Effects of bile salts on transport rates and routes of FITC-labelled compounds across porcine buccal epithelium in vitro

Journal of Controlled Release

Volumn 40, Issue 3, 1996, Pages 211-221

  Hoogstraate, A J ^a,d   Senel, S ^b   Cullander, C ^c   Verhoef, J ^a   Junginger, H E ^a   Bodde H E ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b HACETTEPE UNIVERSITY   (Turkey)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ASTRAZENECA R AND D   (Sweden)

Author keywords

Buccal mucosa; Confocal laser scanning microscopy; Enhancers; FITC dextrans

Indexed keywords

BILE SALT; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; GLYCOCHOLATE SODIUM; GLYCODEOXYCHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID;

ANIMAL TISSUE; ARTICLE; CELL LEVEL; CHEEK MUCOSA; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG MIXTURE; DRUG PENETRATION; DRUG TRANSPORT; DRUG UPTAKE; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE;

EID: 0030005376     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(95)00187-5     Document Type: Article

References (27)

1. M.E. De Vries, H.E. Boddé, J.C. Verhoef and H.E. Junginger. Developments in buccal drug delivery, Crit. Rev. Ther. Drug Carrier Syst. 8 (1991) 271-303.
2. T. Nagai, Adhesive topical drug delivery systems, J. Control. Rel. 2 (1985) 121-134.
3. M.J. Rathbone and J. Hadgraft, Absorption of drugs from the human oral cavity. Int. J. Pharm. 74 (1991) 9-24.
4. V.H.L. Lee, A. Yamamoto and U.B. Kompella, Mucosal penetration enhancers for facilitation of peptide and protein drug absorption. Crit. Rev. Ther. Drug Carrier Syst. 8 (1991) 91-192.
5. A.J. Hoogstraate, C. Cullander, F. Nagelkerke, S. Senel, J.C. Verhoef, H.E. Junginger and H.E. Boddé. Diffusion rates and transport pathways of FITC-labelled model compounds through buccal epithelium, Pharm. Res. 11 (1994) 83-89.
6. Y. Nakada, N. Awata, C. Nakachima and I. Sugimoto, The effects of additives on the oral mucosal absorption of human calcitonin in rats, J. Pharmacobio-Dyn. 12 (1989) 736-743.
7. M. Ishida, Y. Machida, N. Nambu and T. Nagai, New mucosal dosage form of insulin. Chem. Pharm. Bull. 28 (1981) 810-816.
8. B.J. Aungst and N.J. Rogers, Comparison of the effects of various transmucosal absorption promotors on buccal insulin delivery, Int. J. Pharm. 53 (1989) 227-235.
9. J. Zhang, S. Niu, C. Ebert and T.H. Stanley, An in-vivo dog model for studying recovering kinetics of the buccal mucosa permeation barrier after exposure to permeation enhancers: apparent evidence of effective enhancement without tissue damage. Int. J. Pharm. 101 (1994) 15-22.
10. A. Steward, D.L. Bayley and C. Howes, The effect of enhancers on the buccal absorption of hybrid (BDBB) α-interferon, Int. J. Pharm. 104 (1994) 145-149.
11. Y. Lee and Y.W. Chien. Oral mucosal delivery of LHRH: (II) Enhancement of permeation by bile salts and evaluation of mechanism, Pharm. Res. 11 (1994) 145-149.
12. C.D. Ebert. S.J. Heiber. S.C. Dave, S.W. Kim and D. Mix. Mucosal delivery of macromolecules. J. Control. Rel. 28 (1994) 37-44.
13. S. Senel, A.J. Hoogstraate. F. Spies, J.C. Verhoef, A. Bos-van Geest, H.E. Junginger and H.E. Boddé, Enhancement of in-vitro permeability of porcine buccal mucosa by bile salts: kinetic and histological studies. J. Control. Rel. 32 (1994) 45-56.
14. C.A. Lesch, C.A. Squier, A. Cruchley, D.M. Williams and P. Speight, The permeability of human oral mucosa and skin to water, J. Dent. Res. 68 (1989) 1345-1349.
15. M.E. de Vries, H.E. Boddé, J.C. Verhoef, M. Ponec, W.I.H.M. Craane and H.E. Junginger. Localization of the permeability barrier inside porcide bucal mucosa; a combined in vitro study of drug permeability, electrical resistance and tissue morphology. Int. J. Pharm. 76 (1991) 25-35.
16. S. Hell, G. Reiner, C. Cremer and E.H.K. Stelzer, Aberrations in confocal fluorescence microscopy induced by mismatches in refractive index, J. Microsc. Oxford V169 (1993) 391-405.
17. M. Laurent, G. Johannin, N. Gilbert, L. Lucas, D. Cassio. P.X. Petit and A. Fleury, Power and limits of laser scanning confocal microscopy. Biol. Cell 80 (1994) 229-240.
18. P. Kurtzhals, C. Larsen and M. Johansen, High-performance size-exclusion Chromatographic procedure for the determination of fluoresceinyl isothiocyanate dextrans of various molecular masses in biological media, J. Chromatogr. 491 (1989) 117-127.
19. A.J. Hoogstraate and H.E. Boddé, Methods for assessing the buccal mucosa as a route of buccal drug delivery, Adv. Drug Del. Rev. 12 (1993)99-125.
20. G.A. Pico and C. Houssier, bile salts-bovine serum albumin binding: Spectroscopic and thermodynamic studies, Biochim. Biophys. Acta 999 (1989) 128-134.
21. G.P. Martin, L.M. El-hariri and C. Marriott, Bile salt and lysophosphatidylcholine-induced membrane damage in human erythrocytes, J. Pharm. Pharmacol. 44 (1992) 646-650.
22. M. Gibaldi and S. Feldman. Mechanisms of surfactant effects on drug absorption. J. Pharm. Sci. 59 (1970) 579-589.
23. G.S. Gordon, A.C. Moses, R.D. Silver, J.S. Flier and M.C. Carey, Nasal absorption of insulin: Enhancement by hydrophobic bile salts, Proc. Natl. Acad. Sci. 82 (1985) 7419-7423.
24. D. Billington and R. Coleman. Effects of bile salts on human erythrocytes. Plasma membrane vesiculation, Phospholipid solubilisation and their possible relationship to bile secretion, Biochim. Biophys. Acta 509 (1978) 33-47.
25. 2]Kyotorphin, Pharm. Res. 7 (1990) 127-133.
26. Z. Shao and A.K. Mitra. Nasal membrane and intracellular protein and enzyme release by bile salts and bile salt-fatty acids mixed micelles. Correleation with facilitated drug transport. Pharm. Res. 9 (1992) 1184-1189.
27. Y. Rojanasakul, S.W. Paddock and J.R. Robinson, Confocal laser scanning microscopic examination of transport pathways and barriers of some peptides across the cornea. Int. J. Pharm. 61 (1990) 163-172.