Yang, F.3
Tsai, M.Y.4
-
35
-
-
0029903031
-
Molecular and biochemical approaches in the identification of heterozygotes for homocystinuria
-
Tsai MY, Garg U, Key NS, Hanson NQ, Suh A, Schwichtenberg K. Molecular and biochemical approaches in the identification of heterozygotes for homocystinuria. Atherosclerosis. 1996;122:69-77.
-
(1996)
Atherosclerosis
, vol.122
, pp. 69-77
-
-
Tsai, M.Y.1
Garg, U.2
Key, N.S.3
Hanson, N.Q.4
Suh, A.5
Schwichtenberg, K.6
-
36
-
-
0027499627
-
Hepatic one-carbon metabolism in early folate deficiency in rats
-
Balaghi M, Horne DW, Wagner C. Hepatic one-carbon metabolism in early folate deficiency in rats. Biochem J. 1993;291:145-149.
-
(1993)
Biochem J
, vol.291
, pp. 145-149
-
-
Balaghi, M.1
Horne, D.W.2
Wagner, C.3
-
38
-
-
0037372003
-
Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
-
Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003;33(suppl):245-254.
-
(2003)
Nat Genet
, vol.33
, Issue.SUPPL.
, pp. 245-254
-
-
Jaenisch, R.1
Bird, A.2
-
39
-
-
0002268929
-
Role of superoxide in cerebral vascular dysfunction in hyperhomocysteinemic mice
-
Lentz SR, Dayal S, Arning E, Bottiglieri T, Sigmund CD, Faraci FM. Role of superoxide in cerebral vascular dysfunction in hyperhomocysteinemic mice [abstract]. Circulation. 2002;106:II-111.
-
(2002)
Circulation
, vol.106
-
-
Lentz, S.R.1
Dayal, S.2
Arning, E.3
Bottiglieri, T.4
Sigmund, C.D.5
Faraci, F.M.6
-
40
-
-
0037112386
-
Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice
-
Baumbach GL, Sigmund CD, Bottiglieri T, Lentz SR. Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice. Circ Res. 2002;91:931-937.
-
(2002)
Circ Res
, vol.91
, pp. 931-937
-
-
Baumbach, G.L.1
Sigmund, C.D.2
Bottiglieri, T.3
Lentz, S.R.4
-
41
-
-
0033818456
-
Vitamin supplements and cardiovascular risk: Review of the randomized trials of homocysteine-lowering vitamin supplements
-
Clarke R, Armitage J. Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements. Semin Thromb Hemost. 2000;26:341-348.
-
(2000)
Semin Thromb Hemost
, vol.26
, pp. 341-348
-
-
Clarke, R.1
Armitage, J.2
|