Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 20, 2009, Pages 8326-8331

  Zeng, Lingfang ^a   Zampetaki, Anna ^a   Margariti, Andriana ^a   Pepe, Anna Elena ^a   Alam, Saydul ^a   Martin, Daniel ^a   Xiao, Qingzhong ^a   Wang, Wen ^b   Jin, Zheng Gen ^c   Cockerill, Gillian ^d   Mori, Kazutoshi ^e   Li, Yi Shuan Julie ^f   Hu, Yanhua ^a   Chien, Shu ^f   Xu, Qingbo ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^d ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^e KYOTO UNIVERSITY   (Japan)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Caspase; Endothelial integrity; Mouse model; Ve cadherin; Vessel graft

Indexed keywords

ADENOVIRUS VECTOR; APOLIPOPROTEIN E; CASPASE 12; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; MATRIX METALLOPROTEINASE; VASCULAR ENDOTHELIAL CADHERIN; X BOX BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; AORTA GRAFT; APOPTOSIS; ARTICLE; ATHEROGENESIS; BLOOD VESSEL WALL; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME DEGRADATION; EX VIVO STUDY; GENE OVEREXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOGRAFT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION; UMBILICAL VEIN;

ANIMALS; APOLIPOPROTEINS E; APOPTOSIS; ARTERIES; ATHEROSCLEROSIS; CELLS, CULTURED; DNA-BINDING PROTEINS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; MICE; MICE, KNOCKOUT; PROTEIN SPLICING; REGIONAL BLOOD FLOW; TRANSCRIPTION FACTORS;

MUS;

EID: 66249117652     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903197106     Document Type: Article

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