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Volumn 14, Issue 3, 2013, Pages 341-350

Pregnane X receptor (pxr) at the crossroads of human metabolism and disease

Author keywords

Bile acids; Chemotherapeutic agents; Drug resistance; Metabolism; Pregnane X Receptor; Xenobiotics

Indexed keywords

ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; CARBAMAZEPINE; CLOTRIMAZOLE; CYCLOPHOSPHAMIDE; CYPROTERONE ACETATE; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN; GLUTETHIMIDE; GUGGULSTERONE; HYPERICUM PERFORATUM EXTRACT; INDOMETACIN; KAVA; MIFEPRISTONE; MULTIDRUG RESISTANCE PROTEIN 1; NIFEDIPINE; NUCLEAR RECEPTOR COACTIVATOR; PACLITAXEL; PHENOBARBITAL; PREGNANE X RECEPTOR; RIFAMPICIN; RITONAVIR; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; SPIRONOLACTONE; STEROID RECEPTOR COACTIVATOR 1; TAMOXIFEN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL; WARFARIN; XENOBIOTIC AGENT;

EID: 84877934154     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/1389200211314030009     Document Type: Article
Times cited : (36)

References (85)
  • 3
    • 23744464363 scopus 로고    scopus 로고
    • Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver
    • DOI 10.1016/j.bcp.2005.06.018, PII S0006295205004247
    • Albermann, N.; Schmitz-Winnenthal, F.H; Z'Graggen, K.; Volk, C.; Hoffmann, M.M.; Haefeli, W.E.; Weiss, J. Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver. Biochem. Pharmacol., 2005, 70(6), 949-958. (Pubitemid 41138860)
    • (2005) Biochemical Pharmacology , vol.70 , Issue.6 , pp. 949-958
    • Albermann, N.1    Schmitz-Winnenthal, F.H.2    Z'graggen, K.3    Volk, C.4    Hoffmann, M.M.5    Haefeli, W.E.6    Weiss, J.7
  • 4
    • 4444264038 scopus 로고    scopus 로고
    • PXR (NR1I2): Splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators
    • DOI 10.1016/j.taap.2003.12.027, PII S0041008X04000602
    • Lamba, V.; Yasuda, K.; Lamba, J.K.; Assem, M.; Davila, J.; Strom, S.; Schuetz, E.G. PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators. Toxicol. Appl. Pharmacol., 2004, 199(3), 251-265. (Pubitemid 39208725)
    • (2004) Toxicology and Applied Pharmacology , vol.199 , Issue.3 , pp. 251-265
    • Lamba, V.1    Yasuda, K.2    Lamba, J.K.3    Assem, M.4    Davila, J.5    Strom, S.6    Schuetz, E.G.7
  • 5
    • 7244225172 scopus 로고    scopus 로고
    • Expression of pregnane-X-receptor transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA
    • Owen, A.; Chandler, B.; Back, D.J.; Khoo, S.H. Expression of pregnane-X-receptor transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA. Antivir. Ther., 2004, 9(5), 819-821. (Pubitemid 39434346)
    • (2004) Antiviral Therapy , vol.9 , Issue.5 , pp. 819-821
    • Owen, A.1    Chandler, B.2    Back, D.J.3    Khoo, S.H.4
  • 6
    • 0032807743 scopus 로고    scopus 로고
    • The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue
    • Dotzlaw, H.; Leygue, E.; Watson, P.; Murphy, L.C. The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue. Clin. Cancer Res., 1999, 5(8), 2103-2107. (Pubitemid 29399265)
    • (1999) Clinical Cancer Research , vol.5 , Issue.8 , pp. 2103-2107
    • Dotzlaw, H.1    Leygue, E.2    Watson, P.3    Murphy, L.C.4
  • 9
    • 1642498313 scopus 로고    scopus 로고
    • Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): One variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region
    • DOI 10.1124/dmd.32.1.149
    • Koyano, S.; Kurose, K.; Saito, Y.; Ozawa, S.; Hasegawa, R.; Komamura, K.; Ueno, K.; Kamakura, S.; Kitakaze, M.; Nakajima, T.; Matsumoto, K.; Akasawa, A.; Saito, H.; Sawada, J. Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region. Drug Metab. Dispos., 2004, 32(1), 149-154. (Pubitemid 38112547)
    • (2004) Drug Metabolism and Disposition , vol.32 , Issue.1 , pp. 149-154
    • Koyano, S.1    Kurose, K.2    Saito, Y.3    Ozawa, S.4    Hasegawa, R.5    Komamura, K.6    Ueno, K.7    Kamakura, S.8    Kitakaze, M.9    Nakajima, T.10    Matsumoto, K.11    Akasawa, A.12    Saito, H.13    Sawada, J.-I.14
  • 11
    • 0043168030 scopus 로고    scopus 로고
    • Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor
    • DOI 10.1016/S0022-2836(03)00795-2
    • Watkins, R.E.; Davis-Searles, P.R.; Lambert, M.H.; Redinbo, M.R. Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. J. Mol. Biol., 2003, 331(4), 815-828. (Pubitemid 36945439)
    • (2003) Journal of Molecular Biology , vol.331 , Issue.4 , pp. 815-828
    • Watkins, R.E.1    Davis-Searles, P.R.2    Lambert, M.H.3    Redinbo, M.R.4
  • 12
    • 0037333974 scopus 로고    scopus 로고
    • Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR
    • DOI 10.1124/mol.63.3.524
    • Kawana, K.; Ikuta, T.; Kobayashi, Y.; Gotoh, O.; Takeda, K.; Kawajiri, K. Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR. Mol. Pharmacol., 2003, 63(3), 524-531. (Pubitemid 36297321)
    • (2003) Molecular Pharmacology , vol.63 , Issue.3 , pp. 524-531
    • Kawana, K.1    Ikuta, T.2    Kobayashi, Y.3    Gotoh, O.4    Takeda, K.5    Kawajiri, K.6
  • 13
    • 0033931266 scopus 로고    scopus 로고
    • Dexamethasone induces pregnane X receptor and retinoid X receptor-α expression in human hepatocytes: Synergistic increase of CYP3A4 induction by pregnane X receptor activators
    • Pascussi, J.M.; Drocourt, L.; Fabre, J.M.; Maurel, P.; Vilarem, M.J. Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol. Pharmacol., 2000, 58(2), 361-372. (Pubitemid 30497480)
    • (2000) Molecular Pharmacology , vol.58 , Issue.2 , pp. 361-372
    • Pascussi, J.-M.1    Drocourt, L.2    Fabre, J.-M.3    Maurel, P.4    Vilarem, M.-J.5
  • 14
    • 0035038919 scopus 로고    scopus 로고
    • The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
    • DOI 10.1038/87912
    • Synold, T.W.; Dussault, I.; Forman, B.M. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat. Med., 2001, 7(5), 584-590. (Pubitemid 32448326)
    • (2001) Nature Medicine , vol.7 , Issue.5 , pp. 584-590
    • Synold, T.W.1    Dussault, I.2    Forman, B.M.3
  • 16
    • 0038798874 scopus 로고    scopus 로고
    • Drug-activated nuclear receptors CAR and PXR
    • DOI 10.1080/07853890310008224
    • Honkakoski, P.; Sueyoshi, T.; Negishi, M. Drug-activated nuclear receptors CAR and PXR. Ann. Med., 2003, 35(3), 172-182. (Pubitemid 36765230)
    • (2003) Annals of Medicine , vol.35 , Issue.3 , pp. 172-182
    • Honkakoski, P.1    Sueyoshi, T.2    Negishi, M.3
  • 17
    • 32244447844 scopus 로고    scopus 로고
    • Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome P450 induction potential of drugs in vivo in humans
    • DOI 10.1007/s11095-005-8812-5
    • Persson, K.P.; Ekehed, S.; Otter, C.; Lutz, E.S.; McPheat, J.; Masimirembwa, C.M.; Andersson, T.B. Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome p450 induction potential of drugs in vivo in humans. Pharm. Res., 2006, 23(1), 56-69. (Pubitemid 43214661)
    • (2006) Pharmaceutical Research , vol.23 , Issue.1 , pp. 56-69
    • Persson, K.P.1    Ekehed, S.2    Otter, C.3    Lutz, E.S.M.4    McPheat, J.5    Masimirembwa, C.M.6    Andersson, T.B.7
  • 19
    • 33845491066 scopus 로고    scopus 로고
    • Pregnane X receptor and natural products: Beyond drug-drug interactions
    • DOI 10.1517/17425255.2.6.847
    • Staudinger, J.L.; Ding, X.; Lichti, K. Pregnane X receptor and natural products: beyond drug-drug interactions. Expert Opin. Drug Metab. Toxicol., 2006, 2(6), 847-857. (Pubitemid 44911536)
    • (2006) Expert Opinion on Drug Metabolism and Toxicology , vol.2 , Issue.6 , pp. 847-857
    • Staudinger, J.L.1    Ding, X.2    Lichti, K.3
  • 22
    • 69749083669 scopus 로고    scopus 로고
    • Nuclear receptors car and pxr: Molecular functional, and biomedical aspects
    • di Masi, A.; De Marinis, E.; Ascenzi, P.; Marino, M. Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects. Mol. Aspects Med., 2009, 30(5), 297-343.
    • (2009) Mol. Aspects Med , vol.30 , Issue.5 , pp. 297-343
    • Di Masi, A.1    De Marinis, E.2    Ascenzi, P.3    Marino, M.4
  • 23
    • 33846230463 scopus 로고    scopus 로고
    • Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole
    • DOI 10.1038/sj.onc.1209788, PII 1209788
    • Huang, H.; Wang, H.; Sinz, M.; Zoeckler, M.; Staudinger, J.; Redinbo, M.R.; Teotico, D.G.; Locker, J.; Kalpana, G.V.; Mani, S. Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. Oncogene, 2007, 26(2), 258-268. (Pubitemid 46095736)
    • (2007) Oncogene , vol.26 , Issue.2 , pp. 258-268
    • Huang, H.1    Wang, H.2    Sinz, M.3    Zoeckler, M.4    Staudinger, J.5    Redinbo, M.R.6    Teotico, D.G.7    Locker, J.8    Kalpana, G.V.9    Mani, S.10
  • 24
    • 33845904129 scopus 로고    scopus 로고
    • The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor
    • DOI 10.1124/mol.106.029264
    • Zhou, C.; Poulton, E.J.; Grun, F.; Bammler, T.K.; Blumberg, B.; Thummel, K.E.; Eaton, D.L. The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Mol. Pharmacol., 2007, 71(1), 220-229. (Pubitemid 46020992)
    • (2007) Molecular Pharmacology , vol.71 , Issue.1 , pp. 220-229
    • Zhou, C.1    Poulton, E.-J.2    Grun, F.3    Bammler, T.K.4    Blumberg, B.5    Thummel, K.E.6    Eaton, D.L.7
  • 27
    • 55049094158 scopus 로고    scopus 로고
    • Bile acids and signal transduction: Role in glucose homeostasis
    • Nguyen, A.; Bouscarel, B. Bile acids and signal transduction: role in glucose homeostasis. Cell. Signal., 2008, 20(12), 2180-2197.
    • (2008) Cell. Signal , vol.20 , Issue.12 , pp. 2180-2197
    • Nguyen, A.1    Bouscarel, B.2
  • 28
    • 0026548603 scopus 로고
    • Effects of longterm rifampicin administration in primary biliary cirrhosis
    • Bachs, L.; Pares, A.; Elena, M.; Piera, C.; Rodes, J. Effects of longterm rifampicin administration in primary biliary cirrhosis. Gastroenterology, 1992, 102(6), 2077-2080.
    • (1992) Gastroenterology , vol.102 , Issue.6 , pp. 2077-2080
    • Bachs, L.1    Pares, A.2    Elena, M.3    Piera, C.4    Rodes, J.5
  • 29
    • 0036179358 scopus 로고    scopus 로고
    • Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis
    • DOI 10.1136/gut.50.3.436
    • Prince, M.I.; Burt, A.D.; Jones, D.E. Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis. Gut, 2002, 50(3), 436-439. (Pubitemid 34161065)
    • (2002) Gut , vol.50 , Issue.3 , pp. 436-439
    • Prince, M.I.1    Burt, A.D.2    Jones, D.E.J.3
  • 30
    • 79958104994 scopus 로고    scopus 로고
    • Pxr prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts
    • He, J.; Nishida, S.; Xu, M.; Makishima, M.; Xie, W. PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts. Gastroenterology, 2011, 140(7), 2095-2106.
    • (2011) Gastroenterology , vol.140 , Issue.7 , pp. 2095-2106
    • He, J.1    Nishida, S.2    Xu, M.3    Makishima, M.4    Xie, W.5
  • 32
    • 33744948052 scopus 로고    scopus 로고
    • A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway
    • DOI 10.1074/jbc.M511116200
    • Zhou, J.; Zhai, Y.; Mu, Y.; Gong, H.; Uppal, H.; Toma, D.; Ren, S.; Evans, R.M.; Xie, W. A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J. Biol. Chem., 2006, 281(21), 15013-15020. (Pubitemid 43855205)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.21 , pp. 15013-15020
    • Zhou, J.1    Zhai, Y.2    Mu, Y.3    Gong, H.4    Uppal, H.5    Toma, D.6    Ren, S.7    Evans, R.M.8    Xie, W.9
  • 33
    • 41149102969 scopus 로고    scopus 로고
    • Regulatory cross-talk between drug metabolism and lipid homeostasis: Constitutive androstane receptor and pregnane X receptor increase Insig-1 expression
    • DOI 10.1124/mol.107.041012
    • Roth, A.; Looser, R.; Kaufmann, M.; Blattler, S.M.; Rencurel, F.; Huang, W.; Moore, D.D.; Meyer, U.A. Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression. Mol. Pharmacol., 2008, 73(4), 1282-1289. (Pubitemid 351439210)
    • (2008) Molecular Pharmacology , vol.73 , Issue.4 , pp. 1282-1289
    • Roth, A.1    Looser, R.2    Kaufmann, M.3    Blattler, S.M.4    Rencurel, F.5    Huang, W.6    Moore, D.D.7    Meyer, U.A.8
  • 36
    • 33644918326 scopus 로고    scopus 로고
    • Metabolic and cardiovascular complications of highly active antiretroviral therapy for hiv infection
    • Barbaro, G. Metabolic and cardiovascular complications of highly active antiretroviral therapy for HIV infection. Curr. HIV Res., 2006, 4(1), 79-85.
    • (2006) Curr. HIV Res , vol.4 , Issue.1 , pp. 79-85
    • Barbaro, G.1
  • 37
    • 33845970888 scopus 로고    scopus 로고
    • Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis
    • DOI 10.1210/me.2006-0291
    • Zhai, Y.; Pai, H.V.; Zhou, J.; Amico, J.A.; Vollmer, R.R.; Xie, W. Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis. Mol. Endocrinol., 2007, 21(1), 138-147. (Pubitemid 46041695)
    • (2007) Molecular Endocrinology , vol.21 , Issue.1 , pp. 138-147
    • Zhai, Y.1    Pai, H.V.2    Zhou, J.3    Amico, J.A.4    Vollmer, R.R.5    Xie, W.6
  • 39
    • 3242714029 scopus 로고    scopus 로고
    • Urinary 6β-hydroxycortisol/17-hydroxycorticosteroids ratio as a measure of hepatic CYP3A4 capacity after enzyme induction
    • DOI 10.1258/0004563041201527
    • Konishi, H.; Tanaka, K.; Minouchi, T.; Yamaji, A. Urinary 6betahydroxycortisol/17-hydroxycorticosteroids ratio as a measure of hepatic CYP3A4 capacity after enzyme induction. Ann. Clin. Biochem., 2004, 41, 335-337. (Pubitemid 38954884)
    • (2004) Annals of Clinical Biochemistry , vol.41 , Issue.4 , pp. 335-337
    • Konishi, H.1    Tanaka, K.2    Minouchi, T.3    Yamaji, A.4
  • 40
    • 0034800442 scopus 로고    scopus 로고
    • Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16α-hydroxylation of 17β-estradiol
    • DOI 10.1053/meta.2001.25592
    • Badawi, A.F.; Cavalieri, E.L.; Rogan, E.G. Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alphahydroxylation of 17beta-estradiol. Metabolism, 2001, 50(9), 1001-1003. (Pubitemid 32904154)
    • (2001) Metabolism: Clinical and Experimental , vol.50 , Issue.9 , pp. 1001-1003
    • Badawi, A.F.1    Cavalieri, E.L.2    Rogan, E.G.3
  • 41
    • 22144438011 scopus 로고    scopus 로고
    • Potential role for human cytochrome P450 3A4 in estradiol homeostasis
    • DOI 10.1210/en.2004-1248
    • Yu, A.M.; Fukamachi, K.; Krausz, K.W.; Cheung, C.; Gonzalez, F.J. Potential role for human cytochrome P450 3A4 in estradiol homeostasis. Endocrinology, 2005, 146(7), 2911-2919. (Pubitemid 41002798)
    • (2005) Endocrinology , vol.146 , Issue.7 , pp. 2911-2919
    • Yu, A.-M.1    Fukamachi, K.2    Krausz, K.W.3    Cheung, C.4    Gonzalez, F.J.5
  • 42
    • 42249111748 scopus 로고    scopus 로고
    • The roles of nuclear receptors car and pxr in hepatic energy metabolism
    • Konno, Y.; Negishi, M.; Kodama, S. The roles of nuclear receptors CAR and PXR in hepatic energy metabolism. Drug Metab. Pharmacokinet., 2008, 23(1), 8-13.
    • (2008) Drug Metab. Pharmacokinet , vol.23 , Issue.1 , pp. 8-13
    • Konno, Y.1    Negishi, M.2    Kodama, S.3
  • 43
    • 0035042684 scopus 로고    scopus 로고
    • CYP3A regulation: From pharmacology to nuclear receptors
    • Quattrochi, L.C.; Guzelian, P.S. Cyp3A regulation: from pharmacology to nuclear receptors. Drug Metab. Dispos., 2001, 29(5), 615-622. (Pubitemid 32374560)
    • (2001) Drug Metabolism and Disposition , vol.29 , Issue.5 , pp. 615-622
    • Quattrochi, L.C.1    Guzelian, P.S.2
  • 44
    • 0037972688 scopus 로고    scopus 로고
    • Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane x receptor
    • DOI 10.1210/me.2002-0421
    • Rosenfeld, J.M.; Vargas, R., Jr.; Xie, W.; Evans, R.M. Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. Mol. Endocrinol., 2003, 17(7), 1268-1282. (Pubitemid 36819950)
    • (2003) Molecular Endocrinology , vol.17 , Issue.7 , pp. 1268-1282
    • Rosenfeld, J.M.1    Vargas Jr., R.2    Xie, W.3    Evans, R.M.4
  • 46
    • 78649284256 scopus 로고    scopus 로고
    • Overcoming drug resistance by regulating nuclear receptors
    • Chen, T. Overcoming drug resistance by regulating nuclear receptors. Adv. Drug Deliv. Rev., 2010, 62(13), 1257-1264.
    • (2010) Adv. Drug Deliv. Rev , vol.62 , Issue.13 , pp. 1257-1264
    • Chen, T.1
  • 47
    • 34250758597 scopus 로고    scopus 로고
    • Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways
    • DOI 10.1124/dmd.106.014456
    • Cerveny, L.; Svecova, L.; Anzenbacherova, E.; Vrzal, R.; Staud, F.; Dvorak, Z.; Ulrichova, J.; Anzenbacher, P.; Pavek, P. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways. Drug Metab. Dispos., 2007, 35(7), 1032-1041. (Pubitemid 46956421)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.7 , pp. 1032-1041
    • Cerveny, L.1    Svecova, L.2    Anzenbacherova, E.3    Vrzal, R.4    Staud, F.5    Dvorak, Z.6    Ulrichova, J.7    Anzenbacher, P.8    Pavek, P.9
  • 48
    • 0042163137 scopus 로고    scopus 로고
    • Pharmacokinetic interactions with rifampicin: Clinical relevance
    • DOI 10.2165/00003088-200342090-00003
    • Niemi, M.; Backman, J.T.; Fromm, M.F.; Neuvonen, P.J.; Kivisto, K.T. Pharmacokinetic interactions with rifampicin : clinical relevance. Clin. Pharmacokinet., 2003, 42(9), 819-850. (Pubitemid 36995083)
    • (2003) Clinical Pharmacokinetics , vol.42 , Issue.9 , pp. 819-850
    • Niemi, M.1    Backman, J.T.2    Fromm, M.F.3    Neuvonen, P.J.4    Kivisto, K.T.5
  • 49
    • 0030068752 scopus 로고    scopus 로고
    • Rifampin drastically reduces plasma concentrations and effects of oral midazolam
    • DOI 10.1016/S0009-9236(96)90018-1
    • Backman, J.T.; Olkkola, K.T.; Neuvonen, P.J. Rifampin drastically reduces plasma concentrations and effects of oral midazolam. Clin. Pharmacol. Ther., 1996, 59(1), 7-13. (Pubitemid 26046768)
    • (1996) Clinical Pharmacology and Therapeutics , vol.59 , Issue.1 , pp. 7-13
    • Backman, J.T.1    Olkkola, K.T.2    Neuvonen, P.J.3
  • 51
    • 0034707701 scopus 로고    scopus 로고
    • St John's wort for depression: A systematic review
    • Gaster, B.; Holroyd, J. St John's wort for depression: a systematic review. Arch. Intern. Med., 2000, 160(2), 152-156. (Pubitemid 30054333)
    • (2000) Archives of Internal Medicine , vol.160 , Issue.2 , pp. 152-156
    • Gaster, B.1    Holroyd, J.2
  • 53
    • 0034639638 scopus 로고    scopus 로고
    • Acute heart transplant rejection due to Saint John's wort
    • Ruschitzka, F.; Meier, P.J.; Turina, M.; Luscher, T.F.; Noll, G. Acute heart transplant rejection due to Saint John's wort. Lancet, 2000, 355(9203), 548-549. (Pubitemid 30088678)
    • (2000) Lancet , vol.355 , Issue.9203 , pp. 548-549
    • Ruschitzka, F.1    Meier, P.J.2    Turina, M.3    Luscher, T.F.4    Noll, G.5
  • 56
    • 36048965821 scopus 로고    scopus 로고
    • Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene
    • DOI 10.1128/MCB.00813-07
    • Igarashi, M.; Yogiashi, Y.; Mihara, M.; Takada, I.; Kitagawa, H.; Kato, S. Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene. Mol. Cell. Biol., 2007, 27(22), 7947-7954. (Pubitemid 350086427)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.22 , pp. 7947-7954
    • Igarashi, M.1    Yogiashi, Y.2    Mihara, M.3    Takada, I.4    Kitagawa, H.5    Kato, S.6
  • 57
    • 65349091444 scopus 로고    scopus 로고
    • The steroid and xenobiotic receptor (sxr) beyond xenobiotic metabolism
    • Zhou, C.; Verma, S.; Blumberg, B. The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. Nucl. Recept. Signal., 2009, 7, e001.
    • (2009) Nucl. Recept. Signal , vol.7
    • Zhou, C.1    Verma, S.2    Blumberg, B.3
  • 58
    • 39749098685 scopus 로고    scopus 로고
    • PXR and LXR in hepatic steatosis: A new dog and an old dog with new tricks
    • DOI 10.1021/mp700121u
    • Lee, J.H.; Zhou, J.; Xie, W. PXR and LXR in hepatic steatosis: a new dog and an old dog with new tricks. Mol. Pharm., 2008, 5(1), 60-66. (Pubitemid 351300035)
    • (2008) Molecular Pharmaceutics , vol.5 , Issue.1 , pp. 60-66
    • Jung, H.L.1    Zhou, J.2    Xie, W.3
  • 59
    • 42249088859 scopus 로고    scopus 로고
    • Pregnane X receptor is essential for normal progression of liver regeneration
    • DOI 10.1002/hep.22129
    • Dai, G.; He, L.; Bu, P.; Wan, Y.J. Pregnane X receptor is essential for normal progression of liver regeneration. Hepatology, 2008, 47(4), 1277-1287. (Pubitemid 351547914)
    • (2008) Hepatology , vol.47 , Issue.4 , pp. 1277-1287
    • Dai, G.1    He, L.2    Bu, P.3    Wan, Y.-J.Y.4
  • 60
    • 0023134005 scopus 로고
    • Ultrastructural changes in the parenchymal liver cells of rats treated with high doses of rifampicin
    • Piriou, A.; Maissiat, R.; Jacqueson, A.; Warnet, J.M.; Claude, J.R. Ultrastructural changes in the parenchymal liver cells of rats treated with high doses of rifampicin. Br. J. Exp. Pathol., 1987, 68(2), 201-207. (Pubitemid 17051486)
    • (1987) British Journal of Experimental Pathology , vol.68 , Issue.2 , pp. 201-207
    • Piriou, A.1    Maissiat, R.2    Jacqueson, A.3
  • 62
    • 3242735503 scopus 로고    scopus 로고
    • Loss of detoxification in inflammatory bowel disease: Dysregulation of pregnane X receptor target genes
    • DOI 10.1053/j.gastro.2004.04.019, PII S0016508504007140
    • Langmann, T.; Moehle, C.; Mauerer, R.; Scharl, M.; Liebisch, G.; Zahn, A.; Stremmel, W.; Schmitz, G. Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes. Gastroenterology, 2004, 127(1), 26-40. (Pubitemid 38962271)
    • (2004) Gastroenterology , vol.127 , Issue.1 , pp. 26-40
    • Langmann, T.1    Moehle, C.2    Mauerer, R.3    Scharl, M.4    Liebisch, G.5    Zahn, A.6    Stremmel, W.7    Schmitz, G.8
  • 64
    • 34147170945 scopus 로고    scopus 로고
    • Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-κB target gene expression
    • DOI 10.1152/ajpgi.00528.2006
    • Shah, Y.M.; Ma, X.; Morimura, K.; Kim, I.; Gonzalez, F.J. Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression. Am. J. Physiol. Gastrointest. Liver Physiol., 2007, 292(4), G1114-1122. (Pubitemid 46557773)
    • (2007) American Journal of Physiology - Gastrointestinal and Liver Physiology , vol.292 , Issue.4
    • Shah, Y.M.1    Ma, X.2    Morimura, K.3    Kim, I.4    Gonzalez, F.J.5
  • 65
    • 38649128825 scopus 로고    scopus 로고
    • Metabolomics Reveals that Hepatic Stearoyl-CoA Desaturase 1 Downregulation Exacerbates Inflammation and Acute Colitis
    • DOI 10.1016/j.cmet.2007.12.003, PII S1550413107003762
    • Chen, C.; Shah, Y.M.; Morimura, K.; Krausz, K.W.; Miyazaki, M.; Richardson, T.A.; Morgan, E.T.; Ntambi, J.M.; Idle, J.R.; Gonzalez, F.J. Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Cell. Metab., 2008, 7(2), 135-147. (Pubitemid 351168558)
    • (2008) Cell Metabolism , vol.7 , Issue.2 , pp. 135-147
    • Chen, C.1    Shah, Y.M.2    Morimura, K.3    Krausz, K.W.4    Miyazaki, M.5    Richardson, T.A.6    Morgan, E.T.7    Ntambi, J.M.8    Idle, J.R.9    Gonzalez, F.J.10
  • 66
    • 33846892518 scopus 로고    scopus 로고
    • Effects of budesonide on P-glycoprotein expression in intestinal cell lines
    • DOI 10.1038/sj.bjp.0706992, PII 0706992
    • Maier, A.; Zimmermann, C.; Beglinger, C.; Drewe, J.; Gutmann, H. Effects of budesonide on P-glycoprotein expression in intestinal cell lines. Br. J. Pharmacol., 2007, 150(3), 361-368. (Pubitemid 46221044)
    • (2007) British Journal of Pharmacology , vol.150 , Issue.3 , pp. 361-368
    • Maier, A.1    Zimmermann, C.2    Beglinger, C.3    Drewe, J.4    Gutmann, H.5
  • 69
    • 43549100859 scopus 로고    scopus 로고
    • A gut feeling of the PXR, PPAR and NF-κB connection
    • DOI 10.1111/j.1365-2796.2008.01951.x
    • Wahli, W. A gut feeling of the PXR, PPAR and NF-kappaB connection. J. Intern. Med., 2008, 263(6), 613-619. (Pubitemid 351678588)
    • (2008) Journal of Internal Medicine , vol.263 , Issue.6 , pp. 613-619
    • Wahli, W.1
  • 70
    • 18844432520 scopus 로고    scopus 로고
    • Pregnenolone-16α-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms
    • DOI 10.1042/BJ20041598
    • Marek, C.J.; Tucker, S.J.; Konstantinou, D.K.; Elrick, L.J.; Haefner, D.; Sigalas, C.; Murray, G.I.; Goodwin, B.; Wright, M.C. Pregnenolone-16alpha- carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXRindependent mechanisms. Biochem. J., 2005, 387(Pt 3), 601-608. (Pubitemid 40685693)
    • (2005) Biochemical Journal , vol.387 , Issue.3 , pp. 601-608
    • Marek, C.J.1    Tucker, S.J.2    Konstantinou, D.K.3    Elrick, L.J.4    Haefner, D.5    Sigalas, C.6    Murray, G.I.7    Goodwin, B.8    Wright, M.C.9
  • 72
    • 84863219792 scopus 로고    scopus 로고
    • Effect of nuclear receptor downregulation on hepatic expression of cytochrome p450 and transporters in chronic hepatitis c in association with fibrosis development
    • Hanada, K.; Nakai, K.; Tanaka, H.; Suzuki, F.; Kumada, H.; Ohno, Y.; Ozawa, S.; Ogata, H. Effect of nuclear receptor downregulation on hepatic expression of cytochrome p450 and transporters in chronic hepatitis c in association with fibrosis development. Drug Metab. Pharmacokinet., 2012, 27(3), 301-306.
    • (2012) Drug Metab. Pharmacokinet , vol.27 , Issue.3 , pp. 301-306
    • Hanada, K.1    Nakai, K.2    Tanaka, H.3    Suzuki, F.4    Kumada, H.5    Ohno, Y.6    Ozawa, S.7    Ogata, H.8
  • 73
    • 0036239630 scopus 로고    scopus 로고
    • Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen
    • DOI 10.1124/dmd.30.5.608
    • Desai, P.B.; Nallani, S.C.; Sane, R.S.; Moore, L.B.; Goodwin, B.J.; Buckley, D.J.; Buckley, A.R. Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen. Drug Metab. Dispos., 2002, 30(5), 608-612. (Pubitemid 34456986)
    • (2002) Drug Metabolism and Disposition , vol.30 , Issue.5 , pp. 608-612
    • Desai, P.B.1    Nallani, S.C.2    Sane, R.S.3    Moore, L.B.4    Goodwin, B.J.5    Buckley, D.J.6    Buckley, A.R.7
  • 74
    • 24344454303 scopus 로고    scopus 로고
    • Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents
    • DOI 10.1158/1078-0432.CCR-05-0252
    • Mani, S.; Huang, H.; Sundarababu, S.; Liu, W.; Kalpana, G.; Smith, A.B.; Horwitz, S.B. Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubulestabilizing agents. Clin. Cancer Res., 2005, 11(17), 6359-6369. (Pubitemid 41262968)
    • (2005) Clinical Cancer Research , vol.11 , Issue.17 , pp. 6359-6369
    • Mani, S.1    Huang, H.2    Sundarababu, S.3    Liu, W.4    Kalpana, G.5    Smith, A.B.6    Horwitz, S.B.7
  • 75
    • 33646497418 scopus 로고    scopus 로고
    • Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines
    • Huang, R.; Murry, D.J.; Kolwankar, D.; Hall, S.D.; Foster, D.R. Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines. Biochem. Pharmacol., 2006, 71(12), 1695-1704.
    • (2006) Biochem. Pharmacol , vol.71 , Issue.12 , pp. 1695-1704
    • Huang, R.1    Murry, D.J.2    Kolwankar, D.3    Hall, S.D.4    Foster, D.R.5
  • 76
    • 35948961894 scopus 로고    scopus 로고
    • Human pregnane X receptor and resistance to chemotherapy in prostate cancer
    • DOI 10.1158/0008-5472.CAN-06-4758
    • Chen, Y.; Tang, Y.; Wang, M.T.; Zeng, S.; Nie, D. Human pregnane X receptor and resistance to chemotherapy in prostate cancer. Cancer Res., 2007, 67(21), 10361-10367. (Pubitemid 350070811)
    • (2007) Cancer Research , vol.67 , Issue.21 , pp. 10361-10367
    • Chen, Y.1    Tang, Y.2    Wang, M.-T.3    Zeng, S.4    Nie, D.5
  • 77
    • 34748865948 scopus 로고    scopus 로고
    • Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells
    • DOI 10.1124/mol.107.037937
    • Masuyama, H.; Nakatsukasa, H.; Takamoto, N.; Hiramatsu, Y. Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells. Mol. Pharmacol., 2007, 72(4), 1045-1053. (Pubitemid 47481427)
    • (2007) Molecular Pharmacology , vol.72 , Issue.4 , pp. 1045-1053
    • Masuyama, H.1    Nakatsukasa, H.2    Takamoto, N.3    Hiramatsu, Y.4
  • 79
    • 0036194775 scopus 로고    scopus 로고
    • Intravenous cyclosporine-rifampin interaction in a pediatric bone marrow transplant recipient
    • Zelunka, E.J. Intravenous cyclosporine-rifampin interaction in a pediatric bone marrow transplant recipient. Pharmacotherapy, 2002, 22(3), 387-390. (Pubitemid 34205176)
    • (2002) Pharmacotherapy , vol.22 , Issue.3 , pp. 387-390
    • Zelunka, E.J.1
  • 84
    • 0035800525 scopus 로고    scopus 로고
    • Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: A sub-protocol of the 'Arimidex and tamoxifen alone or in combination' (ATAC) trial
    • DOI 10.1054/bjoc.2001.1925
    • Dowsett, M.; Cuzick, J.; Howell, A.; Jackson, I. Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: a sub-protocol of the 'Arimidex and tamoxifen alone or in combination' (ATAC) trial. Br. J. Cancer, 2001, 85(3), 317-324. (Pubitemid 32747695)
    • (2001) British Journal of Cancer , vol.85 , Issue.3 , pp. 317-324
    • Dowsett, M.1    Cuzick, J.2    Howell, A.3    Jackson, I.4
  • 85
    • 0030951908 scopus 로고    scopus 로고
    • Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: Response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines
    • Chang, T.K.; Yu, L.; Maurel, P.; Waxman, D.J. Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. Cancer Res., 1997, 57(10), 1946-1954. (Pubitemid 27209726)
    • (1997) Cancer Research , vol.57 , Issue.10 , pp. 1946-1954
    • Chang, T.K.H.1    Yu, L.2    Maurel, P.3    Waxman, D.J.4


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