In vitro evaluation of various buccal permeation enhancing systems for PACAP (pituitary adenylate cyclase-activating polypeptide)

Pharmaceutical Research

Volumn 22, Issue 12, 2005, Pages 2045-2050

  Langoth, Nina ^a   Bernkop Schnürch, Andreas ^b   Kurka, Peter ^c  

^a Thiomatrix Forschungs und Beratungs GmbH   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c BAYER AG   (Germany)

Author keywords

Buccal drug delivery; Chitosan TBA conjugate; Glutathione; PACAP; Permeation enhancement; Thiolated polymers

Indexed keywords

AMIDINE; BUFFER; CETRIMIDE; CHITOSAN; CHITOSAN 4 THIOBUTYLAMIDINE; DEOXYCHOLATE SODIUM; GLUTATHIONE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; PENETRATION ENHANCING AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BUCCAL DRUG ADMINISTRATION; CHEEK MUCOSA; CONTROLLED STUDY; DRUG CONJUGATION; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALS; CETRIMONIUM COMPOUNDS; CHITIN; CHITOSAN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYCHOLIC ACID; DIFFUSION CHAMBERS, CULTURE; EXCIPIENTS; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; MOLECULAR WEIGHT; MOUTH MUCOSA; PERMEABILITY; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; STIMULATION, CHEMICAL; SWINE;

EID: 29244451820     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-7894-4     Document Type: Article

References (26)

1. M. K. Gutniak H. Larsson S. W. Sanders O. Juneskans J. J. Holst B. Ahren 1997 GLP-1 tablet in type 2 diabetes in fasting and postprandial conditions Diabetes Care 20 1874 1879
2. A. D. Harrower 2000 Comparative tolerability of sulphonylureas in diabetes mellitus Drug Saf. 22 313 320
3. A. T. Calabrese K. C. Coley S. V. DaPos D. Swanson R. H. Rao 2002 Evaluation of prescribing practices: risk of lactic acidosis with metformin therapy Arch. Intern. Med. 162 434 437
4. C. Rosak 2002 The pathophysiologic basis of efficacy and clinical experience with the new oral antidiabetic agents J. Diabetes Complications 16 123 132
5. T. Yada M. Nakata S. Shioda 2000 Insulinotropin PACAP potentiates insulin action. Stimulation of glucose uptake in 3T3-LI adipocytes Ann. N. Y. Acad. Sci. 921 473 477
6. M. Tsutsumi T. H. Claus Y. Liang Y. Li L. Yang J. Zhu F. Dela Cruz X. Peng H. Chen S. L. Yung S. Hamren J. N. Livingston C. Q. Pan 2002 A potent and highly selective VPAC2 agonist enhances glucose-induced insulin release and glucose disposal: a potential therapy for type 2 diabetes Diabetes 51 1453 1460
7. K. Filipsson K. Tornoe J. Holst B. Ahren 1997 Pituitary adenylate cyclase-activating polypeptide stimulates insulin and glucagon secretion in humans J. Clin. Endocrinol. Metab. 82 3093 3098
8. Q. Xiao J. Giguere M. Parisien W. Jeng S. A. St-Pierre P. L. Brubaker M. B. Wheeler 2001 Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo Biochemistry 40 2860 2869
9. M. Lee C. G. Wilson F. Kooshab L. Tetleyc A. I. Graya S. Senel I. F. Uchegbu 2002 The release of model macromolecules may be controlled by the hydrophobicity of palmitoyl glycol chitosan hydrogels J. Control. Release 80 87 100
10. S. Senel A. A. Hincal 2001 Drug permeation enhancement via buccal route: possibilities and limitations J. Control. Release 72 133 144
11. I. A. Siegel H. P. Gordon 1985 Effects of surfactants on the permeability of canine oral mucosa in vitro Toxicol. Lett. 26 153 158
12. I. A. Siegel H. P. Gordon 1986 Surfactant-induced alterations of permeability of rabbit oral mucosa in vitro Exp. Mol. Pathol. 44 132 137
13. S. Senel Y. Capan M. F. Sargon C. B. Giray A. A. Hinca 1998 Histological and bioadhesion studies on buccal bioadhesive tablets containing a penetration enhancer sodium glycodeoxycholate Int. J. Pharm. 170 239 245
14. S. Senel A. J. Hoogstraate F. Spies J. C. Verhoef A. Bos-van Geest H. E. Junginger H. E. Bodde 1994 Enhancement of in vitro permeability of porcine buccal mucosa by bile salts: kinetic and histological studies J. Control. Release 32 45 56
15. S. Senel M. Kremer S. Kas P. W. Wertz A. A. Hincal C. A. Squier 2000 Enhancing effect of chitosan on peptide drug delivery across buccal mucosa Biomaterials 21 2067 2071
16. A. K. Singla M. Chawala 2001 Chitosan: some pharmaceutical and biological aspects-an update J. Pharm. Pharmacol. 53 1047 1067
17. A. Bernkop-Schnürch M. Hornof T. Zoidl 2003 Thiolated polymers-thiomers: modification of chitosan with 2-iminothiolane Int. J. Pharm. 260 229 237
18. A. E. Clausen C. E. Kast A. Bernkop-Schnürch 2002 The role of glutathione in the permeation enhancing effect of thiolated polymers Pharm. Res. 19 602 608
19. P. W. Wertz C. A. Squier 1991 Cellular and molecular basis of barrier function in oral epithelium Crit. Rev. Ther. Drug Carrier Syst. 8 237 269
20. Y. Iiboshi R. Nezu L. Cui K. Chen J. Khan H. Yoshida K. Sando S. Kamata Y. Takagi A. Okada 1996 Adhesive mucous gel layer and mucus release as intestinal barrier in rats J. Parenter. Enteral Nutr. 20 98 104
21. S. Senel Y. Capan M. F. Sargon G. Ikinci D. Solpan O. Güven H. E. Bodde A. A. Hincal 1997 Enhancement of transbuccal permeation of morphine sulfate by sodium glycodeoxycholate in vitro J. Control. Release 45 153 162
22. H. J. Schramm T. Duelffer 1977 Synthesis and application of cleavable and hydrophilic crosslinking reagents Adv. Exp. Med. Biol. 86A 197 206
23. G. Ranaldi I. Marigliano I. Vespignani G. Perozzi Y. Sambuy 2002 The effect of chitosan and other polycations on tight junction permeability in the human intestinal Caco-2 cell line(1) J. Nutr. Biochem. 13 157 167
24. N. Langoth A. Bernkop-Schnürch J. Kalbe 2005 Development of a mucoadhesive and permeation enhancing buccal delivery system for PACAP (pituitary adenylate cyclase-activating polypeptide) Int. J. Pharm. 296 103 111
25. H. E. Junginger J. A. Hoogstraate J. C. Verhoef 1999 Recent advances in buccal drug delivery and absorption-in vitro and in vivo studies J. Control. Release 62 149 159
26. N. Langoth, A. Bernkop-Schürch, and P. Kurka. Glutathione as inhibitor of the enzymatic degradation of peptides on the buccal mucosa J. Drug Del. Sci. Technol. Submitted for publication (2005).