-
1
-
-
33847328289
-
The Bcl-2 apoptotic switch in cancer development and therapy
-
Adams JM, Cory S (2007) The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26: 1324-1337
-
(2007)
Oncogene
, vol.26
, pp. 1324-1337
-
-
Adams, J.M.1
Cory, S.2
-
2
-
-
37849006735
-
A high-throughput screening for mammalian cell death effectors identifies the mitochondrial phosphate carrier as a regulator of cytochrome c release
-
Alcalá S, Klee M, Fernandez J, Fleischer A, Pimentel-Muiños FX (2008) A high-throughput screening for mammalian cell death effectors identifies the mitochondrial phosphate carrier as a regulator of cytochrome c release. Oncogene 27: 44-54
-
(2008)
Oncogene
, vol.27
, pp. 44-54
-
-
Alcalá, S.1
Klee, M.2
Fernandez, J.3
Fleischer, A.4
Pimentel-Muiños, F.X.5
-
3
-
-
0346250162
-
Regulation of apoptosis by endoplasmic reticulum pathways
-
Breckenridge DG, Germain M, Mathai JP, Nguyen M, Shore GC (2003) Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 22: 8608-8618
-
(2003)
Oncogene
, vol.22
, pp. 8608-8618
-
-
Breckenridge, D.G.1
Germain, M.2
Mathai, J.P.3
Nguyen, M.4
Shore, G.C.5
-
4
-
-
33746912767
-
The permeability transition pore complex in cancer cell death
-
Brenner C, Grimm S (2006) The permeability transition pore complex in cancer cell death. Oncogene 25: 4744-4756
-
(2006)
Oncogene
, vol.25
, pp. 4744-4756
-
-
Brenner, C.1
Grimm, S.2
-
5
-
-
0842281645
-
Cell death: Critical control points
-
Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116: 205-219
-
(2004)
Cell
, vol.116
, pp. 205-219
-
-
Danial, N.N.1
Korsmeyer, S.J.2
-
6
-
-
33748668261
-
Bcl- XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line
-
Fiebig AA, Zhu W, Hollerbach C, Leber B, Andrews DW (2006) Bcl- XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line. BMC Cancer 6: 213
-
(2006)
BMC Cancer
, vol.6
, pp. 213
-
-
Fiebig, A.A.1
Zhu, W.2
Hollerbach, C.3
Leber, B.4
Andrews, D.W.5
-
7
-
-
36849043546
-
Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1
-
Fujino G, Noguchi T, Matsuzawa A, Yamauchi S, Saitoh M, Takeda K, Ichijo H (2007) Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. Mol Cell Biol 27: 8152-8163
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8152-8163
-
-
Fujino, G.1
Noguchi, T.2
Matsuzawa, A.3
Yamauchi, S.4
Saitoh, M.5
Takeda, K.6
Ichijo, H.7
-
8
-
-
33750523442
-
Mitochondrial calcium signalling and cell death: Approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis
-
Hajnoczky G, Csordas G, Das S, Garcia-Perez C, Saotome M, Sinha Roy S, Yi M (2006) Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis. Cell Calcium 40: 553-560
-
(2006)
Cell Calcium
, vol.40
, pp. 553-560
-
-
Hajnoczky, G.1
Csordas, G.2
Das, S.3
Garcia-Perez, C.4
Saotome, M.5
Sinha Roy, S.6
Yi, M.7
-
9
-
-
33646237823
-
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
-
Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, Antonsson B, Brandt GS, Iwakoshi NN, Schinzel A, Glimcher LH, Korsmeyer SJ (2006) Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 312: 572-576
-
(2006)
Science
, vol.312
, pp. 572-576
-
-
Hetz, C.1
Bernasconi, P.2
Fisher, J.3
Lee, A.H.4
Bassik, M.C.5
Antonsson, B.6
Brandt, G.S.7
Iwakoshi, N.N.8
Schinzel, A.9
Glimcher, L.H.10
Korsmeyer, S.J.11
-
10
-
-
43449132366
-
Multisite phosphorylation regulates Bim stability and apoptotic activity
-
Hubner A, Barrett T, Flavell RA, Davis RJ (2008) Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell 30: 415-425
-
(2008)
Mol Cell
, vol.30
, pp. 415-425
-
-
Hubner, A.1
Barrett, T.2
Flavell, R.A.3
Davis, R.J.4
-
11
-
-
0037421190
-
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane
-
Kaufmann T, Schlipf S, Sanz J, Neubert K, Stein R, Borner C (2003) Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane. J Cell Biol 160: 53-64
-
(2003)
J Cell Biol
, vol.160
, pp. 53-64
-
-
Kaufmann, T.1
Schlipf, S.2
Sanz, J.3
Neubert, K.4
Stein, R.5
Borner, C.6
-
12
-
-
14744281338
-
Bcl-X(L) specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum
-
Klee M, Pimentel-Muiños FX (2005) Bcl-X(L) specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum. J Cell Biol 168: 723-734
-
(2005)
J Cell Biol
, vol.168
, pp. 723-734
-
-
Klee, M.1
Pimentel-Muiños, F.X.2
-
13
-
-
46349097952
-
Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore
-
Leung AW, Halestrap AP (2008) Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore. Biochim Biophys Acta 1777: 946-952
-
(2008)
Biochim Biophys Acta
, vol.1777
, pp. 946-952
-
-
Leung, A.W.1
Halestrap, A.P.2
-
14
-
-
36049049392
-
IRE1 signaling affects cell fate during the unfolded protein response
-
Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM, Walter P (2007) IRE1 signaling affects cell fate during the unfolded protein response. Science 318: 944-949
-
(2007)
Science
, vol.318
, pp. 944-949
-
-
Lin, J.H.1
Li, H.2
Yasumura, D.3
Cohen, H.R.4
Zhang, C.5
Panning, B.6
Shokat, K.M.7
Lavail, M.M.8
Walter, P.9
-
15
-
-
21244462014
-
BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death
-
Mathai JP, Germain M, Shore GC (2005) BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death. J Biol Chem 280: 23829-23836
-
(2005)
J Biol Chem
, vol.280
, pp. 23829-23836
-
-
Mathai, J.P.1
Germain, M.2
Shore, G.C.3
-
16
-
-
0037163133
-
Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells
-
Mathiasen IS, Sergeev IN, Bastholm L, Elling F, Norman AW, Jaattela M (2002) Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells. J Biol Chem 277: 30738-30745
-
(2002)
J Biol Chem
, vol.277
, pp. 30738-30745
-
-
Mathiasen, I.S.1
Sergeev, I.N.2
Bastholm, L.3
Elling, F.4
Norman, A.W.5
Jaattela, M.6
-
17
-
-
9644295726
-
Translocation of Bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stressinduced apoptosis
-
Morishima N, Nakanishi K, Tsuchiya K, Shibata T, Seiwa E (2004) Translocation of Bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stressinduced apoptosis. J Biol Chem 279: 50375-50381
-
(2004)
J Biol Chem
, vol.279
, pp. 50375-50381
-
-
Morishima, N.1
Nakanishi, K.2
Tsuchiya, K.3
Shibata, T.4
Seiwa, E.5
-
18
-
-
0037390872
-
Spike, a novel BH3-only protein, regulates apoptosis at the endoplasmic reticulum
-
Mund T, Gewies A, Schoenfeld N, Bauer MK, Grimm S (2003) Spike, a novel BH3-only protein, regulates apoptosis at the endoplasmic reticulum. FASEB J 17: 696-698
-
(2003)
FASEB J
, vol.17
, pp. 696-698
-
-
Mund, T.1
Gewies, A.2
Schoenfeld, N.3
Bauer, M.K.4
Grimm, S.5
-
19
-
-
0036606540
-
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
-
Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, Ichijo H (2002) ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 16: 1345-1355
-
(2002)
Genes Dev
, vol.16
, pp. 1345-1355
-
-
Nishitoh, H.1
Matsuzawa, A.2
Tobiume, K.3
Saegusa, K.4
Takeda, K.5
Inoue, K.6
Hori, S.7
Kakizuka, A.8
Ichijo, H.9
-
20
-
-
0037088658
-
Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores
-
Nutt LK, Pataer A, Pahler J, Fang B, Roth J, McConkey DJ, Swisher SG (2002) Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores. J Biol Chem 277: 9219-9225
-
(2002)
J Biol Chem
, vol.277
, pp. 9219-9225
-
-
Nutt, L.K.1
Pataer, A.2
Pahler, J.3
Fang, B.4
Roth, J.5
McConkey, D.J.6
Swisher, S.G.7
-
21
-
-
10644234677
-
Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor
-
Palmer AE, Jin C, Reed JC, Tsien RY (2004) Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor. Proc Natl Acad Sci USA 101: 17404-17409
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 17404-17409
-
-
Palmer, A.E.1
Jin, C.2
Reed, J.C.3
Tsien, R.Y.4
-
22
-
-
0038420824
-
2- Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels
-
Peppiatt CM, Collins TJ, Mackenzie L, Conway SJ, Holmes AB, Bootman MD, Berridge MJ, Seo JT, Roderick HL (2003) 2- Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels. Cell Calcium 34: 97-108
-
(2003)
Cell Calcium
, vol.34
, pp. 97-108
-
-
Peppiatt, C.M.1
Collins, T.J.2
Mackenzie, L.3
Conway, S.J.4
Holmes, A.B.5
Bootman, M.D.6
Berridge, M.J.7
Seo, J.T.8
Roderick, H.L.9
-
23
-
-
0141961772
-
Cytofluorometric quantitation of apoptosis-driven inner mitochondrial membrane permeabilization
-
Poncet D, Boya P, Metivier D, Zamzami N, Kroemer G (2003) Cytofluorometric quantitation of apoptosis-driven inner mitochondrial membrane permeabilization. Apoptosis 8: 521-530
-
(2003)
Apoptosis
, vol.8
, pp. 521-530
-
-
Poncet, D.1
Boya, P.2
Metivier, D.3
Zamzami, N.4
Kroemer, G.5
-
24
-
-
34250758642
-
ER stress triggers apoptosis by activating BH3-only protein Bim
-
Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N, Gotoh T, Akira S, Bouillet P, Strasser A (2007) ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 129: 1337-1349
-
(2007)
Cell
, vol.129
, pp. 1337-1349
-
-
Puthalakath, H.1
O'Reilly, L.A.2
Gunn, P.3
Lee, L.4
Kelly, P.N.5
Huntington, N.D.6
Hughes, P.D.7
Michalak, E.M.8
McKimm-Breschkin, J.9
Motoyama, N.10
Gotoh, T.11
Akira, S.12
Bouillet, P.13
Strasser, A.14
-
25
-
-
0036097786
-
Keeping killers on a tight leash: Transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
-
Puthalakath H, Strasser A (2002) Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ 9: 505-512
-
(2002)
Cell Death Differ
, vol.9
, pp. 505-512
-
-
Puthalakath, H.1
Strasser, A.2
-
26
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
27
-
-
42549144606
-
Bcl-2 protein family members: Versatile regulators of calcium signaling in cell survival and apoptosis
-
Rong Y, Distelhorst CW (2008) Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis. Annu Rev Physiol 70: 73-91
-
(2008)
Annu Rev Physiol
, vol.70
, pp. 73-91
-
-
Rong, Y.1
Distelhorst, C.W.2
-
28
-
-
0037418843
-
BAX and BAK regulation of endoplasmic reticulum Ca2+: A control point for apoptosis
-
Scorrano L, Oakes SA, Opferman JT, Cheng EH, Sorcinelli MD, Pozzan T, Korsmeyer SJ (2003) BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science 300: 135-139
-
(2003)
Science
, vol.300
, pp. 135-139
-
-
Scorrano, L.1
Oakes, S.A.2
Opferman, J.T.3
Cheng, E.H.4
Sorcinelli, M.D.5
Pozzan, T.6
Korsmeyer, S.J.7
-
29
-
-
33750200771
-
Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways
-
Shibue T, Suzuki S, Okamoto H, Yoshida H, Ohba Y, Takaoka A, Taniguchi T (2006) Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways. EMBO J 25: 4952-4962
-
(2006)
EMBO J
, vol.25
, pp. 4952-4962
-
-
Shibue, T.1
Suzuki, S.2
Okamoto, H.3
Yoshida, H.4
Ohba, Y.5
Takaoka, A.6
Taniguchi, T.7
-
30
-
-
33748789479
-
Mediators of endoplasmic reticulum stress-induced apoptosis
-
Szegezdi E, Logue SE, Gorman AM, Samali A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7: 880-885
-
(2006)
EMBO Rep
, vol.7
, pp. 880-885
-
-
Szegezdi, E.1
Logue, S.E.2
Gorman, A.M.3
Samali, A.4
-
31
-
-
33344477350
-
Chemical genetic analysis of the time course of signal transduction by JNK
-
Ventura JJ, Hubner A, Zhang C, Flavell RA, Shokat KM, Davis RJ (2006) Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell 21: 701-710
-
(2006)
Mol Cell
, vol.21
, pp. 701-710
-
-
Ventura, J.J.1
Hubner, A.2
Zhang, C.3
Flavell, R.A.4
Shokat, K.M.5
Davis, R.J.6
-
32
-
-
0242410719
-
p53- and druginduced apoptotic responses mediated by BH3-only proteins puma and noxa
-
Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, Ausserlechner MJ, Adams JM, Strasser A (2003) p53- and druginduced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302: 1036-1038
-
(2003)
Science
, vol.302
, pp. 1036-1038
-
-
Villunger, A.1
Michalak, E.M.2
Coultas, L.3
Mullauer, F.4
Bock, G.5
Ausserlechner, M.J.6
Adams, J.M.7
Strasser, A.8
-
33
-
-
26444593029
-
Mitochondria and endoplasmic reticulum: The lethal interorganelle cross-talk
-
Walter L, Hajnoczky G (2005) Mitochondria and endoplasmic reticulum: the lethal interorganelle cross-talk. J Bioenerg Biomembr 37: 191-206
-
(2005)
J Bioenerg Biomembr
, vol.37
, pp. 191-206
-
-
Walter, L.1
Hajnoczky, G.2
-
34
-
-
0035957653
-
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ (2001) Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
Lindsten, T.4
Panoutsakopoulou, V.5
Ross, A.J.6
Roth, K.A.7
MacGregor, G.R.8
Thompson, C.B.9
Korsmeyer, S.J.10
-
35
-
-
0036830438
-
Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL
-
Yamaguchi H, Wang HG (2002) Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL. J Biol Chem 277: 41604-41612
-
(2002)
J Biol Chem
, vol.277
, pp. 41604-41612
-
-
Yamaguchi, H.1
Wang, H.G.2
-
36
-
-
0037810844
-
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
-
Zong WX, Li C, Hatzivassiliou G, Lindsten T, Yu QC, Yuan J, Thompson CB (2003) Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol 162: 59-69
-
(2003)
J Cell Biol
, vol.162
, pp. 59-69
-
-
Zong, W.X.1
Li, C.2
Hatzivassiliou, G.3
Lindsten, T.4
Yu, Q.C.5
Yuan, J.6
Thompson, C.B.7
-
37
-
-
0035876483
-
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
-
Zong WX, Lindsten T, Ross AJ, MacGregor GR, Thompson CB (2001) BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev 15: 1481-1486
-
(2001)
Genes Dev
, vol.15
, pp. 1481-1486
-
-
Zong, W.X.1
Lindsten, T.2
Ross, A.J.3
MacGregor, G.R.4
Thompson, C.B.5
|