Activation of p38 MAPK by oxidative stress underlying epirubicin-induced vascular endothelial cell injury

Free Radical Biology and Medicine

Volumn 52, Issue 8, 2012, Pages 1285-1293

  Yamada, Takaaki ^a   Egashira, Nobuaki ^a   Bando, Ayami ^a   Nishime, Yui ^a   Tonogai, Yuki ^a   Imuta, Maiko ^a   Yano, Takahisa ^a   Oishi, Ryozo ^a  

^a KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

(MAPK); Apoptosis; Endothelial cell; Epirubicin; Oxidative stress; p38 mitogen activated protein kinase; Vascular injury

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BUTHIONINE SULFOXIMINE; CASPASE 3; CASPASE 7; EPIRUBICIN; GLUTATHIONE; LIPID HYDROPEROXIDE; LIPID PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PIFITHRIN ALPHA; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; AORTA; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GLUTATHIONE METABOLISM; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SWINE; VASCULAR ENDOTHELIUM;

ACETYLCYSTEINE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; ENZYME ACTIVATION; EPIRUBICIN; GLUTATHIONE; IN SITU NICK-END LABELING; MITOCHONDRIA; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SWINE;

SUS;

EID: 84857991374     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.02.003     Document Type: Article

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