Neuropeptide y, the hypothalamus and the regulation of energy homeostasis

Hormone Research in Paediatrics

Volumn 46, Issue 2, 1996, Pages 53-58

  Tomaszuk, Ania ^a   Simpson, Claire ^a   Williams, Gareth ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Energy balance; Glucocorticoids; Hypothalamus; Insulin; Leptin; Neuropeptide Y; Obesity; Rodent

Indexed keywords

GLUCOCORTICOID; INSULIN; NEUROPEPTIDE Y;

ANIMAL CELL; ANIMAL EXPERIMENT; APPETITE; ARCUATE NUCLEUS; BRAIN NERVE CELL; BROWN ADIPOSE TISSUE; CACHEXIA; DIABETES MELLITUS; DRUG DESIGN; ENERGY BALANCE; ENERGY EXPENDITURE; ETIOLOGY; FOOD INTAKE; HOMEOSTASIS; HYPERPHAGIA; HYPOTHALAMUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; REVIEW; STARVATION; THERMOGENESIS; WEIGHT GAIN;

EID: 0029758229     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000184996     Document Type: Article

References (40)

1. Frankish HM, Drvden S, Hopkins DFC, Wang Q, Williams G: Neuropeptide Y, the hypothalamus and diabetes: insights into the control of metabolism, Peptides 1995:16:757-771.
2. Tatemoto K, Neuropeptide Y: Complete amino acid sequence of the brain peptide, Proc Natl Acad Sci USA 1982;79:5485-5489.
3. Bai FL, Yamano M, Shiotani Y, et al: An arcuato-paraventricular and dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat, Brain Res 1985;331:172-175.
4. Stanley BG, Kyrkouli SE, Lampert S, Leibo-witz SF: Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity, Peptides 1986;7:1189-1192.
5. Billington CJ, Briggs J, Grace M, Levine AS: Effects of inlracerebroventricular injection of NPY on energy metabolism, Am J Physiol 1991:260:R321-327.
6. Egawa M, Yoshimatsu H, Bray GA: Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue, Am J Physiol 1991;260:R328-334.
7. Abe M, Saito M, Shiamzu T: Neuropeptide Y and norepinephrine injected into the paraventricular nucleus of the hypothalamus activate endocrine pancreas, Bionicd Res 1989:10:431-436.
8. Zarjcvski N, Cusin I, Vcttor R, Rohner-Jean-renaud F, Jcanrenaud B: Chronic intracercbro-ventricular neuropeptide Y administration to normal rats mimics hormonal and metabolic changes of obesity, Endocrinology 1993:133: 1753-1758.
9. Jeanrcnaud B: An hypothesis on the aetiology of obesity: Dysfunction of the central nervous system as a primary cause, Diabetologia 1985: 28:502-513.
10. Beck B, Uniyal MJ, Burlet A, Chapleur-Cha-tcau M, Leibowitz SF, Burlet C: Rapid and localized alterations of neuropeptide Y in discrete hypothalamic neuclei with feeding status, Brain Res 1990;528:245-249.
11. Williams G, Gill JS, Lee YC, Cardoso HM, Okpere BE, Bloom SR: Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozotocin-induced diabetic rats, Diabetes 1989;38:321-327.
12. Brady LS, Smith MA, Gold PW, Kerkenham M: Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats, Neuroendocrinology 1990;52: 441-447.
13. White JD, Olchowsky D, Kershaw M, Berelo-witz M: Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in streptozotocin-diabetic rats, Endocrinology 1990;126:765-772.
14. Kalra SP, Dube MG, Sahu A, Phelps CP, Kalra PS: Neuropeptide Y increases in the paraventricular nucleus in association with increased appeplide for food, Proc Natl Acad Sci USA 1992;88:10931-10935.
15. Sahu A, Sninsky CA, Phelps CP, Dube MG, Kalra PS, Kalra SP: Neuropeptide Y release from the paraventricular nucleus is increased in association with hyperphagia in strcptozoto-cin-induced diabetic rats, Endocrinology 1992: 131:2979-2985.
16. Frankish HM, McCarthy HD, Drydcn S, Kilpatrick AP, Williams G: Reduced neuropeptide Y receptor numbers of the hypothalamus of streptozotocin-diabetic rat: Further evidence of increased NPY activity, Peptides 1993:14:941-948.
17. Stanley BG, Yee SM, Rosethal MJ, Gunion M: Eating elicited by neuropeptide Y into the pcri-fomical hypothalamus is abolished in streptozotocin-diabetic rats, Ini J Obes 1991:15:43.
18. Schwartz MW, Figlewicz DP, Baskin DG, Woodds SC, Porte D: Insulin in the brain: A hormonal regulator of energy balance, Endocr Rev 1992:13:387-414.
19. Schwartz MW, Sipols AJ, Marks JC, et al: Inhibition of hypothalamic neuropeptide Y gene expression by insulin, Endocrinology 1992; 130:3608-3616.
20. Sipols AJ, Baskin DG, Schwartz MW: Effect of intracercbrovcntricular insulin infusion on diabetic hypcrphagia and hypothalamic neuropeptide gene expression, Diabetes 1995:44:147-151.
21. Cusin I, Dryden S, Wang Q, Rohner-Jeanre-naud F, Jeanrenaud B, Williams G: Effect of sustained physiological hyperinsulinaemia on hypothalamic neuropeptide Y and NPY mRNA levels in the rat, J Neurocndocrino! 1995;7:193-197.
22. Akabayashi A, Watanabe Y, Wahlcstedt C, McEwan BS, Paez X, Leibowitz SF: Hypothalamic neuropeptide Y, its gene expression and receptor activity: Relation to circulating corticosterone in adrcnalectomiscd rats, Brain Res 1994;665:201-202.
23. Strack AM, Sebastian RJ, Schwartz MW, Dalian MF: Glucocorticoids and insulin: Reciprocal signals for energy balance, Am J Physiol 1995;268:R142-R149.
24. Larsen PJ, Jessop DS, Chowdrey HS, Light-man SL, Mikkelsen JD: Chronic administration of glucocorticoids directly upregulates pre-pro-ncuropcptide Y and Y.reccptor mRNA levels in the arcuate nucleus of the rat, J Neu-rocndocrinol 1994;6:153-159.
25. Zhang Y, Proenca R, Maffci M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homolo-gue, Nature 1994:372:425-432.
26. Pclleymounter MA, Cullen MJ, Baker MB, Hechl R, Winters D, Boone T, Collins F: Effects of the obese gene product on body weight regulation in ob/ob mice, Science 1995:269: 540-543.
27. Halaas JL, Gajiwali KS, Maffci M, Cohen SL, Chait BT, Rabinowitz D, Lallonc RL, Burley SK, Friedman JM: Weight reducing effects of the plasma protein encoded by the obese gene, Science 1995;269:543-546.
28. Campfield LA, Smith FJ, Guiscz Y, Devos R, Bum P: Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks, Science 1995:269: 546-549.
29. Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgctt SG, Craft L, Hale J, Hoffmann J, Using NH, Kriaciunas A, MaKel-lar W, Rosteck PR, Schoner B, Smith D, Tinsley FC, Zhang XY, Heiman M: Thc role of neuropeptide Y in the antiobesity action of the obese gene product, Nature 1995,377:530-532.
30. Considine RV, Considine EL, Williams CJ, Nyce MR, Magosin SA, Bauer TL, Rosato EL, Colbcrg J, Caro JF: Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity, J Clin Invest 1995;95:2986-2988.
31. Sanacora G, Kershaw M, Finkclstein JA, White JD: Increased hypothalamic content of prcproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation, Endocrinology 1990;127:730-737.
32. McKibbin PE, Cotton SJ, McMillian S, et al: Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats, Diabetes 1991:40:1423-1429.
33. McCarthy HD, McKibbin PE, Holloway B, Mayers R, Williams G: Hypothalamic neuropeptide Y receptor characteristics and NPY induced feeding responses in lean and obese Zucker rats, Life Sei 1991;49:1491-1497.
34. Dryden S, Pickavance L, Frankish HM, Williams G: Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus obese (fa/fa) Zucker rats, Brain Res 1995:690: 185-188.
35. Wilding JPH, Gilbey SG, Bailey CJ et al: Increased neuropeptide Y messenger RNA and decreased neurotensin messenger RNA in the hypothalamus of the obese (ob/ob) mouse, Endocrinology 1993;132:1939-1944.
36. Ikcda H, West DB, Pustck JJ, et al: Intracere-brovcntricular insulin reduces food intake and body weight of lean but not obese Zucker rats, Appetite 1986;7:381-386.
37. Schwartz MW, Marks JL, Sipols AJ, Baskin DG, Woods SC, Kahn SE, Porte D: Central insulin administration reduces NPY mRNA expression in the arcuate nucleus of food deprived lean (fa/fa) Zucker rats, Endocrinology 1991;128:2645-2647.
38. Gchlcrt DR: Minirevicw: Subtypes of receptors for neuropeptide Y: Implications for the targeting of therapeutics, Life Sei 1994;55:551-562.
39. Stanley BG, Magdalin W, Seirafi S, Nguyen MM, Leibowitz SF: Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect, Peptides 1992: 13:581-587.
40. l2SI neuropeptide Y1.34 as a novel radiogland for neuropeptide Y receptors, Soc Neurosci Abstr 1993:19:727.