Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat

Diabetes

Volumn 47, Issue 12, 1998, Pages 1967-1970

  Jacobs, René L ^a   House, James D ^a   Brosnan, Margaret E ^a   Brosnan, John T ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; HOMOCYSTEINE; INSULIN;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031737909     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.12.1967     Document Type: Article

References (30)

1. Kang SS, Wong PWK, Malinow MR: Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu Rev Nutr 12:279-298, 1992
2. Malinow MR: Homocsyt(e)ine and arterial occlusive diseases. J Intern Med 236:603-617, 1994
3. Ubbink JB, Vermaak WJH, van der Merwe A, Becker PJ: Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia. Am J Clin Nutr 57:47-53, 1993
4. Brattstrom L, Israelsson B, Lindgarde F, Hultberg B: Higher plasma homo cysteine in vitamin B-12 deficiency than in heterozygotes for homocystinuria due to cystathionine β-synthase deficiency. Metabolism 37:175-178, 1988
5. Miller JW, Ribaya-Mercadoo JD, Russell RM, Shepard DC, Morrow FD, Cochary EF, Sadowski JA, Gershoff SN, Selhub J: Effect of vitamin B-6 on fasting plasma homocysteine concentrations. Am J Clin Nutr 55:1154-1160, 1992
6. Ubbink JB, van der Merwe A, Delpoort R, Allen RH, Stabler SP, Riezier R, Vermaak WJH: The effect of a subnormal vitamin B-6 status on homocysteine metabolism. J Clin Invest 98:177-184, 1996
7. Renold AE, Mintz DH, Muller WA, Cahill GF: Diabetes mellitus. In The Metabolic Basis of Inherited Disease. 4th ed. Stanbury HU, Ed. New York, McGraw-Hill, 1978, p 80-109
8. Hultberg B, Agargh E, Andersson A, Brattstrom L, Isaksson A, Israelsson B, Agardh CD: Increased levels of plasma homocysteine are associated with nephropathy, but not severe retinopathy in Type 1 diabetes mellitus. Scand J Clin Lab Invest 51:277-282, 1991
9. Hoogeveen EK, Kostense PJ, Beks PJ, Jakobs C, Bouter LM, Heine RJ, Stehouwer CD: Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus: a population-based study. Arterioscler Thromb Vase Biol 18:133-138, 1998
10. Hofmann MA, Kohl K, Zumbach MS, Borcea V, Bierhaus A, Henkels M, Amiral J, Fichn W, Ziegler R, Wahl P, Nawroth PP: Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM: Diabetes Care 20:1880-1886, 1997
11. Bostom A, Brosnan JT, Hall B, Nadeau MR, Selhub J: Net uptake of plasma homocysteine by the rat kidney in vivo. Atherosclerosis 116:59-62, 1995
12. Robillon JF, Canivet B, Candito M, Sadoul JL, Jullien D, Morand P, Chambon P, Freyrhet P: Type 1 diabetes mellitus and homocyst(e)ine. Diabete Metab 20:494-496, 1994
13. Kolbin DD, Watson JE, Deady JE, Stokstad ELR, Eger EI II: Inactivation of methionine synthase by nitrous oxide in mice. Anesthesiology 54:318-324, 1981
14. Wang JA, Dudman NPB, Lynch J, Wilcken DEL: Betaine:homocysteine methyltransferase: a new assay for the liver enzyme and its absence from human skin fibroblasts and peripheral blood lymphocytes. Clin Chim Acta 204:239-249, 1991
15. Miller JW, Nadeau MR, Smith J, Smith D, Selhub J: Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine s coordinate regulation of homocysteine metabolism. Biochem J 298:415-419, 1994
16. Jones BN, Gillingham TP: o-Phthaldialdehyde precolumn derivatization and reversed-phase high-performance liquid chromatography of polypeptide hydrolysates and physiological fluids. J Chromatogr 266:471-482, 1983
17. Stipanuk MH: Effect of excess dietary methionine on the catabolism of cysteine in rats. J Nutr 109:2126-2139, 1979
18. Engbersen AMT, Franken DG, Boers GHJ, Stevens EMB, Trijbels FJM, Blom HJ: Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia. Am J Hum Genet 56:142-150, 1994
19. Gorrnall AG, Bardawill CJ, David MM: Determination of serum proteins by means of the biuret reaction. J Biol Chem 177:751-766, 1949
20. Jacobs EE, Jacob J, Sanadi DR, Bradley LB: Uncoupling of oxidative phosphorylations by cadmium ion. J Biol Chem 223:147-156, 1956
21. Vester B, Rasmussen K: High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum. Eur J Clin Chem Clin Biochem 29:549-554, 1991
22. Bergmeyer HU, Bernt E, Schmidt F, Stork H: D-glucose: determination with hexokinase and glucose-6-phosphate dehydrogenase. In Methods of Enzymatic Anaylsis. Vol. 3, 2nd ed. Bergmeyer HU, Ed. Deerfield Beach, FL, Verlag Chemie International, 1981, p 1196-1201
23. Stipanuk MH: Metabolism of sulfur-containing amino acids. Annu Rev Nutr 6:170-209, 1986
24. Svardal AM, Djurhuus R, Refsum H, Ueland PM: Disposition of homocysteine in rat hepatocytes and in nontransformed and malignant mouse embryo fibroblasts following exposure to inhibitors of S-adenosylhomocysteine catabolism. Cancer Res 46:5095-5100, 1986
25. Brosnan JT, Man KC, Hall DE, Colbourne SA, Brosnan ME: Interorgan metabolism of amino acids in streptozotocin-diabetic ketoacidotic rat. Am J Physiol 244:E151-E158, 1983
26. Watanabe M, Osada J, Artani Y, Kluckman K, Reddick R, Malinow MR, Maeda N: Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci USA 92:1585-1589, 1995
27. Finkelstein JD: Methionine metabolism in mammals. J Nutr Biochem 1:228-237, 1990
28. O'Brien RM, Granner DK: Regulation of gene expression by insulin. Physiol Rev 76:1109-1161, 1996
29. Goss SJ: Characterization of cystathionine synthase as a selectable, liverspecific trait in rat hepatomas. J Cell Sci 82:309-320, 1986
30. Skovby F, Kravs JP, Rosenberg LE: Biosynthesis and proteolytic activation of cystathionine β-synthase in rat liver. J Biol Chem 259:588-593, 1994