Protection against infections by oral lactoferrin: Evaluation in animal models

BioMetals

Volumn 17, Issue 3, 2004, Pages 231-234

  Teraguchi, Susumu ^a   Wakabayashi, Hiroyuki ^a   Kuwata, Hidefumi ^a   Yamauchi, Koji ^a   Tamura, Yoshitaka ^a  

^a MORINAGA MILK INDUSTRY CO LTD   (Japan)

Author keywords

Host protection; Immunity; Infection; Lactoferrin; Transport

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18 BINDING PROTEIN; LACTOFERRIN; TUMOR NECROSIS FACTOR ALPHA;

BODY FLUID; CELL COUNT; CELL PROTECTION; COLITIS; CYTOKINE PRODUCTION; HOST RESISTANCE; HUMAN; IMMUNITY; INTESTINE ABSORPTION; INTESTINE MUCOSA; LEUKOCYTE; MACROPHAGE; NONHUMAN; PROTEIN TRANSPORT; REVIEW; SWINE;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFECTIVE AGENTS; HUMANS; INTESTINAL ABSORPTION; LACTOFERRIN;

ANIMALIA; BOVINAE; SUS SCROFA;

EID: 3342947834     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:BIOM.0000027697.83706.32     Document Type: Review

References (16)

1. Bhimani RS, Vendrov Y, Furmanski P. 1999 Influence of lactoferrin feeding and injection against systemic staphylococcal infections in mice. J Appl Microbiol 86, 135-144.
2. Harada E, Itoh Y, Sitizyo K, Takeuchi T, Araki Y, Kitagawa H. 1999 Characteristic transport of lactoferrin from the intestinal lumen into the bile via the blood in piglets. Comp Biochem Phys A 124, 321-327.
3. Hutchens TW, Henry JF, Yip T-T. 1991a Structurally intact (78-kDa) forms of maternal lactoferrin purified from urine of preterm infants fed human milk: Identification of a trypsin-like proteolytic cleavage event in vivo that does not result in fragment dissociation. Proc Natl Acad Sci USA 88, 2994-2998.
4. Hutchens TW, Henry JF, Yip T-T, Hachey DL, Schanler RJ, Motil KJ, Garza C. 1991b Origin of intact lactoferrin and its DNA-binding fragments found in the urine of human milk-fed preterm infants. Evaluation by stable isotopic enrichment. Pediatr Res 29, 243-250.
5. Kuhara T, Iigo M, Itoh T, Ushida Y, Sekine K, Terada N, Okamura H, Tsuda H. 2000 Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium. Nutr Cancer 38, 192-199.
6. Takakura N, Wakabayashi H, Ishibashi H, Teraguchi S, Tamura Y, Yamaguchi H, Abe S. 2003 Oral lactoferrin treatment of experimental oral candidiasis in mice. Antimicrob Agents Chemother 47, 2619-2623.
7. Tanaka K, Ikeda M, Nozaki A, Kato N, Tsuda H, Saito S, Sekihara H. 1999 Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C: A pilot study. Jpn J Cancer Res 90, 367-371.
8. Teraguchi S, Shin K, Ogata T, Kingaku M, Kaino A, Miyauchi H, Fukuwatari Y, Shimamura S. 1995 Orally administered bovine lactoferrin inhibits bacterial translocation in mice fed bovine milk. Appl Environ Microbiol 61, 4131-4134.
9. Togawa J, Nagase H, Tanaka K, Inamori M, Umezawa T, Nakajima A, Naito M, Sato S, Saito T, Sekihara H. 2002 Lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance. Am J Physiol Gastrointest Liver Physiol 283, G187-G195.
10. Tomita M, Wakabayashi H, Yamauchi K, Teraguchi S, Hayasawa H. 2002 Bovine lactoferrin and lactoferricin derived from milk: production and applications. Biochem Cell Biol 80, 109-112.
11. Wada T, Aiba Y, Shimizu K, Takagi T, Koga Y. 1999 The therapeutic effect of bovine lactoferrin in the host infected with Helicobacter pylon. Scand J Gastroenterol 34, 238-243.
12. Wakabayashi H, Takakura N, Teraguchi S, Tamura Y. 2003 Lactoferrin feeding augments peritoneal macrophage activities in mice intraperitoneally injected with inactivated Candida albicans. Microbiol Immunol 47, 37-43.
13. Wakabayashi H, Takakura N, Yamauchi K, Teraguchi S, Uchida K, Yamaguchi H, Tamura Y. 2002 Effect of lactoferrin feeding on the host antifungal response in guinea pigs infected or immunized with Trichophyton mentagrophytes. J Med Microbiol 51, 844-850.
14. Wakabayashi H, Uchida K, Yamauchi K, Teraguchi S, Hayasawa H, Yamaguchi H. 2000 Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models. J Antimicrob Chemother 46, 595-601.
15. Wang W-P, Iigo M, Sato J, Sekine K, Adachi I, Tsuda H. 2000 Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin. Jpn J Cancer Res 91, 1022-1027.
16. Yamauchi K, Hiruma M, Yamazaki N, Wakabayashi H, Kuwata H, Teraguchi S, Hayasawa H, Suegara N, Yamaguchi H. 2000 Oral administration of bovine lactoferrin for treatment of tinea pedis. A placebo-controlled, double-blind study. Mycoses 43, 197-202.