Identification of a long-range protein network that modulates active site dynamics in extremophilic alcohol dehydrogenases

Journal of Biological Chemistry

Volumn 288, Issue 20, 2013, Pages 14087-14097

  Nagel, Zachary D ^a,c   Cun, Shujian ^a,b,d   Klinman, Judith P ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; AROMATIC SIDE CHAINS; BACILLUS STEAROTHERMOPHILUS; KINETIC ISOTOPE EFFECTS; RATE DETERMINING STEP; SUBSTRATE-BINDING DOMAINS; SUBUNIT INTERACTIONS; THERMOSTABLE ENZYMES;

ACTIVATION ANALYSIS; BACTERIOLOGY; ISOTOPES;

ENZYMES;

ALCOHOL DEHYDROGENASE; BACTERIAL ENZYME;

ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME REGULATION; ENZYME STABILITY; ENZYME SUBSTRATE COMPLEX; GENE MUTATION; GEOBACILLUS STEAROTHERMOPHILUS; KINETIC ISOTOPE EFFECT; LOW TEMPERATURE; NONHUMAN; PRIORITY JOURNAL; PROKARYOTE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

ALCOHOL DEHYDROGENASE; CONFORMATIONAL SAMPLING; CONVEX ARRHENIUS CURVES; CORRESPONDING STATE HYPOTHESIS; ENZYME CATALYSIS; EXTREMOPHILES; HYDROGEN TUNNELING; ISOTOPE EFFECTS; MUTAGENESIS; PROTEIN DYNAMICS;

ALCOHOL DEHYDROGENASE; BACTERIAL PROTEINS; CATALYSIS; CATALYTIC DOMAIN; CIRCULAR DICHROISM; CLONING, MOLECULAR; COLD TEMPERATURE; GEOBACILLUS STEAROTHERMOPHILUS; HYDROGEN; MUTAGENESIS; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; SPECTROPHOTOMETRY;

EID: 84877899739     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.453951     Document Type: Article

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