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Volumn 19, Issue 2, 2013, Pages 125-134

Oral delivery of lactoferrin: A Review

Author keywords

Chitosan; Gastrointestinal tract (GIT); Lactoferrin (Lf); Liposomes; Nanoparticles; PEGylation

Indexed keywords

ALGINIC ACID; APROTININ; ARGINYLGLYCYLASPARTIC ACID; BACITRACIN; BORONIC ACID DERIVATIVE; BOWMAN BIRK INHIBITOR; BUSERELIN; CHITOSAN; CITRIC ACID; CYCLODEXTRIN; CYCLOSPORIN A; DEXTRAN SULFATE; DODECYL SULFATE SODIUM; EDETIC ACID; INSULIN; LACTOFERRIN; LIPOSOME; MACROGOL; METKEPHAMID; NANOPARTICLE; NANOSPHERE; OCTANOIC ACID; POLYGLACTIN; POLYLACTIC ACID; SALCATONIN; SALICYLIC ACID; SK AND F 106760; SOYBEAN TRYPSIN INHIBITOR; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84877981358     PISSN: 15733149     EISSN: 15733904     Source Type: Journal    
DOI: 10.1007/s10989-012-9326-8     Document Type: Article
Times cited : (27)

References (131)
  • 1
    • 77958468107 scopus 로고    scopus 로고
    • Characterization of lactoferrin oil in water emulsions and their stability in recombined milk
    • 1:CAS:528:DC%2BC3cXht1aktL7F 10.1017/S0022029910000622 20822568
    • Acero-Lopez A, Schell P, Corredig M, Alexander M (2010) Characterization of lactoferrin oil in water emulsions and their stability in recombined milk. J Dairy Res 77:445-451
    • (2010) J Dairy Res , vol.77 , pp. 445-451
    • Acero-Lopez, A.1    Schell, P.2    Corredig, M.3    Alexander, M.4
  • 3
    • 0026739984 scopus 로고
    • A study on factors influencing the droplet size in nonionic oil-in-water microemulsions
    • 1:CAS:528:DyaK3sXms1OntA%3D%3D 10.1016/0378-5173(92)90341-X
    • Attwood D, Mallon C, Ktistis G, Taylor CJ (1992) A study on factors influencing the droplet size in nonionic oil-in-water microemulsions. Int J Pharm 88:417-422
    • (1992) Int J Pharm , vol.88 , pp. 417-422
    • Attwood, D.1    Mallon, C.2    Ktistis, G.3    Taylor, C.J.4
  • 4
    • 10044279371 scopus 로고    scopus 로고
    • Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes
    • 1:CAS:528:DC%2BD2cXhtVChsrvJ 10.1016/j.biomaterials.2004.07.047 15585276
    • Balthasar S, Michaelis K, Dinauer N, Von BH, Kreuter J, Langer K (2005) Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes. Biomaterials 26:2723-2732
    • (2005) Biomaterials , vol.26 , pp. 2723-2732
    • Balthasar, S.1    Michaelis, K.2    Dinauer, N.3    Von, B.H.4    Kreuter, J.5    Langer, K.6
  • 5
    • 3342878515 scopus 로고    scopus 로고
    • The antiviral activity of the milk protein lactoferrin against the human immunodeficiency virus type 1
    • 1:CAS:528:DC%2BD2cXjvFarur0%3D 10.1023/B:BIOM.0000027707.82911.be 15222480
    • Berkhout B, Floris R, Recio I, Visser S (2004) The antiviral activity of the milk protein lactoferrin against the human immunodeficiency virus type 1. Biometals 17:291-294
    • (2004) Biometals , vol.17 , pp. 291-294
    • Berkhout, B.1    Floris, R.2    Recio, I.3    Visser, S.4
  • 6
    • 0032473473 scopus 로고    scopus 로고
    • The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins
    • 1:CAS:528:DyaK1cXhtlaktbo%3D 10.1016/S0168-3659(97)00204-6 9685931
    • Bernkop-Schnurch A (1998) The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. J Control Release 52:1-16
    • (1998) J Control Release , vol.52 , pp. 1-16
    • Bernkop-Schnurch, A.1
  • 7
    • 0036674693 scopus 로고    scopus 로고
    • Biomembrane permeability of peptides: Strategies to improve their mucosal uptake
    • 1:CAS:528:DC%2BD38XltlCqsL4%3D 10.2174/1389557023406007 12370051
    • Bernkop-Schnurch A, Clausen A (2002) Biomembrane permeability of peptides: strategies to improve their mucosal uptake. Mini Rev Med Chem 2:295-305
    • (2002) Mini Rev Med Chem , vol.2 , pp. 295-305
    • Bernkop-Schnurch, A.1    Clausen, A.2
  • 8
    • 0032472305 scopus 로고    scopus 로고
    • Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: Synthesis and evaluation of different chitosan-EDTA conjugates
    • 1:CAS:528:DyaK2sXnvFSnsro%3D 10.1016/S0168-3659(97)00136-3 9685888
    • Bernkop-Schnurch A, Krajicek ME (1998) Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: synthesis and evaluation of different chitosan-EDTA conjugates. J Control Release 50:215-223
    • (1998) J Control Release , vol.50 , pp. 215-223
    • Bernkop-Schnurch, A.1    Krajicek, M.E.2
  • 9
    • 34548803860 scopus 로고    scopus 로고
    • Presystemic metabolism of orally administered peptide drugs and strategies to overcome it
    • 1:STN:280:DC%2BD2szmvFSisQ%3D%3D 10.2174/138920007780866834 17584022
    • Bernkop-Schnurch A, Schmitz T (2007) Presystemic metabolism of orally administered peptide drugs and strategies to overcome it. Curr Drug Metab 8:509-517
    • (2007) Curr Drug Metab , vol.8 , pp. 509-517
    • Bernkop-Schnurch, A.1    Schmitz, T.2
  • 10
    • 0030740816 scopus 로고    scopus 로고
    • Novel bioadhesive chitosan-EDTA conjugate protects leucine enkephalin form degradation by aminopeptidase N
    • 1:CAS:528:DyaK2sXkvVCit78%3D 10.1023/A:1012108118670 9244150
    • Bernkop-Schnurch A, Paikl C, Valenta C (1997) Novel bioadhesive chitosan-EDTA conjugate protects leucine enkephalin form degradation by aminopeptidase N. Pharm Res 14(7):917-922
    • (1997) Pharm Res , vol.14 , Issue.7 , pp. 917-922
    • Bernkop-Schnurch, A.1    Paikl, C.2    Valenta, C.3
  • 11
    • 14544267173 scopus 로고    scopus 로고
    • Thiomers for oral delivery of hydrophilic macromolecular drugs
    • 10.1517/17425247.1.1.87
    • Bernkop-Schurch A, Hoffer MH, Kafedjiiski K (2004) Thiomers for oral delivery of hydrophilic macromolecular drugs. Expert Opin Drug Deliv 1(1):87-98
    • (2004) Expert Opin Drug Deliv , vol.1 , Issue.1 , pp. 87-98
    • Bernkop-Schurch, A.1    Hoffer, M.H.2    Kafedjiiski, K.3
  • 12
    • 0032827971 scopus 로고    scopus 로고
    • Optimising oral absorption of peptides using prodrug strategies
    • 10.1016/S0168-3659(99)00042-5
    • Borchard RT (1999) Optimising oral absorption of peptides using prodrug strategies. J Control Release 62:231-238
    • (1999) J Control Release , vol.62 , pp. 231-238
    • Borchard, R.T.1
  • 13
    • 0017148443 scopus 로고
    • The effect of trypsin on bovine transferrin and lactoferrin
    • 1:CAS:528:DyaE28Xltlyru7s%3D 10.1016/0005-2795(76)90112-4 974113
    • Brock JH, Arzabe F, Lampreave F, Pineiro A (1976) The effect of trypsin on bovine transferrin and lactoferrin. Biochim Biophys Acta 446:214-225
    • (1976) Biochim Biophys Acta , vol.446 , pp. 214-225
    • Brock, J.H.1    Arzabe, F.2    Lampreave, F.3    Pineiro, A.4
  • 14
    • 0024791502 scopus 로고
    • Oral delivery of insulin
    • 1:STN:280:DyaK3c%2FpsleqtQ%3D%3D 10.1016/S0140-6736(89)92954-1 2574783
    • Cho YW, Flynn M (1989) Oral delivery of insulin. Lancet 2:1518-1519
    • (1989) Lancet , vol.2 , pp. 1518-1519
    • Cho, Y.W.1    Flynn, M.2
  • 15
    • 20444505044 scopus 로고    scopus 로고
    • A lecithin-based microemulsion of rh-insulin with aprotinin for oral administration: Investigation of hypoglycemic effects in non-diabetic and STZ-induced diabetic rats
    • 1:CAS:528:DC%2BD2MXlsVCksbo%3D 10.1016/j.ijpharm.2005.04.016 15950411
    • Cilek A, Celebi N, Tirnaksiz F, Tay A (2005) A lecithin-based microemulsion of rh-insulin with aprotinin for oral administration: investigation of hypoglycemic effects in non-diabetic and STZ-induced diabetic rats. Int J Pharm 298:176-185
    • (2005) Int J Pharm , vol.298 , pp. 176-185
    • Cilek, A.1    Celebi, N.2    Tirnaksiz, F.3    Tay, A.4
  • 16
    • 33748743726 scopus 로고    scopus 로고
    • 5-Methyl-pyrrolidinone chitosan films as carriers for buccal administration of proteins
    • 10.1208/pt070370
    • Colonna C, Genta I, Perugini P (2006) 5-Methyl-pyrrolidinone chitosan films as carriers for buccal administration of proteins. AAPS Pharm Sci Tech 7(3):107-113
    • (2006) AAPS Pharm Sci Tech , vol.7 , Issue.3 , pp. 107-113
    • Colonna, C.1    Genta, I.2    Perugini, P.3
  • 17
    • 0028081549 scopus 로고
    • Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides
    • 1:CAS:528:DyaK2MXivFaltLk%3D 10.1023/A:1018927402875 7855039
    • Constantinides PP, Scalart JP, Lancaster C, Marcello J, Marks G, Ellens H, Smith PL (1994) Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides. Pharm Res 11:1385-1390
    • (1994) Pharm Res , vol.11 , pp. 1385-1390
    • Constantinides, P.P.1    Scalart, J.P.2    Lancaster, C.3    Marcello, J.4    Marks, G.5    Ellens, H.6    Smith, P.L.7
  • 19
    • 9944239305 scopus 로고    scopus 로고
    • A study of insulin-chitosan complex nanoparticles used for oral administration
    • 1:CAS:528:DC%2BD2MXotFWluw%3D%3D
    • Cui F, Zhang L, Zheng J, Kawashima Y (2004) A study of insulin-chitosan complex nanoparticles used for oral administration. STP Pharma 14(6):435-439
    • (2004) STP Pharma , vol.14 , Issue.6 , pp. 435-439
    • Cui, F.1    Zhang, L.2    Zheng, J.3    Kawashima, Y.4
  • 20
    • 49049152933 scopus 로고
    • The definition of microemulsion
    • 1:CAS:528:DyaL38Xpt1Wiug%3D%3D 10.1016/0166-6622(81)80064-9
    • Danielsson I, Lindman B (1981) The definition of microemulsion. Colloids Surf 3:391-392
    • (1981) Colloids Surf , vol.3 , pp. 391-392
    • Danielsson, I.1    Lindman, B.2
  • 23
    • 0026095436 scopus 로고
    • Killing of gram-negative bacteria by lactoferrin and lysozyme
    • 1:CAS:528:DyaK3MXmtlSgsb8%3D 10.1172/JCI115407 1918365
    • Ellison RT, Giehl TJ (1991) Killing of gram-negative bacteria by lactoferrin and lysozyme. J Clin Invest 88:1080-1091
    • (1991) J Clin Invest , vol.88 , pp. 1080-1091
    • Ellison, R.T.1    Giehl, T.J.2
  • 24
    • 0037027833 scopus 로고    scopus 로고
    • Positively charged nanoparticles for improving the oral bioavailability of cyclosporin A
    • 1:CAS:528:DC%2BD38XosFagurw%3D 10.1016/S0378-5173(02)00461-1 12433438
    • El-Shabouri MH (2002) Positively charged nanoparticles for improving the oral bioavailability of cyclosporin A. Int J Pharm 249:101-108
    • (2002) Int J Pharm , vol.249 , pp. 101-108
    • El-Shabouri, M.H.1
  • 25
    • 84877952287 scopus 로고    scopus 로고
    • In vitro enhancing effect of 1-dodecylazacycloheptan-2-evaluation of natural and methylated cyclodextrins as buccal permeation enhancing system for omeprazole delivery
    • Figueiras A, Hombach J, Veiga F, Bernkop-Schnurch A (2008) In vitro enhancing effect of 1-dodecylazacycloheptan-2-evaluation of natural and methylated cyclodextrins as buccal permeation enhancing system for omeprazole delivery. Eur J Pharm Biopharm 72(3):561-566
    • (2008) Eur J Pharm Biopharm , vol.72 , Issue.3 , pp. 561-566
    • Figueiras, A.1    Hombach, J.2    Veiga, F.3    Bernkop-Schnurch, A.4
  • 26
    • 34547489931 scopus 로고    scopus 로고
    • Uptake of ingested bovine lactoferrin and its accumulation in adult mouse tissue
    • 10.1016/j.intimp.2007.05.019 1:CAS:528:DC%2BD2sXosF2qsLk%3D
    • Fisher R, Debbabi H, Blais A, Dubarry M, Rautureau M, Boyaka PN, Tome D (2007) Uptake of ingested bovine lactoferrin and its accumulation in adult mouse tissue. Int Immunopharmacol 7:1387-1393
    • (2007) Int Immunopharmacol , vol.7 , pp. 1387-1393
    • Fisher, R.1    Debbabi, H.2    Blais, A.3    Dubarry, M.4    Rautureau, M.5    Boyaka, P.N.6    Tome, D.7
  • 27
    • 0021871421 scopus 로고
    • Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs
    • 1:CAS:528:DyaL2MXltlGltL0%3D 10.1111/j.2042-7158.1985.tb03064.x 2864414
    • Fujii S, Yokoyama T, Ikegaya K, Sato F, Yokoo N (1985) Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs. J Pharm Pharmacol 37:545-549
    • (1985) J Pharm Pharmacol , vol.37 , pp. 545-549
    • Fujii, S.1    Yokoyama, T.2    Ikegaya, K.3    Sato, F.4    Yokoo, N.5
  • 28
    • 0025825167 scopus 로고
    • Liposome-entrapped calcitonin and parathyroid hormone are orally effective in rats
    • 10.1055/s-2007-1003642
    • Fukunga M, Miller MM, Deftos LJ (1991) Liposome-entrapped calcitonin and parathyroid hormone are orally effective in rats. Horm Metab Res 23:166-167
    • (1991) Horm Metab Res , vol.23 , pp. 166-167
    • Fukunga, M.1    Miller, M.M.2    Deftos, L.J.3
  • 29
    • 29144461657 scopus 로고    scopus 로고
    • Polymeric nanoparticles for oral delivery of drugs and vaccines: A critical evaluation of in vivo studies
    • 1:CAS:528:DC%2BD28XkslSksA%3D%3D 10.1615/CritRevTherDrugCarrierSyst.v22. i5.10
    • Galindo-Rodriguez SA, Allemann E, Fessi H, Doelker E (2005) Polymeric nanoparticles for oral delivery of drugs and vaccines: a critical evaluation of in vivo studies. Crit Rev Ther Drug Carr Syst 22:419-464
    • (2005) Crit Rev Ther Drug Carr Syst , vol.22 , pp. 419-464
    • Galindo-Rodriguez, S.A.1    Allemann, E.2    Fessi, H.3    Doelker, E.4
  • 30
    • 0033136871 scopus 로고    scopus 로고
    • Enzymatic degradation of poly(epsilon-caprolactone)/poly(d,l-lactide) blends in phosphate buffer solution
    • 1:CAS:528:DyaK1MXhtFygtbs%3D 10.1016/S0032-3861(98)00549-7
    • Gan ZH, Yu DH, Zhong ZY, Liang QZ, Jing XB (1999) Enzymatic degradation of poly(epsilon-caprolactone)/poly(d,l-lactide) blends in phosphate buffer solution. Polymer 40:2859-2862
    • (1999) Polymer , vol.40 , pp. 2859-2862
    • Gan, Z.H.1    Yu, D.H.2    Zhong, Z.Y.3    Liang, Q.Z.4    Jing, X.B.5
  • 31
    • 0032498581 scopus 로고    scopus 로고
    • Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A
    • 1:CAS:528:DyaK1cXhsFeitLs%3D 10.1016/S0378-5173(97)00325-6
    • Gao ZG, Choi HG, Shin HJ, Park KM, Lim SD, Hwang KJ, Kim CK (1998) Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A. Int J Pharm 161:75-86
    • (1998) Int J Pharm , vol.161 , pp. 75-86
    • Gao, Z.G.1    Choi, H.G.2    Shin, H.J.3    Park, K.M.4    Lim, S.D.5    Hwang, K.J.6    Kim, C.K.7
  • 32
    • 18044366409 scopus 로고    scopus 로고
    • A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly (ethylene glycol) as carriers for oral calcitonin delivery
    • 1:CAS:528:DC%2BD2MXjs1KnurY%3D 10.1016/j.ejps.2005.02.008 15854809
    • Garcia-Fuentes M, Prego C, Torres D, Alonso MJ (2005) A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly (ethylene glycol) as carriers for oral calcitonin delivery. Eur J Pharm Sci 25:133-143
    • (2005) Eur J Pharm Sci , vol.25 , pp. 133-143
    • Garcia-Fuentes, M.1    Prego, C.2    Torres, D.3    Alonso, M.J.4
  • 33
    • 78649852683 scopus 로고    scopus 로고
    • Chemical modifications designed to improve peptide stability: Incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization
    • 1:CAS:528:DC%2BC3cXhsVKlurvN 10.2174/138161210793292555 20687878
    • Gentilucci L, Marco RD, Cerisoli L (2010) Chemical modifications designed to improve peptide stability: incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization. Curr Pharm Des 16:3185-3203
    • (2010) Curr Pharm des , vol.16 , pp. 3185-3203
    • Gentilucci, L.1    Marco, R.D.2    Cerisoli, L.3
  • 34
    • 2342507611 scopus 로고    scopus 로고
    • Oral administration of lactoferrin inhibits inflammation and nociception in rat adjuvant-induced arthritis
    • 1:CAS:528:DC%2BD2cXivVSjsLg%3D 10.1292/jvms.66.149 15031542
    • Hayashida K, Kaneko T, Takeuchi T, Shimizu H, Ando K, Harada E (2004) Oral administration of lactoferrin inhibits inflammation and nociception in rat adjuvant-induced arthritis. J Vet Med Sci 66:149-154
    • (2004) J Vet Med Sci , vol.66 , pp. 149-154
    • Hayashida, K.1    Kaneko, T.2    Takeuchi, T.3    Shimizu, H.4    Ando, K.5    Harada, E.6
  • 35
    • 0037472115 scopus 로고    scopus 로고
    • Chitosan-based gastrointestinal delivery systems
    • 1:CAS:528:DC%2BD3sXjtVegtbg%3D 10.1016/S0168-3659(03)00126-3 12711440
    • Hejazi R, Amiji M (2003) Chitosan-based gastrointestinal delivery systems. J Control Release 89:151-165
    • (2003) J Control Release , vol.89 , pp. 151-165
    • Hejazi, R.1    Amiji, M.2
  • 36
    • 0030005376 scopus 로고    scopus 로고
    • Effects of bile salts on transport rates and routes of FTIC-labelled compounds across porcine buccal epithelium in vitro
    • 1:CAS:528:DyaK28Xkt12qu7Y%3D 10.1016/0168-3659(95)00187-5
    • Hoogstraate AJ, Senel S, Cullander C (1996) Effects of bile salts on transport rates and routes of FTIC-labelled compounds across porcine buccal epithelium in vitro. J Control Release 40:211-221
    • (1996) J Control Release , vol.40 , pp. 211-221
    • Hoogstraate, A.J.1    Senel, S.2    Cullander, C.3
  • 37
    • 59049097859 scopus 로고    scopus 로고
    • Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: In vitro and in vivo evaluations
    • 1:CAS:528:DC%2BD1MXhsFelt7s%3D 10.1016/j.jconrel.2008.10.016 19038299
    • Hu K, Li JW, Shen YH, Lu W, Gao XL, Zhang QZ, Jiang XG (2009) Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: in vitro and in vivo evaluations. J Control Release 134:55-61
    • (2009) J Control Release , vol.134 , pp. 55-61
    • Hu, K.1    Li, J.W.2    Shen, Y.H.3    Lu, W.4    Gao, X.L.5    Zhang, Q.Z.6    Jiang, X.G.7
  • 38
    • 0345712424 scopus 로고    scopus 로고
    • Effect of lactoferrin on oxidative stability of corn oil emulsions and liposomes
    • 1:CAS:528:DyaK1MXitFSgtr4%3D 10.1021/jf9809939 10563980
    • Huang SW, Satue-Gracia MT, Frankel EN, German JB (1999) Effect of lactoferrin on oxidative stability of corn oil emulsions and liposomes. J Agric Food Chem 47(4):1356-1361
    • (1999) J Agric Food Chem , vol.47 , Issue.4 , pp. 1356-1361
    • Huang, S.W.1    Satue-Gracia, M.T.2    Frankel, E.N.3    German, J.B.4
  • 39
    • 35548959221 scopus 로고    scopus 로고
    • The use of lactoferrin as a ligand for targeting the polyamidoamine based gene delivery system to the brain
    • 1:CAS:528:DC%2BD2sXht1Ghs7jO 10.1016/j.biomaterials.2007.09.024 17935779
    • Huang RQ, Ke WL, Liu Y, Jiang Y, Jiang C, Pei YY (2008) The use of lactoferrin as a ligand for targeting the polyamidoamine based gene delivery system to the brain. Biomaterials 29:238-246
    • (2008) Biomaterials , vol.29 , pp. 238-246
    • Huang, R.Q.1    Ke, W.L.2    Liu, Y.3    Jiang, Y.4    Jiang, C.5    Pei, Y.Y.6
  • 41
    • 76749159851 scopus 로고    scopus 로고
    • Lactoferrin modified nanoparticles could mediate efficient gene delivery to the brain in vivo
    • 1:CAS:528:DC%2BC3cXit1Kis7k%3D 10.1016/j.brainresbull.2009.12.008 20026388
    • Huang RQ, Ke WL, Han L, Liu Y, Shao K, Jiang C, Pei YY (2010) Lactoferrin modified nanoparticles could mediate efficient gene delivery to the brain in vivo. Brain Res Bull 81:600-604
    • (2010) Brain Res Bull , vol.81 , pp. 600-604
    • Huang, R.Q.1    Ke, W.L.2    Han, L.3    Liu, Y.4    Shao, K.5    Jiang, C.6    Pei, Y.Y.7
  • 42
    • 0031783879 scopus 로고    scopus 로고
    • Chitosan and its use as a pharmaceutical excipient
    • 10.1023/A:1011929016601
    • IIIum L (1998) Chitosan and its use as a pharmaceutical excipient. Pharm Res 15:1326-1331
    • (1998) Pharm Res , vol.15 , pp. 1326-1331
    • Iiium, L.1
  • 43
    • 24944547407 scopus 로고    scopus 로고
    • Liposomalization of lactoferrin enhanced it's anti-inflammatory effects via oral administration
    • 1:CAS:528:DC%2BD2MXhtFWjurvI 10.1248/bpb.28.1717 16141546
    • Ishikado A, Imanaka H, Tekeuchi T, Harada E, Makino T (2005) Liposomalization of lactoferrin enhanced it's anti-inflammatory effects via oral administration. Biol Pharm Bull 28:1717-1772
    • (2005) Biol Pharm Bull , vol.28 , pp. 1717-1772
    • Ishikado, A.1    Imanaka, H.2    Tekeuchi, T.3    Harada, E.4    Makino, T.5
  • 44
    • 77957999206 scopus 로고    scopus 로고
    • Human trial of liposomal lactoferrin supplementation for periodontal
    • 1:CAS:528:DC%2BC3cXhsFKms7fN 10.1248/bpb.33.1758 20930389
    • Ishikado A, Uesaki S, Suido H, Nomura Y, Sumikawa K (2010) Human trial of liposomal lactoferrin supplementation for periodontal. Biol Pharm Bull 33:1758-1762
    • (2010) Biol Pharm Bull , vol.33 , pp. 1758-1762
    • Ishikado, A.1    Uesaki, S.2    Suido, H.3    Nomura, Y.4    Sumikawa, K.5
  • 45
    • 0001618922 scopus 로고
    • Isolation of an iron containing red protein from human milk
    • 10.3891/acta.chem.scand.14-0510
    • Johansson BG (1960) Isolation of an iron containing red protein from human milk. Acta Chem Scand 14:510-512
    • (1960) Acta Chem Scand , vol.14 , pp. 510-512
    • Johansson, B.G.1
  • 46
    • 0345267307 scopus 로고    scopus 로고
    • Macromolecules as safe penetration enhancers for hydrophilic drugs - A fiction
    • 1:CAS:528:DC%2BD3cXptlWjsA%3D%3D 10.1016/S1461-5347(98)00100-X
    • Junginger HE, Verhoef JC (1998) Macromolecules as safe penetration enhancers for hydrophilic drugs - a fiction. Pharm Sci Tech Today 1:370-376
    • (1998) Pharm Sci Tech Today , vol.1 , pp. 370-376
    • Junginger, H.E.1    Verhoef, J.C.2
  • 47
    • 0033231125 scopus 로고    scopus 로고
    • Structure of buffalo lactoferrin at 2.5 Å resolution using crystals grown at 303 K shows different orientations of the N and C lobes
    • 1:STN:280:DC%2BD3c%2FgtlWgsg%3D%3D 10.1107/S0907444999010951 10531476
    • Karthikeyan S, Paramasivam M, Yadav S, Srinivasan A, Singh TP (1999) Structure of buffalo lactoferrin at 2.5 Å resolution using crystals grown at 303 K shows different orientations of the N and C lobes. Acta Crystallogr D Biol Crystallogr 55:1805-1813
    • (1999) Acta Crystallogr D Biol Crystallogr , vol.55 , pp. 1805-1813
    • Karthikeyan, S.1    Paramasivam, M.2    Yadav, S.3    Srinivasan, A.4    Singh, T.P.5
  • 48
    • 77954527187 scopus 로고    scopus 로고
    • Amino group PEGylation of bovine lactoferrin by linear polyethylene glycol-p-nitrophenyl active ester
    • 1:CAS:528:DC%2BC3cXhtFert7jL 10.1248/bpb.33.1253 20606324
    • Kato K, Tamaki N, Saito Y, Fujimoto T, Sato A (2010) Amino group PEGylation of bovine lactoferrin by linear polyethylene glycol-p-nitrophenyl active ester. Biol Pharm Bull 33(7):1253-1255
    • (2010) Biol Pharm Bull , vol.33 , Issue.7 , pp. 1253-1255
    • Kato, K.1    Tamaki, N.2    Saito, Y.3    Fujimoto, T.4    Sato, A.5
  • 49
    • 0035827177 scopus 로고    scopus 로고
    • Camel lactoferrin, a transferrin-cum-lactoferrin: Crystal structure of camel apolactoferrin at 2.6 Å resolution and structural basis of its dual role
    • 1:CAS:528:DC%2BD3MXkt1Shtb8%3D 10.1006/jmbi.2001.4692 11397094
    • Khan JA, Kumar P, Paramasivam M, Yadav RS, Sahani MS, Sharma S, Srinivasan A, Singh TP (2001) Camel lactoferrin, a transferrin-cum-lactoferrin: crystal structure of camel apolactoferrin at 2.6 Å resolution and structural basis of its dual role. J Mol Biol 309:751-761
    • (2001) J Mol Biol , vol.309 , pp. 751-761
    • Khan, J.A.1    Kumar, P.2    Paramasivam, M.3    Yadav, R.S.4    Sahani, M.S.5    Sharma, S.6    Srinivasan, A.7    Singh, T.P.8
  • 50
    • 0030006079 scopus 로고    scopus 로고
    • Oral administration of insulin as poly (vinyl alcohol)-gel spheres in diabetic rats
    • 1:STN:280:DyaK28zpt1Ojuw%3D%3D 10.1248/bpb.19.897 8799497
    • Kimura T, Sato K, Sugimoto K, Tao R, Murakami T, Kurosaki Y, Nakayama T (1996) Oral administration of insulin as poly (vinyl alcohol)-gel spheres in diabetic rats. Biol Pharm Bull 19:897-900
    • (1996) Biol Pharm Bull , vol.19 , pp. 897-900
    • Kimura, T.1    Sato, K.2    Sugimoto, K.3    Tao, R.4    Murakami, T.5    Kurosaki, Y.6    Nakayama, T.7
  • 51
    • 0026734363 scopus 로고
    • Development of a colonic release capsule dosage form and the absorption of insulin
    • 1:CAS:528:DyaK38XltlOmsbc%3D 1378164
    • Kraeling ME, Ritschel WA (1992) Development of a colonic release capsule dosage form and the absorption of insulin. Methods Find Exp Clin Pharmacol 14:199-209
    • (1992) Methods Find Exp Clin Pharmacol , vol.14 , pp. 199-209
    • Kraeling, M.E.1    Ritschel, W.A.2
  • 52
    • 0000812919 scopus 로고
    • Nanoparticles
    • J. Kreuter (eds) Marcel Dekker Inc. New York
    • Kreuter J (1994) Nanoparticles. In: Kreuter J (ed) Colloidal drug delivery systems. Marcel Dekker Inc., New York, pp 219-242
    • (1994) Colloidal Drug Delivery Systems , pp. 219-242
    • Kreuter, J.1
  • 53
    • 0034906217 scopus 로고    scopus 로고
    • Functional fragments of ingested lactoferrin are resistant to proteolytic degradation in the gastrointestinal tract of adult rats
    • 1:CAS:528:DC%2BD3MXlvFKksLY%3D 11481405
    • Kuwata H, Yamauchi K, Teraguchi S, Ushida Y, Shimokawa Y, Toida T, Hayasawa H (2001) Functional fragments of ingested lactoferrin are resistant to proteolytic degradation in the gastrointestinal tract of adult rats. J Nutr 131:2121-2127
    • (2001) J Nutr , vol.131 , pp. 2121-2127
    • Kuwata, H.1    Yamauchi, K.2    Teraguchi, S.3    Ushida, Y.4    Shimokawa, Y.5    Toida, T.6    Hayasawa, H.7
  • 54
    • 0028049233 scopus 로고
    • Metabolism and transport of the pentapeptide metkephamid by brush-border membrane vesicles of rat intestine
    • 1:CAS:528:DyaK2cXitVyqsLc%3D 10.1111/j.2042-7158.1994.tb03716.x 8201526
    • Langguth P, Bohner V, Biber J, Merkle HP (1994) Metabolism and transport of the pentapeptide metkephamid by brush-border membrane vesicles of rat intestine. J Pharm Pharmacol 46:34-40
    • (1994) J Pharm Pharmacol , vol.46 , pp. 34-40
    • Langguth, P.1    Bohner, V.2    Biber, J.3    Merkle, H.P.4
  • 55
    • 29244451820 scopus 로고    scopus 로고
    • In vitro evaluation of various buccal permeation enhancing systems for PACAP (pituitary adenylate cyclase-activating polypeptide)
    • 1:CAS:528:DC%2BD2MXhtlemtbjI 10.1007/s11095-005-7894-4 16132338
    • Langoth N, Bernkop-Scnhurch A, Kurka P (2005) In vitro evaluation of various buccal permeation enhancing systems for PACAP (pituitary adenylate cyclase-activating polypeptide). Pharm Res 22:2045-2050
    • (2005) Pharm Res , vol.22 , pp. 2045-2050
    • Langoth, N.1    Bernkop-Scnhurch, A.2    Kurka, P.3
  • 56
    • 0000888476 scopus 로고
    • Enzymatic barriers to peptide and protein drug delivery
    • V.H.L. Lee (eds) Marcel Dekker Inc. New York
    • Lee VHL, Traver RD, Taub ME (1991) Enzymatic barriers to peptide and protein drug delivery. In: Lee VHL (ed) Peptide and protein drug delivery. Marcel Dekker Inc., New York, pp 303-358
    • (1991) Peptide and Protein Drug Delivery , pp. 303-358
    • Lee, V.H.L.1    Traver, R.D.2    Taub, M.E.3
  • 57
    • 0141607610 scopus 로고    scopus 로고
    • Preparation and characterization of nanoparticles containing an antihypertensive agent
    • 10.1016/S0939-6411(98)00015-0
    • Leroueil-Le VM, Fluckiger L, Kim YI, Hoffman M, Maincent P (1998) Preparation and characterization of nanoparticles containing an antihypertensive agent. Eur J Pharm Biopharm 46:137-143
    • (1998) Eur J Pharm Biopharm , vol.46 , pp. 137-143
    • Leroueil-Le, V.M.1    Fluckiger, L.2    Kim, Y.I.3    Hoffman, M.4    Maincent, P.5
  • 58
    • 77954558976 scopus 로고    scopus 로고
    • Impact of interfacial composition on physical stability and in vitro lipase digestibility of triacylglycerol oil droplets coated with lactoferrin and/or caseinate
    • 10.1021/jf100703c 1:CAS:528:DC%2BC3cXmvF2rur4%3D
    • Lesme U, Baudot P, McClements DJ (2010) Impact of interfacial composition on physical stability and in vitro lipase digestibility of triacylglycerol oil droplets coated with lactoferrin and/or caseinate. J Agric Food Chem 58:7962-7969
    • (2010) J Agric Food Chem , vol.58 , pp. 7962-7969
    • Lesme, U.1    Baudot, P.2    McClements, D.J.3
  • 59
    • 10044223246 scopus 로고    scopus 로고
    • Solid lipid nanoparticles to improve oral bioavailability of poorly soluble drugs
    • 10.1211/0022357044959 1:CAS:528:DC%2BD2MXhsVSh
    • Lian DH, Xing T, Fu DC (2004) Solid lipid nanoparticles to improve oral bioavailability of poorly soluble drugs. J Pharm Pharmacol 56:1527-1535
    • (2004) J Pharm Pharmacol , vol.56 , pp. 1527-1535
    • Lian, D.H.1    Xing, T.2    Fu, D.C.3
  • 60
    • 0030453145 scopus 로고    scopus 로고
    • Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo
    • 10.1023/A:1016488623022
    • Lueben HL, De Leeuw BJ, Langemeyer MWE, De Boer AG, Verhoef JC, Junginger HE (1996) Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo. Pharm Res 13:1668-1672
    • (1996) Pharm Res , vol.13 , pp. 1668-1672
    • Lueben, H.L.1    De Leeuw, B.J.2    Langemeyer, M.W.E.3    De Boer, A.G.4    Verhoef, J.C.5    Junginger, H.E.6
  • 61
    • 0141997761 scopus 로고    scopus 로고
    • Emerging trends in oral delivery of peptide and protein drugs
    • 1:CAS:528:DC%2BD3sXovVaktbw%3D 10.1615/CritRevTherDrugCarrierSyst.v20. i23.30 14584523
    • Mahato RI, Narang AS, Thoma L (2003) Emerging trends in oral delivery of peptide and protein drugs. Crit Rev Ther Drug Carrier Syst 20:153-214
    • (2003) Crit Rev Ther Drug Carrier Syst , vol.20 , pp. 153-214
    • Mahato, R.I.1    Narang, A.S.2    Thoma, L.3
  • 62
    • 0029928231 scopus 로고    scopus 로고
    • Oral administration of recombinant human erythropoietin in liposomes in rats: Influence of lipid composition and size of liposomes on bioavailability
    • 1:CAS:528:DyaK28XhsFWktbw%3D 10.1021/js950477m 8901085
    • Maitani Y, Hazama M, Tojo Y, Shimoda N, Nagai T (1996) Oral administration of recombinant human erythropoietin in liposomes in rats: influence of lipid composition and size of liposomes on bioavailability. J Pharm Sci 85:440-445
    • (1996) J Pharm Sci , vol.85 , pp. 440-445
    • Maitani, Y.1    Hazama, M.2    Tojo, Y.3    Shimoda, N.4    Nagai, T.5
  • 63
    • 0032934171 scopus 로고    scopus 로고
    • Inhibition of poliovirus type 1 infection by iron-, manganese- and zinc-saturated lactoferrin
    • 1:CAS:528:DyaK1MXis1SnsL8%3D 10.1007/s004300050093 10363676
    • Marchetti M, Superti F, Ammendolia MG, Rossi P, Valenti P, Seganti L (1999) Inhibition of poliovirus type 1 infection by iron-, manganese- and zinc-saturated lactoferrin. Med Microbiol Immunol 187:199-204
    • (1999) Med Microbiol Immunol , vol.187 , pp. 199-204
    • Marchetti, M.1    Superti, F.2    Ammendolia, M.G.3    Rossi, P.4    Valenti, P.5    Seganti, L.6
  • 64
    • 84877936227 scopus 로고    scopus 로고
    • Purification and properties of human intestine alanine aminopeptidase
    • McClellan JB, Garner CW (1998) Purification and properties of human intestine alanine aminopeptidase. Biochim Biophys Acta 613:60-167
    • (1998) Biochim Biophys Acta , vol.613 , pp. 60-167
    • McClellan, J.B.1    Garner, C.W.2
  • 65
    • 0017289856 scopus 로고
    • Hypertrophy and hyperplasia of the neonatal rat exocrine pancreas induced by orally administered soybean trypsin inhibitor
    • 1:CAS:528:DyaE28XhtlSqsLY%3D 10.1016/0304-4165(76)90294-4 1252469
    • Melmed RN, El-Aaser AA, Holt SJ (1976) Hypertrophy and hyperplasia of the neonatal rat exocrine pancreas induced by orally administered soybean trypsin inhibitor. Biochim Biophys Acta 421(2):280-288
    • (1976) Biochim Biophys Acta , vol.421 , Issue.2 , pp. 280-288
    • Melmed, R.N.1    El-Aaser, A.A.2    Holt, S.J.3
  • 66
    • 0028025037 scopus 로고
    • Apical-to-basolateral transepithelial transport of human lactoferrin in the intestinal cell line HT-29cl.19A
    • Mikogami T, Heyman M, Spik G, Desjeux JF (1994) Apical-to-basolateral transepithelial transport of human lactoferrin in the intestinal cell line HT-29cl.19A. Am J Physiol 267:308-315
    • (1994) Am J Physiol , vol.267 , pp. 308-315
    • Mikogami, T.1    Heyman, M.2    Spik, G.3    Desjeux, J.F.4
  • 67
    • 0030719461 scopus 로고    scopus 로고
    • Three-dimensional structure of diferric bovine lactoferrin at 2.8 Å resolution
    • 1:CAS:528:DyaK2sXotVGitbo%3D 10.1006/jmbi.1997.1386
    • Moore SA, Anderson BF, Groom CR, Harides M, Baker EN (1997) Three-dimensional structure of diferric bovine lactoferrin at 2.8 Å resolution. J Mol Bio 274:222-236
    • (1997) J Mol Bio , vol.274 , pp. 222-236
    • Moore, S.A.1    Anderson, B.F.2    Groom, C.R.3    Harides, M.4    Baker, E.N.5
  • 68
    • 0029951359 scopus 로고    scopus 로고
    • Thymopentin in solid lipid nanoparticles
    • 1:CAS:528:DyaK28XjtFSkt7s%3D 10.1016/0378-5173(95)04388-8
    • Morel S, Ugazio E, Cavalli R, Gaosco MR (1996) Thymopentin in solid lipid nanoparticles. Int J Pharm 132:259-261
    • (1996) Int J Pharm , vol.132 , pp. 259-261
    • Morel, S.1    Ugazio, E.2    Cavalli, R.3    Gaosco, M.R.4
  • 69
    • 33744973517 scopus 로고    scopus 로고
    • Oral bioavailability of cyclosporine: Solid lipid nanoparticles (SLN®) versus drug nanocrystals
    • 1:CAS:528:DC%2BD28XlsFCltLo%3D 10.1016/j.ijpharm.2006.02.045 16580159
    • Muller RH, Runge S, Ravelli V, Mehnert W, Thunemannc AF, Souto EB (2006) Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN®) versus drug nanocrystals. Int J Pharm 317:82-89
    • (2006) Int J Pharm , vol.317 , pp. 82-89
    • Muller, R.H.1    Runge, S.2    Ravelli, V.3    Mehnert, W.4    Thunemannc, A.F.5    Souto, E.B.6
  • 70
    • 0035375756 scopus 로고    scopus 로고
    • Characterization of in vitro and in vivo antiviral activity of lactoferrin and ribavirin upon hantavirus
    • 1:CAS:528:DC%2BD3MXlt1Gmtbo%3D 10.1292/jvms.63.637 11459009
    • Murphy ME, Kariwa H, Mizutani T, Tanabe H, Yoshimatsu K, Arikawa J, Takashima I (2001) Characterization of in vitro and in vivo antiviral activity of lactoferrin and ribavirin upon hantavirus. J Vet Med Sci 63:637-645
    • (2001) J Vet Med Sci , vol.63 , pp. 637-645
    • Murphy, M.E.1    Kariwa, H.2    Mizutani, T.3    Tanabe, H.4    Yoshimatsu, K.5    Arikawa, J.6    Takashima, I.7
  • 72
    • 36148996510 scopus 로고    scopus 로고
    • Stable drug encapsulation in micelles and microemulsions
    • 1:CAS:528:DC%2BD2sXhtlWnt7vP 10.1016/j.ijpharm.2007.08.057 17945446
    • Narang AS, Delmarre D, Gao D (2007) Stable drug encapsulation in micelles and microemulsions. Int J Pharm 345:9-25
    • (2007) Int J Pharm , vol.345 , pp. 9-25
    • Narang, A.S.1    Delmarre, D.2    Gao, D.3
  • 73
    • 10644239010 scopus 로고    scopus 로고
    • Effects of lactoferrin, phytic acid, and EDTA on oxidation in two food emulsions enriched with long-chain polyunsaturated fatty acids
    • 1:CAS:528:DC%2BD2cXpvFWisrw%3D 10.1021/jf0492316 15675821
    • Nielsen NS, Petersen A, Meyer AS, Timm-Heinrich M, Jacobsen C (2004) Effects of lactoferrin, phytic acid, and EDTA on oxidation in two food emulsions enriched with long-chain polyunsaturated fatty acids. J Agric Food Chem 52(25):7690-7699
    • (2004) J Agric Food Chem , vol.52 , Issue.25 , pp. 7690-7699
    • Nielsen, N.S.1    Petersen, A.2    Meyer, A.S.3    Timm-Heinrich, M.4    Jacobsen, C.5
  • 74
    • 0020647074 scopus 로고
    • Adjuvant effects of glyceryl esters of acetoacetic acid on rectal absorption of insulin and inulin in rabbits
    • 1:CAS:528:DyaL3sXhvVGmsrs%3D 10.1002/jps.2600720318 6341538
    • Nishihata T, Kim S, Morishita S (1983) Adjuvant effects of glyceryl esters of acetoacetic acid on rectal absorption of insulin and inulin in rabbits. J Pharm Sci 72:280-285
    • (1983) J Pharm Sci , vol.72 , pp. 280-285
    • Nishihata, T.1    Kim, S.2    Morishita, S.3
  • 75
    • 52649101885 scopus 로고    scopus 로고
    • Physicochemical properties, pharmacokinetics, and pharmacodynamics of a reformulated microemulsion propofol in rats
    • 10.1097/ALN.0b013e318182a486 1:CAS:528:DC%2BD1cXhtVWnsbbE
    • Noh GJ, Lee EH, Lee SH, Park DY, Ki KH, Lee EK, Lee DH (2008) Physicochemical properties, pharmacokinetics, and pharmacodynamics of a reformulated microemulsion propofol in rats. Anaesthesiology 109:436-447
    • (2008) Anaesthesiology , vol.109 , pp. 436-447
    • Noh, G.J.1    Lee, E.H.2    Lee, S.H.3    Park, D.Y.4    Ki, K.H.5    Lee, E.K.6    Lee, D.H.7
  • 77
    • 68149163584 scopus 로고    scopus 로고
    • Lactoferrin conjugated with 40-kDA branched PEG has and improved circulating half-life
    • 1:CAS:528:DC%2BD1MXns1Cqsr0%3D 10.1007/s11095-009-9925-z 19554429
    • Nojima Y, Suzuki Y, Yoshida K, Abe F, Shiga T, Takeuchi T, Sugiyama A, Shimizu H, Sato A (2009) Lactoferrin conjugated with 40-kDA branched PEG has and improved circulating half-life. Pharm Res 26:2125-2132
    • (2009) Pharm Res , vol.26 , pp. 2125-2132
    • Nojima, Y.1    Suzuki, Y.2    Yoshida, K.3    Abe, F.4    Shiga, T.5    Takeuchi, T.6    Sugiyama, A.7    Shimizu, H.8    Sato, A.9
  • 78
    • 0032403463 scopus 로고    scopus 로고
    • The effect of physical barriers and properties on the oral absorption of particulates
    • 1:CAS:528:DyaK1cXnsFWltrY%3D 10.1016/S0169-409X(98)00037-4 10837675
    • Norris DA, Puri N, Sinko PJ (1998) The effect of physical barriers and properties on the oral absorption of particulates. Adv Drug Deliv Rev 34:135-154
    • (1998) Adv Drug Deliv Rev , vol.34 , pp. 135-154
    • Norris, D.A.1    Puri, N.2    Sinko, P.J.3
  • 79
    • 34447126911 scopus 로고    scopus 로고
    • Preparation and in vitro characteristics of lactoferrin loaded chitosan microparticles
    • 1:CAS:528:DC%2BD2sXnt1Sisbc%3D 10.1080/03639040601085334 17613028
    • Onishi H, Machida Y, Koyama K (2007) Preparation and in vitro characteristics of lactoferrin loaded chitosan microparticles. Drug Dev Ind Pharm 33:641-647
    • (2007) Drug Dev Ind Pharm , vol.33 , pp. 641-647
    • Onishi, H.1    Machida, Y.2    Koyama, K.3
  • 80
    • 73449147679 scopus 로고    scopus 로고
    • Preparation and in vitro evaluation of chitosan-coated alginate/calcium complex microparticles loaded with fluorescein-labeled lactoferrin
    • 10.1248/yakushi.129.1507 19952530
    • Onishi H, Koyama K, Sakata O, Machida Y (2009) Preparation and in vitro evaluation of chitosan-coated alginate/calcium complex microparticles loaded with fluorescein-labeled lactoferrin. Yakugaku Zasshi 129(12):1507-1514
    • (2009) Yakugaku Zasshi , vol.129 , Issue.12 , pp. 1507-1514
    • Onishi, H.1    Koyama, K.2    Sakata, O.3    Machida, Y.4
  • 81
    • 77954205192 scopus 로고    scopus 로고
    • Preparation of chitosan/alginate/calcium complex microparticles loaded with lactoferrin and their efficacy on carrageenan-induced edema in rats
    • 1:CAS:528:DC%2BC3cXotFemsrg%3D 10.3109/03639040903567109 20345284
    • Onishi H, Koyama K, Sakata O, Machida Y (2010) Preparation of chitosan/alginate/calcium complex microparticles loaded with lactoferrin and their efficacy on carrageenan-induced edema in rats. Drug Dev Ind Pharm 36(8):879-884
    • (2010) Drug Dev Ind Pharm , vol.36 , Issue.8 , pp. 879-884
    • Onishi, H.1    Koyama, K.2    Sakata, O.3    Machida, Y.4
  • 82
    • 37849008649 scopus 로고    scopus 로고
    • Novel preparation of enteric-coated chitosan-prednisolone conjugate microspheres and in vitro evaluation of their potential as a colonic delivery system
    • 1:CAS:528:DC%2BD1cXlsF2lsA%3D%3D 10.1016/j.ejpb.2007.06.016
    • Oosegi T, Onishi H, Machida Y (2008) Novel preparation of enteric-coated chitosan-prednisolone conjugate microspheres and in vitro evaluation of their potential as a colonic delivery system. Eur J Phram Biopharm 68(2):260-266
    • (2008) Eur J Phram Biopharm , vol.68 , Issue.2 , pp. 260-266
    • Oosegi, T.1    Onishi, H.2    Machida, Y.3
  • 84
    • 0037027876 scopus 로고    scopus 로고
    • Bioadhesive polysaccharide in protein delivery system: Chitosan nanoparticles improve the intestinal absorption of insulin in vivo
    • 1:CAS:528:DC%2BD38XosFagu78%3D 10.1016/S0378-5173(02)00486-6 12433442
    • Pan Y, Li YJ, Zhao HY (2002) Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm 249:139-147
    • (2002) Int J Pharm , vol.249 , pp. 139-147
    • Pan, Y.1    Li, Y.J.2    Zhao, H.Y.3
  • 85
    • 55749089970 scopus 로고    scopus 로고
    • Pharmaceutical cyclosporin formulation with improved biopharmaceutical properties, improved physical quality and greater stability, and method for producing said formulation
    • Penkler L, Muller RH, Runger SA, Ravelli V (1999) Pharmaceutical cyclosporin formulation with improved biopharmaceutical properties, improved physical quality and greater stability, and method for producing said formulation. PCT-application PCT/EP99/02892
    • (1999) PCT-application PCT/EP99/02892
    • Penkler, L.1    Muller, R.H.2    Runger, S.A.3    Ravelli, V.4
  • 86
    • 0025980055 scopus 로고
    • Molecular cloning and sequence analysis of bovine lactotransferrin
    • 1:CAS:528:DyaK3MXltVOntb8%3D 10.1111/j.1432-1033.1991.tb15801.x 2001696
    • Pierce A, Colavizza D, Benaissa M, Maes P, Tartar A, Montreuil J, Spik G (1991) Molecular cloning and sequence analysis of bovine lactotransferrin. Eur J Biochem 196:177-184
    • (1991) Eur J Biochem , vol.196 , pp. 177-184
    • Pierce, A.1    Colavizza, D.2    Benaissa, M.3    Maes, P.4    Tartar, A.5    Montreuil, J.6    Spik, G.7
  • 87
    • 0036175453 scopus 로고    scopus 로고
    • The potential of chitosan in enhancing peptide and protein absorption across TR146 cell culture model-an in vitro model of the buccal epithelium
    • 1:CAS:528:DC%2BD38XitVSlsr8%3D 10.1023/A:1014220832384 11883644
    • Portero A, Remunan-Lopez C, Nielsen HM (2002) The potential of chitosan in enhancing peptide and protein absorption across TR146 cell culture model-an in vitro model of the buccal epithelium. Pharm Res 19:169-174
    • (2002) Pharm Res , vol.19 , pp. 169-174
    • Portero, A.1    Remunan-Lopez, C.2    Nielsen, H.M.3
  • 88
    • 33645241398 scopus 로고    scopus 로고
    • Chitosan-PEG nanocapsules as new carriers for oral peptide delivery effect of chitosan pegylation degree
    • 1:CAS:528:DC%2BD28Xisl2lurc%3D 10.1016/j.jconrel.2005.12.015 16481062
    • Prego C, Torres D, Fernandez-Megia E, Novoa-Carballal R, Quinoa E, Alonso MJ (2006) Chitosan-PEG nanocapsules as new carriers for oral peptide delivery effect of chitosan pegylation degree. J Control Release 111:299-308
    • (2006) J Control Release , vol.111 , pp. 299-308
    • Prego, C.1    Torres, D.2    Fernandez-Megia, E.3    Novoa-Carballal, R.4    Quinoa, E.5    Alonso, M.J.6
  • 89
    • 0024262553 scopus 로고
    • The adjuvant effect of bacitracin on nasal absorption of gonadorelin and buserelin in rats
    • 1:CAS:528:DyaL1MXksVygsQ%3D%3D 10.1023/A:1015947509295 3150047
    • Raehs SC, Sandow J, Wirth K, Merkle HP (1988) The adjuvant effect of bacitracin on nasal absorption of gonadorelin and buserelin in rats. Pharm Res 5:689-693
    • (1988) Pharm Res , vol.5 , pp. 689-693
    • Raehs, S.C.1    Sandow, J.2    Wirth, K.3    Merkle, H.P.4
  • 90
    • 1642575957 scopus 로고    scopus 로고
    • Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
    • 1:CAS:528:DC%2BD2cXis1Wnsg%3D%3D 10.1042/BJ20031253 14505488
    • Rejman J, Oberle V, Zuhorn IS, Hoekstra D (2004) Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem J 377:159-169
    • (2004) Biochem J , vol.377 , pp. 159-169
    • Rejman, J.1    Oberle, V.2    Zuhorn, I.S.3    Hoekstra, D.4
  • 91
    • 0029968525 scopus 로고    scopus 로고
    • Proteinase inhibitors induce selective stimulation of human trypsin and chymotrypsin secretion
    • 1:CAS:528:DyaK28XhsVyksbg%3D
    • Reseland JE, Holm H, Jacobsen MB, Jenssen TG, Hanssen LE (1996) Proteinase inhibitors induce selective stimulation of human trypsin and chymotrypsin secretion. Hum Clin Nutr 126:634-642
    • (1996) Hum Clin Nutr , vol.126 , pp. 634-642
    • Reseland, J.E.1    Holm, H.2    Jacobsen, M.B.3    Jenssen, T.G.4    Hanssen, L.E.5
  • 92
    • 33746239950 scopus 로고    scopus 로고
    • Nanoparticle drug delivery to the brain
    • H.S. Nalwa (eds) 7 American Scientific Publishers Stevenson Ranch
    • Ringe K, Walz CM, Sabel BA (2004) Nanoparticle drug delivery to the brain. In: Nalwa HS (ed) Encyclopedia of nanoscience and nanotechnology, vol 7. American Scientific Publishers, Stevenson Ranch, pp 91-104
    • (2004) Encyclopedia of Nanoscience and Nanotechnology , pp. 91-104
    • Ringe, K.1    Walz, C.M.2    Sabel, B.A.3
  • 93
    • 0037124506 scopus 로고    scopus 로고
    • Chemistry for peptide and protein PEGylation
    • 1:CAS:528:DC%2BD38XktFKiu7g%3D 10.1016/S0169-409X(02)00022-4
    • Roberts MJ, Bentley MD, Harris JM (2002) Chemistry for peptide and protein PEGylation. Adv Drug Del Rev 54:459-476
    • (2002) Adv Drug Del Rev , vol.54 , pp. 459-476
    • Roberts, M.J.1    Bentley, M.D.2    Harris, J.M.3
  • 94
    • 77953281074 scopus 로고    scopus 로고
    • Liposomalization of lactoferrin enhanced its anti-tumoral effects on melanoma cells
    • 1:CAS:528:DC%2BC3cXlvFegtLo%3D 10.1007/s10534-010-9312-6 20191307
    • Roseanu A, Florian PE, Moisei M, Sima LE, Evans RW, Trif ML (2010) Liposomalization of lactoferrin enhanced its anti-tumoral effects on melanoma cells. Biometals 23:485-492
    • (2010) Biometals , vol.23 , pp. 485-492
    • Roseanu, A.1    Florian, P.E.2    Moisei, M.3    Sima, L.E.4    Evans, R.W.5    Trif, M.L.6
  • 95
    • 0035286685 scopus 로고    scopus 로고
    • The potential use of receptor-mediated endocytosis for oral drug delivery
    • 10.1016/S0169-409X(00)00127-7
    • Russel-Jones GJ (2001) The potential use of receptor-mediated endocytosis for oral drug delivery. Adv Drug Deliv Rev 46:59-73
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 59-73
    • Russel-Jones, G.J.1
  • 96
    • 0023728781 scopus 로고
    • Vasopressin: A model for the study of effects of additives on the oral and rectal administration of peptide drugs
    • 1:CAS:528:DyaL1cXktVSnu74%3D 10.1002/jps.2600770107 3346821
    • Saffran M, Bedra C, Kumar GS, Neckers DC (1988) Vasopressin: a model for the study of effects of additives on the oral and rectal administration of peptide drugs. J Pharm Sci 77:33-38
    • (1988) J Pharm Sci , vol.77 , pp. 33-38
    • Saffran, M.1    Bedra, C.2    Kumar, G.S.3    Neckers, D.C.4
  • 97
    • 0030895036 scopus 로고    scopus 로고
    • Oral peptide delivery using nanoparticles composed of novel graft copolymers having hydrophobic backbone and hydrophilic branches
    • 1:CAS:528:DyaK2sXjsVGjtbw%3D 10.1016/S0378-5173(96)04861-2
    • Sakuma S, Suzuki H, Kikuchi H, Hiwatari KI, Arikawa K, Kishida A, Akashi M (1997) Oral peptide delivery using nanoparticles composed of novel graft copolymers having hydrophobic backbone and hydrophilic branches. Int J Pharm 149:93-106
    • (1997) Int J Pharm , vol.149 , pp. 93-106
    • Sakuma, S.1    Suzuki, H.2    Kikuchi, H.3    Hiwatari, K.I.4    Arikawa, K.5    Kishida, A.6    Akashi, M.7
  • 98
    • 0023880568 scopus 로고
    • Identification and characterization of the human lactoferrin-binding protein from Neisseria meningitidis
    • 1:CAS:528:DyaL1cXksFSgtbs%3D 3128478
    • Schryvers AB, Morris LJ (1988) Identification and characterization of the human lactoferrin-binding protein from Neisseria meningitidis. Infect Immun 56:1144-1149
    • (1988) Infect Immun , vol.56 , pp. 1144-1149
    • Schryvers, A.B.1    Morris, L.J.2
  • 99
    • 33746872198 scopus 로고    scopus 로고
    • Novel delivery technologies for protein and peptide therapeutic
    • 10.2174/138920106777950852
    • Shantha Kuma TR, Soppomath K, Nachaegari SK (2006) Novel delivery technologies for protein and peptide therapeutic. Curr Pharm Biotechnol 7:261-276
    • (2006) Curr Pharm Biotechnol , vol.7 , pp. 261-276
    • Shantha Kuma, T.R.1    Soppomath, K.2    Nachaegari, S.K.3
  • 100
    • 0031713492 scopus 로고    scopus 로고
    • Structures of buffalo and mare lactoferrins. Similarities, differences, and flexibility
    • 1:CAS:528:DyaK1cXnvFOhtr8%3D 9781338
    • Sharma AK, Karthikeyan S, Sharma S, Yadav S, Srinivasan A, Singh TP (1998) Structures of buffalo and mare lactoferrins. Similarities, differences, and flexibility. Adv Exp Med Biol 443:15-21
    • (1998) Adv Exp Med Biol , vol.443 , pp. 15-21
    • Sharma, A.K.1    Karthikeyan, S.2    Sharma, S.3    Yadav, S.4    Srinivasan, A.5    Singh, T.P.6
  • 101
    • 0033369169 scopus 로고    scopus 로고
    • The role of sorption promoters in increasing the bioavailability of drugs in oral preparations
    • 1:CAS:528:DC%2BD3cXps1yisA%3D%3D 10.1358/dof.1999.024.11.858633
    • Sharma P, Chawla HPS, Panchagnula R (1999) The role of sorption promoters in increasing the bioavailability of drugs in oral preparations. Drugs Future 24:1221-1240
    • (1999) Drugs Future , vol.24 , pp. 1221-1240
    • Sharma, P.1    Chawla, H.P.S.2    Panchagnula, R.3
  • 102
    • 33646357039 scopus 로고    scopus 로고
    • Utilization of lactoferrin as an iron-stabilizer for soybean and fish oil
    • 1:CAS:528:DC%2BD28Xkt1GgsLs%3D 10.1111/j.1365-2621.2006.tb15606.x
    • Shiota M, Uchida T, Oda T, Kawakami H (2006) Utilization of lactoferrin as an iron-stabilizer for soybean and fish oil. J Food Sci 71(3):C120-C123
    • (2006) J Food Sci , vol.71 , Issue.3
    • Shiota, M.1    Uchida, T.2    Oda, T.3    Kawakami, H.4
  • 103
    • 0022179911 scopus 로고
    • Effects of surfactants on the permeability of canine oral mucosa in vitro
    • 1:CAS:528:DyaL2MXlvV2ktbg%3D 10.1016/0378-4274(85)90160-2 4035708
    • Siegel IA, Gordon HP (1985) Effects of surfactants on the permeability of canine oral mucosa in vitro. Toxicol Lett 26:153-158
    • (1985) Toxicol Lett , vol.26 , pp. 153-158
    • Siegel, I.A.1    Gordon, H.P.2
  • 105
    • 0025063122 scopus 로고
    • Insulin administration via liposomes
    • 1:STN:280:DyaK3M%2FjtV2jtA%3D%3D 10.2337/diacare.13.9.911 2226109
    • Spangler RS (1990) Insulin administration via liposomes. Diabetes Care 13:911-922
    • (1990) Diabetes Care , vol.13 , pp. 911-922
    • Spangler, R.S.1
  • 106
    • 33846822906 scopus 로고    scopus 로고
    • Microemulsions as carriers for drugs and nutraceuticals
    • 10.1016/j.cis.2006.11.016 17229398 1:CAS:528:DC%2BD2sXhsFCrs7Y%3D
    • Spernath A, Aserin A (2006) Microemulsions as carriers for drugs and nutraceuticals. Adv Colloid Interface Sci 128:47-64
    • (2006) Adv Colloid Interface Sci , vol.128 , pp. 47-64
    • Spernath, A.1    Aserin, A.2
  • 107
    • 33746468534 scopus 로고    scopus 로고
    • Buccal bioadhesive drug delivery - A promising option for orally less efficient drug
    • 1:CAS:528:DC%2BD28XnsFCrtrw%3D 10.1016/j.jconrel.2006.04.012 16828915
    • Sudhakar Y, Kuotsu K, Bandyopadhyay AK (2006) Buccal bioadhesive drug delivery - a promising option for orally less efficient drug. J Control Release 114:15-40
    • (2006) J Control Release , vol.114 , pp. 15-40
    • Sudhakar, Y.1    Kuotsu, K.2    Bandyopadhyay, A.K.3
  • 108
    • 67349275438 scopus 로고    scopus 로고
    • PEGylated lactoferrin enhanced its hepatoprotective effects on acute liver injury induced by carbon tetrachloride in rats
    • 1:CAS:528:DC%2BD1MXntVKmtL8%3D 10.1016/j.fct.2009.03.030 19341777
    • Sugiyama A, Sato A, Takeuchi T (2009) PEGylated lactoferrin enhanced its hepatoprotective effects on acute liver injury induced by carbon tetrachloride in rats. Food Chem Toxicol 47(7):1453-1456
    • (2009) Food Chem Toxicol , vol.47 , Issue.7 , pp. 1453-1456
    • Sugiyama, A.1    Sato, A.2    Takeuchi, T.3
  • 111
    • 0027986535 scopus 로고
    • Mucoadhesion of polymer-coated liposomes to rat intestine in vitro
    • 1:CAS:528:DyaK2MXktlOgsL8%3D 10.1248/cpb.42.1954 7954945
    • Takeuchi H, Yamamoto H, Niwa T, Hino T, Kawashima Y (1994) Mucoadhesion of polymer-coated liposomes to rat intestine in vitro. Chem Pharm Bull 42:1954-1956
    • (1994) Chem Pharm Bull , vol.42 , pp. 1954-1956
    • Takeuchi, H.1    Yamamoto, H.2    Niwa, T.3    Hino, T.4    Kawashima, Y.5
  • 112
    • 0029895328 scopus 로고    scopus 로고
    • Enteral absorption of insulin in rats
    • 1:CAS:528:DyaK28Xjs1yrt7s%3D 10.1023/A:1016009313548 8792429
    • Takeuchi H, Yamamoto H, Niwa T, Hino T, Kawashima Y (1996) Enteral absorption of insulin in rats. Pharm Res 13:896-901
    • (1996) Pharm Res , vol.13 , pp. 896-901
    • Takeuchi, H.1    Yamamoto, H.2    Niwa, T.3    Hino, T.4    Kawashima, Y.5
  • 113
    • 0037449495 scopus 로고    scopus 로고
    • Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats
    • 1:CAS:528:DC%2BD3sXms1ek 10.1016/S0168-3659(02)00411-X 12526820
    • Takeuchi H, Matsui Y, Yamamoto H, Kawashima Y (2003) Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats. J Control Release 86:235-242
    • (2003) J Control Release , vol.86 , pp. 235-242
    • Takeuchi, H.1    Matsui, Y.2    Yamamoto, H.3    Kawashima, Y.4
  • 114
    • 3342947834 scopus 로고    scopus 로고
    • Protection against infection by oral lactoferrin: Evaluation in animal model
    • 1:CAS:528:DC%2BD2cXjvFaru70%3D 10.1023/B:BIOM.0000027697.83706.32
    • Teraguchi S, Wakabayashi H, Kuwata H, Yamauchi K, Tamura Y (2004) Protection against infection by oral lactoferrin: evaluation in animal model. Bometals 17:231-234
    • (2004) Bometals , vol.17 , pp. 231-234
    • Teraguchi, S.1    Wakabayashi, H.2    Kuwata, H.3    Yamauchi, K.4    Tamura, Y.5
  • 115
    • 0033818771 scopus 로고    scopus 로고
    • Intestinal absorption of octreotide: N-trimethyl chitosan healing of chloride (TMC) ameliorates the permeability and absorption properties of the somatostatin analogue in vitro and in vivo
    • 1:CAS:528:DC%2BD3cXlt1ahurY%3D 10.1002/1520-6017(200007)89:7<951: AID-JPS13>3.0.CO;2-1 10861597
    • Thanou M, Verhoef JC, Marbach P, Junginger HE (2000) Intestinal absorption of octreotide: N-trimethyl chitosan healing of chloride (TMC) ameliorates the permeability and absorption properties of the somatostatin analogue in vitro and in vivo. J Pharm Sci 89:951-957
    • (2000) J Pharm Sci , vol.89 , pp. 951-957
    • Thanou, M.1    Verhoef, J.C.2    Marbach, P.3    Junginger, H.E.4
  • 116
    • 38349112036 scopus 로고    scopus 로고
    • Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin-liposome nanocomplexes
    • 1:CAS:528:DC%2BD1cXhtVGjtLk%3D 10.1016/j.jconrel.2007.10.023 18082282
    • Thirawong N, Thongborisute J, Takeuchi H, Sriamornsak P (2008) Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin-liposome nanocomplexes. J Control Release 125:236-245
    • (2008) J Control Release , vol.125 , pp. 236-245
    • Thirawong, N.1    Thongborisute, J.2    Takeuchi, H.3    Sriamornsak, P.4
  • 117
    • 0036191042 scopus 로고    scopus 로고
    • Bovine lactoferrin and lactoferricin derived from milk: Production and application
    • 1:CAS:528:DC%2BD38XitlCnsbY%3D 10.1139/o01-230 11908633
    • Tomita M, Wakabayashi H, Yamauchi K, Teraguchi S, Hayasawa H (2002) Bovine lactoferrin and lactoferricin derived from milk: production and application. Biochem Cell Biol 80:109-112
    • (2002) Biochem Cell Biol , vol.80 , pp. 109-112
    • Tomita, M.1    Wakabayashi, H.2    Yamauchi, K.3    Teraguchi, S.4    Hayasawa, H.5
  • 118
    • 58149127827 scopus 로고    scopus 로고
    • Twenty-five years of research on bovine lactoferrin application
    • 1:CAS:528:DC%2BD1MXktF2gtg%3D%3D 10.1016/j.biochi.2008.05.021 18585434
    • Tomita M, Wakabayashi H, Shin K, Yamauchi K, Yaeshima T, Iwatsuki K (2009) Twenty-five years of research on bovine lactoferrin application. Biochimie 91:52-57
    • (2009) Biochimie , vol.91 , pp. 52-57
    • Tomita, M.1    Wakabayashi, H.2    Shin, K.3    Yamauchi, K.4    Yaeshima, T.5    Iwatsuki, K.6
  • 119
    • 0036714306 scopus 로고    scopus 로고
    • Orally ingested human lactoferrin is digested and secreted in the upper gastrointestinal tract in vivo in women with ileostomies
    • 1:CAS:528:DC%2BD38XntFOgs74%3D 12221215
    • Troost FJ, Saris WHM, Brummer RJM (2002) Orally ingested human lactoferrin is digested and secreted in the upper gastrointestinal tract in vivo in women with ileostomies. J Nutr 132:2597-2600
    • (2002) J Nutr , vol.132 , pp. 2597-2600
    • Troost, F.J.1    Saris, W.H.M.2    Brummer, R.J.M.3
  • 120
    • 0028998542 scopus 로고
    • Absorption of cyclosporin from conventional and new microemulsion oral formulations in liver transplant recipients with external biliary diversion
    • 1:STN:280:DyaK2MzotlSkuw%3D%3D 10.1111/j.1365-2125.1995.tb05722.x 7654480
    • Trull AK, Tan KK, Tan L, Alexander GJ, Jamieson NV (1995) Absorption of cyclosporin from conventional and new microemulsion oral formulations in liver transplant recipients with external biliary diversion. Br J Clin Pharmacol 39:627-631
    • (1995) Br J Clin Pharmacol , vol.39 , pp. 627-631
    • Trull, A.K.1    Tan, K.K.2    Tan, L.3    Alexander, G.J.4    Jamieson, N.V.5
  • 121
    • 4644298832 scopus 로고    scopus 로고
    • Prolong the action of protein and peptide drug by a novel approach of reversible polyethylene glycol modification
    • 1:CAS:528:DC%2BD2cXnt1OqsLo%3D 10.1074/jbc.M405155200 15190059
    • Tsubery H, Mironchik M, Fridkin M, Shechter Y (2004) Prolong the action of protein and peptide drug by a novel approach of reversible polyethylene glycol modification. J Biol Chem 279:38118-38124
    • (2004) J Biol Chem , vol.279 , pp. 38118-38124
    • Tsubery, H.1    Mironchik, M.2    Fridkin, M.3    Shechter, Y.4
  • 122
    • 0036188351 scopus 로고    scopus 로고
    • Cancer prevention by bovine lactoferrin and underlying mechanisms-A review of experimental and clinical studies
    • 1:CAS:528:DC%2BD38XitlCntrw%3D 10.1139/o01-239 11908637
    • Tsuda H, Sekine K, Fujita K, Iigo M (2002) Cancer prevention by bovine lactoferrin and underlying mechanisms-a review of experimental and clinical studies. Biochem Cell Biol 80:131-136
    • (2002) Biochem Cell Biol , vol.80 , pp. 131-136
    • Tsuda, H.1    Sekine, K.2    Fujita, K.3    Iigo, M.4
  • 123
    • 0026511843 scopus 로고
    • Effect of organic acids, trypsin inhibitors and dietary protein on the pharmacological activity of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats
    • 1:CAS:528:DyaK38XktVWksbc%3D 10.1016/0378-5173(92)90005-M
    • Ushirogawa Y, Nakahigashi Y, Kiriyama A, Takada K (1992) Effect of organic acids, trypsin inhibitors and dietary protein on the pharmacological activity of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats. Int J Pharm 81:133-141
    • (1992) Int J Pharm , vol.81 , pp. 133-141
    • Ushirogawa, Y.1    Nakahigashi, Y.2    Kiriyama, A.3    Takada, K.4
  • 124
    • 0031800880 scopus 로고    scopus 로고
    • Nitric oxide donors enhance rectal absorption of macromolecules in rabbits
    • 1:CAS:528:DyaK1cXjvFWlsbc%3D 10.1023/A:1011920530771 9647352
    • Utoguchi N, Watanabe Y, Shida T, Matsumoto M (1998) Nitric oxide donors enhance rectal absorption of macromolecules in rabbits. Pharm Res 15:870-876
    • (1998) Pharm Res , vol.15 , pp. 870-876
    • Utoguchi, N.1    Watanabe, Y.2    Shida, T.3    Matsumoto, M.4
  • 125
    • 34247098941 scopus 로고    scopus 로고
    • Antibiotic properties and application of lactoferrin
    • 1:CAS:528:DC%2BD2sXlsVagt7w%3D 10.2174/138161207780363095
    • Weinberg ED (2007) Antibiotic properties and application of lactoferrin. Curr Pharma Des 13:801-811
    • (2007) Curr Pharma des , vol.13 , pp. 801-811
    • Weinberg, E.D.1
  • 126
    • 0027988721 scopus 로고
    • Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats
    • 1:CAS:528:DyaK2MXivFalurk%3D 10.1023/A:1018968611962 7855059
    • Yamamoto A, Taniguchi T, Rikyuu K, Tsuji T, Fujita T, Murakami M, Muranishi S (1994) Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. Pharm Res 11:1496-1500
    • (1994) Pharm Res , vol.11 , pp. 1496-1500
    • Yamamoto, A.1    Taniguchi, T.2    Rikyuu, K.3    Tsuji, T.4    Fujita, T.5    Murakami, M.6    Muranishi, S.7
  • 127
    • 77955130666 scopus 로고    scopus 로고
    • Inhibitory effects of orally administrated liposomal bovine lactoferrin on the LPS-induced osteoclastogenesis
    • 1:CAS:528:DC%2BC3cXptl2jt74%3D 10.1038/labinvest.2010.80 20421871
    • Yamano E, Miyauchi M, Furusya H, Kawazoe A, Ishikado A, Makino T, Tanne K, Tanaka E, Takata T (2010) Inhibitory effects of orally administrated liposomal bovine lactoferrin on the LPS-induced osteoclastogenesis. Lab Invest 90:1236-1246
    • (2010) Lab Invest , vol.90 , pp. 1236-1246
    • Yamano, E.1    Miyauchi, M.2    Furusya, H.3    Kawazoe, A.4    Ishikado, A.5    Makino, T.6    Tanne, K.7    Tanaka, E.8    Takata, T.9
  • 128
    • 0021867176 scopus 로고
    • Characterization of enhanced intestinal permeability; Electrophysiological study on the effects of diclofenac and ethylenediamine tetraacetic acid
    • 1:CAS:528:DyaL2MXltV2rtLs%3D 10.1111/j.2042-7158.1985.tb03056.x 2863363
    • Yamashita S, Saitoh H, Nakanishi K (1985) Characterization of enhanced intestinal permeability; electrophysiological study on the effects of diclofenac and ethylenediamine tetraacetic acid. J Pharm Pharmacol 37:512-513
    • (1985) J Pharm Pharmacol , vol.37 , pp. 512-513
    • Yamashita, S.1    Saitoh, H.2    Nakanishi, K.3
  • 129
    • 37349028262 scopus 로고    scopus 로고
    • Linker-based lecithin microemulsions for transdermal delivery of lidocaine
    • 1:CAS:528:DC%2BD1cXhtFCisA%3D%3D 10.1016/j.ijpharm.2007.07.047 17904775
    • Yuan JS, Ansari M, Samaan M (2008) Linker-based lecithin microemulsions for transdermal delivery of lidocaine. Int J Pharm 349(1-2):130-143
    • (2008) Int J Pharm , vol.349 , Issue.1-2 , pp. 130-143
    • Yuan, J.S.1    Ansari, M.2    Samaan, M.3
  • 130
    • 67349112399 scopus 로고    scopus 로고
    • Nanoparticulate systems for growth factor delivery
    • 1:CAS:528:DC%2BD1MXltlylsb4%3D 10.1007/s11095-009-9897-z 19415467
    • Zhang S, Uludag H (2009) Nanoparticulate systems for growth factor delivery. Pharm Res 26:1561-1580
    • (2009) Pharm Res , vol.26 , pp. 1561-1580
    • Zhang, S.1    Uludag, H.2
  • 131
    • 33750501785 scopus 로고    scopus 로고
    • Lectin modified solid lipid nanoparticles as carriers for oral administration of insulin
    • 1:CAS:528:DC%2BD28XhtFKhsb7M 10.1016/j.ijpharm.2006.07.026 16935443
    • Zhang N, Ping Q, Huang G, Xu W, Cheng Y, Han X (2006) Lectin modified solid lipid nanoparticles as carriers for oral administration of insulin. Int J Pharm 327:153-159
    • (2006) Int J Pharm , vol.327 , pp. 153-159
    • Zhang, N.1    Ping, Q.2    Huang, G.3    Xu, W.4    Cheng, Y.5    Han, X.6


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