A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation

Toxicology and Applied Pharmacology

Volumn 212, Issue 3, 2006, Pages 212-223

  Oh, Seon Hee ^a   Lim, Sung Chul ^a  

^a Chosun University   (South Korea)

Author keywords

Apoptosis; Cadmium; Catalase; Fas; N acetylcysteine; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; BONGKREKIC ACID; CADMIUM; CALPAIN; CASPASE; CASPASE 8; CATALASE; CYCLOSPORIN A; CYTOCHROME C; DNA FRAGMENT; FAS ANTIGEN; PROTEIN BAX; PROTEIN BID; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENZYME DEGRADATION; ENZYME REGULATION; ENZYME RELEASE; HEP 2 CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; MITOCHONDRION; MOLECULAR MECHANICS; NICK END LABELING; OXIDATIVE STRESS; PREMEDICATION; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; UPREGULATION;

ACETYLCYSTEINE; ANTIGENS, CD95; APOPTOSIS; CADMIUM; CARCINOMA, HEPATOCELLULAR; CASPASES; CATALASE; CELL LINE; CELL SURVIVAL; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ENVIRONMENTAL POLLUTANTS; HUMANS; IN SITU NICK-END LABELING; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 33646126929     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.07.018     Document Type: Article

References (50)

1. Aronis A., Melendez J.A., Golan O., Shilo S., Dicter N., and Tirosh O. Potentiation of Fas-mediated apoptosis by attenuated production of mitochondria-derived reactive oxygen species. Cell Death Differ. 10 (2003) 335-344
2. Aydin H.H., Celik H.A., Deveci R., Terzioglu E., Karacali S., Mete N., Akarca U., and Batur Y. Characterization of the cellular response during apoptosis induction in cadmium-treated HepG2 human hepatoma cells. Biol. Trace Elem. Res. 95 (2003) 139-153
3. Bauer M.K.A., Vogt M., Ios M., Siegel J., Wesselborg S., and Schulze-Osthoff K. Role of reactive oxygen intermediates in activation-induced CD95 (APO/Fas) ligand expression. J. Biol. Chem. 273 (1998) 8048-8055
4. Bolduc J.S., Denizeau F., and Jumarie C. Cadmium-induced mitochondrial membrane-potential dissipation does not necessarily require cytosolic oxidative stress: studies using rhodamine-123 fluorescence unquenching. Toxicol. Sci. 77 (2004) 299-306
5. Buttke T.M., and Sandstorm P.A. Oxidative stress as a mediator of apoptosis. Immunol. Today 15 (1994) 7-10
6. Castaneda F., and Kinne R.K.H. Apoptosis induced in HepG2 cells by short exposure to millimolar concentrations of ethanol involves the Fas-receptor pathway. J. Cancer Res. Clin. (2001) 418-424
7. Chiba T., Takahashi S., Sato N., Ishii S., and Kikuchi K. Fas-mediated apoptosis is modulated by intercellular glutathione in human T cells. Eur. J. Immunol. 26 (1996) 1164-1169
8. Clement M.V., and Stamenkovic I. Superoxide anion is a natural inhibitor of Fas-mediated cell death. EMBO J. 15 (1996) 216-225
9. Déas O., Dumont C., Mollereau B., Pasquier D.C., Bernard-Pomier G., Hirsch F., Charpentier B., and Senik A. Thiol-mediated inhibition of Fas and CD2 apoptotic signaling in activated human peripheral T cell. Int. Immunol. 9 (1997) 117-125
10. Denning T.L., Takaishi H., Crowe S.E., Boldogh I., Jevnikar A., and Ernst P.B. Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cell. Free Radical Biol. Med. 33 (2002) 1641-1650
11. Devadas S., Hinshaw J.A., Zaritskaya L., and Williams M.S. Fas-stimulated generation of reactive oxygen species or exogenous oxidative stress sensitize cells to Fas-mediated apoptosis. Free Radical Biol. Med. 35 (2004) 648-661
12. Ding W.X., Ni H.M., DiFrancesca D., Stolz D.B., and Yin X.M. Bid-dependent generation of oxygen radicals promotes death receptor activation-induced apoptosis in murine hepatocytes. Hepatology 40 (2004) 403-413
13. Driscoll K.E., Maurer J.K., Poynter J., Higgins J., Asquith T., and Miller N.S. Stimulation of rat alveolar macrophage fibronectin release in a cadmium chloride model of lung injury and fibrosis. Toxicol. Appl. Pharmacol. 116 (1992) 30-37
14. Dudley R.E., Svoboda D.J., and Klaassen C.D. Acute exposure to cadmium causes severe liver injury in rats. Toxicol. Appl. Pharmacol. 65 (1982) 302-313
15. Elinder C.G., Kjellstrom T., Hogstedt C., Andersson K., and Spang G. Cancer mortality of cadmium workers. Br. J. Ind. Med. 42 (1985) 651-655
16. Fadeel B., Orrenius S., and Zhivotovsky B. Apoptosis in human disease: a new skin for the old ceremony?. Biochem. Biophys. Res. Commun. 266 (1999) 699-717
17. Falck F.Y., Jr. Fine L.J., Smith R.G., McClatchey K.D., Annesley T., England B., and Schork A.M. Occupational cadmium exposure and renal status. Am. J. Ind. Med. 4 (1983) 541-549
18. Gao G., and Dou Q.P. N-terminal cleavage of Bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes Bcl-2-independent cytochrome c release and apoptotic cell death. J. Cell. Biochem. 80 (2000) 53-72
19. Gouaze V., Andrieu-Abadie N., Cuvillier O., Malagarie-Cazenave S., Frisach M.F., Mirault M.E., and Levade T. Glutathione peroxidase-1 protects from CD95-induced apoptosis. J. Biol. Chem. 277 (2002) 42867-42874
20. Habeebu S.S., Liu J., and Klaassen C.D. Cadmium-induced apoptosis in mouse liver. Toxicol. Appl. Pharmacol. 149 (1998) 203-209
21. Harstad E.B., Hartley D.P., Kolaja K.L., and Klaassen C.D. Activation of caspase-3 following cadmium chloride treatment in mice. Toxicol. Sci. 48 (1999) 1674 (Abstract)
22. Hart B.A., Lee C.H., Shukla G.S., Shukla A., Osier M., Eneman J.D., and Chiu J.F. Characterization of cadmium-induced apoptosis in rat lung epithelial cells: evidence for the participation of oxidant stress. Toxicology 133 (1999) 43-58
23. IARC. International agency for research on cancer. Monographs on the Evaluation of the Carcinogenic Risks to Humans. Beryllium, Cadmium, Mercury and Exposures in the Glass Manufacturing Industry (1993), IARC Scientific Publications, Lyon, France 119-238
24. Ishido M., Suzuki T., Adachi T., and Kunimoto M. Zinc stimulates DNA synthesis during its antiapoptotic action independently with increments of an antiapoptotic protein, Bcl-2, in porcine kidney LLC-PK1 cells. J. Pharmacol. Exp. Ther. 290 (1999) 923-928
25. Jayanthi S., Ordonez S., McCoy M.T., and Cadet J.L. Dual mechanism of Fas-induced cell death in neuroglioma cells: a role for reactive oxygen species. Brain Res. Mol. Brain Res. 72 (1999) 158-165
26. Kondoh M., Araragi S., Sato K., Higashimoto M., Takiguchi M., and Sato M. Cadmium induces apoptosis partly via caspase-9 activation in HL-60 cells. Toxicology 170 (2002) 111-117
27. Li H., Zhu H., Xu C.J., and Yuan J. Cleavage of BID by caspase-8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 (1998) 491-501
28. 2+-calpain and caspase-mitochondria. J. Biol. Chem. 275 (2000) 39702-39709
29. Li M., Xia T., Jiang C.S., Li L.J., Fu J.L., and Zhou Z.C. Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis. Toxicology 19 (2003) 19-33
30. Narita M., Shimizu S., Ito T., Chittenden T., Lutz R.J., Matsuda H., and Tsujimoto Y. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 14681-14686
31. Orrenius S. Mechanisms of oxidative cell damage. In: Pol G., Albano E., and Dianzani M.U. (Eds). Free Radicals: From Basic Science to Medicine (1993), Birkhauser Verlag, Basel Switzerland 47-64
32. Oh S.H., Lee B.H., and Lim S.C. Cadmium induces apoptotic cell death in WI38 cells via caspase-dependent Bid cleavage and calpain-mediated mitochondrial Bax cleavage by Bcl-2 independent pathway. Biochem. Pharmacol. 68 (2004) 1845-1855
33. 2+. Toxicology 143 (2000) 263-273
34. Poliandri A.H., Cabilla J.P., Velardez M.O., Bodo C.C., and Duvilanski B.H. Cadmium induces apoptosis in anterior pituitary cells that can be reversed by treatment with antioxidants. Toxicol. Appl. Pharmacol. 190 (2003) 17-24
35. Rikans L.E., and Yamano T. Mechanisms of cadmium-mediated acute hepatotoxicity. J. Biochem. Mol. Toxicol. 14 (2000) 110-117
36. Scaffidi C., Fulda S., Srinivasan A., Friesen C., Li F., Tomaselli K.J., Debatin K.M., Krammer P.H., and Peter M.E. Two CD95 (Apo-1/Fas) signaling pathways. EMBO J. 1 (1998) 1675-1687
37. Shih C.M., Ko W.C., Wu J.S., Wei Y.H., Wang L.F., Chang E.E., Lo T.Y., Cheng H.H., and Chen C.T. Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts. J. Cell. Biochem. 91 (2004) 384-397
38. Stohs S.J., Bagchi D., Hassoun E., and Bagchi M. Oxydative mechanisms in the toxicity of chromium and cadmium ion. J. Environ. Pathol., Toxicol. Oncol. 19 (2000) 201-213
39. Sugita M., and Tsuchiya K. Estimation of variation among individuals of biological half-time of cadmium calculated from accumulation data. Environ. Res. 8 (1995) 31-37
40. Thompson C.B. Apoptosis in the pathogenesis and treatment of disease. Science 267 (1995) 1456-1462
41. Toyota H., Yanase N., Yoshimoto T., Moriyama M., Sudo T., and Mizuguchi J. Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax. Cancer Lett. 189 (2003) 221-230
42. Tzirogiannis K.N., Panoutsopoulos G.I., Demonakou M.D., Hereti R.I., Alexandropoulou K.N., Basayannis A.C., and Mykoniatis M.G. Time-course of cadmium-induced acute hepatotoxicity in the rat liver: the role of apoptosis. Arch. Toxicol. 77 (2003) 694-701
43. Um H.D., Orenstein J.M., and Wahl M. Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway. J. Immunol. 156 (1996) 3469-3477
44. Verrier F., Mignotte B., Jan G., and Brenner C. Study of PTPC composition during apoptosis for identification of viral protein target. Ann. N.Y. Acad. Sci. 1010 (2003) 126-142
45. Waalkes M.P. Cadmium carcinogenesis in review. J. Inorg. Biochem. 79 (2000) 241-244
46. Waalkes M.P., Diwan B.A., Rehm S., Ward J.M., Moussa M., Cheria M.G., and Goyer R.A. Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effect of cadmium in mice. J. Pharmacol. Exp. Ther. 27 (1996) 1026-1033
47. Wylli A.H., Beattie G.J., and Hargreaves A.D. Chromatin changes in apoptosis. Histochem. J. 13 (1981) 681-692
48. Yang C.F., Shen H.M., Shen Y., Zhuang Z.X., and Ong C.N. Cadmium-induced oxidative cellular damage in human fetal lung fibroblasts (MRC-5) cells. Environ. Health Perspect. 105 (1997) 712-716
49. Yu R.A., Chen X., and Lu W. Study on cadmium-induced hepatocellular apoptosis in rat. Wei Sheng Yan Jiu 30 (2001) 271-272
50. Zamzami N., el Hamel C., Maisse C., Brenner C., Munoz-Pinedo C., Belzacq A.S., Costantini P., Vieira H., Loeffler M., Molle G., and Kroemer G. Bid acts on the permeability transition pore complex to induce apoptosis. Oncogene 19 (2000) 6342-6350