Prolonging the action of protein and peptide drugs by a novel approach of reversible polyethylene glycol modification

Journal of Biological Chemistry

Volumn 279, Issue 37, 2004, Pages 38118-38124

  Tsubery, Haim ^a   Mironchik, Marina ^a   Fridkin, Mati ^a   Shechter, Yoram ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL LABORATORIES; DRUG PRODUCTS; GROWTH KINETICS; HYDROLYSIS; MOLECULAR STRUCTURE; PROTEINS; SYNTHESIS (CHEMICAL);

HUMAN GROWTH HORMONES; PEPTIDES; PHARMACOLOGICAL FEATURES; PROTEIN CONJUGATES;

POLYETHYLENE GLYCOLS;

9 FLUORENYLMETHYL CHLOROFORMATE; ALPHA LACTALBUMIN; EXENDIN 4; GLUCOSE; HUMAN GROWTH HORMONE; MACROGOL; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; SYNTHESIS; THIN LAYER CHROMATOGRAPHY;

ANHYDRIDES; ANIMALS; BLOOD GLUCOSE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; FLUORENES; GLUCOSE; HUMAN GROWTH HORMONE; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MALEIMIDES; MICE; MODELS, CHEMICAL; PEPTIDES; POLYETHYLENE GLYCOLS; PROPIONATES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROPHOTOMETRY; SUCCINIMIDES; TEMPERATURE; TIME FACTORS; ULTRAVIOLET RAYS; VENOMS;

ANIMALIA;

EID: 4644298832     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M405155200     Document Type: Article

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