Temperature dependence of the flexibility of thermophilic and mesophilic flavoenzymes of the nitroreductase fold

Protein Engineering, Design and Selection

Volumn 23, Issue 5, 2010, Pages 327-336

  Merkley, Eric D ^a   Parson, William W ^a   Daggett, Valerie ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b University of Washington   (United States)

Author keywords

Corresponding states; Flavoproteins; Molecular dynamics simulations; Nitroreductase; Thermophilic proteins

Indexed keywords

ACTIVE SITE; COMPUTATIONAL STUDIES; CORRESPONDING STATE; ELECTROSTATIC INTERACTIONS; FLAVOENZYMES; HIGH TEMPERATURE; MESOPHILIC; MESOPHILIC COUNTERPARTS; MOLECULAR DYNAMICS SIMULATIONS; NADH OXIDASE; NATIVE CONFORMATION; NITROREDUCTASES; TEMPERATURE DEPENDENCE; THERMOPHILIC ENZYMES; THERMOPHILIC PROTEINS; THERMUS THERMOPHILUS; TIME-SCALES;

ESCHERICHIA COLI; MOLECULAR DYNAMICS;

ENZYMES;

FLAVOPROTEIN; NITROREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME STRUCTURE; ESCHERICHIA COLI; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; SEQUENCE ALIGNMENT; TEMPERATURE DEPENDENCE; THERMUS THERMOPHILUS;

AMINO ACID SEQUENCE; ESCHERICHIA COLI PROTEINS; FMN REDUCTASE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; NITROREDUCTASES; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; TEMPERATURE; THERMUS THERMOPHILUS;

ESCHERICHIA COLI; THERMUS THERMOPHILUS;

EID: 77951143923     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzp090     Document Type: Article

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