-
1
-
-
66349134748
-
Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL
-
Brown, M. S. & Goldstein, J. L. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. J. Lipid Res. 50 (suppl.), S15-S27 (2009).
-
(2009)
J. Lipid Res.
, vol.50
, Issue.SUPPL.
-
-
Brown, M.S.1
Goldstein, J.L.2
-
2
-
-
64749083589
-
Protein quality control as a strategy for cellular regulation: Lessons from ubiquitin-mediated regulation of the sterol pathway
-
Hampton, R. Y. & Garza, R. M. Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway. Chem. Rev. 109, 1561-1574 (2009).
-
(2009)
Chem. Rev.
, vol.109
, pp. 1561-1574
-
-
Hampton, R.Y.1
Garza, R.M.2
-
3
-
-
56449097008
-
Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast
-
Burg, J. S. et al. Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast. Cell Metab. 8, 522-531 (2008).
-
(2008)
Cell Metab.
, vol.8
, pp. 522-531
-
-
Burg, J.S.1
-
4
-
-
2942677427
-
Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid
-
Loewen, C. J. et al. Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid. Science 304, 1644-1647 (2004).
-
(2004)
Science
, vol.304
, pp. 1644-1647
-
-
Loewen, C.J.1
-
5
-
-
33947279970
-
Regulation of long chain unsaturated fatty acid synthesis in yeast
-
Martin, C. E., Oh, C. S. & Jiang, Y. Regulation of long chain unsaturated fatty acid synthesis in yeast. Biochim. Biophys. Acta 1771, 271-285 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1771
, pp. 271-285
-
-
Martin, C.E.1
Oh, C.S.2
Jiang, Y.3
-
6
-
-
58149308056
-
Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression
-
Kurat, C. F. et al. Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol. Cell 33, 53-63 (2009).
-
(2009)
Mol. Cell
, vol.33
, pp. 53-63
-
-
Kurat, C.F.1
-
7
-
-
33845900676
-
The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy
-
DOI 10.1038/ng1951, PII NG1951
-
Fischer, J. et al. The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Nature Genet. 39, 28-30 (2007). (Pubitemid 46026498)
-
(2007)
Nature Genetics
, vol.39
, Issue.1
, pp. 28-30
-
-
Fischer, J.1
Lefevre, C.2
Morava, E.3
Mussini, J.-M.4
Lafort, P.5
Negre-Salvayre, A.6
Lathrop, M.7
Salvayre, R.8
-
8
-
-
33748309395
-
Functions and metabolism of sphingolipids in Saccharomyces cerevisiae
-
Dickson, R. C., Sumanasekera, C. & Lester, R. L. Functions and metabolism of sphingolipids in Saccharomyces cerevisiae. Prog. Lipid Res. 45, 447-465 (2006).
-
(2006)
Prog. Lipid Res.
, vol.45
, pp. 447-465
-
-
Dickson, R.C.1
Sumanasekera, C.2
Lester, R.L.3
-
9
-
-
33947238877
-
Yeast sphingolipids: Recent developments in understanding biosynthesis, regulation, and function
-
Cowart, L. A. & Obeid, L. M. Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function. Biochim. Biophys. Acta 1771, 421-431 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1771
, pp. 421-431
-
-
Cowart, L.A.1
Obeid, L.M.2
-
10
-
-
0347611095
-
Molecular machinery for non-vesicular trafficking of ceramide
-
Hanada, K. et al. Molecular machinery for non-vesicular trafficking of ceramide. Nature 426, 803-809 (2003).
-
(2003)
Nature
, vol.426
, pp. 803-809
-
-
Hanada, K.1
-
11
-
-
34548498611
-
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide
-
D'Angelo, G. et al. Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature 449, 62-67 (2007).
-
(2007)
Nature
, vol.449
, pp. 62-67
-
-
D'Angelo, G.1
-
12
-
-
34547096008
-
Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT
-
Kumagai, K., Kawano, M., Shinkai-Ouchi, F., Nishijima, M. & Hanada, K. Interorganelle trafficking of ceramide is regulated by phosphorylation- dependent cooperativity between the PH and START domains of CERT. J. Biol. Chem. 282, 17758-17766 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 17758-17766
-
-
Kumagai, K.1
Kawano, M.2
Shinkai-Ouchi, F.3
Nishijima, M.4
Hanada, K.5
-
13
-
-
66149094592
-
Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network
-
Klemm, R. W. et al. Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network. J. Cell Biol. 185, 601-612 (2009).
-
(2009)
J. Cell Biol.
, vol.185
, pp. 601-612
-
-
Klemm, R.W.1
-
14
-
-
38649105202
-
Regulation of ceramide biosynthesis by TOR complex 2
-
Aronova, S. et al. Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab. 7, 148-158 (2008).
-
(2008)
Cell Metab.
, vol.7
, pp. 148-158
-
-
Aronova, S.1
-
15
-
-
67449147119
-
Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER
-
Vacaru, A. M. et al. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. J. Cell Biol. 185, 1013-1027 (2009).
-
(2009)
J. Cell Biol.
, vol.185
, pp. 1013-1027
-
-
Vacaru, A.M.1
-
16
-
-
38549152194
-
Principles of bioactive lipid signalling: Lessons from sphingolipids
-
Hannun, Y. A. & Obeid, L. M. Principles of bioactive lipid signalling: lessons from sphingolipids. Nature Rev. Mol. Cell Biol. 9, 139-150 (2008).
-
(2008)
Nature Rev. Mol. Cell Biol.
, vol.9
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
17
-
-
50949088162
-
Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling
-
Lebman, D. A. & Spiegel, S. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling. J. Lipid Res. 49, 1388-1394 (2008).
-
(2008)
J. Lipid Res.
, vol.49
, pp. 1388-1394
-
-
Lebman, D.A.1
Spiegel, S.2
-
18
-
-
63449135734
-
Status of childhood asthma in the United States
-
Akinbami, L. J., Moorman, J. E., Garbe, P. L. & Sondik, E. J. Status of childhood asthma in the United States, 1980-2007. Pediatrics 123 (suppl. 3), S131-S145 (2009).
-
(2009)
Pediatrics
, vol.123
, Issue.SUPPL. 3
, pp. 1980-2007
-
-
Akinbami, L.J.1
Moorman, J.E.2
Garbe, P.L.3
Sondik, E.J.4
-
19
-
-
40049100646
-
Discovering susceptibility genes for asthma and allergy
-
Vercelli, D. Discovering susceptibility genes for asthma and allergy. Nature Rev. Immunol. 8, 169-182 (2008).
-
(2008)
Nature Rev. Immunol.
, vol.8
, pp. 169-182
-
-
Vercelli, D.1
-
20
-
-
34547216747
-
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
-
Moffatt, M. F. et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 448, 470-473 (2007).
-
(2007)
Nature
, vol.448
, pp. 470-473
-
-
Moffatt, M.F.1
-
21
-
-
44449150336
-
ORMDL3 gene is associated with asthma in three ethnically diverse populations
-
Galanter, J. et al. ORMDL3 gene is associated with asthma in three ethnically diverse populations. Am. J. Respir. Crit. Care Med. 177, 1194-1200 (2008).
-
(2008)
Am. J. Respir. Crit. Care Med.
, vol.177
, pp. 1194-1200
-
-
Galanter, J.1
-
22
-
-
62449114842
-
Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma
-
Wu, H. et al. Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma. Allergy 64, 629-635 (2009).
-
(2009)
Allergy
, vol.64
, pp. 629-635
-
-
Wu, H.1
-
23
-
-
57349101088
-
Effect of 17q21 variants and smoking exposure in early-onset asthma
-
Bouzigon, E. et al. Effect of 17q21 variants and smoking exposure in early-onset asthma. N. Engl. J. Med. 359, 1985-1994 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 1985-1994
-
-
Bouzigon, E.1
-
24
-
-
69449101386
-
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ ORMDL3 locus associated with the risk of asthma and autoimmune disease
-
Verlaan, D. J. et al. Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am. J. Hum. Genet. 85, 377-393 (2009).
-
(2009)
Am. J. Hum. Genet.
, vol.85
, pp. 377-393
-
-
Verlaan, D.J.1
-
25
-
-
41549111983
-
A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications
-
Tavendale, R., Macgregor, D. F., Mukhopadhyay, S. & Palmer, C. N. A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications. J. Allergy Clin. Immunol. 121, 860-863 (2008).
-
(2008)
J. Allergy Clin. Immunol.
, vol.121
, pp. 860-863
-
-
Tavendale, R.1
MacGregor, D.F.2
Mukhopadhyay, S.3
Palmer, C.N.4
-
26
-
-
0036046814
-
ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins
-
doi:10.1186/gb-2002-3-6-research0027
-
Hjelmqvist, L. et al. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol. 3, doi:10.1186/gb-2002-3- 6-research0027 (2002).
-
(2002)
Genome Biol.
, vol.3
-
-
Hjelmqvist, L.1
-
27
-
-
26844489762
-
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile
-
Schuldiner, M. et al. Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123, 507-519 (2005).
-
(2005)
Cell
, vol.123
, pp. 507-519
-
-
Schuldiner, M.1
-
28
-
-
0037680229
-
Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism
-
Hanada, K. Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim. Biophys. Acta 1632, 16-30 (2003).
-
(2003)
Biochim. Biophys. Acta
, vol.1632
, pp. 16-30
-
-
Hanada, K.1
-
29
-
-
0032515061
-
21-sensitive csg2D mutant
-
21-sensitive csg2D mutant. J. Biol. Chem. 273, 30688-30694 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 30688-30694
-
-
Beeler, T.1
-
30
-
-
60549111243
-
Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry
-
Ejsing, C. S. et al. Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry. Proc. Natl Acad. Sci. USA 106, 2136-2141 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 2136-2141
-
-
Ejsing, C.S.1
-
31
-
-
33845346791
-
Inhibitors of sphingolipid metabolism enzymes
-
Delgado, A., Casas, J., Llebaria, A., Abad, J. L. & Fabrias, G. Inhibitors of sphingolipid metabolism enzymes. Biochim. Biophys. Acta 1758, 1957-1977 (2006).
-
(2006)
Biochim. Biophys. Acta 1758
, pp. 1957-1977
-
-
Delgado, A.1
Casas, J.2
Llebaria, A.3
Abad, J.L.4
Fabrias, G.5
-
32
-
-
33947199781
-
Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae
-
DOI 10.1016/j.bbalip.2007.01.015, PII S1388198107000285, Regulation of Lipid Metabolism in Yeast
-
Strahl, T. & Thorner, J. Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae. Biochim. Biophys. Acta 1771, 353-404 (2007). (Pubitemid 46428617)
-
(2007)
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
, vol.1771
, Issue.3
, pp. 353-404
-
-
Strahl, T.1
Thorner, J.2
-
33
-
-
65549133823
-
Modulation of sphingolipid metabolism by the phosphatidylinositol-4- phosphate phosphatase Sac1p through regulation of phosphatidylinositol in Saccharomyces cerevisiae
-
Brice, S. E., Alford, C. W. & Cowart, L. A. Modulation of sphingolipid metabolism by the phosphatidylinositol-4-phosphate phosphatase Sac1p through regulation of phosphatidylinositol in Saccharomyces cerevisiae. J. Biol. Chem. 284, 7588-7596 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 7588-7596
-
-
Brice, S.E.1
Alford, C.W.2
Cowart, L.A.3
-
34
-
-
0030952220
-
Essential role for diacylglycerol in protein transport from the yeast Golgi complex
-
Kearns, B. G. et al. Essential role for diacylglycerol in protein transport from the yeast Golgi complex. Nature 387, 101-105 (1997).
-
(1997)
Nature
, vol.387
, pp. 101-105
-
-
Kearns, B.G.1
-
35
-
-
33645714857
-
Phosphate-binding tag, a new tool to visualize phosphorylated proteins
-
Kinoshita, E., Kinoshita-Kikuta, E., Takiyama, K. & Koike, T. Phosphate-binding tag, a new tool to visualize phosphorylated proteins. Mol. Cell. Proteomics 5, 749-757 (2006).
-
(2006)
Mol. Cell. Proteomics
, vol.5
, pp. 749-757
-
-
Kinoshita, E.1
Kinoshita-Kikuta, E.2
Takiyama, K.3
Koike, T.4
-
36
-
-
33746506061
-
The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation
-
Tabuchi, M., Audhya, A., Parsons, A. B., Boone, C. & Emr, S. D. The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Mol. Cell. Biol. 26, 5861-5875 (2006).
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 5861-5875
-
-
Tabuchi, M.1
Audhya, A.2
Parsons, A.B.3
Boone, C.4
Emr, S.D.5
-
37
-
-
57449094809
-
SAC1 lipid phosphatase and growth control of the secretory pathway
-
Blagoveshchenskaya, A. & Mayinger, P. SAC1 lipid phosphatase and growth control of the secretory pathway. Mol. Biosyst. 5, 36-42 (2009).
-
(2009)
Mol. Biosyst.
, vol.5
, pp. 36-42
-
-
Blagoveshchenskaya, A.1
Mayinger, P.2
-
38
-
-
34347206332
-
Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?
-
Hornemann, T., Wei, Y. & von Eckardstein, A. Is the mammalian serine palmitoyltransferase a high-molecular-mass complex? Biochem. J. 405, 157-164 (2007).
-
(2007)
Biochem. J.
, vol.405
, pp. 157-164
-
-
Hornemann, T.1
Wei, Y.2
Von Eckardstein, A.3
-
39
-
-
52949108813
-
The alliance of sphingosine-1-phosphate and its receptors in immunity
-
Rivera, J., Proia, R. L. & Olivera, A. The alliance of sphingosine-1-phosphate and its receptors in immunity. Nature Rev. Immunol. 8, 753-763 (2008).
-
(2008)
Nature Rev. Immunol.
, vol.8
, pp. 753-763
-
-
Rivera, J.1
Proia, R.L.2
Olivera, A.3
-
40
-
-
0035348292
-
Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma
-
Ammit, A. J. et al. Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. FASEB J. 15, 1212-1214 (2001).
-
(2001)
FASEB J.
, vol.15
, pp. 1212-1214
-
-
Ammit, A.J.1
-
41
-
-
38749119748
-
Ceramide: A key signaling molecule in a guinea pig model of allergic asthmatic response and airway inflammation
-
Masini, E. et al. Ceramide: a key signaling molecule in a guinea pig model of allergic asthmatic response and airway inflammation. J. Pharmacol. Exp. Ther. 324, 548-557 (2008).
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.324
, pp. 548-557
-
-
Masini, E.1
-
42
-
-
43049137359
-
The role of sphingosine-1-phosphate and its receptors in asthma
-
Ryan, J. J. & Spiegel, S. The role of sphingosine-1-phosphate and its receptors in asthma. Drug News Perspect. 21, 89-96 (2008).
-
(2008)
Drug News Perspect.
, vol.21
, pp. 89-96
-
-
Ryan, J.J.1
Spiegel, S.2
-
43
-
-
33750589822
-
Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function
-
Idzko, M. et al. Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. J. Clin. Invest. 116, 2935-2944 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2935-2944
-
-
Idzko, M.1
-
44
-
-
48349136889
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett, J. C. et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nature Genet. 40, 955-962 (2008).
-
(2008)
Nature Genet.
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
-
45
-
-
67349199566
-
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
-
Barrett, J. C. et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature Genet. 41, 703-707 (2009).
-
(2009)
Nature Genet.
, vol.41
, pp. 703-707
-
-
Barrett, J.C.1
-
46
-
-
67149095289
-
Primary biliary cirrhosis associated with HLA IL12A, and IL12RB2 variants
-
Hirschfield, G. M. et al. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. N. Engl. J. Med. 360, 2544-2555 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 2544-2555
-
-
Hirschfield, G.M.1
|