메뉴 건너뛰기




Volumn 43, Issue 2, 2012, Pages 725-734

Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT

Author keywords

Deprivation; Fat loss; Isoleucine; Valine

Indexed keywords

ISOLEUCINE; UNCOUPLING PROTEIN 1; VALINE;

EID: 84864753443     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-011-1123-8     Document Type: Article
Times cited : (103)

References (56)
  • 1
    • 4344650113 scopus 로고    scopus 로고
    • Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2
    • Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC (2004) Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem 279(35):36553-36561
    • (2004) J Biol Chem , vol.279 , Issue.35 , pp. 36553-36561
    • Anthony, T.G.1    McDaniel, B.J.2    Byerley, R.L.3    McGrath, B.C.4    Cavener, D.R.5    McNurlan, M.A.6    Wek, R.C.7
  • 2
    • 77956191622 scopus 로고    scopus 로고
    • Thermogenesis in CD-1 mice after combined chronic hypoxia and cold acclimation
    • Beaudry JL, McClelland GB (2010) Thermogenesis in CD-1 mice after combined chronic hypoxia and cold acclimation. Comp Biochem Physiol 157(3):301-309
    • (2010) Comp Biochem Physiol , vol.157 , Issue.3 , pp. 301-309
    • Beaudry, J.L.1    McClelland, G.B.2
  • 4
    • 0029050541 scopus 로고
    • Locomotor activity and utilization of energy reserves during fasting after ventromedial hypothalamic lesions
    • Challet E, Le Maho Y, Malan A (1995) Locomotor activity and utilization of energy reserves during fasting after ventromedial hypothalamic lesions. Physiol Behav 58(2):257-264
    • (1995) Physiol Behav , vol.58 , Issue.2 , pp. 257-264
    • Challet, E.1    Le Maho, Y.2    Malan, A.3
  • 5
    • 77449124765 scopus 로고    scopus 로고
    • Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue
    • Cheng Y, Meng Q, Wang C, Li H, Huang Z, Chen S, Xiao F, Guo F (2010) Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue. Diabetes 59(1):17-25
    • (2010) Diabetes , vol.59 , Issue.1 , pp. 17-25
    • Cheng, Y.1    Meng, Q.2    Wang, C.3    Li, H.4    Huang, Z.5    Chen, S.6    Xiao, F.7    Guo, F.8
  • 6
    • 0032810333 scopus 로고    scopus 로고
    • Regional variation of white adipocyte lipolysis during the annual cycle of the alpine marmot
    • Cochet N, Meister R, Florant GL, Barre H (1999) Regional variation of white adipocyte lipolysis during the annual cycle of the alpine marmot. Comp Biochem Physiol 123(3):225-232
    • (1999) Comp Biochem Physiol , vol.123 , Issue.3 , pp. 225-232
    • Cochet, N.1    Meister, R.2    Florant, G.L.3    Barre, H.4
  • 8
    • 24744457955 scopus 로고    scopus 로고
    • Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity
    • Doi M, Yamaoka I, Nakayama M, Mochizuki S, Sugahara K, Yoshizawa F (2005) Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity. J Nutr 135(9):2103-2108
    • (2005) J Nutr , vol.135 , Issue.9 , pp. 2103-2108
    • Doi, M.1    Yamaoka, I.2    Nakayama, M.3    Mochizuki, S.4    Sugahara, K.5    Yoshizawa, F.6
  • 9
    • 34447574828 scopus 로고    scopus 로고
    • Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis
    • Doi M, Yamaoka I, Nakayama M, Sugahara K, Yoshizawa F (2007) Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis. Am J Physiol 292(6):E1683-E1693
    • (2007) Am J Physiol , vol.292 , Issue.6
    • Doi, M.1    Yamaoka, I.2    Nakayama, M.3    Sugahara, K.4    Yoshizawa, F.5
  • 10
    • 0028856273 scopus 로고
    • Essential amino acids regulate fatty acid synthase expression through an uncharged transfer RNA-dependent mechanism
    • Dudek SM, Semenkovich CF (1995) Essential amino acids regulate fatty acid synthase expression through an uncharged transfer RNA-dependent mechanism. J Biol Chem 270(49):29323-29329
    • (1995) J Biol Chem , vol.270 , Issue.49 , pp. 29323-29329
    • Dudek, S.M.1    Semenkovich, C.F.2
  • 12
    • 58749091645 scopus 로고    scopus 로고
    • UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    • Feldmann HM, Golozoubova V, Cannon B, Nedergaard J (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9(2):203-209
    • (2009) Cell Metab , vol.9 , Issue.2 , pp. 203-209
    • Feldmann, H.M.1    Golozoubova, V.2    Cannon, B.3    Nedergaard, J.4
  • 13
    • 0842263981 scopus 로고    scopus 로고
    • The biology of peroxisome proliferator-activated receptors: Relationship with lipid metabolism and insulin sensitivity
    • Ferre P (2004) The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 53(Suppl 1):S43-S50
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Ferre, P.1
  • 14
    • 0023117178 scopus 로고
    • Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity
    • Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S (1987) Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metab Clin Exp 36(1):54-59
    • (1987) Metab Clin Exp , vol.36 , Issue.1 , pp. 54-59
    • Fujioka, S.1    Matsuzawa, Y.2    Tokunaga, K.3    Tarui, S.4
  • 15
    • 0024422811 scopus 로고
    • Dietary amino acid imbalance and neurochemical changes in three hypothalamic areas
    • Gietzen DW, Leung PM, Rogers QR (1989) Dietary amino acid imbalance and neurochemical changes in three hypothalamic areas. Physiol Behav 46(3):503-511
    • (1989) Physiol Behav , vol.46 , Issue.3 , pp. 503-511
    • Gietzen, D.W.1    Leung, P.M.2    Rogers, Q.R.3
  • 16
    • 0035976955 scopus 로고    scopus 로고
    • Stimulation of lipolysis and hormonesensitive lipase via the extracellular signal-regulated kinase pathway
    • Greenberg AS, Shen WJ, Muliro K, Patel S, Souza SC, Roth RA, Kraemer FB (2001) Stimulation of lipolysis and hormonesensitive lipase via the extracellular signal-regulated kinase pathway. J Biol Chem 276(48):45456-45461
    • (2001) J Biol Chem , vol.276 , Issue.48 , pp. 45456-45461
    • Greenberg, A.S.1    Shen, W.J.2    Muliro, K.3    Patel, S.4    Souza, S.C.5    Roth, R.A.6    Kraemer, F.B.7
  • 17
    • 0016242866 scopus 로고
    • Food motivated behavior in genetically obese and hypothalamic-hyperphagic rats and mice
    • Greenwood MR, Quartermain D, Johnson PR, Cruce JA, Hirsch J (1974) Food motivated behavior in genetically obese and hypothalamic-hyperphagic rats and mice. Physiol Behav 13(5):687-692
    • (1974) Physiol Behav , vol.13 , Issue.5 , pp. 687-692
    • Greenwood, M.R.1    Quartermain, D.2    Johnson, P.R.3    Cruce, J.A.4    Hirsch, J.5
  • 18
    • 33846602706 scopus 로고    scopus 로고
    • The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid
    • Guo F, Cavener DR (2007) The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab 5(2):103-114
    • (2007) Cell Metab , vol.5 , Issue.2 , pp. 103-114
    • Guo, F.1    Cavener, D.R.2
  • 19
    • 33845596500 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism
    • Handschin C, Spiegelman BM (2006) Peroxisome proliferatoractivated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev 27(7):728-735
    • (2006) Endocr Rev , vol.27 , Issue.7 , pp. 728-735
    • Handschin, C.1    Spiegelman, B.M.2
  • 20
    • 0028695223 scopus 로고
    • The eIF-2 alpha kinases: Regulators of protein synthesis in starvation and stress
    • Hinnebusch AG (1994) The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress. Semin Cell Biol 5(6):417-426
    • (1994) Semin Cell Biol , vol.5 , Issue.6 , pp. 417-426
    • Hinnebusch, A.G.1
  • 21
    • 41149142315 scopus 로고    scopus 로고
    • Acute and chronic treatment of L-isoleucine ameliorates glucose metabolism in glucose-intolerant and diabetic mice
    • Ikehara O, Kawasaki N, Maezono K, Komatsu M, Konishi A (2008) Acute and chronic treatment of L-isoleucine ameliorates glucose metabolism in glucose-intolerant and diabetic mice. Biol Pharm Bull 31(3):469-472
    • (2008) Biol Pharm Bull , vol.31 , Issue.3 , pp. 469-472
    • Ikehara, O.1    Kawasaki, N.2    Maezono, K.3    Komatsu, M.4    Konishi, A.5
  • 23
    • 0021333571 scopus 로고
    • Influence of cell proliferation and cell cycle phase on expression of estrogen receptor in MCF-7 breast cancer cells
    • Jakesz R, Smith CA, Aitken S, Huff K, Schuette W, Shackney S, Lippman M (1984) Influence of cell proliferation and cell cycle phase on expression of estrogen receptor in MCF-7 breast cancer cells. Cancer Res 44(2):619-625
    • (1984) Cancer Res , vol.44 , Issue.2 , pp. 619-625
    • Jakesz, R.1    Smith, C.A.2    Aitken, S.3    Huff, K.4    Schuette, W.5    Shackney, S.6    Lippman, M.7
  • 24
    • 31544466776 scopus 로고    scopus 로고
    • Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis
    • Kimball SR, Jefferson LS (2006) Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr 136(1 Suppl): 227S-231S
    • (2006) J Nutr , vol.136 , Issue.1 SUPPL.
    • Kimball, S.R.1    Jefferson, L.S.2
  • 26
    • 31544440119 scopus 로고    scopus 로고
    • Potential importance of leucine in treatment of obesity and the metabolic syndrome
    • Layman DK, Walker DA (2006) Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr 136(1 Suppl):319S-323S
    • (2006) J Nutr , vol.136 , Issue.1 SUPPL.
    • Layman, D.K.1    Walker, D.A.2
  • 28
    • 0033787068 scopus 로고    scopus 로고
    • Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
    • Li B, Nolte LA, Ju JS, Han DH, Coleman T, Holloszy JO, Semenkovich CF (2000) Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nat Med 6(10):1115-1120
    • (2000) Nat Med , vol.6 , Issue.10 , pp. 1115-1120
    • Li, B.1    Nolte, L.A.2    Ju, J.S.3    Han, D.H.4    Coleman, T.5    Holloszy, J.O.6    Semenkovich, C.F.7
  • 29
    • 3043003999 scopus 로고
    • Participation of free amino acids in protein synthesis
    • Loftfield RB, Harris A (1956) Participation of free amino acids in protein synthesis. J Biol Chem 219(1):151-159
    • (1956) J Biol Chem , vol.219 , Issue.1 , pp. 151-159
    • Loftfield, R.B.1    Harris, A.2
  • 30
    • 77952549969 scopus 로고    scopus 로고
    • Dietary L-leucine supplementation of lactating rats results in a tendency to increase lean/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamus
    • Lopez N, Sanchez J, Pico C, Palou A, Serra F (2010) Dietary L-leucine supplementation of lactating rats results in a tendency to increase lean/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamus. Peptides 31(7):1361-1367
    • (2010) Peptides , vol.31 , Issue.7 , pp. 1361-1367
    • Lopez, N.1    Sanchez, J.2    Pico, C.3    Palou, A.4    Serra, F.5
  • 31
    • 0034611678 scopus 로고    scopus 로고
    • Towards a molecular understanding of adaptive thermogenesis
    • Lowell BB, Spiegelman BM (2000) Towards a molecular understanding of adaptive thermogenesis. Nature 404(6778):652-660
    • (2000) Nature , vol.404 , Issue.6778 , pp. 652-660
    • Lowell, B.B.1    Spiegelman, B.M.2
  • 32
    • 38949105881 scopus 로고    scopus 로고
    • Serum concentration of amino acids versus nutritional status in hemodialysis patients
    • Malgorzewicz S, Debska-Slizien A, Rutkowski B, Lysiak-Szydlowska W (2008) Serum concentration of amino acids versus nutritional status in hemodialysis patients. J Ren Nutr 18(2):239-247
    • (2008) J Ren Nutr , vol.18 , Issue.2 , pp. 239-247
    • Malgorzewicz, S.1    Debska-Slizien, A.2    Rutkowski, B.3    Lysiak-Szydlowska, W.4
  • 33
    • 0019519889 scopus 로고
    • Effects of isoleucine deprivation on synthesis of sterols and fatty acids in LM-cells
    • Maltese WA, Reitz BA, Volpe JJ (1981) Effects of isoleucine deprivation on synthesis of sterols and fatty acids in LM-cells. J Biol Chem 256(5):2185-2193
    • (1981) J Biol Chem , vol.256 , Issue.5 , pp. 2185-2193
    • Maltese, W.A.1    Reitz, B.A.2    Volpe, J.J.3
  • 35
    • 0034682795 scopus 로고    scopus 로고
    • Thermogenic responses in brown fat cells are fully UCP1-dependent UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis
    • Matthias A, Ohlson KB, Fredriksson JM, Jacobsson A, Nedergaard J, Cannon B (2000) Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis. J Biol Chem 275(33):25073-25081
    • (2000) J Biol Chem , vol.275 , Issue.33 , pp. 25073-25081
    • Matthias, A.1    Ohlson, K.B.2    Fredriksson, J.M.3    Jacobsson, A.4    Nedergaard, J.5    Cannon, B.6
  • 36
    • 34548493015 scopus 로고    scopus 로고
    • Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight
    • Meister B (2007) Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight. Physiol Behav 92(1-2):263-271
    • (2007) Physiol Behav , vol.92 , Issue.1-2 , pp. 263-271
    • Meister, B.1
  • 37
    • 0034703021 scopus 로고    scopus 로고
    • Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway
    • Mordier S, Deval C, Bechet D, Tassa A, Ferrara M (2000) Leucine limitation induces autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of rapamycin-independent signaling pathway. J Biol Chem 275(38):29900-29906
    • (2000) J Biol Chem , vol.275 , Issue.38 , pp. 29900-29906
    • Mordier, S.1    Deval, C.2    Bechet, D.3    Tassa, A.4    Ferrara, M.5
  • 38
    • 64049117998 scopus 로고    scopus 로고
    • Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice
    • Nairizi A, She P, Vary TC, Lynch CJ (2009) Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice. J Nutr 139(4):715-719
    • (2009) J Nutr , vol.139 , Issue.4 , pp. 715-719
    • Nairizi, A.1    She, P.2    Vary, T.C.3    Lynch, C.J.4
  • 39
    • 77249137784 scopus 로고    scopus 로고
    • Isoleucine prevents the accumulation of tissue triglycerides and upregulates the expression of PPARalpha and uncoupling protein in diet-induced obese mice
    • Nishimura J, Masaki T, Arakawa M, Seike M, Yoshimatsu H (2010) Isoleucine prevents the accumulation of tissue triglycerides and upregulates the expression of PPARalpha and uncoupling protein in diet-induced obese mice. J Nutr 140(3):496-500
    • (2010) J Nutr , vol.140 , Issue.3 , pp. 496-500
    • Nishimura, J.1    Masaki, T.2    Arakawa, M.3    Seike, M.4    Yoshimatsu, H.5
  • 40
    • 34548420614 scopus 로고    scopus 로고
    • Insulin efficiently stores triglycerides in adipocytes by inhibiting lipolysis and repressing PGC-1alpha induction
    • Nishino N, Tamori Y, Kasuga M (2007) Insulin efficiently stores triglycerides in adipocytes by inhibiting lipolysis and repressing PGC-1alpha induction. Kobe J Med Sci 53(3):99-106
    • (2007) Kobe J Med Sci , vol.53 , Issue.3 , pp. 99-106
    • Nishino, N.1    Tamori, Y.2    Kasuga, M.3
  • 41
    • 77950484269 scopus 로고    scopus 로고
    • Atg8-family interacting motif crucial for selective autophagy
    • Noda NN, Ohsumi Y, Inagaki F (2010) Atg8-family interacting motif crucial for selective autophagy. FEBS Lett 584(7):1379-1385
    • (2010) FEBS Lett , vol.584 , Issue.7 , pp. 1379-1385
    • Noda, N.N.1    Ohsumi, Y.2    Inagaki, F.3
  • 42
    • 22744449345 scopus 로고    scopus 로고
    • Leptin decreases lipogenic enzyme gene expression through modification of SREBP-1c gene expression in white adipose tissue of aging rats
    • Nogalska A, Sucajtys-Szulc E, Swierczynski J (2005) Leptin decreases lipogenic enzyme gene expression through modification of SREBP-1c gene expression in white adipose tissue of aging rats. Metab Clin Exp 54(8):1041-1047
    • (2005) Metab Clin Exp , vol.54 , Issue.8 , pp. 1041-1047
    • Nogalska, A.1    Sucajtys-Szulc, E.2    Swierczynski, J.3
  • 44
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
    • Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z (2007) Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 26(7):1749-1760
    • (2007) EMBO J , vol.26 , Issue.7 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 47
    • 33646785781 scopus 로고    scopus 로고
    • Regulation of protein synthesis by leucine starvation involves distinct mechanisms in mouse C2C12 myoblasts and myotubes
    • Talvas J, Obled A, Fafournoux P, Mordier S (2006) Regulation of protein synthesis by leucine starvation involves distinct mechanisms in mouse C2C12 myoblasts and myotubes. J Nutr 136(6):1466-1471
    • (2006) J Nutr , vol.136 , Issue.6 , pp. 1466-1471
    • Talvas, J.1    Obled, A.2    Fafournoux, P.3    Mordier, S.4
  • 48
    • 0010386018 scopus 로고
    • Random and food-directed activity in hyperphagic and normal rats
    • Teitelbaum P (1957) Random and food-directed activity in hyperphagic and normal rats. J Comp Physiol Psychol 50(5):486-490
    • (1957) J Comp Physiol Psychol , vol.50 , Issue.5 , pp. 486-490
    • Teitelbaum, P.1
  • 49
    • 0036733453 scopus 로고    scopus 로고
    • Determinants affecting physical activity levels in animal models
    • Tou JC, Wade CE (2002) Determinants affecting physical activity levels in animal models. Exp Biol Med 227(8):587-600
    • (2002) Exp Biol Med , vol.227 , Issue.8 , pp. 587-600
    • Tou, J.C.1    Wade, C.E.2
  • 50
    • 0018367486 scopus 로고
    • Thermoregulation in the diabetic-obese (db/db) mouse the role of non-shivering thermogenesis in energy balance
    • Trayhurn P (1979) Thermoregulation in the diabetic-obese (db/db) mouse. The role of non-shivering thermogenesis in energy balance. Pflugers Arch 380(3):227-232
    • (1979) Pflugers Arch , vol.380 , Issue.3 , pp. 227-232
    • Trayhurn, P.1
  • 51
    • 44349126700 scopus 로고    scopus 로고
    • Cold-induced changes in gene expression in brown adipose tissue: Implications for the activation of thermogenesis
    • Watanabe M, Yamamoto T, Mori C, Okada N, Yamazaki N, Kajimoto K, Kataoka M, Shinohara Y (2008) Cold-induced changes in gene expression in brown adipose tissue: implications for the activation of thermogenesis. Biol Pharm Bull 31(5): 775-784
    • (2008) Biol Pharm Bull , vol.31 , Issue.5 , pp. 775-784
    • Watanabe, M.1    Yamamoto, T.2    Mori, C.3    Okada, N.4    Yamazaki, N.5    Kajimoto, K.6    Kataoka, M.7    Shinohara, Y.8
  • 53
    • 77953914540 scopus 로고    scopus 로고
    • Central amylin acts as an adiposity signal to control body weight and energy expenditure
    • Wielinga PY, Lowenstein C, Muff S, Munz M, Woods SC, Lutz TA (2010) Central amylin acts as an adiposity signal to control body weight and energy expenditure. Physiol Behav 101(1):45-52
    • (2010) Physiol Behav , vol.101 , Issue.1 , pp. 45-52
    • Wielinga, P.Y.1    Lowenstein, C.2    Muff, S.3    Munz, M.4    Woods, S.C.5    Lutz, T.A.6
  • 56
    • 34249680883 scopus 로고    scopus 로고
    • Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms
    • Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH (2007) Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 56(6):1647-1654
    • (2007) Diabetes , vol.56 , Issue.6 , pp. 1647-1654
    • Zhang, Y.1    Guo, K.2    Leblanc, R.E.3    Loh, D.4    Schwartz, G.J.5    Yu, Y.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.